Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics
Open accessAbstract
Fatty acids (FAs) provide cellular energy under starvation, yet how they mobilize and move into mitochondria in starved cells, driving oxidative respiration, is unclear. Here, we clarify this process by visualizing FA trafficking with a fluorescent FA probe. The labeled FA accumulated in lipid droplets (LDs) in well-fed cells but moved from LDs into mitochondria when cells were starved. Autophagy in starved cells replenished LDs with FAs, increasing LD number over time. Cytoplasmic lipases removed FAs from LDs, enabling their transfer into mitochondria. This required mitochondria to be highly fused and localized near LDs. When mitochondrial fusion was prevented in starved cells, FAs neither homogeneously distributed within mitochondria nor became efficiently metabolized. Instead, FAs reassociated with LDs and fluxed into neighboring cells. Thus, FAs engage in complex trafficking itineraries regulated by cytoplasmic lipases, autophagy, and mitochondrial fusion dynamics, ensuring maximum oxidative metabolism and avoidance of FA toxicity in starved cells.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mitochondrial fission products are less efficient in distributing and oxidizing fatty acids compared to fused, tubular mitochondria.
“which are less efficient in distributing and oxidizing FAs compared to fused, tubular mitochondria (Rambold et al., 2015).”
From ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism (2021) · cites this paper as Rambold et al., 2015
In GRN−/− mice, neuroinflammation is most pronounced in the thalamus.
“This is of particular interest because it has been shown that in GRN−/− mice, neuroinflammation is most pronounced in the thalamus40.”
From Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain (2020) · cites this paper as [40]
The Results passages concern fatty-acid trafficking in starved cells and mitochondrial-fusion-deficient cells, not neuroinflammation in GRN−/− mice. Searches for GRN−/− mice, thalamus, and progranulin-related neuroinflammation found no passage addressing the claim; page numbers were unavailable. (LLM, conf=0.78)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cellular Fatty Acid Metabolism and Cancer
Currie, E., Schulze, A., Zechner, R., Walther, T. C., & Farese, R. V. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.017 · Cited by 2,123 · see citing works
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
Gomes, L. C., Benedetto, G. D., & Scorrano, L. (2011) · Nature Cell Biology · doi:10.1038/ncb2220 · Cited by 1,735 · see citing works
OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
Frezza, C., Cipolat, S., Martins de Brito, O., Micaroni, M., Beznoussenko, G. V., Rudka, T., Bartoli, D., Polishuck, R. S., Danial, N. N., De Strooper, B., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.025 · Cited by 1,673 · see citing works
Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction
Chen, H., Chomyn, A., & Chan, D. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503062200 · Cited by 1,376 · cited 3× · see citing works
“Mfn1KO cells were used as a primary model since, unlike Opa1KO and Mfn1/2KO MEFs (Chen et al., 2005; Cogliati et al., 2013; Frezza et al., 2006) (Figure S5A), their respiration levels under fed conditions (Figures 5E and 5F) and mitophagy levels under starvation conditions (Figure S5B) were…”
BackgroundMethodResultAutophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase
Ouimet, M., Franklin, V., Mak, E., Liao, X., Tabas, I., & Marcel, Y. L. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.023 · Cited by 774 · see citing works
Kim, K. H., Jeong, Y. T., Oh, H., Kim, S. H., Cho, J. M., Kim, Y.-N., Kim, S. S., Kim, D. H., Hur, K. Y., Kim, H. K., et al. (2013) · Nature Medicine · doi:10.1038/nm.3014 · Cited by 774 · see citing works
Tarnopolsky, M. A., Rennie, C. D., Robertshaw, H. A., Fedak-Tarnopolsky, S. N., Devries, M. C., & Hamadeh, M. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00472.2006 · Cited by 457 · see citing works
AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity.
