The Hippo Signaling Pathway in Development and Disease

Zheng, Yonggang, Pan, Duojia·2019·Developmental Cell

DOI 10.1016/j.devcel.2019.06.003

Cited by (891)

Items 101–200 of 891

YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasis
ZhengMing Wu, Junhui Su, Fu-long Li, Tao Chen, Jaimie Mayner, Adam Jeffrey Engler, Shenghong Ma, Qingquan Li, Kun‐Liang Guan · 2023 · Nature Communications
Genome‐wide association studies of preweaning growth and in vivo carcass composition traits in Esme sheep
Onur Yılmaz, Mehmet Kızılaslan, Yunus Arzık, Sedat Behrem, Nezi̇h Ata, Orhan Karaca, Cengiz Elmacı, İ̇brahim Cemal · 2021 · Journal of Animal Breeding and Genetics
Caveolae Mechanotransduction at the Interface between Cytoskeleton and Extracellular Matrix
Laura Sotodosos-Alonso, Marta Pulgarín-Alfaro, Miguel Á. del Pozo · 2023 · Cells
Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells
Yu-chen Xiang, Peng Peng, Xuewen Liu, Xin Jin, Jie Ming Shen, Te Zhang, Liang Zhang, Fang Wan, Yuqing Ren, Qingqing Yu et al. · 2021 · Acta Pharmacologica Sinica
YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling
Boksik Cha, Yen‐Chun Ho, Xin Geng, Md. Riaj Mahamud, Lijuan Chen, Yeunhee Kim, Dongwon Choi, Tae Hoon Kim, Gwendalyn J. Randolph, Xinwei Cao et al. · 2020 · Development
Targeting the Hippo pathway in heart repair
Fansen Meng, Bing Xie, James F. Martin · 2021 · Cardiovascular Research
Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK
Ruth Nussinov, Bengi Ruken Yavuz, M Kaan Arici, Habibe Cansu Demirel, Mingzhen Zhang, Yonglan Liu, Chung‐Jung Tsai, Hyunbum Jang, Nurcan Tunçbağ · 2023 · Biophysical Reviews
Inhibition of thioredoxin reductase 1 sensitizes glucose-starved glioblastoma cells to disulfidptosis
Miaolu Tang, Kaitlyn Dirks, Soo Yeon Kim, Zhiqiang Qiu, Yan Gao, Dongxiao Sun, Gabrielle A. Peruggia, Jessica Sallavanti, Wei Li · 2024 · Cell Death and Differentiation
Control of skeletal morphogenesis by the Hippo-YAP/TAZ pathway
Hannah Kate Vanyai, Fabrice Prin, Oriane Guillermin, N. Bishara Marzook, Stefan Boeing, Alexander Howson, Rebecca E. Saunders, Thomas J. A. Snoeks, Michael T. Howell, Timothy J. Mohun et al. · 2020 · Development
Two Hippo signaling modules orchestrate liver size and tumorigenesis
Sixian Qi, Zhenxing Zhong, Yuwen Zhu, Yebin Wang, Mingyue Ma, Yu Wang, Xincheng Liu, Ruxin Jin, Zhihan Jiao, Rui Zhu et al. · 2023 · The EMBO Journal
Long noncoding RNAs: fine-tuners hidden in the cancer signaling network
Shanshan Zhao, Xue Zhang, Shuo Chen, Song Zhang · 2021 · Cell Death Discovery
Advances of targeting the YAP/TAZ-TEAD complex in the hippo pathway for the treatment of cancers
Mengxin Luo, Yongjin Xu, Haifeng Chen, Yiquan Wu, Ao Pang, Junjie Hu, Xiaowu Dong, Jinxin Che, Haiyan Yang · 2022 · European Journal of Medicinal Chemistry
Genome editing in the unicellular holozoan Capsaspora owczarzaki suggests a premetazoan role for the Hippo pathway in multicellular morphogenesis
Jonathan E Phillips, Maribel Santos, Mohammed Konchwala, Chao Xing, Duojia Pan · 2022 · eLife
