The Hippo Signaling Pathway in Development and Disease

Role of YAP/TAZ in mechanotransduction

Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979 · see citing works

Oncogenic Signaling Pathways in The Cancer Genome Atlas

Sanchez-Vega, F., Mina, M., Armenia, J., Chatila, W. K., Luna, A., La, K. C., Dimitriadoy, S., Liu, D. L., Kantheti, H. S., Saghafinia, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.035 · Cited by 3,201 · see citing works

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092 · see citing works

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

Discher, D. E., Mooney, D. J., & Zandstra, P. W. (2009) · Science · doi:10.1126/science.1171643 · Cited by 2,666 · see citing works

TEAD mediates YAP-dependent gene induction and growth control

Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498 · see citing works

Elucidation of a universal size-control mechanism in Drosophila and mammals

Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370 · see citing works

The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP

Huang, J., Wu, S., Barrera, J. A., Matthews, K. A., & Pan, D. (2005) · Cell · doi:10.1016/j.cell.2005.06.007 · Cited by 1,870 · see citing works

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

Aragona, M., Panciera, T., Manfrin, A., Giulitti, S., Michielin, F., Elvassore, N., Dupont, S., & Piccolo, S. (2013) · Cell · doi:10.1016/j.cell.2013.07.042 · Cited by 1,651 · see citing works

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

Yu, F.-X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.037 · Cited by 1,628 · see citing works

Force triggers YAP nuclear entry by regulating transport across nuclear pores

Elosegui-Artola, A., Andreu, I., Beedle, A. E. M., Lezamiz, A., Uroz, M., Kosmalska, A. J., Oria, R., Kechagia, J. Z., Rico-Lastres, P., Le Roux, A.-L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.008 · Cited by 1,491 · see citing works

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2756 · Cited by 1,478 · see citing works

Genetic and pharmacological disruption of the TEAD–YAP complex suppresses the oncogenic activity of YAP

Liu-Chittenden, Y., Huang, B., Shim, J. S., Chen, Q., Lee, S.-J., Anders, R. A., Liu, J. O., & Pan, D. (2012) · Genes & Development · doi:10.1101/gad.192856.112 · Cited by 1,452 · see citing works

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF ^β-TRCP

Zhao, B., Li, L., Tumaneng, K., Wang, C.-Y., & Guan, K.-L. (2010) · Genes & Development · doi:10.1101/gad.1843810 · Cited by 1,418 · see citing works

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

Rouleau, G. A., Merel, P., Lutchman, M., Sanson, M., Zucman‐Rossi, J., Marineau, C., Hoang‐Xuan, K., Demczuk, S., Desmaze, C., Plougastel-Douglas, B., et al. (1993) · Nature · doi:10.1038/363515a0 · Cited by 1,398 · see citing works

The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

Cordenonsi, M., Zanconato, F., Azzolin, L., Forcato, M., Rosato, A., Frasson, C., Inui, M., Montagner, M., Parenti, A. R., Poletti, A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.048 · Cited by 1,381 · see citing works

YAP1 increases organ size and expands undifferentiated progenitor cells

Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.039 · Cited by 1,252 · see citing works

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

Pajtler, K. W., Witt, H., Sill, M., Jones, D., Hovestadt, V., Kratochwil, F., Wani, K., Tatevossian, R., Punchihewa, C., Johann, P. D., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.002 · Cited by 1,224 · see citing works

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

Zanconato, F., Forcato, M., Battilana, G., Azzolin, L., Quaranta, E., Bodega, B., Rosato, A., Bicciato, S., Cordenonsi, M., & Piccolo, S. (2015) · Nature Cell Biology · doi:10.1038/ncb3216 · Cited by 1,219 · see citing works

hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and warts

Wu, S., Huang, J., Dong, J., & Pan, D. (2003) · Cell · doi:10.1016/s0092-8674(03)00549-x · Cited by 1,101 · see citing works

YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response

Azzolin, L., Panciera, T., Soligo, S., Enzo, E., Bicciato, S., Dupont, S., Bresolin, S., Frasson, C., Basso, G., Guzzardo, V., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.013 · Cited by 1,094 · see citing works

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

Heallen, T. R., Zhang, M., Wang, J., Bonilla-Claudio, M., Klysik, E., Johnson, R. L., & Martin, J. F. (2011) · Science · doi:10.1126/science.1199010 · Cited by 1,092 · see citing works

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

Nishioka, N., Inoue, K., Adachi, K., Kiyonari, H., Ota, M., Ralston, A., Yabuta, N., Hirahara, S., Stephenson, R. O., Ogonuki, N., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.003 · Cited by 1,083 · see citing works

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

Zender, L., Spector, M. S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S.-T., Luk, J. M., Wigler, M., Hannon, G. J., et al. (2006) · Cell · doi:10.1016/j.cell.2006.05.030 · Cited by 1,065 · see citing works

Yap1 acts downstream of α-catenin to control epidermal proliferation

Schlegelmilch, K., Mohseni, M., Kirak, O., Pruszak, J., Rodriguez, J. R., Zhou, D., Kreger, B. T., Vasioukhin, V., Avruch, J., Brummelkamp, T. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.031 · Cited by 1,036 · see citing works

The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis

Harvey, K. F., Pfleger, C. M., & Hariharan, I. K. (2003) · Cell · doi:10.1016/s0092-8674(03)00557-9 · Cited by 983 · see citing works

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.

Justice, R. W., Zilian, O., Woods, D. F., Noll, M., & Bryant, P. J. (1995) · Genes & Development · doi:10.1101/gad.9.5.534 · Cited by 977 · see citing works

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

Lei, Q., Zhang, H., Zhao, B., Zha, Z., Bai, F., Pei, X., Zhao, S., Xiong, Y., & Guan, K. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01874-07 · Cited by 925 · see citing works

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

Zhou, D., Conrad, C. H., Xia, F., Park, J.-S., Payer, B., Yin, Y., Lauwers, G. Y., Thasler, W. E., Lee, J. T., Avruch, J., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.09.026 · Cited by 916 · see citing works

Hippo pathway effector Yap promotes cardiac regeneration

Xin, M., Kim, Y., Sutherland, L. B., Murakami, M., Qi, X., McAnally, J., Porrello, E. R., Mahmoud, A. I., Tan, W., Shelton, J. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313192110 · Cited by 895 · see citing works

Transforming properties of YAP , a candidate oncogene on the chromosome 11q22 amplicon

Overholtzer, M., Zhang, J., Smolen, G. A., Muir, B., Li, W., Sgroi, D. C., Deng, C., Brugge, J. S., & Haber, D. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605579103 · Cited by 885 · see citing works

salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and Is Mutated in Human Cancer Cell Lines

Tapon, N., Harvey, K. F., Bell, D. W., Wahrer, D. C. R., Schiripo, T. A., Haber, D. A., & Hariharan, I. K. (2002) · Cell · doi:10.1016/s0092-8674(02)00824-3 · Cited by 858 · see citing works

Hippo Pathway Activity Influences Liver Cell Fate

Yimlamai, D., Christodoulou, C., Galli, G. G., Yanger, K., Pepe-Mooney, B., Gurung, B., Shrestha, K., Cahan, P., Stanger, B. Z., & Camargo, F. D. (2014) · Cell · doi:10.1016/j.cell.2014.03.060 · Cited by 857 · see citing works

Hippo pathway regulation by cell morphology and stress fibers

Wada, K., Itoga, K., Okano, T., Yonemura, S., & Sasaki, H. (2011) · Development · doi:10.1242/dev.070987 · Cited by 852 · see citing works

A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span

Lehtinen, M. K., Yuan, Z., Boag, P. R., Yang, Y., Villén, J., Becker, E. B. E., DiBacco, S., de la Iglesia, N., Gygi, S. P., Blackwell, T. K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.03.046 · Cited by 842 · see citing works

