Metabolic regulation of somatic stem cells in vivo

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

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Putting p53 in context

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.

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NAD+ metabolism and its roles in cellular processes during ageing

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FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

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An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis

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Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

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Autophagy maintains stemness by preventing senescence

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Lactate Metabolism in Human Lung Tumors

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Haematopoietic stem cell release is regulated by circadian oscillations

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

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NAD ⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

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Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

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Direct measurement of local oxygen concentration in the bone marrow of live animals

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Clonal hematopoiesis in human aging and disease

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Metabolic regulation of gene expression through histone acylations

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The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

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mTOR signalling and cellular metabolism are mutual determinants in cancer

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A specialized vascular niche for adult neural stem cells

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Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions

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Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

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MYC as a regulator of ribosome biogenesis and protein synthesis

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Autophagy maintains the metabolism and function of young and old stem cells

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Foxo3a is essential for maintenance of the hematopoietic stem cell pool

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Metabolomics and Isotope Tracing

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High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

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In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics

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PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

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Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

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Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury

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mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

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mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

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Redox regulation of FoxO transcription factors

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Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

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Haematopoietic stem cells require a highly regulated protein synthesis rate

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Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

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The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

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Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression

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Tissue oxygen tension and brain sensitivity to hypoxia

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Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase

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Mechanisms of Stem Cell Self-Renewal

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The Hallmarks of Ferroptosis

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FoxO3 Regulates Neural Stem Cell Homeostasis

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The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

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Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

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Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

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Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

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Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

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Interplay between metabolic identities in the intestinal crypt supports stem cell function

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Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells

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Analysis and Interpretation of Microplate-Based Oxygen Consumption and pH Data

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Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

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Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

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Regulation of chromatin and gene expression by metabolic enzymes and metabolites

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Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

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2-Oxoglutarate-Dependent Oxygenases

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Bone marrow adipocytes promote the regeneration of stem cells and hematopoiesis by secreting SCF

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FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis

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Stem cell function and stress response are controlled by protein synthesis

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FXR Regulates Intestinal Cancer Stem Cell Proliferation

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Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue

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Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy

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Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

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The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs

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mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance

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Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial–Mesenchymal Interactions

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The sirtuin family in health and disease

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Generation of three-dimensional meat-like tissue from stable pig epiblast stem cells

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Inflammation-induced epigenetic imprinting regulates intestinal stem cells

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Neural stem cell metabolism revisited: a critical role for mitochondria.

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Mitochondrial serine catabolism safeguards maintenance of the hematopoietic stem cell pool in homeostasis and injury.

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Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration

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Macrophage-stem cell crosstalk: regulation of the stem cell niche

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Mitochondrial stress and aging: Lessons from C. elegans

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The role of PKM2-mediated metabolic reprogramming in the osteogenic differentiation of BMSCs under diabetic periodontitis conditions

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Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia

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Thermodynamically stable ionic liquid microemulsions pioneer pathways for topical delivery and peptide application

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Stem cell therapy in pulmonary hypertension: current practice and future opportunities

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Functional-metabolic coupling in distinct renal cell types coordinates organ-wide physiology and delays premature ageing

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Optical and MRI Multimodal Tracing of Stem Cells In Vivo

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Metabolic regulation in adult and aging skeletal muscle stem cellsPreprint

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Isotopic Tracing of Nucleotide Sugar Metabolism in Human Pluripotent Stem Cells

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Emerging Functional Connections Between Metabolism and Epigenetic Remodeling in Neural Differentiation

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Nutritional control of developmental processes

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Glucose modulates IRF6 transcription factor dimerization to enable epidermal differentiation

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Metabolism and HSC fate: what NADPH is made for

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In-depth transcriptomic analysis of Anopheles gambiae hemocytes uncovers novel genes and the oenocytoid developmental lineage

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Cancer stem cells: advances in the glucose, lipid and amino acid metabolism

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Biomimetic 3D bioprinting approaches to engineer the tumor microenvironment