O’Neill, H. M., Holloway, G. P., & Steinberg, G. R. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.019 · Cited by 364 · see citing works
Dietrich, M. O., Liu, Z.-W., & Horvath, T. L. (2013) · Cell · doi:10.1016/j.cell.2013.09.004 · Cited by 306 · see citing works
Mitochondrial fusion is frequent in skeletal muscle and supports excitation–contraction coupling
Eisner, V., Lenaers, G., & Hajnóczky, G. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201312066 · Cited by 177 · see citing works
Flagged first, then by citations
Research works printed but not linked: 58
- Axe EL Walker SA Manifava M Chandra P Roderick HL Habermann A Griffiths G Ktistakis NT 2008 Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum The Journal of cell biology 182 685 701 18725538 PMC2518708
- Bjorkoy G Lamark T Brech A Outzen H Perander M Overvatn A Stenmark H Johansen T 2005 p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death The Journal of cell biology 171 603 614 16286508 PMC2171557
- Calder PC 2013 Long chain fatty acids and gene expression in inflammation and immunity Current opinion in clinical nutrition and metabolic care 16 425 433 23657154
- Cabodevilla AG Sanchez-Caballero L Nintou E Boiadijieva VG Picatoste F Gubern A Claro E 2013 Cell survival during complete nutrient deprivation depends on lipid droplet-fueled b-oxidation of fatty acids The Journal of biological chemistry 288 27777 27788 23940052 PMC3784694
- Cogliati S Frezza C Soriano ME Varanita T Quintana-Cabrera R Corrado M Cipolat S Costa V Casarin A Gomes LC Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency Cell 155 160 171 24055366 PMC3790458
- Dalen KT Dahl T Holter E Arntsen B Londos C Sztalryd C Nebb HI 2007 LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues Biochim Biophys Acta 1771 210 227 17234449
- Dupont N Chauhan S Arko-Mensah J Castillo EF Masedunskas A Weigert R Robenek H Proikas-Cezanne T Deretic V 2014 Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis Current biology: CB 24 609 620 24613307 PMC4016984
- Eaton S 2002 Control of mitochondrial beta-oxidation flux Prog Lipid Res 41 197 239 11814524
- Eaton S Pourfarzam M Bartlett K 1996 The effect of respiratory chain impairment of beta-oxidation in rat heart mitochondria Biochem J 319 Pt 2 633 640 8912705 PMC1217814
- Finn PF Dice JF 2006 Proteolytic and lipolytic responses to starvation Nutrition 22 830 844 16815497
- Fritz IB Davis DG Holtrop RH Dundee H 1958 Fatty acid oxidation by skeletal muscle during rest and activity The American journal of physiology 194 379 386 13559483
- Furuhashi M Hotamisligil GS 2008 Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets Nature reviews Drug discovery 7 489 503 PMC2821027 18511927
- Galloway CA Yoon Y 2012 Perspectives on: SGP symposium on mitochondrial physiology and medicine: what comes first, misshape or dysfunction? The view from metabolic excess J Gen Physiol 139 455 463 22641640 PMC3362522
- Galloway CA Yoon Y 2013 Mitochondrial morphology in metabolic diseases Antioxidants & redox signaling 19 415 430 22793999 PMC3700066
- Granneman JG Moore HP Mottillo EP Zhu Z Zou L 2011 Interactions of perilipin-5 (Plin5) with adipose triglyceride lipase The Journal o fbiological chemistry 286 5126 5135 PMC3037624 21148142
- Grynberg A Demaison L 1996 Fatty acid oxidation in the heart Journal of cardiovascular pharmacology 28 Suppl 1 S11 17 8891866
- Haemmerle G Moustafa T Woelkart G Buttner S Schmidt A van de Weijer T Hesselink M Jaeger D Kienesberger PC Zierler K 2011 ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-alpha and PGC-1 Nature medicine 17 1076 1085 PMC3244833 21857651
- Hayashi-Nishino M Fujita N Noda T Yamaguchi A Yoshimori T Yamamoto A 2009 A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation Nat Cell Biol 11 1433 1437 19898463
