The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo
Open accessAbstract
Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the bloodstream, reach distant organs, and locally modify the microenvironment. However, visualizing these events in vivo still faces major hurdles. Here, we describe an approach for tracking circulating tumor EVs in a living organism: we combine chemical and genetically encoded probes with the zebrafish embryo as an animal model. We provide a first description of tumor EVs' hemodynamic behavior and document their intravascular arrest. We show that circulating tumor EVs are rapidly taken up by endothelial cells and blood patrolling macrophages and subsequently stored in degradative compartments. Finally, we demonstrate that tumor EVs activate macrophages and promote metastatic outgrowth. Overall, our study proves the usefulness and prospects of zebrafish embryo to track tumor EVs and dissect their role in metastatic niches formation in vivo.
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Cites
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Shedding light on the cell biology of extracellular vesicles
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Extracellular vesicles: Exosomes, microvesicles, and friends
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Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
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Tumour exosome integrins determine organotropic metastasis
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Self-citationKowal, J., Arras, G., Colombo, M., Jouve, M., Morath, J. P., Primdal-Bengtson, B., Dingli, F., Loew, D., Tkach, M., & Théry, C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521230113 · Cited by 3,426
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Self-citationSyndecan–syntenin–ALIX regulates the biogenesis of exosomes
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Cited by
Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12404 · Cited by 4,663
Challenges and directions in studying cell–cell communication by extracellular vesicles
van Niel, G., Carter, D. R. F., Clayton, A., Lambert, D. W., Raposo, G., & Vader, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00460-3 · Cited by 1,229
Self-citationStrategies for delivering therapeutics across the blood–brain barrier
Terstappen, G. C., Meyer, A. H., Bell, R. D., & Zhang, W. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00139-y · Cited by 1,138
Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering
Teng, F., & Fussenegger, M. (2021) · Advanced Science · doi:10.1002/advs.202003505 · Cited by 382
Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo
Verweij, F. J., Revenu, C., Arras, G., Dingli, F., Loew, D., Pegtel, D. M., Follain, G., Allio, G., Goetz, J. G., Zimmermann, P., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.01.004 · Cited by 346
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Metadata
- Authors
- Hyenne, V., Ghoroghi, S., Collot, M., Bons, J., Follain, G., Harlepp, S., Mary, B., Bauer, J., Mercier, L., Busnelli, I., Lefebvre, O., Fekonja, N., Garcia-Leon, M. J., Machado, P., Delalande, F., López, A. A., Silva, S. G., Verweij, F. J., van Niel, G., Djouad, F., Peinado, H., Carapito, C., Klymchenko, A. S., & Goetz, J. G.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 48
- Issue
- 4
- Pages
- 554-572.e7
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2950891082
- Cited by
- 231
- References
- 16
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hyenne, V., Ghoroghi, S., Collot, M., Bons, J., Follain, G., Harlepp, S., Mary, B., Bauer, J., Mercier, L., Busnelli, I., Lefebvre, O., Fekonja, N., Garcia-Leon, M. J., Machado, P., Delalande, F., López, A. A., Silva, S. G., Verweij, F. J., van Niel, G., . . . Goetz, J. G. (2019). Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo. Developmental Cell. https://doi.org/10.1016/j.devcel.2019.01.014
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