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Rodent incisor as a model to study mesenchymal stem cells in tissue homeostasis and repair

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Glycolytic state of aortic endothelium favors hematopoietic transition during the emergence of definitive hematopoiesis

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Oxaloacetate sensing promotes innate immune antiviral defence against influenza virus infection

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Stem cells in organogenesis and regeneration

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Regional Differences in Progenitor Consumption Dynamics Shape Brain Growth during DevelopmentPreprint

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Regulatory Network of Methyltransferase-Like 3 in Stem Cells: Mechanisms and Medical Implications

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Polydeoxyribonucleotide enhances the bioactivities of stem cells from human exfoliated deciduous teeth through Akt activation

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Exudate Management, Facile Detachment, and Immunometabolism Regulation for Wound Healing Using Breathable Dressings

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ABHD17C, a metabolic and immune-related gene signature, predicts prognosis and anti-PD1 therapy response in pancreatic cancer

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Biodegradable metabotissugenic citrate-based polymer derived self-sealing pro-regenerative membrane for tendon anti-biofouling and repair

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Glucose modulates transcription factor dimerization to enable tissue differentiationPreprint

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Cholesterol metabolism on stem cell fate determination: a frontier horizon

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A JAK/STAT-Pdk1-S6K axis bypasses systemic growth restrictions to promote regeneration

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Primary and Immortalized Cultures of Human Proximal Tubule Cells Possess Both Progenitor and Non-Progenitor Cells That Can Impact Experimental Results

Shrestha, S., Haque, M. E., Ighofose, E., Mcmahon, M., Kalyan, G., Guyer, R., Kalonick, M., Kochanowski, J., Wegner, K., Somji, S., et al. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13040613 · Cited by 4 · see citing works

Cancer Therapies Targeting Cellular MetabolismPreprint

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Cathepsin K inhibition promotes efficient differentiation of human embryonic stem cells to mature cardiomyocytes by mediating glucolipid metabolism and cellular energy homeostasis

Wang, Y., Cui, Y., Liu, X., Liang, S., Zhong, L., & Guo, R. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04231-7 · Cited by 3 · see citing works

L-2-hydroxyglutarate regulates centromere and heterochromatin conformation in the male germline

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A Time-Scheduled Oxygen Modulation System Facilitates Bone Regeneration by Powering Periosteal Stem Cells

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Assessment of mesenchymal stem cells for the treatment of spinal cord injury: a systematic review and network meta-analysis

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2-hydroxyglutarate controls centromere and heterochromatin conformation and function in the male germlinePreprint

Mayorek, N., Schlossberg, M., Mansour, Y., Pillar, N., Stein, I., Mushasha, F., Baziza, G., Medvedev, E., Manevitch, Z., Menzel, J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.29.493890 · Cited by 3 · see citing works

Cardiomyocyte regeneration after infarction: changes, opportunities and challenges

Cao, C., Yang, L., Song, J., Liu, Z., Li, H., Li, L., Fu, J., & Liu, J. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05251-w · Cited by 2 · see citing works

Mitochondrial structure and function in OCRL depleted cells

Philip, R. G., Bhatia, P., Sharma, Y., & Raghu, P. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1679675 · Cited by 2 · see citing works

Chemigenetic Nanoprobe for Proximity Sensing Dynamics of Lactate Efflux

Xu, Q., Zhao, X., Chen, L., Shao, A., & Yan, X. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c05718 · Cited by 2 · see citing works

Heterogeneity of glucose metabolism and uptake identifies distinct cancer cell and cancer stem cell phenotypes

Tylichová, Z., Krkoška, M., Hrabal, V., Stenckova, M., Vojtěšek, B., & Coates, P. J. (2026) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00837-0 · Cited by 2 · see citing works

Development of an Efficient Synthetic Process for Irisquinone

Zheng, K. C., Zhang, Q., Ga, L., Ma, Y., Liang, G., & Zhao, Y. (2024) · Synlett · doi:10.1055/s-0042-1751560 · Cited by 2 · see citing works

