Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence

Simultaneous Inference in General Parametric Models

Hothorn, T., Bretz, F., & Westfall, P. H. (2008) · Biometrical Journal · doi:10.1002/bimj.200810425 · Cited by 13,950 · see citing works

ImageJ2: ImageJ for the next generation of scientific image data

Rueden, C., Schindelin, J., Hiner, M., DeZonia, B. E., Walter, A., Arena, E. T., & Eliceiri, K. W. (2017) · BMC Bioinformatics · doi:10.1186/s12859-017-1934-z · Cited by 5,895 · see citing works

Regulation mechanisms and signaling pathways of autophagy

He, C., & Klionsky, D. J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102808-114910 · Cited by 3,609 · see citing works

Cellular Senescence: Defining a Path Forward

Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.005 · Cited by 3,225 · see citing works

Hallmarks of Cellular Senescence

Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.001 · Cited by 2,605 · see citing works

Chromosomal instability drives metastasis through a cytosolic DNA response

Bakhoum, S. F., Ngo, B., Laughney, A. M., Cavallo, J.-A., Murphy, C. J., Ly, P., Shah, P., Sriram, R. K., Watkins, T. B. K., Taunk, N. K., et al. (2018) · Nature · doi:10.1038/nature25432 · Cited by 1,638 · see citing works

Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast

Noda, T., & Ohsumi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.3963 · Cited by 1,308 · see citing works

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS.

Pandey, U. B., Nie, Z., Batlevi, Y., McCray, B. A., Ritson, G. P., Nedelsky, N. B., Schwartz, S. L., DiProspero, N. A., Knight, M. A., Schuldiner, O., et al. (2007) · Nature · doi:10.1038/nature05853 · Cited by 1,234 · see citing works

Expression of baculovirus P35 prevents cell death in Drosophila

Hay, B. A., Wolff, T., & Rubin, G. M. (1994) · Development · doi:10.1242/dev.120.8.2121 · Cited by 1,066 · see citing works

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

Phinney, D. G., Di Giuseppe, M., Njah, J., Sala, E., Shiva, S., St Croix, C. M., Stolz, D. B., Watkins, S. C., Di, Y. P., Leikauf, G. D., et al. (2015) · Nature Communications · doi:10.1038/ncomms9472 · Cited by 1,007 · see citing works

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

Shpilka, T., & Haynes, C. M. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.110 · Cited by 716 · see citing works

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

Sykiotis, G. P., & Bohmann, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.12.002 · Cited by 675 · see citing works

puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in DrosophilaPreprint

Martı́n-Blanco, E., Gampel, A., Ring, J., Virdee, K., Kirov, N., Tolkovsky, A. M., & Martínez-Arias, A. (1998) · Genes & Development · doi:10.1101/gad.12.4.557 · Cited by 673 · see citing works

Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies

Tillberg, P. W., Chen, F., Piatkevich, K. D., Zhao, Y., Yu, C.-C., English, B. P., Gao, L. A., Martorell, A. J., Suk, H., Yoshida, F., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3625 · Cited by 673 · see citing works

Context is everything: aneuploidy in cancer

Ben‐David, U., & Amon, A. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0171-x · Cited by 651 · see citing works

Mitochondria as signaling organelles

Chandel, N. S. (2014) · BMC Biology · doi:10.1186/1741-7007-12-34 · Cited by 576 · see citing works

Role and regulation of the ER chaperone BiP

Gething, M.-J. H. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1999.0318 · Cited by 557 · see citing works

Short- and long-term effects of chromosome mis-segregation and aneuploidy

Santaguida, S., & Amon, A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4025 · Cited by 551 · see citing works

Microenvironmental autophagy promotes tumour growth

Katheder, N. S., Khezri, R., O’Farrell, F., Schultz, S. W., Jain, A., Rahman, M. M., Schink, K. O., Theodossiou, T. A., Johansen, T., Juhász, G., et al. (2017) · Nature · doi:10.1038/nature20815 · Cited by 452 · see citing works

Drosophila p53 Is a Structural and Functional Homolog of the Tumor Suppressor p53

Ollmann, M. M., Young, L. M., Como, C. J. D., Karim, F. D., Belvin, M. P., Robertson, S., Whittaker, K. L., Demsky, M., Fisher, W. W., Buchman, A. R., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)80626-1 · Cited by 413 · see citing works

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

Owusu-Ansah, E., Song, W., & Perrimon, N. (2013) · Cell · doi:10.1016/j.cell.2013.09.021 · Cited by 395 · see citing works

JNK‐ and Fos‐regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila

Uhlirova, M., & Bohmann, D. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601401 · Cited by 395 · see citing works

Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals

Levine, M. S., Bakker, B., Boeckx, B., Moyett, J., Lu, J. T., Vitre, B., Spierings, D. C. J., Lansdorp, P. M., Cleveland, D. W., Lambrechts, D., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2016.12.022 · Cited by 378 · see citing works

Identification of Aneuploidy-Tolerating Mutations

Torres, E. M., Dephoure, N., Panneerselvam, A., Tucker, C. M., Whittaker, C. A., Gygi, S. P., Dunham, M. J., & Amon, A. (2010) · Cell · doi:10.1016/j.cell.2010.08.038 · Cited by 371 · see citing works

Ref(2)P, the <i>Drosophila melanogaster</i> homologue of mammalian p62, is required for the formation of protein aggregates in adult brain

Nezis, I. P., Simonsen, A., Sagona, A. P., Finley, K., Gaumer, S., Contamine, D., Rusten, T. E., Stenmark, H., & Brech, A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200711108 · Cited by 370 · see citing works

Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System

Santaguida, S., Richardson, A., Iyer, D., M’Saad, O., Zasadil, L. M., Knouse, K. A., Wong, Y. L., Rhind, N., Desai, A. B., & Amon, A. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.05.022 · Cited by 355 · see citing works

Deubiquitinating Enzyme Ubp6 Functions Noncatalytically to Delay Proteasomal Degradation

Hanna, J. W., Hathaway, N. A., Tone, Y., Crosas, B., Elsasser, S., Kirkpatrick, D. S., Leggett, D., Gygi, S. P., King, R. W., & Finley, D. J. (2006) · Cell · doi:10.1016/j.cell.2006.07.038 · Cited by 354 · see citing works

Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin

Lee, J. J., Sánchez-Martínez, Á., Martinez, A., Benincá, C., Mayor, U., Clague, M. J., & Whitworth, A. J. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201801044 · Cited by 343 · see citing works

Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila

Takáts, S., Nagy, P., Varga, Á., Pircs, K., Kárpáti, M., Varga, K., Kovács, A. L., Hegedűs, K., & Juhász, G. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201211160 · Cited by 337 · see citing works

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

Rana, A., Rera, M., & Walker, D. W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216197110 · Cited by 335 · see citing works

eC-CLEM: flexible multidimensional registration software for correlative microscopies

Paul‐Gilloteaux, P., Heiligenstein, X., Belle, M., Domart, M., Larijani, B., Collinson, L., Raposo, G., & Salamero, J. (2017) · Nature Methods · doi:10.1038/nmeth.4170 · Cited by 327 · see citing works

Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition

Suraweera, A., Münch, C., Hanssum, A., & Bertolotti, A. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.003 · Cited by 299 · see citing works

Unfolded protein response in a Drosophila model for retinal degeneration

Ryoo, H. D., Domingos, P. M., Kang, M., & Steller, H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601477 · Cited by 292 · see citing works

Fly-FUCCI: A Versatile Tool for Studying Cell Proliferation in Complex Tissues

Zielke, N., Korzelius, J., van Straaten, M., Bender, K., Schuhknecht, G. F. P., Dutta, D., Xiang, J., & Edgar, B. A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.020 · Cited by 286 · see citing works

Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation

Rong, Y., McPhee, C. K., Deng, S., Huang, L., Chen, L., Liu, M., Tracy, K., Baehrecke, E. H., Yu, L., & Lenardo, M. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013800108 · Cited by 273 · see citing works

The ATM–p53 pathway suppresses aneuploidy-induced tumorigenesis

Li, M., Fang, X., Baker, D. J., Guo, L., Gao, X., Wei, Z., Han, S., van Deursen, J. M., & Zhang, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005960107 · Cited by 257 · see citing works

A Novel MitoTimer Reporter Gene for Mitochondrial Content, Structure, Stress, and Damage in Vivo

Laker, R. C., Xu, P., Ryall, K. A., Sujkowski, A. L., Kenwood, B. M., Chain, K. H., Zhang, M., Royal, M. A., Hoehn, K. L., Driscoll, M., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.530527 · Cited by 254 · see citing works

Control of the Hypoxic Response in Drosophila melanogaster by the Basic Helix-Loop-Helix PAS Protein Similar

Lavista-Llanos, S., Centanin, L., Irisarri, M., Russo, D. M., Gleadle, J., Bocca, S. N., Muzzopappa, M., Ratcliffe, P. J., & Wappner, P. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.19.6842-6853.2002 · Cited by 243 · see citing works

The effects of X-rays on the proliferation dynamics of cells in the imaginal wing disc ofDrosophila melanogaster

Haynie, J. L., & Bryant, P. J. (1977) · Development Genes and Evolution · doi:10.1007/bf00848779 · Cited by 231 · see citing works