- Herms A Bosch M Ariotti N Reddy BJ Fajardo A Fernandez-Vidal A Alvarez-Guaita A Fernandez-Rojo MA Rentero C Tebar F Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity Current biology: CB 23 1489 1496 23871243 PMC3746173
- Hoppins S Lackner L Nunnari J 2007 The machines that divide and fuse mitochondria Annual review of biochemistry 76 751 780 17362197
- Hoppins S Nunnari J 2009 The molecular mechanism of mitochondrial fusion Biochim Biophys Acta 1793 20 26 18691613
- Jagerstrom S Polesie S Wickstrom Y Johansson BR Schroder HD Hojlund K Bostrom P 2009 Lipid droplets interact with mitochondria using SNAP23 Cell Biol Int 33 934 940 19524684
- Kassan A Herms A Fernandez-Vidal A Bosch M Schieber NL Reddy BJ Fajardo A Gelabert-Baldrich M Tebar F Enrich C 2013 Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains The Journal of cell biology 203 985 1001 24368806 PMC3871434
- Kerner J Hoppel C 2000 Fatty acid import into mitochondria Biochim Biophys Acta 1486 1 17 10856709
- Krahmer N Farese RV Jr Walther TC Balancing the fat: lipid droplets and human disease EMBO Mol Med 5 905 915 23740690 PMC3721468
- Kristensen AR Schandorff S Hoyer-Hansen M Nielsen MO Jaattela M Dengjel J Andersen JS 2008 Ordered organelle degradation during starvation-induced autophagy Molecular & cellular proteomics: MCP 7 2419 2428 18687634
- Kuma A Hatano M Matsui M Yamamoto A Nakaya H Yoshimori T Ohsumi Y Tokuhisa T Mizushima N 2004 The role of autophagy during the early neonatal starvation period Nature 432 1032 1036 15525940
- Mitra K Wunder C Roysam B Lin G Lippincott-Schwartz J 2009 A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase Proc Natl Acad Sci U S A 106 11960 11965 19617534 PMC2710990
- Mizushima N 2007 Autophagy: process and function Genes Dev 21 2861 2873 18006683
- Mizushima N Yamamoto A Hatano M Kobayashi Y Kabeya Y Suzuki K Tokuhisa T Ohsumi Y Yoshimori T 2001 Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells The Journal of cell biology 152 657 668 11266458 PMC2195787
- Nada MA Rhead WJ Sprecher H Schulz H Roe CR 1995 Evidence for intermediate channeling in mitochondrial beta-oxidation The Journal of biological chemistry 270 530 535 7822275
- Peterson TR Sengupta SS Harris TE Carmack AE Kang SA Balderas E Guertin DA Madden KL Carpenter AE Finck BN 2011 mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway Cell 146 408 420 21816276 PMC3336367
- Rambold AS Kostelecky B Elia N Lippincott-Schwartz J Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation Proc Natl Acad Sci U S A 108 10190 10195 21646527 PMC3121813
- Schaefer J Pourfarzam M Bartlett K Jackson S Turnbull DM 1995 Fatty acid oxidation in peripheral blood cells: characterization and use for the diagnosis of defects of fatty acid oxidation Pediatr Res 37 354 360 7784145
- Schulze RJ Weller SG Schroeder B Krueger EW Chi S Casey CA McNiven MA 2013 Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes The Journal of cell biology 203 315 326 24145164 PMC3812963
- Shaw CS Jones DA Wagenmakers AJ 2008 Network distribution of mitochondria and lipid droplets in human muscle fibres Histochem Cell Biol 129 65 72 17938948
- Shibata M Yoshimura K Furuya N Koike M Ueno T Komatsu M Arai H Tanaka K Kominami E Uchiyama Y 2009 The MAP1-LC3 conjugation system is involved in lipid droplet formation Biochem Biophys Res Commun 382 419 423 19285958
- Shibata M Yoshimura K Tamura H Ueno T Nishimura T Inoue T Sasaki M Koike M Arai H Kominami E LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation Biochem Biophys Res Commun 393 274 279 20132792
- Singh R Kaushik S Wang Y Xiang Y Novak I Komatsu M Tanaka K Cuervo AM Czaja MJ 2009a Autophagy regulates lipid metabolism Nature 458 1131 1135 19339967 PMC2676208
- Singh R Xiang Y Wang Y Baikati K Cuervo AM Luu YK Tang Y Pessin JE Schwartz GJ Czaja MJ 2009b Autophagy regulates adipose mass and differentiation in mice J Clin Invest 119 3329 3339 19855132 PMC2769174
