The Hippo Signaling Pathway in Development and Disease

Zheng, Yonggang, Pan, Duojia·2019·Developmental Cell

Cited by (891)

Items 501–600 of 891

  1. A tale of two Hippo pathway modules
    Han Han, Wenqi Wang · 2023 · The EMBO Journal
  2. Neuronopathic Gaucher disease models reveal defects in cell growth promoted by Hippo pathway activation
    Daria Messelodi, Silvia Strocchi, Salvatore Nicola Bertuccio, Pascale Baden, Valentina Indio, Federico Manuel Giorgi, Alberto Taddia, Salvatore Serravalle, Sabrina Valente, Alessio Di Fonzo et al. · 2023 · Communications Biology
  3. Emerging Roles of Signal Transduction Pathways in Neurodegenerative Diseases. Hunting New Possible Therapeutic Molecular Targets
    Vincenza Rita Lo Vasco · 2023 · OBM Geriatrics
  4. E2 enzyme Bruce negatively regulates Hippo signaling through POSH-mediated expanded degradation
    Sha Song, Xianjue Ma · 2023 · Cell Death and Disease
  5. Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system
    Elisabeth A. Rutledge, Nils O. Lindström, Odyssé Michos, Andrew P. McMahon · 2019 · Developmental Biology
  6. Loss of BAP1 Leads to More YAPing in Pancreatic Cancer
    Rolf A. Brekken · 2020 · Cancer Research
  7. Yorkie-Warts Complexes are an Ensemble of Interconverting Conformers Formed by Multivalent Interactions
    Kasie Baker, Ethiene Kwok, Patrick N. Reardon, Diego J. Rodriguez, Amber D. Rolland, Jesse Wilson, James S. Prell, Afua Nyarko · 2020 · Journal of Molecular Biology
  8. Reuse of Molecules for Glioblastoma Therapy
    Abigail Koehler, Aniruddha Sunil Karve, Pankaj B. Desai, Jack L. Arbiser, David R. Plas, Xiaoyang Qi, Renee D Read, Atsuo T. Sasaki, Vaibhavkumar S. Gawali, Donatien Kamdem Toukam et al. · 2021 · Pharmaceuticals
  9. Troglitazone inhibits hepatic oval cell proliferation by inducing cell cycle arrest through Hippo/YAP pathway regulation
    Yifeng He, Haijian Li, Yunhe He, Caijie Lu, Peiyi Zhu, Mingyi Li, Juan Duan, Zhixin Fang · 2021 · Digestive and Liver Disease
  10. The Chlamydia trachomatis Tarp effector targets the Hippo pathway
    Michael G. Shehat, George F. Aranjuez, Jongeon Kim, Travis J. Jewett · 2021 · Biochemical and Biophysical Research Communications
  11. Zinc finger protein 367 exerts a cancer-promoting role in small cell lung cancer by influencing the CIT/LATS2/YAP signaling cascade
    Ranran Kong, Yuefeng Ma, Wendeng Li, Zhengshui Xu, Songyu Gong, Aoran Liu, Chuantao Cheng, Xinwu Zhang, Jie Qin, Shaomin Li et al. · 2024 · Toxicology and Applied Pharmacology
  12. The Hippo pathway kinase MST1 mediates a feedback loop to maintain NLRP3 inflammasome homeostasis
    Xiawei Huang, Jiahui Wang, Yao Liu, Huimin Pan, Kewei Zheng, Bo Liu · 2025 · Cell Reports
  13. Hippo cooperates with p53 to maintain foregut homeostasis and suppress the malignant transformation of foregut basal progenitor cells
    Yu Jiang, Haidi Huang, Jiangying Liu, Dan Luo, Rongzi Mu, Jianghong Yuan, Jihong Lin, Qiyue Chen, Wufan Tao, Ling Yang et al. · 2024 · Proceedings of the National Academy of Sciences
  14. Genetic circuitry controlling Drosophila female germline overgrowth
    Qian Zhang, Le Li, Qi Zhang, Yang Zhang, Lizhong Yan, Yanfang Wang, Yuejia Wang, Shaowei Zhao · 2024 · Developmental Biology
  15. Hippo effector, Yorkie, is a tumor suppressor in select Drosophila squamous epithelia
    Rachita Bhattacharya, Jaya Kumari, Shweta Banerjee, Jyoti Tripathi, Saurabh Singh Parihar, Nitin Mohan, Pradip Sinha · 2024 · Proceedings of the National Academy of Sciences
  16. Specific Deletion of the FHA Domain Containing SLMAP3 Isoform in Postnatal Myocardium Has No Impact on Structure or Function