WNT5a Signaling through ROR2 Activates the Hippo Pathway to Suppress YAP1 Activity and Tumor Growth
Keshan Wang, Fen Ma, Seiji Arai, Yun Wang, Andreas S. Varkaris, Larysa Poluben, Olga S. Voznesensky, Fang Xie, Xiaoping Zhang, Xin Yuan et al. · 2023 · Cancer Research
The Hippo pathway: Organ size control and beyond
Pengfei Guo, Sicheng Wan, Kun‐Liang Guan · 2024 · Pharmacological Reviews
YAP/TAZ Are Required to Suppress Osteogenic Differentiation of Vascular Smooth Muscle Cells
Lei Wang, Ramesh Chennupati, Young‐June Jin, Rui Li, Shengpeng Wang, Stefan Günther, Stefan Offermanns · 2020 · iScience
CircRNA-ceRNA Network Revealing the Potential Regulatory Roles of CircRNA in Alzheimer’s Disease Involved the cGMP-PKG Signal Pathway
Yuan Zhang, Lili Qian, Yingying Liu, Ying Liu, Wanpeng Yu, Yanfang Zhao · 2021 · Frontiers in Molecular Neuroscience
Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation
Laura Maarit Pikkupeura, Raul Bardini Bressan, Jordi Guiu, Yun Chen, Martti Maimets, Daniela Mayer, Pawel J. Schweiger, Stine Lind Hansen, Grzegorz Jerzy Maciag, Hjalte List Larsen et al. · 2023 · Science Advances
YAP condensates are highly organized hubs
Siyuan Hao, Ye Jin Lee, Nadav Benhamou Goldfajn, Eduardo Flores, Jindayi Liang, Hannah Fuehrer, Justin Demmerle, Jennifer Lippincott‐Schwartz, Zhe J. Liu, Shahar Sukenik et al. · 2024 · iScience
Genetic driver mutations introduced in identical cell‐of‐origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade
Zhihong Chen, Cameron J. Herting, James Ross, Ben Gabanic, Montse Puigdelloses, Frank Szulzewsky, Megan L. Wojciechowicz, Patrick Joseph Cimino, Ravesanker Ezhilarasan, Erik P. Sulman et al. · 2020 · Glia
Functional aspects of primary cilium in signaling, assembly and microenvironment in cancer
Bo Wang, Zheyong Liang, Peijun Liu · 2020 · Journal of Cellular Physiology
The Bumpy Road to Stem Cell Therapies: Rational Design of Surface Topographies to Dictate Stem Cell Mechanotransduction and Fate
James Carthew, Jason B. J. Taylor, Maria R. Garcia-Cruz, Nasim Kiaie, Nicolas Hans Voelcker, Víctor J. Cadarso, Jessica Ellen Frith · 2022 · ACS Applied Materials & Interfaces
mTORC1 Promotes ARID1A Degradation and Oncogenic Chromatin Remodeling in Hepatocellular Carcinoma
Shanshan Zhang, Yu-Feng Zhou, Jian Ping Cao, Stephen Kevin Burley, Hui‐Yun Wang, Xiaohui Zheng · 2021 · Cancer Research
The biophysical property of the limbal niche maintains stemness through YAP
Swarnabh Bhattacharya, Abhishek Mukherjee, Sabrina Pisano, Shalini Dimri, Eman Knaane, Anna Altshuler, Waseem Nasser, Sunanda Dey, Lidan Shi, Ido Mizrahi et al. · 2023 · Cell Death and Differentiation
Crosstalk between colorectal CSCs and immune cells in tumorigenesis, and strategies for targeting colorectal CSCs
Qi Zhao, Hong Zong, Pingping Zhu, Chang Su, Wenxue Tang, Zhenzhen Chen, Shuiling Jin · 2024 · Experimental Hematology and Oncology
Spectrin couples cell shape, cortical tension, and Hippo signaling in retinal epithelial morphogenesis