Cellular Stress Associated with Aneuploidy

Zhu, J., Tsai, H.-J., Gordon, M. R., & Li, R. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.02.002 · Cited by 221 · see citing works

Inactivation of Both foxo and reaper Promotes Long-Term Adult Neurogenesis in Drosophila

Siegrist, S. E., Haque, N. S., Chen, C., Hay, B. A., & Hariharan, I. K. (2010) · Current Biology · doi:10.1016/j.cub.2010.01.060 · Cited by 213 · see citing works

Dosage Compensation inDrosophilaPreprint

Lucchesi, J. C., & Kuroda, M. I. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019398 · Cited by 212 · see citing works

The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy

Hegedűs, K., Takáts, S., Boda, A., Jipa, A., Nagy, P., Varga, K., Kovács, A. L., & Juhász, G. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-03-0205 · Cited by 207 · see citing works

Epithelial junctions maintain tissue architecture by directing planar spindle orientation

Nakajima, Y.-I., Meyer, E. J., Kroesen, A., McKinney, S. A., & Gibson, M. C. (2013) · Nature · doi:10.1038/nature12335 · Cited by 204 · see citing works

Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis

McEwen, D. G., & Peifer, M. A. (2005) · Development · doi:10.1242/dev.01949 · Cited by 189 · see citing works

Aneuploidy-induced cellular stresses limit autophagic degradationPreprint

Santaguida, S., Vasile, E., White, E., & Amon, A. (2015) · Genes & Development · doi:10.1101/gad.269118.115 · Cited by 168 · see citing works

Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1

Takeda, K., Komuro, Y., Hayakawa, T., Oguchi, H., Ishida, Y., Murakami, S., Noguchi, T., Kinoshita, H., Sekine, Y., Iemura, S.-I., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901823106 · Cited by 147 · see citing works

Meddling with Fate: The Proteasomal Deubiquitinating Enzymes

de Poot, S. A. H., Tian, G., & Finley, D. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.09.015 · Cited by 134 · see citing works

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

Macedo, J. C., Vaz, S., Bakker, B., Ribeiro, R., Bakker, P. L., Escandell, J. M., Ferreira, M. G., Medema, R., Foijer, F., & Logarinho, E. (2018) · Nature Communications · doi:10.1038/s41467-018-05258-6 · Cited by 131 · see citing works

JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy

Wu, H., Wang, M. C., & Bohmann, D. (2009) · Mechanisms of Development · doi:10.1016/j.mod.2009.06.1082 · Cited by 130 · see citing works

Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila

Aparicio, R., Rana, A., & Walker, D. W. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.070 · Cited by 129 · see citing works

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis

Ramdzan, Y. M., Trubetskov, M. M., Ormsby, A. R., Newcombe, E. A., Sui, X., Tobin, M. J., Bongiovanni, M. N., Gras, S. L., Dewson, G., Miller, J. M. L., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.029 · Cited by 124 · see citing works

Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia

Dekanty, A., Barrio, L., Muzzopappa, M., Auer, H., & Milán, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206675109 · Cited by 115 · see citing works

USP14 inhibition corrects an in vivo model of impaired mitophagy

Chakraborty, J., von Stockum, S., Marchesan, E., Caicci, F., Ferrari, V., Raković, A., Klein, C., Antonini, A., Bubacco, L., & Ziviani, E. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201809014 · Cited by 110 · see citing works

DrosophilaMitf regulates the V-ATPase and the lysosomal-autophagic pathway

Bouchè, V., Perez, A. M., Leone, L., Sardiello, M., Ballabio, A., & Botas, J. (2016) · Autophagy · doi:10.1080/15548627.2015.1134081 · Cited by 108 · see citing works

REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1

Tiebe, M., Lutz, M., Garza, A. D. L., Buechling, T., Boutros, M., & Teleman, A. A. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.03.013 · Cited by 95 · see citing works

In vivo genetic dissection of tumor growth and the Warburg effect

Wang, C., Purkayastha, A., Jones, K. T., Thaker, S. K., & Banerjee, U. K. (2016) · eLife · doi:10.7554/elife.18126 · Cited by 90 · see citing works

Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth

Rowald, K., Mantovan, M., Passos, J., Buccitelli, C., Mardin, B. R., Korbel, J. O., Jechlinger, M., & Sotillo, R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.048 · Cited by 84 · see citing works

The Kelch Repeat Protein KLHDC10 Regulates Oxidative Stress-Induced ASK1 Activation by Suppressing PP5

Sekine, Y., Hatanaka, R., Watanabe, T., Sono, N., Iemura, S.-I., Natsume, T., Kuranaga, E., Miura, M., Takeda, K., & Ichijo, H. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.018 · Cited by 82 · see citing works