    Taha Rehmani, Jana Mlynarova, Joseph T. Byers, Maysoon Salih, Balwant S. Tuana · 2021 · Cardiogenetics
  17. Arg-Gly-Asp-binding integrins activate hepatic stellate cells via the hippo signaling pathway
    Kensuke Kitsugi, Hidenao Noritake, Moe Matsumoto, Tomohiko Hanaoka, Masahiro Umemura, M. Yamashita, Shingo Takatori, Jun Ito, Kazuyoshi Ohta, Takeshi Chida et al. · 2022 · Cellular Signalling
  18. Heat exposure promotes apoptosis and pyroptosis in Sertoli cells
    CHEN WANG, Chaofan He, Yuanyuan Gao, KAIXIAN WANG, Meng Liang · 2022 · Biocell
  19. Activating the Hippo pathway by nevadensin overcomes Yap-drived resistance to sorafenib in hepatocellular carcinoma
    Hewen Shi, Ying Zou, Xiaoxue Wang, Guoli Wang, Yijia Gao, Fan Yi, Junqing Xu, Yancun Yin, Defang Li, Minjing Li · 2023 · Discover Oncology
  20. Hippo-YAP signaling pathway regulates autophagy of human periodontal ligament cells under cyclic tensile stress.
    Xiaofang Wan, Haiyan He, Lü Jialing, Yujie Wu, Guannan Zhong, Xiaomei Xu · 2023 · PubMed Central
  21. Identification and characterization of enhancer elements controlling cell type-specific and signalling dependent chromatin programming during hematopoietic development
    Alexander Maytum, Benjamin Edginton‐White, Constanze Bonifer · 2023 · Stem Cell Investigation
  22. Proteomic analysis reveals oxidative stress-induced activation of Hippo signaling in thiamethoxam-exposed Drosophila
    Xiaoqin Li, Mingquan Li, Xianle Xue, Xing Wang · 2023 · Chemosphere
  23. Comparison of gene mutation profile in different lung adenocarcinoma subtypes by targeted next-generation sequencing
    Shaowen Zhang, Ping Dong, Zongwei Pan, Qian Chen, Junqi Zhu, Zhangfan Mao · 2023 · Medical Oncology
  24. Regulation of Hippo-YAP/CTGF signaling by combining an HDAC inhibitor and 5-fluorouracil in gastric cancer cells
    Yanling Wu, Cong Shan Li, Ruo Yu Meng, Hua Jin, Ok Hee Chai, Soo Mi Kim · 2023 · Toxicology and Applied Pharmacology
  25. Lats1 and Lats2 regulate YAP and TAZ activity to control the development of mouse Sertoli cells
    Nour Abou Nader, L. Charrier, Marie-Charlotte Meisnsohn, Laurence Banville, Bérengère Deffrennes, G. St-Jean, D. Boerboom, G. Zamberlam, J. Brind'Amour, D. Pépin et al. · 2024 · The FASEB Journal
  26. PDLIM3 Regulates Migration and Invasion of Head and Neck Squamous Cell Carcinoma via YAP–Mediated Epithelial–Mesenchymal Transition
    Fan Yang, Ying Zhou, You Zhang, Weideng Wei, Fei Huang, Dan Yang, Yixin Zhang, Rui Zhang, Xiaoqiang Xia, Qianming Chen et al. · 2025 · International Journal of Molecular Sciences
  27. Expression pattern of transcriptional enhanced associate domain family member 1 (Tead1) in developing mouse molar tooth
    Yuki Niki, Yukiho Kobayashi, Keiji Moriyama · 2021 · Gene Expression Patterns
  28. Activation of the Hippo Pathway in Rana sylvatica: Yapping Stops in Response to Anoxia
    Aakriti Gupta, Kenneth B. Storey · 2021 · Life
  29. Induction of apoptosis using ATN as a novel Yes‐associated protein inhibitor in human oral squamous cell carcinoma cells
    Po‐Chen Chu, Eman M.E. Dokla, Jing‐Lan Hu, Jing‐Ru Weng · 2022 · Environmental Toxicology
  30. Myotubularin functions through actomyosin to interact with the Hippo pathway
    Liang Hu, Wyatt Brichalli, Naren Li, Shifan Chen, Yaqing Cheng, Qinfang Liu, Yulan Xiong, Jianzhong Yu · 2022 · EMBO Reports
  31. Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Promote Proliferation and Migration via Upregulation Yes-Associated Protein/Transcriptional Coactivator with PDZ Binding Motif Expression in Breast Cancer Cells
