Cited by 32Neurobiology and Insect Physiology ResearchGenetics, Aging, and Longevity in Model OrganismsOlfactory and Sensory Function Studies

Caspase inhibition in select olfactory neurons restores innate attraction behavior in aged Drosophila

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Chihara, Takahiro, Kitabayashi, Aki, Morimoto, Michie, Takeuchi, Ken-ichi, Masuyama, Kaoru, Tonoki, Ayako, Davis, Ronald L., Wang, Jing W. +1 more·2014·PLoS Genetics

Abstract

Sensory and cognitive performance decline with age. Neural dysfunction caused by nerve death in senile dementia and neurodegenerative disease has been intensively studied; however, functional changes in neural circuits during the normal aging process are not well understood. Caspases are key regulators of cell death, a hallmark of age-related neurodegeneration. Using a genetic probe for caspase-3-like activity (DEVDase activity), we have mapped age-dependent neuronal changes in the adult brain throughout the lifespan of Drosophila. Spatio-temporally restricted caspase activation was observed in the antennal lobe and ellipsoid body, brain structures required for olfaction and visual place memory, respectively. We also found that caspase was activated in an age-dependent manner in specific subsets of Drosophila olfactory receptor neurons (ORNs), Or42b and Or92a neurons. These neurons are essential for mediating innate attraction to food-related odors. Furthermore, age-induced impairments of neural transmission and attraction behavior could be reversed by specific inhibition of caspase in these ORNs, indicating that caspase activation in Or42b and Or92a neurons is responsible for altering animal behavior during normal aging.

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  • A transgenic reporter for caspase-3 activity was activated during aging in a subset of nervous tissue cell types, including the ellipsoid body, the antennal lobe and a sub-set of olfactory receptor neurons.

    “However, a transgenic reporter for caspase-3 activity was activated during aging in a subset of nervous tissue cell types, including the ellipsoid body that functions in visual memory, and the antennal lobe and a sub-set of olfactory receptor neurons involved in olfaction(Chihara et al., 2014).”

    From Programmed cell death in aging (2015) · cites this paper as Chihara et al., 2014

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Authors
Chihara, T., Kitabayashi, A., Morimoto, M., Takeuchi, K.-I., Masuyama, K., Tonoki, A., Davis, R. L., Wang, J. W., & Miura, M.
Affiliations
  • Japan Science and Technology Agency (JP)
  • The University of Tokyo (JP)
  • University of California San Diego (US)
  • Scripps Research Institute (US)
Corresponding author
  • Chihara, Takahiro
  • Miura, Masayuki
Venue
PLoS Genetics
Published
2014-06-26
Volume
10
Issue
6
Pages
e1004437
ISSN
  • 1553-7390 (ISSN-L)
  • 1553-7404
OpenAlex
W2062917376
Cited by
29
References
45
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 5 · 2015: 4
FWCI
1.52
Type
journal article
Language
en
Open access
Locations
  • PLoS Genetics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
  • Hiroshima University Institutional Repository (submittedVersion, other-oa)
  • Hiroshima University Acedemic Information Repository (Hiroshima University) (submittedVersion, cc-by)
Funders
  • Uehara Memorial Foundation
  • Ministry of Education, Culture, Sports, Science and Technology
  • National Institutes of Health (NS19904)
  • Japan Society for the Promotion of Science (26115505)
  • National Institute on Deafness and Other Communication Disorders (R01DC009597)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK092640, R01DK092640)
  • National Institute of Neurological Disorders and Stroke (2R37NS19904-30, R37NS019904)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords
caspase inhibition, caspase-3, olfactory sensory neurons, aging, Drosophila, food odor, antennal lobe, ellipsoid body, age-related neurodegeneration, neural transmission, olfaction
MeSH terms
Aging, Animals, Behavior, Animal, Brain Mapping, Chemotaxis, Dendrites, Drosophila melanogaster, Synaptic Transmission, Smell, Apoptosis, Olfactory Receptor Neurons, Receptors, Odorant, Malus, Drosophila Proteins, Animals, Genetically Modified, Caspase 3

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