Mitf is a master regulator of the v-ATPase forming an Mitf/v-ATPase/TORC1 control module for cellular homeostasis

Zhang, T., Zhou, Q., Ogmundsdottir, M. H., Möller, K., Siddaway, R., Larue, L., Hsing, M., Kong, S. W., Goding, C. R., Pálsson, A., et al. (2015) · Journal of Cell Science · doi:10.1242/jcs.173807 · Cited by 75 · see citing works

Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila

Lőw, P., Varga, Á., Pircs, K., Nagy, P., Szatmári, Z., Sass, M., & Juhász, G. (2013) · BMC Cell Biology · doi:10.1186/1471-2121-14-29 · Cited by 70 · see citing works

JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress

Cosolo, A., Jaiswal, J., Csordás, G., Grass, I., Uhlířová, M., & Classen, A.-K. (2019) · eLife · doi:10.7554/elife.41036 · Cited by 67 · see citing works

A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition

da Silva, S. M., Moutinho‐Santos, T., & Sunkel, C. E. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201210018 · Cited by 63 · see citing works

Gene Dosage Imbalance Contributes to Chromosomal Instability-Induced Tumorigenesis

Clemente‐Ruiz, M., Murillo-Maldonado, J. M., Benhra, N., Barrio, L., Pérez, L., Quiroga-Artigas, G., Nebreda, Á. R., & Milán, M. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.01.008 · Cited by 62 · see citing works

Feedback amplification loop drives malignant growth in epithelial tissues

Muzzopappa, M., Murcia, L., & Milán, M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701791114 · Cited by 61 · see citing works

Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase

Sasaki, T., Lian, S., Khan, A., Llop, J. R., Samuelson, A. V., Chen, W., Klionsky, D. J., & Kishi, S. (2017) · Autophagy · doi:10.1080/15548627.2016.1256934 · Cited by 60 · see citing works

PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila

Jensen, M. B., Qi, Y., Riley, R. R., Rabkina, L., & Jasper, H. (2017) · eLife · doi:10.7554/elife.26952 · Cited by 59 · see citing works

Small‐molecule inhibition of aging‐associated chromosomal instability delays cellular senescence

Barroso‐Vilares, M., Macedo, J. C., Reis, M., Warren, J. D., Compton, D. A., & Logarinho, E. (2020) · EMBO Reports · doi:10.15252/embr.201949248 · Cited by 53 · see citing works

Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis inDrosophila melanogaster

Tognon, E., Kobia, F., Busi, I., Fumagalli, A., Masi, F. D., & Vaccari, T. (2016) · Autophagy · doi:10.1080/15548627.2015.1134080 · Cited by 45 · see citing works

How to get to the other side of the mitochondrial inner membrane – the protein import motor

Mokranjac, D. (2020) · Biological Chemistry · doi:10.1515/hsz-2020-0106 · Cited by 44 · see citing works

Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure

Gerlach, S. U., Eichenlaub, T., & Herranz, H. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.006 · Cited by 43 · see citing works

Activation of autophagy in cells with abnormal karyotype

Stingele, S., Stoehr, G., & Štorchová, Z. (2012) · Autophagy · doi:10.4161/auto.22558 · Cited by 39 · see citing works

Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues

Benhra, N., Barrio, L., Muzzopappa, M., & Milán, M. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.08.021 · Cited by 39 · see citing works

A genetically encoded biosensor for visualizing hypoxia responsesin vivo

Misra, T., Baccino-Calace, M., Meyenhofer, F., Rodríguez-Crespo, D., Akarsu, H., Armenta-Calderón, R., Gorr, T. A., Frei, C., Cantera, R., Egger, B., et al. (2016) · Biology Open · doi:10.1242/bio.018226 · Cited by 38 · see citing works

A genetically encoded fluorescent probe for imaging of oxygenation gradients in living Drosophila

Lidsky, P. V., Lukyanov, K. A., Misra, T., Handke, B., Mishin, A. S., & Lehner, C. F. (2018) · Development · doi:10.1242/dev.156257 · Cited by 29 · see citing works

Tumor suppressor roles of CENP-E and Nsl1 inDrosophilaepithelial tissues

Clemente‐Ruiz, M., Muzzopappa, M., & Milán, M. (2014) · Cell Cycle · doi:10.4161/cc.28417 · Cited by 26 · see citing works

A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast

Serpionov, G. V., Alexandrov, A. I., Antonenko, Y. N., & Ter‐Avanesyan, M. D. (2015) · Scientific Reports · doi:10.1038/srep18407 · Cited by 23 · see citing works