Histone demethylase inhibitor KDM5-C70 regulates metabolomic and lipidomic programming during an astrocyte differentiation of rat neural stem cell

Shim, M., San, T. T., Shin, B., Lee, H., Han, S. B., Lee, D., & Kim, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-88636-7 · Cited by 2 · see citing works

SKP2 ubiquitylation modifies IDH1 to regulate hepatoblastoma cell cycle and glucose metabolism

Yu, P., Li, J., Feng, W., Tao, L., Jia, W., He, Y., & Bi, Y. (2025) · BMC Cancer · doi:10.1186/s12885-025-14644-5 · Cited by 2 · see citing works

Diet-induced chromatin states influence intestinal stem cell memoryPreprint

Saiz, D. R., Millan, Y. B., McDermott, T. H., Cerna, G., Sankar, S., Farnsworth, F., Uher, E., Lahiri, G., Lintecum, K., Mullen, K. F., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.19.706894 · Cited by 2 · see citing works

Galectin-8 drives ERK-dependent mitochondrial fragmentation, perinuclear relocation and mitophagy, with metabolic adaptations for cell proliferation

de la Peña, A., Retamal, C., Pérez-Molina, F., Díaz-Valdivia, N., Veloso-Bahamondes, F., Tapia, D., Cancino, J., Randow, F., González, A., Oyanadel, C., et al. (2025) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2025.151488 · Cited by 1 · see citing works

NMR metabolomics assessment of neural commitment of human dental pulp-derived stem cells

Chirico, M., Pisanu, M. E., Mari, E., Manganelli, V., Pulcini, F., Lancia, L., Benedetto, R. D., Monache, S. D., Iorio, E., & Mattei, V. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1735166 · Cited by 1 · see citing works

Metabolic regulation of stem cell plasticity

Kuuluvainen, E., Gopalakrishnan, S., & Katajisto, P. (2026) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2026.102530 · Cited by 1 · see citing works

A JAK/STAT-Pdk1-S6K axis bypasses systemic growth restrictions to promote regenerationPreprint

Maya, A. V., Neuhaus, L., Nogay, L., Singh, A., Heckmann, L., Grass, I., Buescher, J. M., Kierdorf, K., & Classen, A.-K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.05.606658 · Cited by 1 · see citing works

Mitochondrial and Lysosomal Metabolism in Hematopoietic Stem Cells

Mochizuki‐Kashio, M., Ito, K., & Nakamura‐Ishizu, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00077-8

Activation and Metabolic Shifting: An Essential Process to Mesenchymal Stromal Cells Function

Semedo, P., Pereira, G., de Almeida, D. C., & Câmara, N. O. S. (2023) · Biochemistry · doi:10.5772/intechopen.109273

Anti-aging and Rejuvenation Based on Stem Cell Therapy

Muñoz, M. F., Marotta, F., Ahmadi, A. M., Yazdani, A., He, F., Catanzaro, R., Garzón-Rodriguez, C., & Ayala, A. (2023) · Springer eBooks · doi:10.1007/978-981-19-7443-4_5

Understanding Ferroptosis from a Free Radical Perspective

Fujii, J. (2023) · Springer eBooks · doi:10.1007/978-3-031-39171-2_9

Approaches to Study Tumor Metabolism in MicePreprint

Gültekin, Y., Heiden, M. G. V., & Lien, E. C. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041420

Impact of S100A4 Deletion on the Macrophage Metabolome and DifferentiationPreprint

Jiao, X., Cui, J., Li, Y., Li, X., Chu, Z., & Wu, X. (2024) · Research Square · doi:10.21203/rs.3.rs-4004494/v1

Energy Metabolism Pathways in Stem Cell Fate RegulationPreprint

Wang, M., Yang, X., & Cao, H. (2024) · Preprints.org · doi:10.20944/preprints202405.0923.v1

IRF6 hits the sweet spot

Reznick, J., & Niessen, C. M. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.04.002