Hua Deng, Limin Yang, Pei Wen, Huiyan Lei, Paul Blount, Duojia Pan · 2020 · The Journal of Cell Biology
WWC Proteins: Important Regulators of Hippo Signaling in Cancer
Verena Höffken, Anke Hermann, Hermann Josef Pavenstädt, Joachim Kremerskothen · 2021 · Cancers
An Overview of in vivo Functions of Chondroitin Sulfate and Dermatan Sulfate Revealed by Their Deficient Mice
Shuji Mizumoto, Shuhei Yamada · 2021 · Frontiers in Cell and Developmental Biology
Physiological and pathological roles of the Hippo‐YAP/TAZ signaling pathway in liver formation, homeostasis, and tumorigenesis
Hiroshi Nishina · 2022 · Cancer Science
Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with FoxA2 and Shh expression
Caiqi Cheng, Qian Cong, Yuchen Liu, Yizhong Hu, Guoyan Liang, Kevin Marc Manquiquis Dioneda, Yingzi Yang · 2023 · Science Advances
Transcriptional regulation of cancer stem cell: regulatory factors elucidation and cancer treatment strategies
Zhengyue Zhang, Yanjie Zhang · 2024 · Journal of Experimental & Clinical Cancer Research
The potential role of YAP in head and neck squamous cell carcinoma
Eunbie Shin, Joon Kim · 2020 · Experimental & Molecular Medicine
YAP–VGLL4 antagonism defines the major physiological function of the Hippo signaling effector YAP
Jing Cai, Kyungsuk Choi, Hongde Li, Katiuska Daniela Pulgar Prieto, Yonggang Zheng, Duojia Pan · 2022 · Genes & Development
Phase separation of Hippo signalling complexes
Teresa Bonello, Danfeng Cai, Georgina Fletcher, Kyler Wiengartner, Victoria Pengilly, Kimberly Lange, Zhe J. Liu, Jennifer Lippincott‐Schwartz, Jennifer M. Kavran, Barry J. Thompson · 2023 · The EMBO Journal
Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2
Rui Li, Jingchen Shao, Young‐June Jin, Haruya Kawase, Yu Ting Ong, Kerstin Troidl, Qi Quan, Lei Wang, Rémy Bonnavion, Astrid Wietelmann et al. · 2023 · Nature Communications
PI4P-mediated solid-like Merlin condensates orchestrate Hippo pathway regulation
Pengfei Guo, Bing Li, Wei Dong, Huabin Zhou, Li Wang, Ting Su, Christopher Carl, Yonggang Zheng, Yang Hong, Hua Deng et al. · 2024 · Science
Interplay Between Notch and YAP/TAZ Pathways in the Regulation of Cell Fate During Embryo Development
Carolyn Engel-Pizcueta, Cristina Pujades · 2021 · Frontiers in Cell and Developmental Biology
Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer
Farhoud Faraji, Sydney I. Ramirez, Paola Y. Anguiano Quiroz, Amaya N. Mendez-Molina, Jorge Silvio Gutkind · 2022 · Cells
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression
Yan Sun, Xin Jin, Junpeng Meng, Feng Guo, Taoyu Chen, Xiaoyan Zhao, Heshui Wu, Dianyun Ren · 2023 · The EMBO Journal
YAP/TAZ maintain the proliferative capacity and structural organization of radial glial cells during brain development
Alfonso Lavado, Ruchika Gangwar, Joshua Paré, Shibiao Wan, Yiping Fan, Xinwei Cao · 2021 · Developmental Biology
Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
Yuan Gu, Yu Wang, Zhao Sha, Chenxi He, Yuwen Zhu, Jian Li, Aijuan Yu, Zhenxing Zhong, Xuefei Wang, Yihong Sun et al. · 2022 · Cell Reports