A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant

Rimkus, S. A., & Wassarman, D. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190821 · Cited by 15 · see citing works

A genetically encoded biosensor for visualising hypoxia responses in vivo

Misra, T., Baccino-Calace, M., Meyenhofer, F., Rodríguez-Crespo, D., Akarsu, H., Armenta-Calderón, R., Gorr, T. A., Frei, C., Cantera, R., Egger, B., et al. (2017) · reroDoc Digital Library · doi:10.3929/ethz-b-000129913 · Cited by 15 · see citing works

Aneuploidy and tumorigenesis in Drosophila

Milán, M., Clemente‐Ruiz, M., Dekanty, A., & Muzzopappa, M. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.03.014 · Cited by 15 · see citing works

Cytoplasmic DNA: sources, sensing, and role in aging and disease

Miller, K. N., Victorelli, S. G., Salmonowicz, H., Dasgupta, N., Liu, T., Passos, J. F., & Adams, P. D. (2021) · Cell · doi:10.1016/j.cell.2021.09.034 · Cited by 288 · see citing works

The two sides of chromosomal instability: drivers and brakes in cancer

Hosea, R., Hillary, S., Naqvi, S., Wu, S., & Kasim, V. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01767-7 · Cited by 205 · see citing works

Senescent glia link mitochondrial dysfunction and lipid accumulation

Byrns, C. N., Perlegos, A. E., Miller, K. N., Jin, Z., Carranza, F. R., Manchandra, P., Beveridge, C. H., Randolph, C. E., Chaluvadi, V. S., Zhang, S., et al. (2024) · Nature · doi:10.1038/s41586-024-07516-8 · Cited by 141 · see citing works

Redox signaling at the crossroads of human health and disease

Zuo, J., Zhang, Z., Luo, M., Zhou, L., Nice, E. C., Zhang, W., Wang, C., & Huang, C. (2022) · MedComm · doi:10.1002/mco2.127 · Cited by 120 · see citing works

Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence

Zheng, H., Liang, X., Han, Q., Shao, Z., Zhang, Y., Shi, L., Hong, Y., Li, W., Mai, C., Mo, Q., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01077-y · Cited by 99 · see citing works

Carbon Dots from Lycium barbarum Attenuate Radiation-Induced Bone Injury by Inhibiting Senescence via METTL3/Clip3 in an m 6 A-Dependent Manner

Guo, Z., Wang, Z., Liu, Y., Wu, H., Zhang, Q., Han, J., Liu, J., & Zhang, C. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c01322 · Cited by 47 · see citing works

Mitochondrial dysfunction in cellular senescence: a bridge to neurodegenerative disease

Hruby, A. J., & Higuchi‐Sanabria, R. (2025) · npj Aging · doi:10.1038/s41514-025-00291-4 · Cited by 44 · see citing works

Genomic instability drives tumorigenesis and metastasis and its implications for cancer therapy

Guo, S., Zhu, X. M., Huang, Z., Wei, C., Yu, J., Zhang, L., Feng, J., Li, M., & Li, Z. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114036 · Cited by 41 · see citing works

Apoptotic signaling: Beyond cell death

Nano, M., & Montell, D. J. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.11.002 · Cited by 37 · see citing works

Nutritional components as mitigators of cellular senescence in organismal aging: a comprehensive review

Diwan, B., & Sharma, R. (2022) · Food Science and Biotechnology · doi:10.1007/s10068-022-01114-y · Cited by 36 · see citing works

Cellular senescence and premature aging in Down Syndrome

Peng, L., Baradar, A. A., Aguado, J., & Wolvetang, E. J. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111824 · Cited by 34 · see citing works

Resveratrol drives cancer cell senescence via enhancing p38MAPK and DLC1 expressions

Bian, Y., Wang, X., Zheng, Z., Ren, G., Zhu, H., Qiao, M., & Li, G. (2022) · Food & Function · doi:10.1039/d1fo02365a · Cited by 27 · see citing works

PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity

Li, C., Pan, Y., Tan, Y., Wang, Y., & Sun, X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.896014 · Cited by 25 · see citing works

Lack of apoptosis leads to cellular senescence and tumorigenesis in Drosophila epithelial cells

Garcia-Arias, J. M., Pinal, N., Cristobal-Vargas, S., Estella, C., & Morata, G. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01583-y · Cited by 19 · see citing works

Chromosomal instability-induced cell invasion through caspase-driven DNA damage

Barrio, L., Gaspar, A.-E., Muzzopappa, M., Ghosh, K., Romão, D., Clemente‐Ruiz, M., & Milán, M. (2023) · Current Biology · doi:10.1016/j.cub.2023.09.004 · Cited by 19 · see citing works

Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing

Pan, C. C., Maeso‐Díaz, R., Lewis, T. R., Xiang, K., Tan, L., Liang, Y., Wang, L., Yang, F., Yin, T., Wang, C., et al. (2023) · Cell Research · doi:10.1038/s41422-023-00820-4 · Cited by 19 · see citing works

Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative Disorders

Otsuka, T., & Matsui, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087079 · Cited by 17 · see citing works

Aneuploidy-induced proteostasis disruption impairs mitochondrial functions and mediates aggregation of mitochondrial precursor proteins through SQSTM1/p62

Amponsah, P. S., Bökenkamp, J.-E., Kurpa, O., Lenhard, S., Myronova, A., Velazquez, D., Hirschelmann, C., Behrends, C., Herrmann, J. M., Räschle, M., et al. (2024) · bioRxiv · doi:10.1038/s41467-025-60857-4 · Cited by 15 · see citing works

The mystery of phospho-Drp1 with four adaptors in cell cycle: when mitochondrial fission couples to cell fate decisions

Wu, N.-S., Ma, I.-C., Lin, Y., Ko, H.-J., Loh, J., & Hong, Y. (2023) · Cell Cycle · doi:10.1080/15384101.2023.2289753 · Cited by 13 · see citing works

Targeting vulnerabilities of aneuploid cells for cancer therapy

Zerbib, J., Bloomberg, A., & Ben‐David, U. (2025) · Trends in cancer · doi:10.1016/j.trecan.2025.04.005 · Cited by 10 · see citing works

Cell-cell interactions that drive tumorigenesis in Drosophila

Enomoto, M., & Igaki, T. (2022) · Fly · doi:10.1080/19336934.2022.2148828 · Cited by 9 · see citing works

Nondiploid cancer cells: Stress, tolerance and therapeutic inspirations

Du, M., Zhang, S., Liu, X., Xu, C., & Zhang, X. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188794 · Cited by 10 · see citing works

Reducing the aneuploid cell burden – cell competition and the ribosome connection

Baker, N. E., & Montagna, C. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049673 · Cited by 10 · see citing works

Unraveling the meta-hallmarks between senescent and tumor cells: A new perspective for senolytic drug discovery

Liu, W., Fan, B., Fang, T., Li, H., Zhang, J., Liu, B., & Liu, Z. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.08.010 · Cited by 10 · see citing works

Dual contributions of Xrp1 to genome integrity through the DNA damage response and cell competition

Khan, C., Rusan, N. M., & Baker, N. E. (2026) · PLoS Genetics · doi:10.1371/journal.pgen.1012309 · Cited by 10 · see citing works

An unscheduled switch to endocycles induces a reversible senescent arrest that impairs growth of the Drosophila wing disc

Huang, Y., Hesting, L. L., & Calvi, B. R. (2024) · PLoS Genetics · doi:10.1371/journal.pgen.1011387 · Cited by 7 · see citing works

Chromosomal instability in development and disease: Beyond cancer evolution

Milán, M. (2025) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2025.102537 · Cited by 8 · see citing works

Mechanisms of aging-related secretory phenotype regulation in osteoporosis: Network regulation, trade-offs and homeostasis

Wang, D., & Guan, H. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156115 · Cited by 8 · see citing works

Label-Free Target Identification Reveals the Anticancer Mechanism of a Rhenium Isonitrile Complex

Yim, J., & Park, S. B. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.850638 · Cited by 8 · see citing works

Aneuploidy confers a unique transcriptional and phenotypic profile to Candida albicans

Mackey, A. I., Fillinger, R. J., Hendricks, P. S., Thomson, G. J., Cuomo, C. A., Bennett, R. J., & Anderson, M. Z. (2025) · Nature Communications · doi:10.1038/s41467-025-58457-3 · Cited by 8 · see citing works

Quercetin alleviates ethanol‐induced hepatic steatosis in L02 cells by activating TFEB translocation to compensate for inadequate autophagy

Zhao, X., Xue, X., Wang, J., Dai, S., Peng, C. Y., & Li, Y. (2022) · Phytotherapy Research · doi:10.1002/ptr.7593 · Cited by 8 · see citing works

Nicotinamide riboside modulates the reactive species interactome, bioenergetic status and proteomic landscape in a brain-region-specific manner

Marmolejo-Garza, A., Châtre, L., Croteau, D. L., Herrón-Bedoya, A., Luu, M. D. A., Bernay, B., Pontin, J., Bohr, V. A., Boddeke, E., & Dolga, A. M. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106645 · Cited by 7 · see citing works

Emerging roles of mitotic autophagy

Almacellas, E., & Mauvezin, C. (2022) · Journal of Cell Science · doi:10.1242/jcs.255802 · Cited by 8 · see citing works