    Wanming Wu, Renfeng Huang, Linyang Ou, Ruiwen Lei · 2022 · The Chinese Journal of Physiology
  32. Molecular divergence with major morphological consequences: development and evolution of organ size and shape
    John P. Masly, Md. Golam Azom · 2022 · Essays in Biochemistry
  33. Comprehensive analysis of the prognostic value and biological function of TDG in hepatocellular carcinoma
    Guo‐Liang Wang, Yinwen Zhou, Bin Yi, Yanli Long, Bo Ma, Yi Zhang · 2023 · Cell Cycle
  34. Hippo Signaling: Autophagy Waits in the Wings
    Thomas P. Neufeld · 2020 · Developmental Cell
  35. Hyd/UBR5 defines a tumor suppressor pathway that links Polycomb repressive complex to regulated protein degradation in tissue growth control and tumorigenesis
    Pei Wen, Huiyan Lei, Hua Deng, Su Deng, Carla R. Tirado, Meiling Wang, Ping Mu, Yonggang Zheng, Duojia Pan · 2024 · Genes & Development
  36. Activation of Hippo/YAP signaling pathway exacerbates vascular remodeling and aggravates hypertension by upregulating Foxm1
    Jing Bai, Yujuan Yang · 2025 · Journal of Molecular Histology
  37. Mechano-matching hydrogel patch promotes myocardial infarction repair via YAP-Bcl-2 pathway activation
    Yanyan Zhao, Jie Shen, Rurong Lin, Jianxing Huang, Xiaoming Zou, Honghao Hou, Xiaozhong Qiu · 2025 · Materials Today Bio
  38. Proteasome stress activates YAP/TAZ through the RAP2–MAP4Ks–LATS1/2 pathway and its therapeutic implications in solid tumors
    Xin Wang, Yuan Gu, Zhenxing Zhong, Pengcheng Yu, Wenshuai Liu, Rui Zhu, Yu Wang, Zhaocai Zhou, Yihong Sun, Xuefei Wang et al. · 2025 · Proceedings of the National Academy of Sciences
  39. Recent advances on Hippo-YAP pathway in skin diseases
    Xuxia Cai, Kexin Chen, Xiahong Li, Kaoyuan Zhang, Jiaxu Gu, Changbing Shen, Bo Yu, Cong Huang · 2026 · Frontiers in Immunology
  40. Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in a Hippo-dependent cancer model
    Thijs J. Hagenbeek, Jason R. Zbieg, Russell Smith, Sayantanee Paul, Luca Gerosa, Consuelo Torrini, Alissa D. Guarnaccia, Christy C. Ong, Jennifer Arca Lacap, Miaoran Ning et al. · 2026 · Nature Communications
  41. Non-coding RNAs as regulators of the Hippo pathway in cardiac development and cardiovascular disease
    Mengyang Song, He Wang, Caixia Liu, Sijie Jin, Bin Liu, Wei Sun · 2024 · Frontiers in Pharmacology
  42. PICK1 links KIBRA and AMPA receptor subunit GluA2 in coiled-coil-driven supramolecular complexes
    Xin Shao, Lenora J. Volk · 2025 · Journal of Biological Chemistry
  43. Microtubule associated serine/threonine kinase-3 inhibits the malignant phenotype of breast cancer by promoting phosphorylation-mediated ubiquitination degradation of yes-associated protein
    Ning Deng, Wei Cherng Malvin Kang, Jiang Du, Xuezhu Rong, Qiang Han · 2025 · Breast Cancer Research
  44. Crosstalk between MST1-Hippo and Wnt/β-Catenin, Notch, and PI3K/Akt pathways in cardiac physiology and pathology
    Jin Wang, Kai Jing, Vadim M. Mitrokhin, Stanislav A. Shileiko, Anastasija Rodina, Alexandra Zolotareva, Valentin I. Zolotarev, Natalia Bocharnikova, Dmitry D. Kaminer, Emilija Antova et al. · 2025 · Journal of Physiology and Biochemistry
  45. Crosstalk between YAP/TAZ and ERα in mechanical and hormonal signaling in the skeletal system
    Ruiying Han, Tianyi Wang, Yikai He, Ding Bai, Jing Xie, Yongwen Guo · 2025 · Acta Biochimica et Biophysica Sinica
  46. TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells
    Yiran Wang, Jindayi Liang, Kimberly Lange, Justin Demmerle, Eleanor A. Liu, Ethan Black, Britney Jiayu He, Christopher J. Ricketts, Shawn R. Yoshida, Shasha Chong et al. · 2026 · Nature Cell Biology