Statins and the Risk of Colorectal Cancer

Poynter, J. N., Gruber, S. B., Higgins, P., Almog, R., Bonner, J. D., Rennert, H. S., Low, M., Greenson, J. K., & Rennert, G. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043792 · Cited by 815 · see citing works

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

Zhang, N., Bai, H., David, K. K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R. A., & Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.015 · Cited by 804 · see citing works

Identifying tumor suppressors in genetic mosaics: the <i>Drosophila lats</i> gene encodes a putative protein kinase

Xu, T., Wang, W., Zhang, S., Stewart, R. A., & Yu, W. (1995) · Development · doi:10.1242/dev.121.4.1053 · Cited by 799 · see citing works

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikisPreprint

Zhao, B., Li, L., Wang, L., Wang, C.-Y., Yu, J., & Guan, K. (2012) · Genes & Development · doi:10.1101/gad.173435.111 · Cited by 794 · see citing works

Metabolic control of YAP and TAZ by the mevalonate pathway

Sorrentino, G., Ruggeri, N., Specchia, V., Cordenonsi, M., Mano, M., Dupont, S., Manfrin, A., Ingallina, E., Sommaggio, R., Piazza, S., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2936 · Cited by 779 · see citing works

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

Hamaratoǧlu, F., Willecke, M., Kango‐Singh, M., Nolo, R. M., Hyun, E., Tao, C., Jafar‐Nejad, H., & Halder, G. A. (2005) · Nature Cell Biology · doi:10.1038/ncb1339 · Cited by 767 · see citing works

Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

Udan, R. S., Kango-Singh, M., Nolo, R., Tao, C., & Halder, G. (2003) · Nature Cell Biology · doi:10.1038/ncb1050 · Cited by 747 · see citing works

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

Shao, D. D., Xue, W., Krall, E. B., Bhutkar, A., Piccioni, F., Wang, X., Schinzel, A. C., Sood, S., Rosenbluh, J., Kim, J. W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.004 · Cited by 744 · see citing works

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiationPreprint

Lian, I., Kim, J., Okazawa, H., Zhao, J. J., Zhao, B., Yu, J., Chinnaiyan, A. M., Israel, M. A., Goldstein, L. S. B., Abujarour, R., et al. (2010) · Genes & Development · doi:10.1101/gad.1903310 · Cited by 738 · see citing works

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

Lu, L., Li, Y., Kim, S. M., Bossuyt, W., Liu, P., Qiu, Q., Wang, Y., Halder, G. A., Finegold, M. J., Lee, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911427107 · Cited by 721 · see citing works

TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm

Vassilev, A., Kaneko, K. J., Shu, H., Zhao, Y., & DePamphilis, M. L. (2001) · Genes &amp; Development · doi:10.1101/gad.888601 · Cited by 719 · see citing works

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

Kapoor, A., Yao, W., Ying, H., Hua, S., Liewen, A., Wang, Q., Zhong, Y., Wu, C.-J., Sadanandam, A., Hu, B., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.003 · Cited by 716 · cited 3× · see citing works

Alternative Wnt Signaling Activates YAP/TAZ

Park, H. W., Kim, Y. C., Yu, B., Moroishi, T., Mo, J., Plouffe, S. W., Meng, Z., Lin, K. C., Yu, F., Alexander, C. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.013 · Cited by 708 · see citing works

E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components

Kim, N.-G., Koh, E., Chen, X., & Gumbiner, B. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103345108 · Cited by 698 · see citing works

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

Varelas, X., Samavarchi‐Tehrani, P., Narimatsu, M., Weiss, A., Cockburn, K., Larsen, B. G., Rossant, J., & Wrana, J. L. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.11.012 · Cited by 683 · see citing works

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

Wang, L., Luo, J., Li, B., Tian, X. Y., Chen, L., Huang, Y., Liu, J., Deng, D., Lau, C. W., Wan, S., et al. (2016) · Nature · doi:10.1038/nature20602 · Cited by 672 · see citing works

C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma

Parker, M. D., Mohankumar, K. M., Punchihewa, C., Weinlich, R., Dalton, J., Li, Y., Lee, R. P., Tatevossian, R., Phoenix, T. N., Thiruvenkatam, R., et al. (2014) · Nature · doi:10.1038/nature13109 · Cited by 668 · see citing works

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

Varelas, X., Sakuma, R., Samavarchi‐Tehrani, P., Peerani, R., Rao, B. M., Dembowy, J., Yaffe, M. B., Zandstra, P. W., & Wrana, J. L. (2008) · Nature Cell Biology · doi:10.1038/ncb1748 · Cited by 666 · see citing works

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoproteinPreprint

Zhao, B., Li, L., Lu, Q. R., Wang, L. H., Liu, C., Lei, Q., & Guan, K. (2011) · Genes & Development · doi:10.1101/gad.2000111 · Cited by 665 · see citing works

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

Lamar, J. M., Stern, P., Liu, H., Schindler, J. W., Jiang, Z.-G., & Hynes, R. O. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212021109 · Cited by 656 · see citing works

The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway

Wu, S., Liu, Y., Zheng, Y., Dong, J., & Pan, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.007 · Cited by 640 · see citing works

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control

Zhang, L., Ren, F., Zhang, Q., Chen, Y., Wang, B., & Jiang, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.006 · Cited by 630 · see citing works

Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts

Li, S., Shen, D., Shao, J., Crowder, R. J., Liu, W., Prat, A., He, X., Liu, S., Hoog, J., Lu, C., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.022 · Cited by 623 · see citing works

A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

Jiao, S., Wang, H., Shi, Z., Dong, A., Zhang, W., Song, X., He, F., Wang, Y., Zhang, Z., Wang, W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.01.010 · Cited by 605 · see citing works

Novel YAP1‐TFE3 fusion defines a distinct subset of epithelioid hemangioendothelioma

Antonescu, C. R., Loarer, F. L., Mosquera, J., Sboner, A., Zhang, L., Chen, C., Chen, H., Pathan, N., Krausz, T. N., Dickson, B. C., et al. (2013) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22073 · Cited by 596 · see citing works

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

Song, H., Mak, K. K., Topol, L. Z., Yun, K., Hu, J., Garrett, L. J., Chen, Y., Park, O., Chang, J., Simpson, R. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911409107 · Cited by 583 · see citing works

YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy

von Gise, A., Lin, Z., Schlegelmilch, K., Honor, L. B., Pan, G. M., Buck, J. N., Ma, Q., Ishiwata, T., Zhou, B., Camargo, F. D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116136109 · Cited by 573 · see citing works

Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats

Lai, Z.-C., Wei, X., Shimizu, T., Ramos, E., Rohrbaugh, M., Nikolaidis, N., Ho, L., & Li, Y. (2005) · Cell · doi:10.1016/j.cell.2004.12.036 · Cited by 570 · see citing works

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

Feng, X., Degese, M. S., Iglesias‐Bartolomé, R., Vaque, J. P., Molinolo, A., Rodrigues, M. W., Zaidi, M. R., Ksander, B. R., Merlino, G. T., Sodhi, A., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.016 · Cited by 559 · see citing works

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

Mo, J.-S., Meng, Z., Kim, Y. C., Park, H. W., Hansen, C. G., Kim, S., Lim, D.-S., & Guan, K.-L. (2015) · Nature Cell Biology · doi:10.1038/ncb3111 · Cited by 557 · see citing works

Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

Wang, G., Lü, X., Dey, P., Deng, P., Wu, C.-C., Jiang, S., Fang, Z., Zhao, K., Konaparthi, R., Hua, S., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0224 · Cited by 556 · see citing works

The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila

Pantalacci, S., Tapon, N., & Léopold, P. (2003) · Nature Cell Biology · doi:10.1038/ncb1051 · Cited by 552 · see citing works