Disrupting bile acid metabolism by suppressing Fxr causes hepatocellular carcinoma induced by YAP activation
Yuchen Liu, Juanjuan Zhu, Yu Jin, Zhonghe Sun, Xiaolin Wu, Huiping Zhou, Yingzi Yang · 2025 · Nature Communications
Various Uses of PD1/PD-L1 Inhibitor in Oncology: Opportunities and Challenges
Zhitao Li, Guoqiang Sun, Guangshun Sun, Ye Cheng, Liangliang Wu, Qian Wang, Chengyu Lv, Yichan Zhou, Yongxiang Xia, Weiwei Tang · 2021 · Frontiers in Oncology
Deubiquitinase ubiquitin‐specific peptidase 10 maintains cysteine rich angiogenic inducer 61 expression via Yes1 associated transcriptional regulator to augment immune escape and metastasis of pancreatic adenocarcinoma
Xun Liu, Bobo Chen, Jiahui Chen, Zuoyuan Su, Shaolong Sun · 2022 · Cancer Science
The unfolding of the Hippo signaling pathway
Duojia Pan · 2022 · Developmental Biology
A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models
Hanne Hillen, Aurélie Candi, Bart Vanderhoydonck, Weronika Kowalczyk, Leticia Sansores-García, Elena C. Kesikiadou, Leen Van Huffel, Lore Spiessens, Marnik Nijs, Erik Soons et al. · 2023 · Molecular Cancer Therapeutics
Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites
Atanu Paul, Stefano Annunziato, Bo Lu, Tianliang Sun, Olivera Evrova, Lara Planas‐Paz, Vanessa Orsini, Luigi Terracciano, Olga Charlat, Zinger Yang et al. · 2022 · Nature Communications
The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease
Antonio Cigliano, Shanshan Zhang, Silvia Ribback, Sara Martina Steinmann, Marcella Sini, Cindy Eva Ament, Kirsten Utpatel, Xinhua Song, Jingxiao Wang, Maria G. Pilo et al. · 2022 · Journal of Experimental & Clinical Cancer Research
PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma
Song Peng, Ze Wang, Peng Tang, Shuo Wang, Yiqiang Huang, Qiubo Xie, Yapeng Wang, Xintao Tan, Tang Tang, Xuzhi Yan et al. · 2023 · Science Advances
Systematic analysis of the Hippo pathway organization and oncogenic alteration in evolution
Yuxuan Chen, Han Han, Gayoung Seo, Rebecca Elizabeth Vargas, Bing Yang, Kimberly Chuc, Huabin Zhao, Wenqi Wang · 2020 · Scientific Reports
Tumors overcome the action of the wasting factor ImpL2 by locally elevating Wnt/Wingless
Jiae Lee, Katelyn G.‐L. Ng, Kenneth M. Dombek, Dae Seok Eom, Young V. Kwon · 2021 · Proceedings of the National Academy of Sciences
Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer
Amelia U. Schirmer, Lucy M. Driver, Megan T. Zhao, Carrow I. Wells, Julie E. Pickett, Sean N. O’Byrne, Benjamin J. Eduful, Xuan Yang, Lauren E. Howard, Sungyong You et al. · 2021 · Molecular Therapy
Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation
Yang Ying, Pekka Päivinen, Chang Xie, Alexis Leigh Krup, Tomi P. Mäkelä, Keith E. Mostov, Jeremy F. Reiter · 2021 · Nature Communications
Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension
Yuanjun Shen, Dmitry A. Goncharov, Andressa Z. Pena, Jeffrey Baust, Andres Chavez Barragan, Arnab Ray, Analise Rode, Timothy N. Bachman, Baojun Chang, Lifeng Jiang et al. · 2022 · Science Signaling
