Programmed Cell Death in Neurodevelopment
Open accessAbstract
Programmed cell death (PCD) is an evolutionarily conserved contributor to nervous system development. In the vertebrate peripheral nervous system, PCD is the basis of the neurotrophic theory, whereby cell death results from a surplus of neurons relative to target and competition for neurotrophic factors. In addition to stochastic cell death, PCD can be intrinsically determined by cell lineage or position and timing in both invertebrate and vertebrate central nervous systems. The underlying PCD molecular mechanisms include intrinsic transcription factor cascades and regulators of competence/susceptibility to cell death. Here, we provide a framework for understanding neural PCD from its regulation to its functions.
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In neurons, ribosomes and mRNA hitch a ride along lysosomes for anterograde trafficking.
“Additionally, in neurons, ribosomes and mRNA hitch a ride along lysosomes for anterograde trafficking.163”
From The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases (2025) · cites this paper as [163]
The supplied passage on neuronal projections and caspase activity (labeled Abstract; page unavailable) discusses axonal degeneration and pruning, not transport of ribosomes or mRNA. Searches for lysosomes, ribosomes, mRNA, and anterograde transport found no passage in our copy addressing the claimed trafficking mechanism. (LLM, conf=0.76)
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- Authors
- Yamaguchi, Y., & Miura, M.
- Affiliations
- Japan Science and Technology Agency (JP)
- Corresponding author
- Yamaguchi, Yoshifumi
- Miura, Masayuki
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 32
- Issue
- 4
- Pages
- 478-490
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1992517146
- Cited by
- 258
- References
- 7
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 26 · 2023: 28 · 2022: 24 · 2021: 36 · 2020: 31 · 2019: 24 · 2018: 22 · 2017: 12 · 2016: 15 · 2015: 4
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- programmed cell death, brain development, peripheral nervous system, central nervous system, transcription factor cascade, neurotrophic factors
- MeSH terms
- Animals, Central Nervous System, Humans, Nerve Growth Factors, Neurons, Signal Transduction, Apoptosis, Cell Lineage
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