Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth
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Chromosome instability (CIN) is associated with poor survival and therapeutic outcome in a number of malignancies. Despite this correlation, CIN can also lead to growth disadvantages. Here, we show that simultaneous overexpression of the mitotic checkpoint protein Mad2 with Kras(G12D) or Her2 in mammary glands of adult mice results in mitotic checkpoint overactivation and a delay in tumor onset. Time-lapse imaging of organotypic cultures and pathologic analysis prior to tumor establishment reveals error-prone mitosis, mitotic arrest, and cell death. Nonetheless, Mad2 expression persists and increases karyotype complexity in Kras tumors. Faced with the selective pressure of oncogene withdrawal, Mad2-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow.
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The emergence, and subsequent tolerance, of CIN represents an important bottleneck during tumor evolution.
“The emergence, and subsequent tolerance, of CIN represents an important bottleneck during tumor evolution38–40.”
From Chromosomal instability drives metastasis through a cytosolic DNA response (2018) · cites this paper as [40]
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Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455 · see citing works
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160 · see citing works
ONCOMINE: A Cancer Microarray Database and Integrated Data-Mining Platform
Rhodes, D. R., Yu, J., Sundaram, S. K., Deshpande, N., Varambally, R., Ghosh, D., Barrette, T. R., Pander, A., & Chinnaiyan, A. M. (2004) · Neoplasia · doi:10.1016/s1476-5586(04)80047-2 · Cited by 3,615 · see citing works
RAS oncogenes: weaving a tumorigenic web
Pylayeva-Gupta, Y., Grabocka, E., & Bar-Sagi, D. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3106 · Cited by 1,789 · see citing works
The landscape of cancer genes and mutational processes in breast cancer
Stephens, P. J., Tarpey, P. S., Davies, H. R., Loo, P. V., Greenman, C., Wedge, D. C., Nik‐Zainal, S., Martin, S., Varela, I., Bignell, G. R., et al. (2012) · Nature · doi:10.1038/nature11017 · Cited by 1,686 · see citing works
Moasser, M. M. (2007) · Oncogene · doi:10.1038/sj.onc.1210477 · Cited by 1,229 · see citing works
Carter, S. L., Eklund, A. C., Kohane, I. S., Harris, L. N., & Szállási, Z. (2006) · Nature Genetics · doi:10.1038/ng1861 · Cited by 1,199 · see citing works
A Big Bang model of human colorectal tumor growth
Sottoriva, A., Kang, H., Ma, Z., Graham, T. A., Salomon, M. P., Zhao, J., Marjoram, P., Siegmund, K. D., Press, M. F., Shibata, D. K., et al. (2015) · Nature Genetics · doi:10.1038/ng.3214 · Cited by 1,010 · see citing works
Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast
Torres, E. M., Sokolsky, T., Tucker, C. M., Chan, L. Y., Boselli, M., Dunham, M. J., & Amon, A. (2007) · Science · doi:10.1126/science.1142210 · Cited by 935 · see citing works
Mad2 Overexpression Promotes Aneuploidy and Tumorigenesis in Mice
Sotillo, R., Hernando, E., Díaz-Rodríguez, E., Teruya-Feldstein, J., Cordón-Cardo, C., Lowe, S. W., & Benezra, R. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.10.019 · Cited by 612 · see citing works
Self-citationRosenblatt, J., RAFF, M. C., & Cramer, L. P. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00587-5 · Cited by 602 · see citing works
Gilmore, A. P. (2005) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401723 · Cited by 597 · see citing works
Fisher, G. H., Wellen, S. L., Klimstra, D., Lenczowski, J. M., Tichelaar, J. W., Lizak, M. J., Whitsett, J. A., Koretsky, A., & Varmus, H. E. (2001) · Genes & Development · doi:10.1101/gad.947701 · Cited by 582 · see citing works
Proliferation of aneuploid human cells is limited by a p53-dependent mechanism