  47. Deficiency of large tumor suppressor kinase 1 causes congenital hearing loss associated with cochlear abnormalities in mice
    Takanori Nishiyama, Masato Fujioka, Chika Saegusa, Naoki Oishi, Tatsuhiko Harada, Makoto Hosoya, Hideyuki Saya, Kaoru Ogawa · 2020 · Biochemical and Biophysical Research Communications
  48. The Tumor Suppressor DAB2IP Is Regulated by Cell Contact and Contributes to YAP/TAZ Inhibition in Confluent Cells
    Mattia Apollonio, Arianna Bellazzo, Nicoletta Franco, Silvia Lombardi, Beatrice Senigagliesi, Loredana Casalis, Pietro Parisse, Agnes Thalhammer, Gabriele Baj, Rossella De Florian Fania et al. · 2023 · Cancers
  49. Prolactin promotes crop epithelial proliferation of domestic pigeons (Columba livia) through the Hippo signaling pathway
    Jianguo Zhu, Xingyi Teng, L.X. Wang, Mingde Zheng, Yu Meng, Tingwu Liu, Ying Liu, Haixia Huan, Daoqing Gong, Peng Xie · 2023 · Journal of Animal Science
  50. FK-binding protein 5: Possible relevance to the pathogenesis of metabolic dysfunction and alcohol-associated liver disease
    Jing Ma, Zhihong Yang, Hui Gao, Nazmul Huda, Yanchao Jiang, Suthat Liangpunsakul · 2023 · Journal of Investigative Medicine
  51. STRN3 promotes tumour growth in hepatocellular carcinoma by inhibiting the hippo pathway
    Jie Zhu, Wenjia Tang, Peiqi Fang, Chong Wang, Meixiu Gu, Wenjing Yang, Baishen Pan, Beili Wang, Wei Guo · 2024 · Journal of Cellular and Molecular Medicine
  52. The AAA-ATPase Ter94 regulates wing size in Drosophila by suppressing the Hippo pathway
    Mingming Li, Wenhao Ding, Yanran Deng, Yunhe Zhao, Qingxin Liu, Zizhang Zhou · 2024 · Communications Biology
  53. Hapalindole Q suppresses autophagosome−lysosome fusion by promoting YAP1 degradation via chaperone-mediated autophagy
    Yali Wu, Shaonan Wang, Zhicong Guo, Min Sun, Zhen Xu, Yu Mei Du, Fahui Zhu, Yajuan Su, Xu Zhou, Yi Xu et al. · 2024 · Proceedings of the National Academy of Sciences
  54. Mesenchymal Hippo signaling regulates intestinal homeostasis in adult mice
    Kyvan Dang, Alka Singh, Xin Chen, Jennifer L. Cotton, Susu Guo, Xiaodi Hu, Zhipeng Tao, Haibo Liu, Lihua Julie Zhu, Yicktung Tony Ip et al. · 2025 · iScience
  55. Extracellular matrix: Dystroglycan interactions—Roles for the dystrophin‐associated glycoprotein complex in skeletal tissue dynamics
    Mark Hopkinson, Andrew A. Pitsillides · 2025 · International Journal of Experimental Pathology
  56. Noncoding RNAs as mechanistic regulators and therapeutic modulators of YAP/TAZ signaling in colorectal cancer
    Mehrnaz Mostafavi, Elham Dehbashi, Faraz Rahmani Khajeh, Masoumeh Nouri, Mahdis kadkhodaei Eliaderani, Nahal Aghajamal Avval, Moein Ghasemi, Dina Seyedi, Malihe Sharafi, Reza Morovatshoar et al. · 2025 · Medical Oncology
  57. Syd/JIP3 controls tissue size by regulating Diap1 protein turnover downstream of Yorkie/YAP
    Vakil Ahmad, Gangadhara Prasadachari Vadla, Chiswili Yves Chabu · 2020 · Developmental Biology
  58. Wallenda-Nmo Axis Regulates Growth via Hippo Signaling
    Xianping Wang, Hui Liang, Wenyan Xu, Xianjue Ma · 2021 · Frontiers in Cell and Developmental Biology
  59. Biochemical properties of VGLL4 from Homo sapiens and Tgi from Drosophila melanogaster and possible biological implications
    Yannick Mesrouze, Marco Meyerhofer, Catherine Zimmermann, Patrizia Fontana, Dirk Erdmann, Patrick Chêne · 2021 · Protein Science
  60. Mitosis, a springboard for epithelial-mesenchymal transition?
    Evangéline Despin‐Guitard, Isabelle Migeotte · 2021 · Cell Cycle
