The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis
Open accessAbstract
Naive pluripotency is manifest in the preimplantation mammalian embryo. Here we determine transcriptome dynamics of mouse development from the eight-cell stage to postimplantation using lineage-specific RNA sequencing. This method combines high sensitivity and reporter-based fate assignment to acquire the full spectrum of gene expression from discrete embryonic cell types. We define expression modules indicative of developmental state and temporal regulatory patterns marking the establishment and dissolution of naive pluripotency in vivo. Analysis of embryonic stem cells and diapaused embryos reveals near-complete conservation of the core transcriptional circuitry operative in the preimplantation epiblast. Comparison to inner cell masses of marmoset primate blastocysts identifies a similar complement of pluripotency factors but use of alternative signaling pathways. Embryo culture experiments further indicate that marmoset embryos utilize WNT signaling during early lineage segregation, unlike rodents. These findings support a conserved transcription factor foundation for naive pluripotency while revealing species-specific regulatory features of lineage segregation.
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Self-citationFast and SNP-tolerant detection of complex variants and splicing in short reads
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Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing
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Defining an essential transcription factor program for naïve pluripotency
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Self-citationSnapShot: The Epithelial-Mesenchymal Transition
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SC3: consensus clustering of single-cell RNA-seq data
Kiselev, V. Y., Kirschner, K., Schaub, M. T., Andrews, T., Yiu, A., Chandra, T., Natarajan, K. N., Reik, W., Barahona, M., Green, A. R., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4236 · Cited by 1,500
Dynamic stem cell states: Naive to primed pluripotency in rodents and humans
Weinberger, L., Ayyash, M., Novershtern, N., & Hanna, J. H. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.28 · Cited by 622
Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
Rehman, S. K., Haynes, J., Collignon, E., Brown, K. R., Wang, Y., Nixon, A. M. L., Bruce, J. P., Wintersinger, J. A., Singh Mer, A., Lo, E. B. L., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.018 · Cited by 495
A test metric for assessing single-cell RNA-seq batch correction
Büttner, M., Miao, Z., Wolf, F. A., Teichmann, S. A., & Theis, F. J. (2019) · Nature Methods · doi:10.1038/s41592-018-0254-1 · Cited by 511
Formative pluripotency: the executive phase in a developmental continuum
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Metadata
- Authors
- Boroviak, T., Loos, R., Lombard, P., Okahara, J., Behr, R., Sasaki, E., Nichols, J., Smith, A., & Bertone, P.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 35
- Issue
- 3
- Pages
- 366-382
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2117895812
- Cited by
- 439
- References
- 8
- FWCI
- 15.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Boroviak, T., Loos, R., Lombard, P., Okahara, J., Behr, R., Sasaki, E., Nichols, J., Smith, A., & Bertone, P. (2015). Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis. Developmental Cell. https://doi.org/10.1016/j.devcel.2015.10.011
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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