Thompson, S. L., & Compton, D. A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200905057 · Cited by 494 · see citing works
Comprehensive identification of mutational cancer driver genes across 12 tumor types
Tamborero, D., González-Pérez, A., Perez-Llamas, C., Deu-Pons, J., Kandoth, C., Reimand, J., Lawrence, M. S., Getz, G. A., Bader, G. D., Li, J., et al. (2013) · Scientific Reports · doi:10.1038/srep02650 · Cited by 475 · see citing works
Chromosomal Instability Confers Intrinsic Multidrug Resistance
Lee, A. J. X., Endesfelder, D., Rowan, A., Walther, A., Birkbak, N. J., Futreal, P. A., Downward, J., Szállási, Z., Tomlinson, I. P. M., Howell, M. T., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3604 · Cited by 466 · see citing works
Mitotic chromosomal instability and cancer: mouse modelling of the human disease
Schvartzman, J. M., Sotillo, R., & Benezra, R. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2781 · Cited by 411 · see citing works
Self-citationAneuploidy Drives Genomic Instability in Yeast
Sheltzer, J. M., Blank, H. M., Pfau, S. J., Tange, Y., George, B. M., Humpton, T. J., Brito, I., Hiraoka, Y., Niwa, O., & Amon, A. (2011) · Science · doi:10.1126/science.1206412 · Cited by 398 · see citing works
Moody, S. E., Sarkisian, C. J., Hahn, K. T., Gunther, E. J., Pickup, S., Dugan, K. D., Innocent, N., Cardiff, R. D., Schnall, M. D., & Chodosh, L. A. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00212-x · Cited by 345 · see citing works
Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal
Sotillo, R., Schvartzman, J. M., Socci, N. D., & Benezra, R. (2010) · Nature · doi:10.1038/nature08803 · Cited by 273 · see citing works
Self-citationThe ATM–p53 pathway suppresses aneuploidy-induced tumorigenesis
Li, M., Fang, X., Baker, D. J., Guo, L., Gao, X., Wei, Z., Han, S., van Deursen, J. M., & Zhang, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005960107 · Cited by 257 · see citing works
Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors
Silk, A. D., Zasadil, L. M., Holland, A., Vitre, B., Cleveland, D., & Weaver, B. A. (2013) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1317042110 · Cited by 256 · see citing works
Dynamic in vivo imaging and cell tracking using a histone fluorescent protein fusion in mice
Hadjantonakis, A., & Papaioannou, V. E. (2004) · BMC Biotechnology · doi:10.1186/1472-6750-4-33 · Cited by 252 · see citing works
A novel doxycycline‐inducible system for the transgenic analysis of mammary gland biology
Gunther, E., Belka, G., Wertheim, G. B. W., Wang, J. Y., Hartman, J., Boxer, R. B., & Chodosh, L. A. (2002) · The FASEB Journal · doi:10.1096/fj.01-0551com · Cited by 237 · see citing works
Fata, J. E., Chaudhary, V., & Khokha, R. (2001) · Biology of Reproduction · doi:10.1095/biolreprod65.3.680 · Cited by 196 · see citing works
Schvartzman, J.-M., Duijf, P. H. G., Sotillo, R., Coker, C., & Benezra, R. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.04.017 · Cited by 181 · see citing works
Self-citationMYC Is a Major Determinant of Mitotic Cell Fate
Topham, C. H., Tighe, A., Ly, P., Bennett, A., Sloss, O., Nelson, L., Ridgway, R. A., Huels, D. J., Littler, S., Schandl, C., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.06.001 · Cited by 142 · see citing works
A cell‐based model system links chromothripsis with hyperploidy
Mardin, B. R., Drainas, A. P., Waszak, S. M., Weischenfeldt, J., Isokane, M., Stütz, A. M., Raeder, B., Efthymiopoulos, T., Buccitelli, C., Segura‐Wang, M., et al. (2015) · Molecular Systems Biology · doi:10.15252/msb.20156505 · Cited by 140 · see citing works
Self-citationTargeting the Adaptability of Heterogeneous Aneuploids