  61. Cell and Tissue Nanomechanics: From Early Development to Carcinogenesis
    Mikhail E. Shmelev, Sergei Titov, Andrei S. Belousov, Vladislav M. Farniev, Valeriia Zhmenia, Daria Lanskikh, Alina O. Penkova, Vadim Vladimirovich Kumeiko · 2022 · Biomedicines
  62. Competition between myosin II and βH-spectrin regulates cytoskeletal tension
    Consuelo Ibar, Krishna Chinthalapudi, Sarah M. Heissler, Kenneth D. Irvine · 2023 · eLife
  63. Targeting the Divergent Roles of STK3 Inhibits Breast Cancer Cell Growth and Opposes Doxorubicin-Induced Cardiotoxicity In Vitro
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  64. Competition between myosin II and βH-spectrin regulates cytoskeletal tension
    Consuelo Ibar, Krishna Chinthalapudi, Sarah M. Heissler, Kenneth D. Irvine · 2023 · eLife
  65. Interaction of de novo cholesterol biosynthesis and Hippo signaling pathway in ductal carcinoma in situ (DCIS)—comparison with the corresponding normal breast epithelium
    Danila Coradini · 2023 · Translational Breast Cancer Research
  66. Wnt16Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in MaleLDLR−/−Mice
    Abraham Behrmann, Dalian Zhong, Li Li, Shangkui Xie, Megan Mead, Parastoo Sabaeifard, Mohammad Goodarzi, Andrew S. Lemoff, Julia Kozlitina, Dwight A. Towler · 2023 · Endocrinology
  67. Targeting the Hippo Pathway in Cutaneous Melanoma
    Urszula Kazimierczak, Anna Przybyła, Marianna Smielowska, Tomasz Kolenda, Andrzej Adam Mackiewicz · 2024 · Cells
  68. Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis
    Jeongkyung Lee, Ruya Liu, Byung S. Kim, Yiqun Zhang, Feng Li, Rajaganapti Jagannathan, Ping Yang, Vinny Negi, Joseph Danvers, Eliana Melissa Perez-Garcia et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  69. YAP1-2α heterodimerization with TAZ promotes cancer aggressiveness through BRD4-dependent liquid-liquid phase separation at super-enhancers
    Takuya Ooki, Takeru Hayashi, Yui Yamamoto, Masanori Hatakeyama · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  70. Extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD
    Teng Han, Zhen Sun, Matthew Lange, Y Zoe Cho, Patrick D. McGillivray, Maren Büttner, Nathaniel R. Kastan, Subhiksha Nandakumar, HuiYong Zhao, Eralda Salataj et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  71. Interplay of Glucose Metabolism and Hippo Pathway in Chondrocytes: Pathophysiology and Therapeutic Targets
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  72. The Hippo pathway in bone and cartilage: implications for development and disease
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  73. Vasopressin‐Sensitive Aqp2 Regulation Mediated by the TAZ ‐ NR4A1 Axis in Renal Collecting Duct Cells
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  74. Pharmacological targeting of large tumor suppressor kinases (LATS) 1 and 2 augments tissue repair and regeneration
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  75. Deciphering the enigma: long noncoding RNAs in disease pathogenesis and therapeutic prospects
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  76. Epithelial MST1 deficiency promotes pyroptosis and aggravates inflammatory bowel disease via the YAP/p73 signaling pathway
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  77. PARP1-mediated PARylation of TEAD4 stabilizes the YAP1-TEAD4 complex and promotes growth and immune evasion in breast cancer cells
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  78. Constitutive YAP activation in distal nephron segments disrupts epithelial identity and nephron patterning