Regulation of Insulin-Like Growth Factor Signaling by Yap Governs Cardiomyocyte Proliferation and Embryonic Heart Size

Xin, M., Kim, Y., Sutherland, L. B., Qi, X., McAnally, J., Schwartz, R. J., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2011) · Science Signaling · doi:10.1126/scisignal.2002278 · Cited by 549 · see citing works

AMPK modulates Hippo pathway activity to regulate energy homeostasis

Wang, W., Xiao, Z.-D., Li, X., Aziz, K. E., Gan, B., Johnson, R. L., & Chen, J. (2015) · Nature Cell Biology · doi:10.1038/ncb3113 · Cited by 549 · see citing works

Mechanical strain induces E-cadherin–dependent Yap1 and β-catenin activation to drive cell cycle entry

Benham-Pyle, B. W., Pruitt, B. L., & Nelson, W. J. (2015) · Science · doi:10.1126/science.aaa4559 · Cited by 539 · see citing works

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase

Liu, C.-Y., Zha, Z.-Y., Zhou, X., Zhang, H., Huang, W., Zhao, D., Li, T., Chan, S. W., Lim, C. J., Hong, W., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152942 · Cited by 525 · see citing works

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

Meng, Z., Moroishi, T., Mottier, V., Plouffe, S. W., Hansen, C. G., Hong, A. W., Park, H. W., Mo, J., Lü, W., Lu, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms9357 · Cited by 524 · see citing works

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

Saburi, S., Hester, I., Fischer, E. A., Pontoglio, M., Eremina, V., Gessler, M., Quaggin, S., Harrison, R. V., Mount, R. J., & McNeill, H. (2008) · Nature Genetics · doi:10.1038/ng.179 · Cited by 517 · see citing works

Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway

Li, Z., Razavi, P., Li, Q., Toy, W., Liu, B., Ping, C., Hsieh, W., Sanchez-Vega, F., Brown, D. N., Da Cruz Paula, A. F., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.11.006 · Cited by 508 · see citing works

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

Yin, F., Yu, J., Zheng, Y., Chen, Q., Zhang, N., & Pan, D. (2013) · Cell · doi:10.1016/j.cell.2013.08.025 · Cited by 506 · see citing works

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

Wang, Y., Xu, X., Maglic, D., Dill, M. T., Mojumdar, K., Ng, P. K.-S., Jeong, K. J., Tsang, Y. H., Moreno, D., Bhavana, V. H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.001 · Cited by 500 · see citing works

Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded

Yu, J., Zheng, Y., Dong, J., Klusza, S., Deng, W.-M., & Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.012 · Cited by 496 · see citing works

The Hippo–Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

Lee, K., Lee, J., Kim, T., Kim, T., Park, H.-D., Byun, J., Kim, M., Jeong, W., Calvisi, D. F., Kim, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912203107 · Cited by 494 · see citing works

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration programPreprint

Cai, J., Zhang, N., Zheng, Y., de Wilde, R. F., Maitra, A., & Pan, D. (2010) · Genes & Development · doi:10.1101/gad.1978810 · Cited by 491 · see citing works

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

Bonilla, X., Parmentier, L., King, B., Bezrukov, F., Kaya, G., Zoete, V., Seplyarskiy, V. B., Sharpe, H. J., McKee, T., Letourneau, A., et al. (2016) · Nature Genetics · doi:10.1038/ng.3525 · Cited by 486 · see citing works

Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signalingPreprint

Barolo, S., & Posakony, J. W. (2002) · Genes & Development · doi:10.1101/gad.976502 · Cited by 465 · see citing works

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

Yu, F., Luo, J., Mo, J., Liu, G., Kim, Y. C., Meng, Z., Zhao, L., Peyman, G. A., Ouyang, H. W., Jiang, W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.017 · Cited by 464 · see citing works

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

Bertero, T., Oldham, W. M., Cottrill, K. A., Pisano, S., Vanderpool, R. R., Yu, Q., Zhao, J., Tai, Y., Tang, Y., Zhang, Y.-Y., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86387 · Cited by 438 · see citing works

Delineation of a Fat tumor suppressor pathway

Cho, E., Feng, Y., Rauskolb, C., Maitra, S., Fehon, R. G., & Irvine, K. D. (2006) · Nature Genetics · doi:10.1038/ng1887 · Cited by 432 · see citing works

Modulating F‐actin organization induces organ growth by affecting the Hippo pathway

Sansores-García, L., Bossuyt, W., Wada, K., Yonemura, S., Tao, C., Sasaki, H., & Halder, G. A. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.157 · Cited by 430 · see citing works

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

Zhang, J., Ji, J., Yu, M., Overholtzer, M., Smolen, G. A., Wang, R., Brugge, J. S., Dyson, N. J., & Haber, D. A. (2009) · Nature Cell Biology · doi:10.1038/ncb1993 · Cited by 427 · see citing works

Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos

Hirate, Y., Hirahara, S., Inoue, K., Suzuki, A., Alarcón, V. B., Akimoto, K., Hirai, T., Hara, T., Adachi, M., Chida, K., et al. (2013) · Current Biology · doi:10.1016/j.cub.2013.05.014 · Cited by 427 · see citing works

Hippo pathway deficiency reverses systolic heart failure after infarction

Leach, J. P., Heallen, T. R., Zhang, M., Rahmani, M., Morikawa, Y., Hill, M. C., Segura, A., Willerson, J. T., & Martin, J. F. (2017) · Nature · doi:10.1038/nature24045 · Cited by 425 · see citing works

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

Kim, N., & Gumbiner, B. M. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201501025 · Cited by 423 · see citing works

MOBKL1A/MOBKL1B Phosphorylation by MST1 and MST2 Inhibits Cell Proliferation

Praskova, M. D., Xia, F., & Avruch, J. (2008) · Current Biology · doi:10.1016/j.cub.2008.02.006 · Cited by 423 · see citing works

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

Zhang, H., Pasolli, H. A., & Fuchs, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019603108 · Cited by 419 · see citing works

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

Wang, X., Zheng, Z., Caviglia, J. M., Corey, K. E., Herfel, T. M., Cai, B., Masia, R., Chung, R. T., Lefkowitch, J. H., Schwabe, R. F., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.016 · Cited by 413 · see citing works

Structural insights into the YAP and TEAD complexPreprint

Li, Z., Zhao, B., Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K., & Xu, Y. (2010) · Genes & Development · doi:10.1101/gad.1865810 · Cited by 406 · see citing works

Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network

Genevet, A., Wehr, M. C., Brain, R., Thompson, B. J., & Tapon, N. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.011 · Cited by 402 · see citing works

Identification of a Disease-Defining Gene Fusion in Epithelioid Hemangioendothelioma

Tanas, M. R., Sboner, A., Oliveira, A. M., Erickson‐Johnson, M. R., Hespelt, J., Hanwright, P. J., Flanagan, J., Luo, Y., Fenwick, K., Natrajan, R., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002409 · Cited by 399 · see citing works

YAP regulates neural progenitor cell number via the TEA domain transcription factorPreprint

Cao, X., Pfaff, S. L., & Gage, F. H. (2008) · Genes & Development · doi:10.1101/gad.1726608 · Cited by 398 · see citing works

The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosisPreprint

Jia, J., Zhang, W., Wang, B., Trinko, R., & Jiang, J. (2003) · Genes & Development · doi:10.1101/gad.1134003 · Cited by 392 · see citing works

Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling

Ota, M., & Sasaki, H. (2008) · Development · doi:10.1242/dev.027151 · Cited by 391 · see citing works

Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver

Stanger, B. Z., Tanaka, A., & Melton, D. A. (2007) · Nature · doi:10.1038/nature05537 · Cited by 385 · see citing works

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

Fan, F., He, Z., Kong, L., Chen, Q., Yuan, Q., Zhang, S., Ye, J., Liu, H., Sun, X., Geng, J., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf2304 · Cited by 385 · see citing works