Chen, G., Mulla, W. A., Kucharavy, A., Tsai, H.-J., RUBINSTEIN, B. Y., Conkright, J. J., McCroskey, S., Bradford, W. D., Weems, L., Haug, J. S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.026 · Cited by 130 · see citing works
Habermann, J. K., Doering, J., Hautaniemi, S., Roblick, U. J., Bündgen, N. K., Nicorici, D., Kronenwett, U., Rathnagiriswaran, S., Mettu, R. R., Ma, Y., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.24017 · Cited by 129 · see citing works
Podsypanina, K., Politi, K. A., Beverly, L. J., & VARMUS, H. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801197105 · Cited by 128 · see citing works
The cancer biology of whole-chromosome instability
Duijf, P. H. G., & Benezra, R. (2013) · Oncogene · doi:10.1038/onc.2012.616 · Cited by 124 · see citing works
Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution
Laughney, A. M., Elizalde, S., Genovese, G., & Bakhoum, S. F. W. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.065 · Cited by 117 · see citing works
2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells
Zasadil, L. M., Britigan, E. M. C., & Weaver, B. A. A. (2013) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2013.02.001 · Cited by 106 · see citing works
Rudmann, D. G., Cardiff, R. D., Chouinard, L., Goodman, D. G., Küttler, K., Marxfeld, H., Molinolo, A., Treumann, S., Yoshizawa, K., & For the INHAND Mammary, Z. (2012) · Toxicologic Pathology · doi:10.1177/0192623312454242 · Cited by 106 · see citing works
Genetic instability: tipping the balance
Janssen, A., & Medema, R. H. (2012) · Oncogene · doi:10.1038/onc.2012.576 · Cited by 97 · see citing works
Montagna, C., Andrechek, E. R., Padilla‐Nash, H. M., Muller, W. J., & Ried, T. (2002) · Oncogene · doi:10.1038/sj.onc.1205146 · Cited by 94 · see citing works
Integration of Genomic Data Enables Selective Discovery of Breast Cancer Drivers
Sanchez-Garcia, F., Villagrasa, P., Matsui, J., Kotliar, D., Castro, V., Akavia, U.-D., Chen, B.-J., Saucedo-Cuevas, L. P., Barrueco, R. R., Llobet‐Navàs, D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.048 · Cited by 92 · see citing works
McCormack, S. J., Ohler, Z. W., Deming, S., Natarajan, G., Torri, J., Johnson, M. D., Liyanage, M., Ried, T., & Dickson, R. B. (1998) · Oncogene · doi:10.1038/sj.onc.1201804 · Cited by 88 · see citing works
Jamal‐Hanjani, M., A’Hern, R., Birkbak, N. J., Gorman, P., Gronroos, E. C., Ngang, S., Nicola, P. A., Rahman, L., Thanopoulou, E., Kelly, G. P., et al. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv178 · Cited by 86 · see citing works
Whole chromosome aneuploidy: Big mutations drive adaptation by phenotypic leap
Chen, G., RUBINSTEIN, B. Y., & Li, R. (2012) · BioEssays · doi:10.1002/bies.201200069 · Cited by 79 · see citing works
Checkpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human Cells
Kabeche, L., & Compton, D. A. (2012) · Current Biology · doi:10.1016/j.cub.2012.02.030 · Cited by 78 · see citing works
Zeng, X., Shaikh, F. Y., Harrison, M. K., Adon, A. M., Trimboli, A. J., Carroll, K. A., Sharma, N., Timmers, C. D., Chodosh, L. A., Leone, G. W., et al. (2010) · Oncogene · doi:10.1038/onc.2010.253 · Cited by 78 · see citing works
Endesfelder, D., Burrell, R. A., Kanu, N., McGranahan, N., Howell, M., Parker, P. J., Downward, J., Swanton, C., & Kschischo, M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2664 · Cited by 74 · see citing works
Jechlinger, M., Podsypanina, K., & VARMUS, H. E. (2009) · Genes & Development · doi:10.1101/gad.1801809 · Cited by 68 · see citing works
Self-citationProgrammed elimination of cells by caspase-independent cell extrusion in C. elegans
Denning, D. P., Hatch, V., & Horvitz, H. R. (2012) · Nature · doi:10.1038/nature11240 · Cited by 68 · see citing works
Requirements for Aurora-A in Tissue Regeneration and Tumor Development in Adult Mammals
