The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Niches that regulate stem cells and hematopoiesis in adult bone marrow
Open accessAbstract
In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult life within the bone marrow where they produce the mature cells necessary to maintain blood cell counts and immune function. In the bone marrow and spleen, HSCs are sustained in perivascular niches (microenvironments) associated with sinusoidal blood vessels - specialized veins found only in hematopoietic tissues. Endothelial cells and perivascular Leptin Receptor+ stromal cells produce the known factors required to maintain HSCs and many restricted progenitors in the bone marrow. Various other cells synthesize factors that maintain other restricted progenitors or modulate HSC or niche function. Recent studies identified new markers that resolve some of the heterogeneity among stromal cells and refine the localization of restricted progenitor niches. Other recent studies identified ways in which niches regulate HSC function and hematopoiesis beyond growth factors. We summarize the current understanding of hematopoietic niches, review recent progress, and identify important unresolved questions.
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Cites
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Cited by
Bandyopadhyay, S., Duffy, M. P., Ahn, K. J., Sussman, J. H., Pang, M., Smith, D., Duncan, G., Zhang, I., Huang, J., Lin, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.04.013 · Cited by 300
Skull bone marrow channels as immune gateways to the central nervous system
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Metabolic regulation of somatic stem cells in vivo
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Metadata
- Authors
- Comazzetto, S., Shen, B., & Morrison, S. J.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 56
- Issue
- 13
- Pages
- 1848-1860
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W3166197489
- Cited by
- 289
- References
- 20
- FWCI
- 25.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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