- Smirnova E Goldberg EB Makarova KS Lin L Brown WJ Jackson CL 2006 ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells EMBO reports 7 106 113 16239926 PMC1369222
- Sturmey RG O’Toole PJ Leese HJ 2006 Fluorescence resonance energy transfer analysis of mitochondrial:lipid association in the porcine oocyte Reproduction 132 829 837 17127743
- Thumser AE Storch J 2007 Characterization of a BODIPY-labeled fluorescent fatty acid analogue. Binding to fatty acid-binding proteins, intracellular localization, and metabolism Molecular and cellular biochemistry 299 67 73 16645726
- Tondera D Grandemange S Jourdain A Karbowski M Mattenberger Y Herzig S Da Cruz S Clerc P Raschke I Merkwirth C 2009 SLP-2 is required for stress-induced mitochondrial hyperfusion Embo J 28 1589 1600 19360003 PMC2693158
- Unger RH Clark GO Scherer PE Orci L Lipid homeostasis, lipotoxicity and the metabolic syndrome Biochim Biophys Acta 1801 209 214 19948243
- Valetti C Wetzel DM Schrader M Hasbani MJ Gill SR Kreis TE Schroer TA 1999 Role of dynactin in endocytic traffic: effects of dynamitin overexpression and colocalization with CLIP-170 Mol Biol Cell 10 4107 4120 10588646 PMC25746
- Vock R Hoppeler H Claassen H Wu DX Billeter R Weber JM Taylor CR Weibel ER 1996 Design of the oxygen and substrate pathways. VI. structural basis of intracellular substrate supply to mitochondria in muscle cells J Exp Biol 199 1689 1697 8708576
- Wahli W Michalik L 2012 PPARs at the crossroads of lipid signaling and inflammation Trends in endocrinology and metabolism: TEM 23 351 363 22704720
- Walther TC Farese RV Jr Lipid droplets and cellular lipid metabolism Annual review of biochemistry 81 687 714 PMC3767414 22524315
- Wang H Sreenivasan U Hu H Saladino A Polster BM Lund LM Gong DW Stanley WC Sztalryd C Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria Journal of lipid research 52 2159 2168 21885430 PMC3220284
- Wang H Sreenivasan U Hu H Saladino A Polster BM Lund LM Gong DW Stanley WC Sztalryd C 2011 Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria Journal of lipid research 52 2159 2168 21885430 PMC3220284
- Wang S Soni KG Semache M Casavant S Fortier M Pan L Mitchell GA 2008 Lipolysis and the integrated physiology of lipid energy metabolism Mol Genet Metab 95 117 126 18762440
- Watmough NJ Bhuiyan AK Bartlett K Sherratt HS Turnbull DM 1988 Skeletal muscle mitochondrial beta-oxidation. A study of the products of oxidation of [U-14C]hexadecanoate by h.p.l.c. using continuous on-line radiochemical detection Biochem J 253 541 547 3178728 PMC1149331
- Welte MA Cermelli S Griner J Viera A Guo Y Kim DH Gindhart JG Gross SP 2005 Regulation of lipid-droplet transport by the perilipin homolog LSD2 Current biology: CB 15 1266 1275 16051169
- Wolins NE Quaynor BK Skinner JR Tzekov A Corce MA Gropler MC Yamaguchi T Matsushita S Motojima K Hirose F Osumi T 2006 MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha The Journal of biological chemistry 281 14232 14240 16571721
- Yla-Anttila P Vihinen H Jokitalo E Eskelinen EL 2009 3D tomography reveals connections between the phagophore and endoplasmic reticulum Autophagy 5 1180 1185 19855179
- Yoon Y Galloway CA Jhun BS Yu T 2011 Mitochondrial dynamics in diabetes Antioxidants & redox signaling 14 439 457 20518704 PMC3025181
- Zechner R Zimmermann R Eichmann TO Kohlwein SD Haemmerle G Lass A Madeo F 2012 FAT SIGNALS–lipases and lipolysis in lipid metabolism and signaling Cell metabolism 15 279 291 22405066 PMC3314979
Cited by
Sorted by citations
Mechanisms, regulation and functions of the unfolded protein response
Hetz, C., Zhang, K., & Kaufman, R. J. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0250-z · Cited by 2,666 · see citing works
Marschallinger, J., Iram, T., Zardeneta, M., Lee, S. E., Lehallier, B., Haney, M. S., Pluvinage, J. V., Mathur, V., Hahn, O., Morgens, D. W., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0566-1 · Cited by 1,384 · see citing works
AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
Toyama, E. Q., Herzig, S., Courchet, J., Lewis, T. L., Losón, O. C., Hellberg, K., Young, N. P., Chen, H., Polleux, F., Chan, D. C., et al. (2016) · Science · doi:10.1126/science.aab4138 · Cited by 1,085 · see citing works
Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity
Ioannou, M. S., Jackson, J., Sheu, S.-H., Chang, C.-L., Weigel, A. V., Liu, H., Pasolli, H. A., Xu, C. S., Pang, S., Matthies, D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.001 · Cited by 760 · see citing works
Self-citationMitochondrial dynamics in adaptive and maladaptive cellular stress responses
Eisner, V., Picard, M., & Hajnóczky, G. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0133-0 · Cited by 622 · see citing works
Diverse Cellular Roles of Autophagy
Morishita, H., & Mizushima, N. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100818-125300 · Cited by 376 · see citing works
ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism
Qi, G., Mi, Y., Shi, X., Gu, H., Brinton, R. D., & Yin, F. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108572 · Cited by 379 · see citing works
Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling
Weir, H. J., Yao, P., Huynh, F. K., Escoubas, C. C., Goncalves, R. L., Burkewitz, K., Laboy, R., Hirschey, M. D., & Mair, W. B. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.024 · Cited by 372 · see citing works
Targeting autophagy in obesity: from pathophysiology to management
Zhang, Y., Sowers, J. R., & Ren, J. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0009-1 · Cited by 338 · see citing works
A Stromal Lysolipid–Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression
Auciello, F. R., Bulusu, V., Oon, C., Tait-Mulder, J., Berry, M., Bhattacharyya, S., Tumanov, S., Allen-Petersen, B. L., Link, J., Kendsersky, N. D., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1212 · Cited by 332 · see citing works
Lipid droplets in the nervous system
Ralhan, I., Chang, C.-L., Lippincott-Schwartz, J., & Ioannou, M. S. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202102136 · Cited by 281 · see citing works
Self-citationClement, E., Lazar, I., Attané, C., Carrié, L., Dauvillier, S., Ducoux‐Petit, M., Esteve, D., Menneteau, T., Moutahir, M., Le Gonidec, S., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019102525 · Cited by 240 · see citing works
A new perspective on lipid research in age-related macular degeneration
van Leeuwen, E. M., Emri, E., Merle, B. M. J., Colijn, J. M., Kersten, E., Cougnard-Gregoire, A., Dammeier, S., Meester-Smoor, M., Pool, F. M., de Jong, E. K., et al. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.04.006 · Cited by 247 · see citing works
Integrative metabolism in MASLD and MASH: Pathophysiology and emerging mechanisms
Steinberg, G. R., Valvano, C. M., De Nardo, W., & Watt, M. J. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.02.033 · Cited by 240 · see citing works
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy
Chen, Z.-P., Wang, S., Zhao, X., Fang, W., Wang, Z., Ye, H., Wang, M.-J., Ke, L., Huang, T., Lv, P., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01288-6 · Cited by 214 · see citing works
Organelle-Specific Initiation of Autophagy
Sica, V., Galluzzi, L., Bravo-San Pedro, J. M., Izzo, V., Maiuri, M. C., & Kroemer, G. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.021 · Cited by 205 · see citing works
Kim, S. M., Nguyen, T. T., Ravi, A., Kubiniok, P., Finicle, B. T., Jayashankar, V., Malacrida, L., Hou, J., Robertson, J., Gao, D., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1215 · Cited by 199 · see citing works
Autophagy regulates lipid metabolism through selective turnover of NCoR1