de Castro, I. P., Aguirre‐Portolés, C., Fernández‐Miranda, G., Cañamero, M., Cowley, D. O., Dyke, T. V., & Malumbres, M. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0586 · Cited by 26 · see citing works
Valind, A., Jin, Y., & Gisselsson, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070445 · Cited by 24 · see citing works
Heterogeneity in MYC-induced mammary tumors contributes to escape from oncogene dependence
Leung, J. Y., Andrechek, E. R., Cardiff, R. D., & Nevins, J. R. (2011) · Oncogene · doi:10.1038/onc.2011.433 · Cited by 21 · see citing works
Boveri, T. (1912) · Science · doi:10.1126/science.36.928.453 · Cited by 11 · see citing works
On the Role of the Microenvironment in Mammary Gland Development and CancerPreprint
Radisky, D. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a013458 · Cited by 7 · see citing works
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- Boveri T. ANTON DOHBN Science 36 1912 453 468 17770611
- Gilmore A.P. Anoikis Cell Death Differ. 12 Suppl 2 2005 1473 1477 16247493
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Chromosomal instability drives metastasis through a cytosolic DNA response
Bakhoum, S. F., Ngo, B., Laughney, A. M., Cavallo, J.-A., Murphy, C. J., Ly, P., Shah, P., Sriram, R. K., Watkins, T. B. K., Taunk, N. K., et al. (2018) · Nature · doi:10.1038/nature25432 · Cited by 1,638 · see citing works
Matthews, H. K., Bertoli, C., & de Bruin, R. A. M. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00404-3 · Cited by 1,506 · see citing works
The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment
Bakhoum, S. F. W., & Cantley, L. C. (2018) · Cell · doi:10.1016/j.cell.2018.08.027 · Cited by 717 · see citing works
Context is everything: aneuploidy in cancer
Ben‐David, U., & Amon, A. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0171-x · Cited by 651 · see citing works
Determinants and clinical implications of chromosomal instability in cancer
Sansregret, L., Vanhaesebroeck, B., & Swanton, C. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.198 · Cited by 396 · see citing works
Genomic evolution of cancer models: perils and opportunities
Ben‐David, U., Beroukhim, R., & Golub, T. R. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0095-3 · Cited by 220 · see citing works
The two sides of chromosomal instability: drivers and brakes in cancer
Hosea, R., Hillary, S., Naqvi, S., Wu, S., & Kasim, V. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01767-7 · Cited by 205 · see citing works
Plk1 overexpression induces chromosomal instability and suppresses tumor development
de Cárcer, G., Venkateswaran, S. V., Salgueiro, L., Bakkali, A. E., Somogyi, K., Rowald, K., Montañés-Agudo, P., Sanclemente, M., Escobar, B., Martino, A. D., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05429-5 · Cited by 168 · see citing works
Self-citationChromosomal Instability as a Driver of Tumor Heterogeneity and EvolutionPreprint
Bakhoum, S. F. W., & Landau, D. A. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029611 · Cited by 166 · see citing works
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
Kanu, N., Cerone, M. A., Goh, G., Zalmas, L., Bártková, J., Dietzen, M., McGranahan, N., Rogers, R. F., Law, E. K., Gromova, I., et al. (2016) · Genome biology · doi:10.1186/s13059-016-1042-9 · Cited by 157 · see citing works
Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression
Hrycyniak, L., Zasadil, L. M., & Weaver, B. A. A. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.10.023 · Cited by 141 · see citing works
Tijhuis, A. E., Johnson, S. C., & McClelland, S. E. (2019) · Molecular Cytogenetics · doi:10.1186/s13039-019-0429-1 · Cited by 127 · see citing works
Guo, X., Ni, J., Liang, Z., Xue, J., Fenech, M. F., & Wang, X. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.11.001 · Cited by 125 · see citing works
Aneuploidy: Cancer strength or vulnerability?