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  79. Hippo-YAP/TAZ signaling in gastric cancer: molecular pathogenesis and emerging therapeutic horizons
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  80. Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
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  81. Dihydroartemisinin promotes ABCG5/G8-mediated cholesterol efflux to potentiate anti-PD-1 therapy through YAP1-TEAD1 complex disruption in hepatocellular carcinoma
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  82. Dachsous and Fat coordinately repress the Dachs–Dlish–Approximated complex to control growth
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  84. Role of ferroptosis mediated by abnormal membrane structure in DEHP-induced reproductive injury
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  85. Overexpression of DDR1 contributes to gastric cancer progression by inhibiting the Hippo pathway
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  86. Methoxypoly(ethylene glycol)-poly(salicylic acid) nanoparticles alleviate intervertebral disc degeneration by inhibiting ferroptosis of nucleus pulposus cells
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  87. Temporal transcriptomic changes during neurodevelopment in a mouse model of Smith-Lemli-Opitz syndrome
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  88. Role of nuclear-cytoplasmic protein localization during Drosophila neuroblast development
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  89. Weighted gene co-expression network analysis of embryos and first instar larvae of the horseshoe crab Tachypleus tridentatus uncovers development gene networks
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  90. Interplay Between Fatty Acids, Stearoyl-Co-A Desaturase, Mechanistic Target of Rapamycin, and Yes-Associated Protein/Transcriptional Coactivator With PDZ-Binding Motif in Promoting Hepatocellular Carcinoma
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  91. YAP affects the efficacy of liver progenitor cells transplantation in CCl4-induced acute liver injury
    Weiming Dai, Zhenyang Shen, Yuecheng Guo, Junjun Wang, Xiaoman Li, Jianxiang Wang, Lungen Lu, Xiaobo Cai, Yan Li · 2022 · Biochemical and Biophysical Research Communications
  92. LATS in cancer repression: Extracting its role in hippo pathway and beyond
    Salman Akhtar · 2023 · Gene Reports
  93. An integrative pan-cancer analysis of WWC family genes and functional validation in lung cancer
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  94. TGF-β and HIPPO Signaling Pathways Interplay in Distinct Hepatic Contexts
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  95. Hepatocyte-Specific Yap1 Knockout Maintained the Liver Homeostasis of Lipid Metabolism in Mice
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  96. Whole genome profiling of rare pediatric thoracic tumors elucidates a YAP1::LEUTX fusion in an unclassified biphasic embryonal neoplasm
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  97. Advances towards potential cancer therapeutics targeting Hippo signaling
    Rui Zhu, Zhihan Jiao, Fa‐Xing Yu · 2024 · Biochemical Society Transactions
  98. ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression
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  99. Regulatory mechanisms of the Hippo/YAP axis by G-protein coupled estrogen receptor in gastric signet-ring cell carcinoma
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  100. Yes-associated protein gene overexpression regulated by β-catenin promotes gastric cancer cell tumorigenesis
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