Saito, T., Kuma, A., Sugiura, Y., Ichimura, Y., Obata, M., Kitamura, H., Okuda, S., Lee, H.-C., Ikeda, K., Kanegae, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08829-3 · Cited by 193 · see citing works
Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases
Yang, D., Wang, X., Zhang, L., Fang, Y., Zheng, Q., Liu, X., Yu, W., Chen, S., Ying, J., & Hua, F. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00828-0 · Cited by 179 · see citing works
Pernas, L., Bean, C., Boothroyd, J. C., & Scorrano, L. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.018 · Cited by 144 · see citing works
Adipose tissue hyperplasia and hypertrophy in common and syndromic obesity-the case of BBS obesity
Horwitz, A., & Birk, R. (2023) · Nutrients · doi:10.3390/nu15153445 · Cited by 143 · see citing works
Iershov, A., Nemazanyy, I., Alkhoury, C., Girard, M., Barth, E., Cagnard, N., Montagner, A., Chretien, D., Rugarli, E. I., Guillou, H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09598-9 · Cited by 109 · see citing works
Han, X., Zhu, J., Zhang, X., Song, Q., Ding, J., Lu, M., Sun, S., & Hu, G. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00397 · Cited by 91 · see citing works
Lipid Droplets Mediate Salt Stress Tolerance in <i>Parachlorella kessleri</i> 1
You, Z., Zhang, Q., Peng, Z., & Miao, X. (2019) · Plant Physiology · doi:10.1104/pp.19.00666 · Cited by 87 · see citing works
Functional multi-organelle units control inflammatory lipid metabolism of macrophages
Zimmermann, J. A., Lucht, K., Stecher, M., Badhan, C., Glaser, K. M., Epple, M. W., Koch, L. R., Deboutte, W., Manke, T., Ebnet, K., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01457-0 · Cited by 79 · see citing works
Self-citationMetabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells
Matsuda, J., Takahashi, A., Takabatake, Y., Sakai, S., Minami, S., Yamamoto, T., Fujimura, R., Namba-Hamano, T., Yonishi, H., Nakamura, J., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1712107 · Cited by 44 · see citing works
Koh, H. E., Nielsen, J., Saltin, B., Holmberg, H., & Ørtenblad, N. (2017) · The Journal of Physiology · doi:10.1113/jp274462 · Cited by 38 · see citing works
Gotvaldová, K., Špačková, J., Novotný, J., Baslarová, K., Ježek, P., Rossmeislová, L., Gojda, J., & Smolková, K. (2024) · Cancer & Metabolism · doi:10.1186/s40170-024-00335-5 · Cited by 27 · see citing works
Demine, S., Tejerina, S., Bihin, B., Thiry, M., Reddy, N., Renard, P., Raes, M., Jadot, M., & Arnould, T. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25994 · Cited by 21 · see citing works
Cuní-López, C., Root, J. T., Hao, Y., Blomberg, N., Koppes-den Hertog, S. J., Sacks, D., Trujillo, A. E., Ghirlando, R., Kowal, I., Epstein, J., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-76565-6
- Authors
- Rambold, A. S., Cohen, S., & Lippincott-Schwartz, J.
- Affiliations
- National Institutes of Health (US)
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 32
- Issue
- 6
- Pages
- 678-692
- ISSN
- 1534-5807 (ISSN-L)
- PMC
- PMC4375018
- OpenAlex
- W2035310767
- Cited by
- 1,038
- References
- 10
- Citations by year
- 2026: 98 · 2025: 113 · 2024: 112 · 2023: 128 · 2022: 92 · 2021: 104 · 2020: 101 · 2019: 83 · 2018: 78 · 2017: 57 · 2016: 45 · 2015: 25
- FWCI
- 34.15
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-05-26)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (Z01HD001609)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- fatty acid trafficking, starvation, lipid droplets, autophagy, mitochondrial fusion, fatty acid metabolism, oxidative respiration
- MeSH terms
- Animals, Autophagy, Biological Transport, Cell Line, Fatty Acids, Fibroblasts, Fluorescent Dyes, Lipase, Lipolysis, Mitochondria, Oxidation-Reduction, Respiration, Starvation, Lipid Metabolism, Mice, Mitochondrial Dynamics, Lipid Droplets
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