Simonetti, G., Bruno, S., Padella, A., Tenti, E., & Martinelli, G. (2018) · International Journal of Cancer · doi:10.1002/ijc.31718 · Cited by 110 · see citing works
Chromosomal instability and aneuploidy as causes of cancer drug resistance
Lukow, D. A., & Sheltzer, J. M. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.09.002 · Cited by 80 · see citing works
Chromosome Abnormalities: New Insights into Their Clinical Significance in Cancer
Kou, F., Wu, L., Ren, X., & Yang, L. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.05.010 · Cited by 79 · see citing works
Transient genomic instability drives tumorigenesis through accelerated clonal evolutionPreprint
Shoshani, O., Bakker, B., de Haan, L., Tijhuis, A. E., Wang, Y., Kim, D. H., Maldonado, M., Demarest, M. A., Artates, J., Ouyang, Z., et al. (2021) · Genes & Development · doi:10.1101/gad.348319.121 · Cited by 77 · see citing works
Mutation–selection balance and compensatory mechanisms in tumour evolution
Persi, E., Wolf, Y. I., Horn, D., Ruppin, E., Demichelis, F., Gatenby, R. A., Gillies, R. J., & Koonin, E. V. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-00299-4 · Cited by 62 · see citing works
Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence
Joy, J., Barrio, L., Santos-Tapia, C., Romão, D., Giakoumakis, N. N., Clemente-Ruiz, M., & Milán, M. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.06.009 · Cited by 63 · see citing works
Pan-cancer analysis distinguishes transcriptional changes of aneuploidy from proliferationPreprint
Buccitelli, C., Salgueiro, L., Rowald, K., Sotillo, R., Mardin, B. R., & Korbel, J. O. (2017) · Genome Research · doi:10.1101/gr.212225.116 · Cited by 61 · see citing works
Self-citationCIN and Aneuploidy: Different Concepts, Different Consequences
Schukken, K. M., & Foijer, F. (2017) · BioEssays · doi:10.1002/bies.201700147 · Cited by 61 · see citing works
Acquisition of chromosome instability is a mechanism to evade oncogene addiction
Salgueiro, L., Buccitelli, C., Rowald, K., Somogyi, K., Kandala, S., Korbel, J. O., & Sotillo, R. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201910941 · Cited by 56 · see citing works
Self-citationA population genetics perspective on the determinants of intra-tumor heterogeneity
Hu, Z., Sun, R., & Curtis, C. N. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.03.001 · Cited by 52 · see citing works
Mad1 destabilizes p53 by preventing PML from sequestering MDM2
Wan, J., Block, S., Scribano, C. M., Thiry, R., Esbona, K., Audhya, A., & Weaver, B. A. A. (2019) · Nature Communications · doi:10.1038/s41467-019-09471-9 · Cited by 37 · see citing works
Chromosome Missegregation as a Modulator of Radiation Sensitivity
Cosper, P. F., Copeland, S. E., Tucker, J. B., & Weaver, B. A. A. (2021) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2021.09.002 · Cited by 34 · see citing works
A Markov chain for numerical chromosomal instability in clonally expanding populations
Elizalde, S., Laughney, A. M., & Bakhoum, S. F. W. (2018) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006447 · Cited by 32 · see citing works
Andrade, J., Gallagher, A., Maharaj, J., & McClelland, S. E. (2023) · Chromosome Research · doi:10.1007/s10577-023-09737-5 · Cited by 32 · see citing works
Targeting chromosomal instability and aneuploidy in cancer
Bhatia, S., Khanna, K. K., & Duijf, P. H. G. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2024.01.009 · Cited by 28 · see citing works
Polar Chromosomes—Challenges of a Risky Path
Vukušić, K., & Tolić, I. M. (2022) · Cells · doi:10.3390/cells11091531 · Cited by 27 · see citing works
Zhou, A. S., Tucker, J. B., Scribano, C. M., Lynch, A. R., Carlsen, C. L., Pop-Vicas, S. T., Pattaswamy, S. M., Burkard, M. E., & Weaver, B. A. A. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002339 · Cited by 27 · see citing works
The Role of Human Centromeric RNA in Chromosome Stability
Leclerc, S., & Kitagawa, K. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.642732 · Cited by 25 · see citing works
Cosper, P. F., Hrycyniak, L., Paracha, M., Lee, D. L., Wan, J., Jones, K. M., Bice, S. A., Nickel, K. P., Mallick, S., Taylor, A. M., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2216700120 · Cited by 25 · see citing works