Targeting regulatory T cells in gastric cancer: Pathogenesis, immunotherapy, and prognosis
Bingyu Wang, Zaibo Zhang, Wenbo Liu, Bibo Tan · 2022 · Biomedicine & Pharmacotherapy
Multi-Functional Regulation by YAP/TAZ Signaling Networks in Tumor Progression and Metastasis
Hannah L. Thrash, Ann Marie Pendergast · 2023 · Cancers
Mesenchymal Stem Cell‐Derived Exosomes: A Promising Therapeutic Strategy for Age‐Related Diseases
Bohua Wei, Mengting Wei, Haonan Huang, Ting Fan, Zhichang Zhang, Xiaoyu Song · 2024 · Cell Proliferation
Mob Family Proteins: Regulatory Partners in Hippo and Hippo-Like Intracellular Signaling Pathways
Duhart, Juan Carlos, Raftery, Laurel A. · 2020 · Frontiers in Cell and Developmental Biology
YAP activation in melanoma contributes to anoikis resistance and metastasis
Bei Zhao, Jun Xie, Xiyuan Zhou, Lixia Zhang, Xiankui Cheng, Chenglin Liang · 2020 · Experimental Biology and Medicine
Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives
Jiaxin Yong, Yuan Li, Sihan Lin, Zhenning Wang, Yan Hua Xu · 2021 · Drug Design Development and Therapy
WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein
Jian‐Ping Zou, Ling Zhou, Yi Le, Zhi Fang, Min Zhong, Fengting Nie, Xianpin Wei, Xiaomei Zhang, Zhen Chen, Lingling Cai et al. · 2023 · Cell Communication and Signaling
<scp>SIRT7</scp> promotes Hippo/<scp>YAP</scp> activation and cancer cell proliferation in hepatocellular carcinoma via suppressing <scp>MST1</scp>
Gu, Yiying, Ding, Cong, Yu, Tingzi, Liu, Bohao, Tang, Wenbin, Wang, Zhiqiang, Tang, Xiaohui, Liang, Gaoshuang, Peng, Jinying, Zhang, Xiangwen et al. · 2024 · Cancer Science
Endothelial YAP Mediates Hyperglycemia-Induced Platelet Hyperactivity and Arterial Thrombosis
Zhiyu Li, Jiachen Zhang, Zejun Ma, Guobing Zhao, Xue He, Xuefang Yu, Qiang Fu, Naishi Wu, Zhongren Ding, Haipeng Sun et al. · 2023 · Arteriosclerosis Thrombosis and Vascular Biology
Linc00887 suppresses tumorigenesis of cervical cancer through regulating the miR-454-3p/FRMD6-Hippo axis
Pei Li, Jinsheng Wang, Lingran Zhi, Fengmei Cai · 2021 · Cancer Cell International
Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis
Yu Wang, Yuwen Zhu, Yuan Gu, Mingyue Ma, Yebin Wang, Sixian Qi, Yan Jun Zeng, Rui Zhu, Xueying Wang, Pengcheng Yu et al. · 2021 · Cell Reports
Multiple roles and context-specific mechanisms underlying YAP and TAZ-mediated resistance to anti-cancer therapy
Francesca Reggiani, Giulia Gobbi, Alessia Ciarrocchi, Davide Carlo Ambrosetti, Valentina Sancisi · 2020 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibition
Sayantanee Paul, Thijs J. Hagenbeek, Julien Tremblay, Vasumathi Kameswaran, Christy C. Ong, Chad Liu, Alissa D. Guarnaccia, James A. Mondo, Peter Hsu, Noelyn M. Kljavin et al. · 2025 · Nature Communications
NGF Signaling Interacts With the Hippo/YAP Pathway to Regulate Cervical Cancer Progression
Lijun Wang, Jing Li, Rongli Wang, He Chen, Ruiqi Wang, Wei Wang, Xinyuan Yang · 2021 · Frontiers in Oncology
Targeting the Hippo pathway in cancer: kidney toxicity as a class effect of TEAD inhibitors?