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferationPreprint

Fernández-L, A., Northcott, P. A., Dalton, J., Fraga, C. H., Ellison, D. W., Angers, S., Taylor, M. D., & Kenney, A. M. (2009) · Genes & Development · doi:10.1101/gad.1824509 · Cited by 378 · see citing works

RAP2 mediates mechanoresponses of the Hippo pathway

Meng, Z., Qiu, Y., Lin, K. C., Kumar, A., Placone, J. K., Fang, C., Wang, K.-C., Lu, S., Pan, M., Hong, A. W., et al. (2018) · Nature · doi:10.1038/s41586-018-0444-0 · Cited by 377 · see citing works

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

Ganem, N. J., Cornils, H., Chiu, S.-Y., O’Rourke, K. P., Arnaud, J., Yimlamai, D., Théry, M., Camargo, F. D., & Pellman, D. S. (2014) · Cell · doi:10.1016/j.cell.2014.06.029 · Cited by 375 · see citing works

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasisPreprint

Moroishi, T., Park, H. W., Qin, B., Chen, Q., Meng, Z., Plouffe, S. W., Taniguchi, K., Yu, F., Karin, M., Pan, D., et al. (2015) · Genes & Development · doi:10.1101/gad.262816.115 · Cited by 369 · see citing works

Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2Preprint

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YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis

Wang, X., Valls, A. F., Schermann, G., Shen, Y., Moya, I. M., Castro, L., Urban, S., Solecki, G. M., Winkler, F., Riedemann, L., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.08.002 · Cited by 369 · see citing works

A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein

Goudreault, M., D'Ambrosio, L. M., Kean, M. J., Mullin, M. J., Larsen, B. G., Sanchez, A., Chaudhry, S., Chen, G. I., Sicheri, F., Nesvizhskii, A. I., et al. (2009) · Molecular &amp; Cellular Proteomics · doi:10.1074/mcp.m800266-mcp200 · Cited by 359 · see citing works

Cytoskeletal Tension Inhibits Hippo Signaling through an Ajuba-Warts Complex

Rauskolb, C., Sun, S., Sun, G., Pan, Y., & Irvine, K. D. (2014) · Cell · doi:10.1016/j.cell.2014.05.035 · Cited by 353 · see citing works

Shar-pei mediates cell proliferation arrest during imaginal disc growth inDrosophila

Kango‐Singh, M., Nolo, R. M., Tao, C., Verstreken, P., Hiesinger, P. R., Bellen, H. J., & Halder, G. A. (2002) · Development · doi:10.1242/dev.00168 · Cited by 349 · see citing works

Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras

Praskova, M. D., KHOKLATCHEV, A., Ortiz-Vega, S., & Avruch, J. (2004) · Biochemical Journal · doi:10.1042/bj20040025 · Cited by 342 · see citing works

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

Grzeschik, N. A., Parsons, L. M., Allott, M. L., Harvey, K. F., & Richardson, H. E. (2010) · Current Biology · doi:10.1016/j.cub.2010.01.055 · Cited by 341 · see citing works

Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

Fan, R., Kim, N., & Gumbiner, B. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216462110 · Cited by 339 · see citing works

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiationPreprint

Yu, F., Zhang, Y., Park, H. W., Jewell, J. L., Chen, Q., Deng, Y., Pan, D., Taylor, S. S., Lai, Z.-C., & Guan, K. (2013) · Genes & Development · doi:10.1101/gad.219402.113 · Cited by 337 · see citing works

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ

Chang, L., Azzolin, L., Biagio, D. D., Zanconato, F., Battilana, G., Xiccato, R. L., Aragona, M., Giulitti, S., Panciera, T., Gandin, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0658-1 · Cited by 328 · see citing works

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

Chen, L., Zheng, Y., Yin, F., Yu, J., Huang, J., Hong, Y., Wu, S., & Pan, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004279107 · Cited by 320 · see citing works

The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila

Baumgartner, R., Poernbacher, I., Buser, N., Hafen, E., & Stocker, H. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.013 · Cited by 320 · see citing works

The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration

Karpowicz, P. A., Perez, J. N., & Perrimon, N. (2010) · Development · doi:10.1242/dev.060483 · Cited by 318 · see citing works

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

Wang, Z., Wu, Y., Wang, H., Zhang, Y., Mei, L., Fang, X., Zhang, X., Zhang, F., Chen, H., Liu, Y., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319190110 · Cited by 317 · see citing works

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

DeRan, M., Yang, J., Shen, C.-H., Peters, E. C., Fitamant, J., Chan, P., Hsieh, M., Zhu, S., Asara, J. M., Zheng, B., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.036 · Cited by 316 · cited 2× · see citing works

Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways

Ren, F., Wang, B., Yue, T., Yun, E.-Y., Ip, Y. T., & Jiang, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012759107 · Cited by 316 · see citing works

Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

Chan, P., Han, X., Zheng, B., DeRan, M., Yu, J., Jarugumilli, G. K., Deng, H., Pan, D., Luo, X., & Wu, X. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2036 · Cited by 313 · see citing works

Crumbs Regulates Salvador/Warts/Hippo Signaling in Drosophila via the FERM-Domain Protein Expanded

Robinson, B. S., Huang, J., Hong, Y., & Moberg, K. H. (2010) · Current Biology · doi:10.1016/j.cub.2010.03.019 · Cited by 312 · see citing works

Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers

Cottini, F., Hideshima, T., Xu, C., Sattler, M., Dori, M., Agnelli, L., ten Hacken, E., Bertilaccio, M. T. S., Antonini, E., Neri, A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3562 · Cited by 310 · see citing works

Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance

Nakajima, H., Yamamoto, K., Agarwala, S., Terai, K., Fukui, H., Fukuhara, S., Ando, K., Miyazaki, T., Yokota, Y., Schmelzer, E., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.02.019 · Cited by 308 · see citing works

The Hippo pathway regulates intestinal stem cell proliferation duringDrosophilaadult midgut regeneration

Shaw, R. L., Kohlmaier, A., Polesello, C., Veelken, C., Edgar, B. A., & Tapon, N. (2010) · Development · doi:10.1242/dev.052506 · Cited by 307 · see citing works

Integrin signalling regulates YAP/TAZ to control skin homeostasis

Elbediwy, A., Vincent‐Mistiaen, Z. I., Spencer‐Dene, B., Stone, R. K., Boeing, S., Wculek, S. K., Cordero, J., Tan, E. H., Ridgway, R., Brunton, V. G., et al. (2016) · Development · doi:10.1242/dev.133728 · Cited by 307 · see citing works

The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1

van Rensburg, H. J. J., Azad, T., Ling, M., Hao, Y., Snetsinger, B., Khanal, P., Minassian, L. M., Graham, C. H., Rauh, M. J., & Yang, X. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3139 · Cited by 307 · see citing works

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

Chen, C., Gajewski, K. M., Hamaratoǧlu, F., Bossuyt, W., Sansores-García, L., Tao, C., & Halder, G. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004060107 · Cited by 303 · see citing works

Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development

Reginensi, A., Scott, R. P., Gregorieff, A., Bagherie-Lachidan, M., Chung, C., Lim, D., Pawson, T. J., Wrana, J. L., & McNeill, H. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003380 · Cited by 295 · see citing works

Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ

Makita, R., Uchijima, Y., Nishiyama, K., Amano, T., Chen, Q., Takeuchi, T., Mitani, A., Nagase, T., Yatomi, Y., Aburatani, H., et al. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00201.2007 · Cited by 294 · see citing works

A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

Mohseni, M., Sun, J., Lau, A., Curtis, S., Goldsmith, J., Fox, V. L., Wei, C., Frazier, M., Samson, O., Wong, K.-K., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2884 · Cited by 294 · see citing works

Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila

Fernández, B. G., Gaspar, P., Brás‐Pereira, C., Jezowska, B., Rebelo, S. P., & Janody, F. (2011) · Development · doi:10.1242/dev.063545 · Cited by 293 · see citing works

YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers

Galli, G. G., Carrara, M., Yuan, W.-C., Valdes-Quezada, C., Gurung, B., Pepe-Mooney, B., Zhang, T., Geeven, G., Gray, N. S., de Laat, W., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.09.001 · Cited by 290 · see citing works

Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap

Neto-Silva, R. M., de Beco, S., & Johnston, L. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.009 · Cited by 289 · see citing works

Single tumor-initiating cells evade immune clearance by recruiting type II macrophagesPreprint

Guo, X., Zhao, Y., Yan, H., Yang, Y., Shen, S., Dai, X., Ji, X., Ji, F., Gong, X., Li, L., et al. (2017) · Genes & Development · doi:10.1101/gad.294348.116 · Cited by 283 · see citing works

Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation

Peng, C., Zhu, Y., Zhang, W., Liao, Q., Chen, Y., Zhao, X., Guo, Q., Shen, P., Zhen, B., Qian, X., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.10.010 · Cited by 283 · see citing works

The Hippo Effector Yorkie Controls Normal Tissue Growth by Antagonizing Scalloped-Mediated Default Repression

Koontz, L. M., Liu‐Chittenden, Y., Yin, F., Zheng, Y., Yu, J., Huang, B., Chen, Q., Wu, S., & Pan, D. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.04.021 · Cited by 282 · see citing works

MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival

Nehme, N. T., Schmid, J. P., Debeurme, F., André‐Schmutz, I., Lim, A., Nitschké, P., Rieux‐Laucat, F., Lutz, P., Pïcard, C., Mahlaoui, N., et al. (2011) · Blood · doi:10.1182/blood-2011-09-378364 · Cited by 281 · see citing works

The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy

Chen, S. N., Gurha, P., Lombardi, R., Ruggiero, A., Willerson, J. T., & Marian, A. J. (2014) · Circulation Research · doi:10.1161/circresaha.114.302810 · Cited by 275 · see citing works

Characterization of Hippo Pathway Components by Gene Inactivation

Plouffe, S. W., Meng, Z., Lin, K. C., Lin, B., Hong, A. W., Chun, J. V., & Guan, K.-L. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.034 · Cited by 275 · see citing works

Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling

Noland, C. L., Gierke, S., Schnier, P. D., Murray, J. M., Sandoval, W. N., Sagolla, M. S., Dey, A., Hannoush, R. N., Fairbrother, W. J., & Cunningham, C. N. (2015) · Structure · doi:10.1016/j.str.2015.11.005 · Cited by 268 · see citing works

Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase

Ma, B., Chen, Y., Chen, L., Cheng, H., Mu, C., Li, J., Gao, R., Zhou, C., Cao, L., Liu, J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3073 · Cited by 266 · see citing works

Kinases mst1 and mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

Geng, J., Sun, X., Wang, P., Zhang, S., Wang, X., Wu, H., Hong, L., Xie, C., Li, X., Zhao, H., et al. (2015) · Nature Immunology · doi:10.1038/ni.3268 · Cited by 264 · see citing works

A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive Functions

Yi, C., Troutman, S. A., Fera, D., Stemmer-Rachamimov, A. O., Avila, J. L., Christian, N., Persson, N. L., Shimono, A., Speicher, D. W., Marmorstein, R., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.02.017 · Cited by 260 · see citing works

LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma

Murakami, H., Mizuno, T., Taniguchi, T., Fujii, M., Ishiguro, F., Fukui, T., Akatsuka, S., Horio, Y., Hida, T., Kondo, Y., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2164 · Cited by 260 · see citing works

Structural basis of YAP recognition by TEAD4 in the Hippo pathwayPreprint

Chen, L., Chan, S. W., Zhang, X., Walsh, M. A., Lim, C. J., Hong, W., & Song, H. (2010) · Genes & Development · doi:10.1101/gad.1865310 · Cited by 251 · see citing works

Tao-1 Phosphorylates Hippo/MST Kinases to Regulate the Hippo-Salvador-Warts Tumor Suppressor Pathway

Boggiano, J. C., Vanderzalm, P. J., & Fehon, R. G. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.08.028 · Cited by 249 · see citing works

Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila

Liu, B., Zheng, Y., Yin, F., Yu, J., Silverman, N. S., & Pan, D. (2016) · Cell · doi:10.1016/j.cell.2015.12.029 · Cited by 249 · see citing works

The Hippo Pathway Effector Yap Controls Patterning and Differentiation of Airway Epithelial Progenitors

Mahoney, J. E., Mori, M., Szymaniak, A. D., Varelas, X., & Cardoso, W. V. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.06.003 · Cited by 248 · see citing works

Neurofibromatosis: A Review of NF1, NF2, and Schwannomatosis

Walsh, M. A., & Kresak, J. L. (2016) · Journal of Pediatric Genetics · doi:10.1055/s-0036-1579766 · Cited by 243 · see citing works

Regulation of YAP by Mechanical Strain through Jnk and Hippo Signaling

Codelia, V. A., Sun, G., & Irvine, K. D. (2014) · Current Biology · doi:10.1016/j.cub.2014.07.034 · Cited by 239 · see citing works

Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling

Ribeiro, P. S., Josué, F., Wepf, A., Wehr, M. C., Rinner, O., Kelly, G. P., Tapon, N., & Gstaiger, M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.002 · Cited by 235 · see citing works

YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity

Ni, X., Tao, J., Barbi, J. J., Chen, Q., Park, B. V., Li, Z., Zhang, N., Lebid, A., Ramaswamy, A., Wei, P., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1124 · Cited by 235 · see citing works

The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway

Poon, C. L. C., Lin, J. I., Zhang, X., & Harvey, K. F. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.09.012 · Cited by 227 · see citing works

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase

Serrano, I., McDonald, P. C., Lock, F. E., Muller, W. J., & Dedhar, S. (2013) · Nature Communications · doi:10.1038/ncomms3976 · Cited by 226 · see citing works

The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in DrosophilaPreprint

Halder, G. A., Polaczyk, P., Kraus, M. E., Hudson, A., Kim, J., Laughon, A. S., & Carroll, S. B. (1998) · Genes & Development · doi:10.1101/gad.12.24.3900 · Cited by 222 · see citing works

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesisPreprint

Chen, Q., Zhang, N., Gray, R. S., Li, H., Ewald, A. J., Zahnow, C. A., & Pan, D. (2014) · Genes & Development · doi:10.1101/gad.233676.113 · Cited by 220 · see citing works

Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade

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Yap Tunes Airway Epithelial Size and Architecture by Regulating the Identity, Maintenance, and Self-Renewal of Stem Cells

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cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes

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Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling

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Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins

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Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation

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Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

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Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms

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YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKɛ-mediated phosphorylation

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LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

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The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance.