Banerjee, R., Liu, M., Bellile, E. L., Schmitd, L. B., Goto, M., Hutchinson, M.-K. N. D., Singh, P. A., Zhang, S., Damodaran, D., Nyati, M. K., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.06.009 · Cited by 24 · see citing works
Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma
Gong, Y., Zou, S., Deng, D., Wang, L., Hu, H., Qiu, Z., Wei, T., Yang, P., Zhou, J., Zhang, Y., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2022.12.012 · Cited by 24 · see citing works
p53 Is Not Required for High CIN to Induce Tumor Suppression
Hrycyniak, L., Wan, J., Ryan, S. D., Kaur, C., Sullivan, R., Roopra, A., & Weaver, B. A. A. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0488 · Cited by 21 · see citing works
Lashen, A., Toss, M. S., Wootton, L. M., Green, A. R., Mongan, N. P., Srinivasan, M., & Rakha, E. A. (2023) · Histopathology · doi:10.1111/his.14960 · Cited by 23 · see citing works
Permission to pass: on the role of p53 as a gatekeeper for aneuploidy
Marques, J. F., & Kops, G. J. P. L. (2023) · Chromosome Research · doi:10.1007/s10577-023-09741-9 · Cited by 24 · see citing works
Cytokinesis Failure Leading to Chromosome Instability in v-Src-Induced Oncogenesis
Nakayama, Y., Soeda, S., Ikeuchi, M., Kakae, K., & Yamaguchi, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040811 · Cited by 23 · see citing works
Guo, X., Ni, J., Dai, X., Zhou, T., Yang, G., Xue, J., & Wang, X. (2017) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2017.11.004 · Cited by 23 · see citing works
Singh, A. K., Denu, R. A., Wolfe, S. K., Sperger, J. M., Schehr, J. L., Witkowsky, T., Esbona, K., Chappell, R. J., Weaver, B. A. A., Burkard, M. E., et al. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12687 · Cited by 21 · see citing works
Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancer
Kandala, S., Ramos, M., von Voithenberg, L. V., Diaz-Jimenez, A., Chocarro, S., Keding, J., Brors, B., Imbusch, C. D., & Sotillo, R. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113266 · Cited by 21 · see citing works
Self-citationWiegmans, A. P., Ward, A., Ivanova, E., Duijf, P. H. G., Adams, M. N., Najib, I. M., Oosterhout, R. V., Sadowski, M. C., Kelly, G., Morrical, S. W., et al. (2021) · NAR Cancer · doi:10.1093/narcan/zcab022 · Cited by 20 · see citing works
Chromosomal instability-induced cell invasion through caspase-driven DNA damage
Barrio, L., Gaspar, A.-E., Muzzopappa, M., Ghosh, K., Romão, D., Clemente‐Ruiz, M., & Milán, M. (2023) · Current Biology · doi:10.1016/j.cub.2023.09.004 · Cited by 19 · see citing works
Jiang, W., Yang, X. F., Shi, K., Zhang, Y., Shi, X., Wang, J., Wang, Y., Chenyan, A., Shan, J., Wang, Y., et al. (2023) · Oncogene · doi:10.1038/s41388-023-02849-6 · Cited by 18 · see citing works
Chromosomal Instability as Enabling Feature and Central Hallmark of Breast Cancer
Castellanos, G., Valbuena, D. S., Pérez, E., Villegas, V. E., & Rondón‐Lagos, M. (2023) · Breast Cancer Targets and Therapy · doi:10.2147/bctt.s383759 · Cited by 18 · see citing works
Hosea, R., Duan, W., Meliala, I. T. S., Li, W., Wei, M., Hillary, S., Zhao, H., Miyagishi, M., Wu, S., & Kasim, V. (2024) · Advanced Science · doi:10.1002/advs.202308690 · Cited by 16 · see citing works
Recent insights into the causes and consequences of chromosome mis-segregation
Devillers, R., dos Santos, A., Destombes, Q., Laplante, M., & Elowe, S. (2024) · Oncogene · doi:10.1038/s41388-024-03163-5 · Cited by 15 · see citing works
FOXM1 is critical for the fitness recovery of chromosomally unstable cells
Pan, F., Chocarro, S., Ramos, M. J., Chen, Y., de la Vega, A. A., Somogyi, K., & Sotillo, R. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05946-2 · Cited by 15 · see citing works
Self-citationVoutsadakis, I. A. (2019) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-019-00420-2 · Cited by 15 · see citing works
Chromosomal instability upregulates interferon in acute myeloid leukemia
Jin, N. Y., Lera, R. F., Yan, R., Guo, F., Oxendine, K., Horner, V. L., Hu, Y., Wan, J., Mattison, R. J., Weaver, B. A. A., et al. (2020) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22880 · Cited by 14 · see citing works