Sayantanee Paul, Jessica Sims, Trang Pham, Anwesha Dey · 2024 · Trends in cancer
Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Marjolaine Bauzone, Mouloud Souidi, Anne‐Frédérique Dessein, Maxence Wisztorski, Audrey Vincent, Jean‐Pascal Gimeno, Didier Monté, Isabelle VAN SEUNINGEN, Christian P. Gespach, Guillemette Huet · 2021 · Molecular Cancer Research
Normal tissue adjacent to tumor expression profile analysis developed and validated a prognostic model based on Hippo‐related genes in hepatocellular carcinoma
Qingbo Pan, Fanbo Qin, Hanyu Yuan, Baoning He, Ni Yang, Yitong Zhang, Hong Ren, Yi Arial Zeng · 2021 · Cancer Medicine
Imipramine impedes glioma progression by inhibiting YAP as a Hippo pathway independent manner and synergizes with temozolomide
Yan Wang, Xiang Wang, Xu Wang, Di Wu, Ji Qi, Yu Zhang, Kai Wang, Ding Zhou, Qingming Meng, Er Nie et al. · 2021 · Journal of Cellular and Molecular Medicine
RBFOX2-regulated TEAD1 alternative splicing plays a pivotal role in Hippo-YAP signaling
Sunkyung Choi, Hyo Seong Lee, Namjoon Cho, Inyoung Kim, Seongmin Cheon, Chungoo Park, Eun‐Mi Kim, Wantae Kim, Kee Kwang Kim · 2022 · Nucleic Acids Research
Inhibition of colorectal cancer tumorigenesis by ursolic acid and doxorubicin is mediated by targeting the Akt signaling pathway and activating the Hippo signaling pathway
Dan Hu, Ruo Yu Meng, Thi Van Nguyen, Ok Hee Chai, Byung S. Park, Ju‐Seog Lee, Soo‐Jeong Kim · 2022 · Molecular Medicine Reports
ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3
Shiyang Wang, Xi Wu, Wenxin Bi, Jiuzhi Xu, Liyuan Hou, Guilin Li, Yuwei Pan, Hanfu Zhang, Mengzhen Li, Sujuan Du et al. · 2025 · Nature Communications
SASH1 suppresses triple-negative breast cancer cell invasion through YAP-ARHGAP42-actin axis
Ke Jiang, Peng Liu, Huizhe Xu, Dapeng Liang, Kun Fang, Sha Du, Wei Cheng, Leiguang Ye, Tong Liu, Xiaohong Zhang et al. · 2020 · Oncogene
Regulatory mechanisms governing epidermal stem cell function during development and homeostasis
Pooja Flora, Elena Ezhkova · 2020 · Development
MST1 inhibits the progression of breast cancer by regulating the Hippo signaling pathway and may serve as a prognostic biomarker
Xiang Jin, Lihua Zhu, Sheng Xiao, Zhuhong Cui, Jing Tang, Jiangyong Yu, Mingjun Xie · 2021 · Molecular Medicine Reports
NEK2 inactivates the Hippo pathway to advance the proliferation of cervical cancer cells by cooperating with STRIPAK complexes
Yanru Zhang, Peng‐Sheng Zheng · 2022 · Cancer Letters
Yap governs a lineage-specific neuregulin1 pathway-driven adaptive resistance to RAF kinase inhibitors
María E.R. García-Rendueles, Gnana Prakasam Krishnamoorthy, Mahesh Saqcena, Adrián Acuña-Ruíz, Giovanna Revilla, Elisa de Stanchina, Jeffrey A. Knauf, Rona Lester, Bin Xu, Ronald A. Ghossein et al. · 2022 · Molecular Cancer
The Roles of Par3, Par6, and aPKC Polarity Proteins in Normal Neurodevelopment and in Neurodegenerative and Neuropsychiatric Disorders
Lili Zhang, Xiangyun Wei · 2022 · Journal of Neuroscience
Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration
Shijie Liu, Vaibhav Deshmukh, Fansen Meng, Yidan Wang, Yuka Morikawa, Jeffrey D. Steimle, Gang Li, Jun Wang, James F. Martin · 2024 · Circulation
Oncogenic Pathways in Neurodegenerative Diseases
Luis Varela, María E.R. García-Rendueles · 2022 · International Journal of Molecular Sciences
Mutant p53, the Mevalonate Pathway and the Tumor Microenvironment Regulate Tumor Response to Statin Therapy
Madison Pereira, Kathy Matuszewska, Alice Glogova, Jim Petrik · 2022 · Cancers
The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress
Gayoung Seo, Clinton Yu, Han Han, Xing Li, Rebecca Elizabeth Kattan, Jeongmin An, Amrutha Kizhedathu, Bing Yang, Annabella Luo, Abigail L. Buckle et al. · 2023 · Molecular Cell
A comprehensive review of stroke-related signaling pathways and treatment in western medicine and traditional Chinese medicine
Binhao Chen, Weifeng Jin · 2023 · Frontiers in Neuroscience
Epstein-Barr virus infection upregulates extracellular OLFM4 to activate YAP signaling during gastric cancer progression
Fuping Wen, Yi Han, Hui Zhang, Zhangting Zhao, Wenjia Wang, Fan Chen, Weimin Qin, Junyi Ju, Liwei An, Meng Yan et al. · 2024 · Nature Communications
Regulation and functions of the Hippo pathway in stemness and differentiation
Xiaolei Cao, Chenliang Wang, Jiyang Liu, Bin Zhao · 2020 · Acta Biochimica et Biophysica Sinica
Role of Clostridium perfringens Enterotoxin on YAP Activation in Colonic Sessile Serrated Adenoma/Polyps with Dysplasia
Rina Fujiwara‐Tani, Kiyomu Fujii, Shiori Mori, Shingo Kishi, Takamitsu Sasaki, Hitoshi Ohmori, Chie Nakashima, Isao Kawahara, Yukiko Nishiguchi, Takuya Mori et al. · 2020 · International Journal of Molecular Sciences
Inducible Deletion of YAP and TAZ in Adult Mouse Smooth Muscle Causes Rapid and Lethal Colonic Pseudo-Obstruction
Fatima Daoud, Johan Holmberg, Azra Alajbegovic, Mario Grossi, Catarina Rippe, Karl Swärd, Sebastian Albinsson · 2020 · Cellular and Molecular Gastroenterology and Hepatology
LATS2 condensates organize signalosomes for Hippo pathway signal transduction
Min Qin, Ershuo Geng, Jingning Wang, Man Yu, Tianqi Dong, Shasha Li, Xiao Zhang, Jiaming Lin, Mingjun Shi, Juebei Li et al. · 2024 · Nature Chemical Biology
Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells
Abdulaziz B. Hamid, Ruben C. Petreaca · 2020 · Cancers
Role of miRNA-424 in Cancers
Shulin Li, Yuqi Wu, Jiawei Zhang, Hao Sun, Xiangwei Wang · 2020 · OncoTargets and Therapy
Wound-induced polyploidization is dependent on Integrin-Yki signaling
R. Besen-McNally, K. J. Gjelsvik, Vicki P. Losick · 2020 · Biology Open
HERC3 promotes YAP/TAZ stability and tumorigenesis independently of its ubiquitin ligase activity
Bo Yuan, Jinquan Liu, Aiping Shi, Jin Cao, Yi Yu, Yezhang Zhu, Chengbin Zhang, Yifei Qiu, Hongjie Luo, Jiaxian Shi et al. · 2023 · The EMBO Journal
An MRTF-A–ZEB1–IRF9 axis contributes to fibroblast–myofibroblast transition and renal fibrosis
Qianwen Zhao, Tinghui Shao, Yuwen Zhu, Gengjie Zong, Junjie Zhang, Shifan Tang, Yanshan Lin, Hongzhen Ma, Zhifan Jiang, Yong Xu et al. · 2023 · Experimental & Molecular Medicine
An injury-responsivemmp14benhancer is required for heart regeneration
Ivana Zlatanova, Fei Sun, Roland S. Wu, Xiaoxin Chen, Bryan Hill-Fung Lau, Pauline Colombier, Tanvi Sinha, Barbara Celona, Shan-Mei Xu, Stefan C. Materna et al. · 2023 · Science Advances
A chaperone-like function of FUS ensures TAZ condensate dynamics and transcriptional activation
Yangqing Shao, Xin Shu, Yi Lu, Wenxuan Zhu, Ran Li, Huanyi Fu, Chengyu Li, Wei Sun, Zhuo Li, Yitong Zhang et al. · 2024 · Nature Cell Biology
Molecular pathways and targeted therapies in head and neck cancers pathogenesis
Marian Constantin, Mariana Carmen Chifiriuc, Coralia Bleoţu, Corneliu Ovidiu Vrâncianu, Roxana-Elena Cristian, Serban Vifor Bertesteanu, Raluca Grigore, Gloria Simona Berteșteanu · 2024 · Frontiers in Oncology
Targeting limbal epithelial stem cells: master conductors of corneal epithelial regeneration from the bench to multilevel theranostics
Shiding Li, Hao Sun, Liangbo Chen, Yao Fu · 2024 · Journal of Translational Medicine