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YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells

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Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b -deficient mice

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Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development

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αE-catenin inhibits a Src–YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway

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β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesisPreprint

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Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

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C11ORF95-RELA FUSIONS DRIVE ONCOGENIC NF-KB SIGNALING IN EPENDYMOMA

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Control of the Hippo Pathway by Set7-Dependent Methylation of Yap

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Structural and functional analysis of the YAP-binding domain of human TEAD2

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Phosphorylation by NLK inhibits YAP‐14‐3‐3‐interactions and induces its nuclear localization

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A neonatal blueprint for cardiac regeneration

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SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity

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Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis

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Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signalingPreprint

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Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration

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The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment

Skibinski, A., Breindel, J. L., Prat, A., Galván, P., Smith, E., Rolfs, A., Gupta, P. B., LaBaer, J., & Kuperwasser, C. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.038 · Cited by 159 · see citing works

The Growth Regulators warts/lats and melted Interact in a Bistable Loop to Specify Opposite Fates in Drosophila R8 Photoreceptors

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Osmotic stress‐induced phosphorylation by NLK at Ser128 activates YAP

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Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap

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Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells

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Hippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas

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Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

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Organ Size Control: Lessons from Drosophila

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Genome-wide Association of Yorkie with Chromatin and Chromatin-Remodeling Complexes

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The Conserved Misshapen-Warts-Yorkie Pathway Acts in Enteroblasts to Regulate Intestinal Stem Cells in Drosophila

Li, Q., Li, S., Mana‐Capelli, S., Flach, R. J. R., Danai, L. V., Amcheslavsky, A., Nie, Y., Kaneko, S., Yao, X., Chen, X., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.09.012 · Cited by 142 · see citing works

Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP

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Regulation of Organ Growth by Morphogen GradientsPreprint

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Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAPPreprint

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The Spectrin cytoskeleton regulates the Hippo signalling pathway

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Hippo Signaling Regulates Pancreas Development through Inactivation of Yap

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A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney diseasePreprint

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A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration)

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SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK

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Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer

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The Hippo signalling pathway and its implications in human health and diseases

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Liquid–liquid phase separation in human health and diseases

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Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis

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Lipid metabolism in cancer progression and therapeutic strategies

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YAP/TAZ functions and their regulation at a glance

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The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

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Glycogen accumulation and phase separation drives liver tumor initiation

Liu, Q., Li, J., Zhang, W., Xiao, C., Zhang, S., Nian, C., Li, J., Su, D., Chen, L., Zhao, Q. C., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.001 · Cited by 312 · see citing works

Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression

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TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection

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Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of <i>NF2</i> -deficient Mesothelioma

Tang, T. T., Konradi, A. W., Feng, Y., Peng, X., Ma, M., Li, J., Yu, F.-X., Guan, K.-L., & Post, L. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0717 · Cited by 245 · see citing works

Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation

Yu, M., Peng, Z., Qin, M., Liu, Y., Wang, J., Zhang, C., Lin, J., Dong, T., Wang, L., Li, S., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.01.010 · Cited by 250 · see citing works

YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches

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The Hippo Pathway in Liver Homeostasis and Pathophysiology

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A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy

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Insights into recent findings and clinical application of YAP and TAZ in cancer

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An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance

Hagenbeek, T. J., Zbieg, J. R., Hafner, M., Mroue, R., Lacap, J. A., Sodir, N. M., Noland, C. L., Afghani, S., Kishore, A., Bhat, K. P., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00577-0 · Cited by 215 · see citing works

Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis

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Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

Wang, X., Cai, B., Yang, X., Sonubi, O. O., Zheng, Z., Ramakrishnan, R., Shi, H., Valenti, L., Pajvani, U. B., Sandhu, J., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.03.010 · Cited by 204 · see citing works

Interactions between Muscle and Bone—Where Physics Meets Biology

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Liver Regeneration after Hepatectomy and Partial Liver Transplantation

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Integration of Hippo-YAP Signaling with Metabolism

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Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity

Pearson, J. D., Huang, K., Pacal, M., McCurdy, S. R., Lü, S., Aubry, A., Yu, T., Wadosky, K. M., Zhang, L., Wang, T., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.06.016 · Cited by 172 · see citing works

Molecular mechanisms of exercise contributing to tissue regeneration

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Control of stem cell renewal and fate by YAP and TAZ

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YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance

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Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosis

Franzén, L., Lindvall, M. O., Hühn, M. H., Ptasinski, V., Setyo, L. C., Keith, B. P., Collin, A., Oag, S., Volckaert, T., Borde, A., et al. (2024) · Nature Genetics · doi:10.1038/s41588-024-01819-2 · Cited by 149 · see citing works

Therapeutic targeting of TEAD transcription factors in cancer

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Screening membraneless organelle participants with machine-learning models that integrate multimodal features

Chen, Z., Hou, C., Wang, L., Yu, C., Chen, T., Shen, B., Hou, Y., Li, P., & Li, T. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2115369119 · Cited by 134 · see citing works

Prenatal and postnatal exposure to polystyrene microplastics induces testis developmental disorder and affects male fertility in mice

Zhao, T., Shen, L., Ye, X., Bai, G., Chen, L., Chen, Z., Peng, T., Li, X., Kang, X., & An, G. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130544 · Cited by 138 · see citing works

YAP/TAZ Transcriptional Coactivators Create Therapeutic Vulnerability to Verteporfin in EGFR-mutant Glioblastoma

Vigneswaran, K., Boyd, N., Oh, S.-Y., Lallani, S. B., Boucher, A. B., Neill, S. G., Olson, J. J., & Read, R. D. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-0018 · Cited by 132 · see citing works

Yap-Sox9 signaling determines hepatocyte plasticity and lineage-specific hepatocarcinogenesis

Liu, Y., Zhuo, S., Zhou, Y., Ma, L., Sun, Z., Wu, X., Wang, X. W., Gao, B., & Yang, Y. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.11.010 · Cited by 129 · see citing works

Laminar flow inhibits the Hippo/YAP pathway via autophagy and SIRT1-mediated deacetylation against atherosclerosis

Yuan, P., Hu, Q., He, X., Long, Y., Song, X., Wu, F., He, Y., & Zhou, X. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2343-1 · Cited by 125 · see citing works

The wing imaginal disc

Tripathi, B., & Irvine, K. (2022) · Genetics · doi:10.1093/genetics/iyac020 · Cited by 80 · see citing works

TEAD family transcription factors in development and disease

Currey, L., Thor, S., & Piper, M. (2021) · Development · doi:10.1242/dev.196675 · Cited by 120 · see citing works

Neutrophil Extracellular Traps Delay Diabetic Wound Healing by Inducing Endothelial-to-Mesenchymal Transition via the Hippo pathway

Yang, S., Wang, S., Chen, L., Wang, Z., Chen, J., Ni, Q., Guo, X., Zhang, L., & Xue, G. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.78046 · Cited by 118 · see citing works

M2 Macrophage-Derived Exosomal miR-590-3p Attenuates DSS-Induced Mucosal Damage and Promotes Epithelial Repair via the LATS1/YAP/ β-Catenin Signalling Axis

Deng, F., Yan, J., Lu, J., Luo, M., Xia, P., Liu, S., Wang, X., Zhi, F., & Liu, D. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa214 · Cited by 115 · see citing works

WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy

Qi, S., Zhu, Y., Liu, X., Li, P., Wang, Y., Zeng, Y. J., Yu, A., Wang, Y., Sha, Z., Zhong, Z., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.03.027 · Cited by 115 · see citing works

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth

Ong, Y. T., Andrade, J., Armbruster, M., Shi, C., Castro, M., Costa, A. S. H., Sugino, T., Eelen, G., Zimmermann, B., Wilhelm, K., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00584-y · Cited by 111 · see citing works

Hippo pathway dysregulation in gastric cancer: from Helicobacter pylori infection to tumor promotion and progression

Messina, B., Sardo, F. L., Scalera, S., Memeo, L., Colarossi, C., Mare, M., Blandino, G., Ciliberto, G., Maugeri‐Saccà, M., & Bon, G. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05568-8 · Cited by 112 · see citing works

Multiphase coalescence mediates Hippo pathway activation

Wang, L., Choi, K., Su, T., Li, B., Wu, X., Zhang, R., Driskill, J. H., Li, H., Lei, H., Guo, P., et al. (2022) · Cell · doi:10.1016/j.cell.2022.09.036 · Cited by 110 · see citing works

MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer’s disease

Wang, H., Shang, Y., Wang, E., Xu, X., Zhang, Q., Qian, C., Yang, Z., Wu, S., & Zhang, T. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102280 · Cited by 107 · see citing works

Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo

Little, D. R., Lynch, A. M., Yan, Y., Akiyama, H., Kimura, S., & Chen, J. (2021) · Nature Communications · doi:10.1038/s41467-021-22817-6 · Cited by 105 · see citing works

YAP/TAZ drives cell proliferation and tumour growth via a polyamine–eIF5A hypusination–LSD1 axis

Li, H., Wu, B.-K., Kanchwala, M., Cai, J., Wang, L., Xing, C., Zheng, Y., & Pan, D. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00848-5 · Cited by 102 · see citing works

The cellular niche for intestinal stem cells: a team effort

Zhu, G., Hu, J., & Xi, R. (2021) · Cell Regeneration · doi:10.1186/s13619-020-00061-5 · Cited by 97 · see citing works

Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets

Jeon, S., Jeon, Y., Lim, J.-Y., Kim, Y., Cha, B., & Kim, W. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02070-1 · Cited by 97 · see citing works

The two sides of Hippo pathway in cancer

Li, F., & Guan, K. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.07.006 · Cited by 92 · see citing works

YAP induces an oncogenic transcriptional program through TET1-mediated epigenetic remodeling in liver growth and tumorigenesis

Wu, B.-K., Mei, S.-C., Chen, E. H., Zheng, Y., & Pan, D. (2022) · Nature Genetics · doi:10.1038/s41588-022-01119-7 · Cited by 90 · see citing works

Hippo signaling pathway and respiratory diseases

Tang, W., Li, M., Yangzhong, X., Zhang, X., Zu, A., Hou, Y., Li, L., & Sun, S. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01020-6 · Cited by 90 · see citing works

The Hippo Signaling Pathway in Drug Resistance in Cancer

Zeng, R., & Dong, J. (2021) · Cancers · doi:10.3390/cancers13020318 · Cited by 89 · see citing works

Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing

Lang, G., Jiang, Y., Shi, J., Yang, F., Li, X., Pei, Y., Zhang, C., Ma, D., Xiao, Y., Hu, P.-C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19342-3 · Cited by 87 · see citing works

Hippo signaling instructs ectopic but not normal organ growth

Kowalczyk, W., Romanelli, L., Atkins, M., Hillen, H., González‐Blas, C. B., Jacobs, J., Xie, J., Soheily, S., Verboven, E., Moya, I. M., et al. (2022) · Science · doi:10.1126/science.abg3679 · Cited by 87 · see citing works

The regulation of Yorkie, YAP and TAZ: new insights into the Hippo pathway

Manning, S. A., Kroeger, B., & Harvey, K. F. (2020) · Development · doi:10.1242/dev.179069 · Cited by 84 · see citing works

Hippo signalling maintains ER expression and ER+ breast cancer growth

Ma, S., Wu, Z., Yang, F., Zhang, J., Johnson, R. L., Rosenfeld, M. G., & Guan, K. (2021) · Nature · doi:10.1038/s41586-020-03131-5 · Cited by 82 · see citing works

Mechanical forces in the tumor microenvironment: roles, pathways, and therapeutic approaches

Zhang, Y., Fu, Q., Sun, W., Yue, Q., He, P., Niu, D., & Zhang, M. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06306-8 · Cited by 82 · see citing works

Lymph node metastasis-derived gastric cancer cells educate bone marrow-derived mesenchymal stem cells via YAP signaling activation by exosomal Wnt5a

Wang, M., Zhao, X.-X., Qiu, R., Gong, Z., Huang, F., Yu, W.-J., Shen, B., Sha, X., Dong, H.-B., Huang, J.-Y., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01722-8 · Cited by 65 · see citing works

YAP promotes ocular neovascularization by modifying PFKFB3-driven endothelial glycolysis

Feng, Y., Zou, R., Zhang, X., Shen, M., Chen, X., Wang, J., Niu, W., Yuan, Y., & Yuan, F. (2021) · Angiogenesis · doi:10.1007/s10456-020-09760-8 · Cited by 79 · see citing works

Roles of YAP/TAZ in ferroptosis

Magesh, S., & Cai, D. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.05.005 · Cited by 79 · see citing works

Hippo Signaling-Mediated Mechanotransduction in Cell Movement and Cancer Metastasis

Chang, Y.-C., Wu, J.-W., Wang, C.-W., & Jang, A. C.-C. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00157 · Cited by 77 · see citing works

The Hippo Pathway as a Driver of Select Human Cancers

Kulkarni, A., Chang, M. T., Vissers, J. H. A., Dey, A., & Harvey, K. F. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.04.004 · Cited by 77 · see citing works

YAP inhibits ERα and ER+ breast cancer growth by disrupting a TEAD-ERα signaling axis

Li, X., Zhuo, S., Zhuang, T., Cho, Y. S., Wu, G., Liu, Y., Mu, K., Zhang, K., Su, P., Yang, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30831-5 · Cited by 77 · see citing works

Multiple Roles of Vestigial-Like Family Members in Tumor Development

Yamaguchi, N. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01266 · Cited by 75 · see citing works

miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells

Luo, Y., Liu, W. Y., Tang, P., Jiang, D., Gu, C., Huang, Y., Gong, F., Rong, Y., Qian, D., Chen, J., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1491-6 · Cited by 74 · see citing works

YAP and TAZ protect against white adipocyte cell death during obesity

Wang, L., Wang, S., Shi, Y. X., Li, R., Günther, S., Ong, Y. T., Potente, M., Yuan, Z., Liu, E., & Offermanns, S. (2020) · Nature Communications · doi:10.1038/s41467-020-19229-3 · Cited by 73 · see citing works

miRNA in cardiac development and regeneration

Ouyang, Z., & Wei, K. (2021) · Cell Regeneration · doi:10.1186/s13619-021-00077-5 · Cited by 73 · see citing works

Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair

Wang, H., Yu, H., Huang, T., Wang, B., & Xiang, L.-L. (2023) · Genes and Diseases · doi:10.1016/j.gendis.2022.12.012 · Cited by 73 · see citing works

Signaling pathways in liver cancer: pathogenesis and targeted therapy

Xue, Y., Ruan, Y., Wang, Y., Xiao, P., & Xu, J. (2024) · Molecular Biomedicine · doi:10.1186/s43556-024-00184-0 · Cited by 81 · see citing works

Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway

Hori, N., Okada, K., Takakura, Y., Takano, H., Yamaguchi, N., & Yamaguchi, N. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.012781 · Cited by 70 · see citing works

Influence of the Hippo-YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment

Yang, W., Yang, S., Zhang, F., Cheng, F., Wang, X., & Rao, J. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.02.11 · Cited by 69 · see citing works

Hepatic Hippo signaling inhibits development of hepatocellular carcinoma

Liu, Y.-C., Wang, X.-H. L., & Yang, Y.-Z. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0178 · Cited by 65 · see citing works

Molecular pathways involved in injury-repair and ADPKD progression

Formica, C., & Peters, D. J. M. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109648 · Cited by 68 · see citing works

EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1

Ando, T., Arang, N., Wang, Z., Costea, D. E., Feng, X., Goto, Y., Izumi, H., Gilardi, M., Ando, K., & Gutkind, J. S. (2021) · Communications Biology · doi:10.1038/s42003-021-02744-4 · Cited by 67 · see citing works

MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway

An, L., Nie, P., Chen, M., Tang, Y., Zhang, H., Guan, J., Cao, Z., Hou, C., Wang, W., Zhao, Y., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20191817 · Cited by 68 · see citing works

The oncogenic roles and clinical implications of YAP/TAZ in breast cancer

Luo, J., Zou, H., Guo, Y., Tong, T., Chen, Y., Xiao, Y., Pan, Y., & Li, P. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02182-5 · Cited by 66 · see citing works