Domingues, P. H., Nanduri, L. S. Y., Seget, K., Venkateswaran, S. V., Agorku, D., Viganó, C., von Schubert, C., Nigg, E. A., Swanton, C., Sotillo, R., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3052 · Cited by 12 · see citing works
Self-citationYu, D., Chen, X., Li, X., Zhou, H., Yu, D., Yu, X., Hu, Y., Zhang, R., Zhang, X., Zhang, K., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-89628-z · Cited by 11 · see citing works
Role of micronucleus-activated cGAS-STING signaling in antitumor immunity
Qin, S. H. E. N., Xu, P., & Chen, M. (2024) · Journal of Zhejiang University (Medical Sciences) · doi:10.3724/zdxbyxb-2023-0485 · Cited by 11 · see citing works
Microtubule poleward flux as a target for modifying chromosome segregation errors
Risteski, P., Martinčić, J., Jagrić, M., Tintor, E., Petelinec, A., & Tolić, I. M. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2405015121 · Cited by 9 · see citing works
Too much to handle — how gaining chromosomes destabilizes the genome
Passerini, V., & Štorchová, Z. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1231285 · Cited by 9 · see citing works
Wu, Y., Tan, L., Chen, J., Li, H., Ying, H., Jiang, Y., Wu, Q., Yu, G., Tian, Y., Yu, J., et al. (2018) · Medical Science Monitor · doi:10.12659/msm.909772 · Cited by 8 · see citing works
The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance
Carloni, V., Morganti, E., Galli, A., & Mazzocca, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010245 · Cited by 7 · see citing works
Bronder, D., & Bakhoum, S. F. W. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012017 · Cited by 7 · see citing works
Kras in OrganoidsPreprint
Cheng, D. K., & Tuveson, D. A. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031575 · Cited by 7 · see citing works
Aneuploidy-induced cellular behaviors: Insights from Drosophila
Joy, J., Fusari, E., & Milán, M. (2024) · Developmental Cell · doi:10.1016/j.devcel.2023.12.009 · Cited by 6 · see citing works
Alikhanyan, K., Chen, Y., Somogyi, K., Kraut, S., & Sotillo, R. (2021) · Cancers · doi:10.3390/cancers13236027 · Cited by 4 · see citing works
Self-citationThe Link Between Chromosomal Instability and Immunity in Cancer
Kumari, L., Kumar, Y., & Bhatia, A. (2022) · Springer eBooks · doi:10.1007/978-3-030-80962-1_51-1 · Cited by 4 · see citing works
Chromosomal instability increases radiation sensitivityPreprint
Cosper, P. F., Paracha, M., Jones, K. M., Hrycyniak, L., Henderson, L., Bryan, A., Eyzaguirre, D., McCunn, E., Boulanger, E., Wan, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.13.612942 · Cited by 4 · see citing works
Atypical R-loops in cancer: decoding molecular chaos for therapeutic gain
Sun, Y., Wang, S., Ge, N., Guo, J., Wang, G., Yang, F., & Sun, S. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06929-x · Cited by 3 · see citing works
Chronic spindle assembly checkpoint activation causes myelosuppression and gastrointestinal atrophy
Karbon, G., Schuler, F., Braun, V. Z., Eichin, F., Haschka, M. D., Drach, M. C., Sotillo, R., Geley, S., Spierings, D. C. J., Tijhuis, A. E., et al. (2024) · EMBO Reports · doi:10.1038/s44319-024-00160-3 · Cited by 2 · see citing works
Self-citationAlladin, A., & Jechlinger, M. (2017) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2017.10.004 · Cited by 2 · see citing works
Self-citationSarkar, S., Pal, R., Choudhury, T., Vernekar, M., Chatterjee, P., Mukherjee, K. K., Nath, P., Behera, S. K., Kumar, S., & Nasare, V. D. (2025) · Journal of Current Oncological Trends · doi:10.4103/jcot.jcot_2_25 · Cited by 1 · see citing works
The Link Between Chromosomal Instability and Immunity in Cancer
Kumari, L., Kumar, Y., & Bhatia, A. (2025) · Springer eBooks · doi:10.1007/978-3-032-00749-0_51 · Cited by 1 · see citing works
Pretreatment Chromosomal Instability Correlates With Radiation Sensitivity in Squamous Cell Cancers
Cosper, P. F., Paracha, M., Jones, K. M., Hrycyniak, L., Henderson, L., Bryan, A., Eyzaguirre, D., McCunn, E., Boulanger, E., Wan, J., et al. (2026) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2025.12.014 · Cited by 1 · see citing works
Modification of Single Cells Within Mouse Mammary Gland Derived Acini via Viral Transduction