G2 and S phase‐expressed‐1 induces chromosomal instability in esophageal squamous cell carcinoma cells and inhibits cell apoptosis through ROS/JNK signaling

Zhang, M., Wang, X., Liu, C., Zheng, Z., Wan, J., Yang, Y., Chen, S., & Liu, H. (2022) · Molecular Carcinogenesis · doi:10.1002/mc.23470 · Cited by 7 · see citing works

Di(2-ethylexyl) phthalate and chromosomal damage: Insight on aneugenicity from the cytochalasin-block micronucleus assay

Amadio, F., Bongiorni, S., Varalda, G. M., Marcon, F., & Meschini, R. (2024) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2024.503791 · Cited by 6 · see citing works

The proteostasis burden of aneuploidy

Amponsah, P. S., & Štorchová, Z. (2025) · Biological Chemistry · doi:10.1515/hsz-2024-0163 · Cited by 6 · see citing works

The mitochondrial poison carbonyl cyanide 3-chlorophenyl hydrazone (CCCP) induces aneugenic effects in primary human fibroblasts: a possible link between mitochondrial dysfunction and chromosomal loss

Marcon, F., Battistis, F. D., Siniscalchi, E., Crebelli, R., & Meschini, R. (2022) · Mutagenesis · doi:10.1093/mutage/geac008 · Cited by 6 · see citing works

Aneuploidy-induced cellular behaviors: Insights from Drosophila

Joy, J., Fusari, E., & Milán, M. (2024) · Developmental Cell · doi:10.1016/j.devcel.2023.12.009 · Cited by 6 · see citing works

RagC GTPase regulates mTOR to promote chemoresistance in senescence-like HepG2 cells

Jiang, W., Ou, Z., Zhu, Q., Yao, Y., & Zai, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.949737 · Cited by 5 · see citing works

Tumour–host interactions in Drosophila : mechanisms in the tumour micro‐ and macroenvironment

Teles-Reis, J., & Rusten, T. E. (2026) · Molecular Oncology · doi:10.1002/1878-0261.70207 · Cited by 3 · see citing works

Genome-Wide Expression Analysis of Long Noncoding RNAs and Their Target Genes in Metafemale Drosophila

Liu, X., Yan, R., Liu, H., Zhang, S., Wang, R., Zhang, B., & Sun, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098381 · Cited by 3 · see citing works

Drosophila wing is a high-throughput and versatile screening tool for Tau-mediated disease mechanisms and drug discovery

Moreno, M. R., Cooper, A. S., Lian, T., Liu, J., Abtahi, S., Skoulakis, E. M. C., Sivanantharajah, L., Allan, D. W., & Mudher, A. K. (2026) · Disease Models & Mechanisms · doi:10.1242/dmm.052492 · Cited by 2 · see citing works

Tissue mechanics and systemic signaling safeguard epithelial tissue against spindle misorientation

Bosveld, F., Tesson, B., van Leen, E., Amirebrahimi, S., Thinat, R., & Bellaı̈che, Y. (2026) · Developmental Cell · doi:10.1016/j.devcel.2026.01.012 · Cited by 3 · see citing works

Altered mitochondrial functionality in metabolic disorders: insights from Drosophila studies

Zeng, Y., Yang, Y., Zhu, Y., Xu, P., Cheong, C., Zhao, Y. J., & Baeg, G. H. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1817121 · Cited by 2 · see citing works

Senotypes define the diverse landscape of senescent cells

Schafer, M. J., Basisty, N., Hertzel, A. V., Rindone, A. N., Elisseeff, J. H., Suryadevara, V., Aliferis, C., Robbins, P. D., Niedernhofer, L. J., Miller, K. N., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01148-5 · Cited by 2 · see citing works

Dysregulated proteostasis

Al-Mufti, Y., Cranwell, S., & Samant, R. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91617-2.00004-3 · Cited by 1 · see citing works

Analysis of Bub3 and Nup75 in the Drosophila male germline lineage

Yildirim, K., y Sanchez, P. V. N., & Lohmann, I. (2023) · Cells and Development · doi:10.1016/j.cdev.2023.203863 · Cited by 1 · see citing works

Understanding Cellular Senescence and Senotherapeutics for Nutri-geriatric Solutions

Chawla, S., Bhattacharya, S., & Gupta, A. (2025) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/3214 · Cited by 1 · see citing works

Enhancing Mitophagy with PEP-1-CAT Attenuates Vascular Inflammation and Atherogenesis in Mice