Cryo-EM structure of the Hippo signaling integrator human STRIPAK

Jeong, B., Bae, S. J., Ni, L., Zhang, X., Bai, X., & Luo, X. (2021) · Nature Structural & Molecular Biology · doi:10.1038/s41594-021-00564-y · Cited by 66 · see citing works

WWTR1(TAZ)-CAMTA1 gene fusion is sufficient to dysregulate YAP/TAZ signaling and drive epithelioid hemangioendothelioma tumorigenesisPreprint

Seavey, C. N., Pobbati, A. V., Hallett, A., Ma, S., REYNOLDS, J. P., Kanai, R., Lamar, J. M., & Rubin, B. P. (2021) · Genes & Development · doi:10.1101/gad.348220.120 · Cited by 66 · see citing works

Intracellular Signals Activated by Canonical Wnt Ligands Independent of GSK3 Inhibition and β-Catenin Stabilization

de Herreros, A. G., & Duñach, M. (2019) · Cells · doi:10.3390/cells8101148 · Cited by 64 · see citing works

Epithelial to Mesenchymal Transition: Key Regulator of Pancreatic Ductal Adenocarcinoma Progression and Chemoresistance

Palamaris, K., Felekouras, E. S., & Sakellariou, S. (2021) · Cancers · doi:10.3390/cancers13215532 · Cited by 65 · see citing works

Targeting the Hippo pathway in cancer

Harvey, K. F., & Tang, T. T.-L. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01234-0 · Cited by 64 · see citing works

CDK7 regulates organ size and tumor growth by safeguarding the Hippo pathway effector Yki/Yap/Taz in the nucleusPreprint

Cho, Y. S., Li, S., Wang, X., Zhu, J., Zhuo, S., Han, Y., Yue, T., Yang, Y., & Jiang, J. (2019) · Genes & Development · doi:10.1101/gad.333146.119 · Cited by 64 · see citing works

Isoforms of the p53 Family and Gastric Cancer: A Ménage à Trois for an Unfinished Affair

Blanchet, A., Bourgmayer, A., Kurtz, J., Mellitzer, G., & Gaiddon, C. (2021) · Cancers · doi:10.3390/cancers13040916 · Cited by 63 · see citing works

Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides

Li, F., Fu, V. X., Liu, G., Tang, T. T.-L., Konradi, A. W., Peng, X., Kemper, E. K., Cravatt, B. F., Franklin, J. M., Wu, Z., et al. (2022) · Nature Chemical Biology · doi:10.1038/s41589-022-01061-z · Cited by 63 · see citing works

Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma

Laraba, L., Hillson, L., de Guibert, J. G., Hewitt, A., Jaques, M. R., Tang, T. T.-L., Post, L. E., Ercolano, E., Rai, G., Yang, S., et al. (2022) · Brain · doi:10.1093/brain/awac342 · Cited by 63 · see citing works

The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression

Tu, C., Yang, K., Wan, L., He, J., Qi, L., Wang, W., Lu, Q., & Li, Z. (2020) · Cell Proliferation · doi:10.1111/cpr.12887 · Cited by 62 · see citing works

Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration

Liu, S., Tang, L., Zhao, X., Nguyen, B., Heallen, T. R., Li, M., Wang, J., Wang, J., & Martin, J. F. (2021) · Circulation Research · doi:10.1161/circresaha.121.318966 · Cited by 62 · see citing works

MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation

Seo, G., Han, H., Vargas, R. E., Yang, B., Li, X., & Wang, W. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107860 · Cited by 58 · see citing works

Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson’s disease

Ahn, E. H., Kang, S. S., Qi, Q., Liu, X., & Ye, K. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004087117 · Cited by 58 · see citing works

Mechanosignaling via Integrins: Pivotal Players in Liver Fibrosis Progression and Therapy

Sharip, A., & Kunz, J. (2025) · Cells · doi:10.3390/cells14040266 · Cited by 58 · see citing works

Hippo/YAP signaling pathway protects against neomycin-induced hair cell damage in the mouse cochlea

Wang, M., Dong, Y., Gao, S., Zhong, Z., Cheng, C., Qiang, R., Zhang, Y., Shi, X., Qian, X., Gao, X., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04029-9 · Cited by 57 · see citing works

Crosstalk between CAFs and tumour cells in head and neck cancer

Li, X., González-Maroto, C., & Tavassoli, M. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02053-9 · Cited by 58 · see citing works

WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendotheliomaPreprint

Driskill, J. H., Zheng, Y., Wu, B.-K., Wang, L., Cai, J., Rakheja, D., Dellinger, M. T., & Pan, D. (2021) · Genes & Development · doi:10.1101/gad.348221.120 · Cited by 57 · see citing works

Mechanisms of Fibroblast Activation and Myocardial Fibrosis: Lessons Learned from FB-Specific Conditional Mouse Models

Umbarkar, P., Ejantkar, S., Tousif, S., & Lal, H. (2021) · Cells · doi:10.3390/cells10092412 · Cited by 56 · see citing works

Cancer chemoprevention: signaling pathways and strategic approaches

Ren, J., Yan, G., Yang, L., Kong, L., Guan, Y., Sun, H., Liu, C., Liu, L., Han, Y., & Wang, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02167-1 · Cited by 62 · see citing works

The N6-methyladenosine reader protein YTHDC2 promotes gastric cancer progression via enhancing YAP mRNA translation

Yuan, W., Chen, S., Li, B., Han, X., Meng, B., Zou, Y., & Chang, S. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101308 · Cited by 54 · see citing works

YAP and β-catenin cooperate to drive H. pylori -induced gastric tumorigenesis

Li, N., Xu, X., Zhan, Y., Xiao, F., Ouyang, Y., Zheng, P., Zhou, Y., He, C., Xie, C., Hu, Y., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2192501 · Cited by 54 · see citing works

RP11-323N12.5 promotes the malignancy and immunosuppression of human gastric cancer by increasing YAP1 transcription

Wang, J., Huang, F., Shi, Y., Zhang, Q., Xu, S., Yao, Y., & Jiang, R. (2020) · Gastric Cancer · doi:10.1007/s10120-020-01099-9 · Cited by 54 · see citing works

A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification

Cong, Q., Liu, Y., Zhou, T., Zhou, Y., Xu, R., Cheng, C., Chung, H. S., Yan, M., Zhou, H., Liao, Z., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb2233 · Cited by 52 · see citing works

Chronic exposure to the star polycation (SPc) nanocarrier in the larval stage adversely impairs life history traits in Drosophila melanogaster

Yan, S., Li, N., Guo, Y., Chen, Y., Ji, C., Yin, M., Shen, J., & Zhang, J. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01705-1 · Cited by 53 · see citing works

Epithelial tissue confinement inhibits cell growth and leads to volume-reducing divisions

Devany, J. M., Falk, M. J., Holt, L. J., Murugan, A., & Gardel, M. L. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.05.018 · Cited by 50 · see citing works

Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View

Cho, Y. S., & Jiang, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.658481 · Cited by 53 · see citing works

Disease and the Hippo Pathway

Hansen, C. G. (2019) · MDPI eBooks · doi:10.3390/books978-3-03921-777-9

Structural dissection of Hippo signaling

Shi, Z., Jiao, S., & Zhou, Z. (2014) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmu107 · Cited by 15 · see citing works

The Hippo signalling pathway and its implications in human health and diseases

Fu, M., Hu, Y., Lan, T., Guan, K., Luo, T., & Luo, M. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01191-9 · Cited by 767 · see citing works

The Hippo Pathway: A Master Regulatory Network Important in Cancer

Liu, Q., Liu, X., & Song, G. (2021) · Cells · doi:10.3390/cells10061416 · Cited by 30 · see citing works

The Hippo signaling pathway in development and regeneration

Zhong, Z., Jiao, Z., & Yu, F. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113926 · Cited by 204 · see citing works