del Valle, L. G., Montero, M. G., & Jechlinger, M. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2193-6_9 · Cited by 1 · see citing works
Self-citationChromosome instability: From molecular mechanisms to disease
de Cárcer, G., Huertas, P., & Lopez-Contreras, A. J. (2018) · DNA repair · doi:10.1016/j.dnarep.2018.04.006 · Cited by 1 · see citing works
scUnique: Measuring Ongoing Chromosomal InstabilityPreprint
Schneider, M. P., Shafighi, S. D., Cullen, A. E., Ota, A., Bradley, T., Couturier, D., Smith, P. S., Piskorz, A., Brenton, J. D., & Markowetz, F. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.28.721240 · Cited by 1 · see citing works
Wiegmans, A. P., Ward, A., Ivanova, E., Duijf, P. H. G., VanOosterhout, R., Sadowski, M. C., Kelly, G., Morrical, S. W., Lee, J. S., & Richard, D. J. (2020) · doi:10.21203/rs.3.rs-103661/v1
La proteína MAD2 como posible biomarcador diagnóstico en cáncer
Alcázar, D. G. (2021) · doi:10.24275/uami.v979v329b
Data from p53 Is Not Required for High CIN to Induce Tumor Suppression
Funk, L. C., Wan, J., Ryan, S. D., Kaur, C., Sullivan, R., Roopra, A., & Weaver, B. A. A. (2023) · doi:10.1158/1541-7786.c.6544973
Karbon, G., Schuler, F., Haschka, M. D., Drach, M. C., Sotillo, R., Geley, S., Spierings, D. C. J., Tijhuis, A. E., Foijer, F., & Villunger, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.08.556836
Self-citationYY2/BUB3 axis-mediated SAC hyperactivity determines tumor cell fate through chromosomal instabilityPreprint
Hosea, R., Duan, W., Meliala, I. T. S., Li, W., Wei, M., Hillary, S., Zhao, H., Miyagishi, M., Wu, S., & Kasim, V. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.07.561167
Ghosh, K., Kunchur, A., & Milán, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.24.678048
Immunofluorescent microscopy to quantify and characterize chromosomal instability (CIN)
Jones, K. M., Choi, Y., Leelasukseree, R., Messick, N. N., Bryan, A., Bice, S. A., & Cosper, P. F. (2026) · Methods in cell biology · doi:10.1016/bs.mcb.2025.10.013
Le génome remanié comme oncogène des sarcomes pléomorphes ?
Delespaul, L. (2018) · theses.fr (ABES) · doi:10.70675/12f3b234zd503z4d00za731z88e607a39433
Influence of centrosome amplification on the response to chemotherapy in epithelial ovarian cancer
Fantozzi, G. (2023) · theses.fr (ABES) · doi:10.70675/9023fab1z003az407bz9b02z2054939e787d
Targeting the cell cycle : A novel therapeutic strategy against ATIP3- deficient breast cancer
Haykal, M. M. (2023) · theses.fr (ABES) · doi:10.70675/03dee32bz395cz469ez9a0dzf4c5f2e84330
Sthanam, L. K., Mendez, P. M., McBeath, E., Cruz, L., Bagheri‐Yarmand, R., & Hofmann, M.-C. C. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218619
A tumour-host feed-forward loop contributes to the growth of chromosomal instability-induced tumours
Ghosh, K., Kunchur, A., & Milán, M. (2026) · EMBO Reports · doi:10.1038/s44319-026-00811-7
- Authors
- Rowald, K., Mantovan, M., Passos, J., Buccitelli, C., Mardin, B. R., Korbel, J. O., Jechlinger, M., & Sotillo, R.
- Affiliations
- European Molecular Biology Laboratory (IT)
- European Molecular Biology Laboratory (DE)
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 15
- Issue
- 12
- Pages
- 2679-2691
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC4920917
- OpenAlex
- W2410399749
- Cited by
- 84
- References
- 52
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 9 · 2023: 16 · 2022: 4 · 2021: 11 · 2020: 8 · 2019: 4 · 2018: 12 · 2017: 8 · 2016: 3
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- Mad2, chromosomal instability, breast cancer, spindle assembly checkpoint, KRAS G12D, HER2, tumor remission, karyotype complexity, mitotic arrest
- MeSH terms
- Aneuploidy, Animals, Breast Neoplasms, Cells, Cultured, Epithelial Cells, Female, Humans, Mammary Neoplasms, Experimental, Mitosis, Spindle Apparatus, Oncogenes, Phenotype, Proto-Oncogene Proteins p21(ras), Apoptosis, Receptor, ErbB-2, Erb-b2 Receptor Tyrosine Kinases, Transgenes, Chromosome Segregation, Chromosomal Instability, Cell Proliferation, Mice, Time-Lapse Imaging, Cell Cycle Checkpoints, Carcinogenesis, Mad2 Proteins
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