The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis
Open accessAbstract
SUMMARY Selective autophagy performs an array of tasks to maintain intracellular homeostasis, sterility, and organellar and cellular functionality. The fidelity of these processes depends on precise target recognition and limited activation of the autophagy apparatus in a localized fashion. Here we describe cooperation in such processes between the TRIM family and Galectin family of proteins. TRIMs, which are E3 ubiquitin ligases, displayed propensity to associate with Galectins. One specific TRIM, TRIM16, interacted with Galectin-3 in an ULK1-dependent manner. TRIM16, through integration of Galectin- and ubiquitin-based processes, coordinated recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1, ULK1, and Beclin 1 in response to damaged endomembranes. TRIM16 affected mTOR, interacted with TFEB and influenced TFEB’s nuclear translocation. The cooperation between TRIM16 and Galectin-3 in targeting and activation of selective autophagy protects cells from lysosomal damage and Mycobacterium tuberculosis invasion.
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Cites
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“Galectins participate in autophagic response to endomembrane perforations caused by lysosomal damaging agents and by bacteria (Fujita et al., 2013; Maejima et al., 2013; Thurston et al., 2012).”
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Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
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Molecular definitions of autophagy and related processes
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The mechanisms and roles of selective autophagy in mammals
Vargas, J. N. S., Hamasaki, M., Kawabata, T., Youle, R. J., & Yoshimori, T. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00542-2 · Cited by 1,016
Metadata
- Authors
- Chauhan, S., Kumar, S., Jain, A., Ponpuak, M., Mudd, M. H., Kimura, T., Choi, S. W., Peters, R., Mandell, M., Bruun, J.-A., Johansen, T., & Deretic, V.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 39
- Issue
- 1
- Pages
- 13-27
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2525950393
- Cited by
- 480
- References
- 11
- FWCI
- 25.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chauhan, S., Kumar, S., Jain, A., Ponpuak, M., Mudd, M. H., Kimura, T., Choi, S. W., Peters, R., Mandell, M., Bruun, J.-A., Johansen, T., & Deretic, V. (2016). TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis. Developmental Cell. https://doi.org/10.1016/j.devcel.2016.08.003
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