Wei, S., Zhang, L., Wang, X.-R., Zheng, F., Yan, Y.-W., Wang, L., Yang, J., Fu, J., & Wang, Z.-J. (2026) · Inflammation · doi:10.1007/s10753-026-02463-0 · Cited by 1 · see citing works

Developmental tolerance and disease implications of aneuploidy

Fusari, E., & Milán, M. (2026) · Current Biology · doi:10.1016/j.cub.2026.01.056 · Cited by 1 · see citing works

Studying Cellular Senescence Using the Model Organism Drosophila melanogaster

Louka, X. P., Gumeni, S., & Trougakos, I. P. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4426-3_17 · Cited by 1 · see citing works

Activation of a Src-JNK pathway in unscheduled endocycling cells of the Drosophila wing disc induces a chronic wounding response

Huang, Y., & Calvi, B. R. (2025) · Genetics · doi:10.1093/genetics/iyaf147 · Cited by 1 · see citing works

Proteostasis failure and mitochondrial dysfunction contribute to chromosomal instability-induced microcephaly

González-Blanco, A., Higaki, A. R. A., Boettger, D., Joy, J., & Milán, M. (2026) · Nature Communications · doi:10.1038/s41467-026-70521-0 · Cited by 1 · see citing works

Ribosome Quality Control Mitigates Proteotoxic Stress in Aneuploid CellsPreprint

Viganò, S., Ippolito, M. R., Scorzoni, S., Barrio, L., Loffreda, A., Rodriguez‐Muñoz, M., Donzel, D., Eliezer, Y., Vaites, L. P., Paulo, J. A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.19.700285 · Cited by 1 · see citing works

Roles of mTOR-regulating GTPases in regulating drug resistance in senescence-like hepatoma cellsPreprint

Jiang, W., Ou, Z., Zhu, Q., Yao, Y., & Zai, H. (2021) · Research Square · doi:10.21203/rs.3.rs-1014270/v1

Lack of apoptosis leads to cellular senescence and tumorigenesis in Drosophila epithelial cellsPreprint

García-Arias, J. M., Pinal, N., Cristobal‐Vargas, S., Estella, C., & Morata, G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.08.539867

A tumour-host feed-forward loop contributes to malignant growth in chromosomal instability-induced epithelial tumoursPreprint

Ghosh, K., Kunchur, A., & Milán, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.24.678048

Additional file 1 of Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence

Zheng, H., Liang, X., Han, Q., Shao, Z., Zhang, Y., Shi, L., Hong, Y., Li, W., Mai, C., Mo, Q., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16851174

From stress to strength: mechanotransducing poly(aneu)ploidy into a community-level advantage in cancer

Herrera-Fernández, V., Dremsek, P., Hengstschläger, M., & Lomakin, A. J. (2026) · Cancer and Metastasis Reviews · doi:10.1007/s10555-026-10330-5

Hematopoietic stem cell senescence and opportunities for intervention

Barve, A., Dabas, P., Cain, T. L., & McKinney‐Freeman, S. (2026) · Experimental Hematology · doi:10.1016/j.exphem.2026.105425 · Cited by 1 · see citing works

Dpp and immune response pathway factors mediate paracrine induction of senescent cells in Drosophila

García-Arias, J. M., Ruiz-Losada, M., Azpiazu, N., & Morata, G. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2602167123

A tumour-host feed-forward loop contributes to the growth of chromosomal instability-induced tumours

Ghosh, K., Kunchur, A., & Milán, M. (2026) · EMBO Reports · doi:10.1038/s44319-026-00811-7

Chromosomal instability in cancer: sources, consequences and new therapeutic opportunities

Serpico, A. F., & Grieco, D. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02940-w

Chromosomal instability : interplay between proteotoxic and metabolic stress

Joy, J. (2020) · Repositori digital de la UPF (Universitat Pompeu Fabra)

Understanding chromosomal instability-induced senescence

Santos Tapia, C. (2019) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)

Impaired mitochondrial quality control and stress signalling machinery modulate senescence induction by genotoxic challenge

Weston, M. S., Domínguez-Prieto, M., & Moisoi, N. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112763

Prolonged disturbance of proteostasis induces cellular senescence via temporal mitochondrial dysfunction and subsequent mitochondrial accumulation in human fibroblasts

Takenaka, Y., Inoue, I., Nakano, T., Ikeda, M., & Kakinuma, Y. (2021) · FEBS Journal · doi:10.1111/febs.16249 · Cited by 29 · see citing works

Prolonged disturbance of proteostasis induces cellular senescence via temporal mitochondrial dysfunction and enhanced mitochondrial biogenesis in human fibroblastsPreprint

Takenaka, Y., Inoue, I., Nakano, T., Ikeda, M., & Kakinuma, Y. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.22.916221 · Cited by 1 · see citing works