Radical TTM-DMODPA for Ascorbic Acid Non-Catalytic Visual Detection

Zhong, Q., Zong, H., Xie, X., Rong, X., & Yan, C. (2025) · Chemosensors · doi:10.3390/chemosensors13080277

Additional file 1 of In-depth transcriptomic analysis of Anopheles gambiae hemocytes uncovers novel genes and the oenocytoid developmental lineage

Saha, B., McNinch, C. M., Lu, S., Ho, M. C. W., de Carvalho, S. S., & Barillas-Mury, C. V. (2024) · Figshare · doi:10.6084/m9.figshare.25034403

O-GlcNAcylation regulates PPAR-driven metabolic programming in intestinal stem cellsPreprint

McDermott, T. H., Saiz, D. R., Millan, Y. B., Ho, N. A., Torel, M., Uher, E., Aboagye, C. I., Farnsworth, F., Lahiri, G., Thiriveedi, V., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.13.711696

Stem cell function in vivo is supported by an alternative glycolysis endpointPreprint

Kwarteng, E. O., Li, Y., Nguyen, D. L., & Agathocleous, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.30.715412 · Cited by 1 · see citing works

Caloric restriction rejuvenates aged adult stem cells: From mechanisms to interventions

Chai, Y., Liu, X., Bi, J., Zeng, J., Yao, M., Shi, F., & Xu, S. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103204

ROS-mitochondrial nexus in stem cell growth and differentiation and implications in cancer and degenerative diseases

Akhtar, M. J., & Panwar, S. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189663

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Chen, C., Wang, J., Yu, J., Zhou, Y., Liu, L., Liu, J., & Wang, L. (2026) · Interdisciplinary medicine · doi:10.1002/inmd.70159

A reduction in A-to-I RNA editing by ADAR disrupts Pumilio-mediated inhibition of MAPK signaling to drive intestinal stem cell aging

Zhang, Q., Zhu, Y., Chen, Y., Hou, W., Sun, A., Yan, L., Liu, X., Yuan, Y., Gao, C., Xie, J., et al. (2026) · Science Signaling · doi:10.1126/scisignal.aee6812

Heatwave exposure impairs airway epithelial repair via the Lkb1–Glut1 axis in juvenile mice

Zhang, J., Jian, X., Cheng, P., Wang, B., Miao, X., Yuan, P., Zhou, X., Chen, H., & Feng, F. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.128862

Nutrient-sensing pathways in adult stem cells: Orchestrating homeostasis, aging, and disease

Xiao, T., Xie, Z., Yao, L., Zhao, K., Zeng, Y. A., & Hu, C. (2026) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2026.103690

Interaction of light-dark and dietary cues prime Drosophila ovarian stem cell properties by precisely tuning Drp1 recruitment and organization on mitochondriaPreprint

Sriramkumar, Y., Wali, R., & Mitra, K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.04.749535

Polyethylene Terephthalate Microplastics Induce More Pronounced Physiological and Molecular Responses in Pepper Plants than Polyethylene: Insights from Physiological, Transcriptomic, and Metabolomic Perspectives

Liu, G., Wang, S., Li, C., Xu, D., Liang, Y., Liang, Z., Ji, C., Wang, H., Han, B. Q., Su, S., et al. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6c06488

Flavins in Focus: Vitamin B 2 as a Metabolic Keystone for Neuronal Repair in Regenerating PlanariansPreprint

Heleven, M., Jaenen, V., Maes, R., Abril, J. F., Voglar, R., Segnana, C., Artois, T., Saenen, N. D., Cebrià, F., & Smeets, K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.12.758197

Molecular mechanisms of cellular metabolic homeostasis in stem cells

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Energy Metabolism Plays a Critical Role in Stem Cell Maintenance and Differentiation

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Metabolic regulation of stem cell plasticity

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Metabolic Regulation of Mammalian Stem Cell Differentiation

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Nutrient-sensing pathways and metabolic regulation in stem cells

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