A pilot study of gestational diabetes mellitus not controlled by diet alone: First-line medical treatment with myoinositol may limit the need for insulin
Abstract
Aim This study assessed whether myoinositol might be a first-line medical treatment for gestational diabetes mellitus (GDM).Methods For 12 months, women with GDM not controlled by diet (n=32) were prospectively treated with myoinositol 1200mg and folic acid 400μg/day, while consecutive women (n=28) with insulin-requiring GDM treated during the previous year at our centre constituted the control group. Baseline characteristics and care were similar in both groups.Results Insulin was required in eight women (25%) in the myoinositol group who, compared with the 24 who did not need insulin, were older (37±5 vs. 32±5 years, respectively; P=0.018) and had a larger percentage of high self-monitored glucose values (45±8% vs. 32±14%; P<0.0001) during the week prior to the introduction of myoinositol treatment. All of the women had similar pregnancy outcomes regardless of their GDM management, although less labour induction was required in the myoinositol group (OR: 0.22 [0.07-0.65]), which had no side effects.Conclusion This pilot study suggests that myoinositol may be a safe first-line medical treatment for uncontrolled GDM.
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Several clinical studies demonstrated significant efficacy of inositols, mainly myo-inositol, in gestational diabetes mellitus prevention.
“In the last years, several clinical studies demonstrated the significant efficacy of inositols (mainly myo-inositol) in GDM prevention [76–80].”
From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [78]
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- Authors
- Lubin, V., Shojai, R., Darmon, P., & Cosson, E.
- Affiliations
- Hôpital de la Conception (FR)
- Inserm (FR)
- Conservatoire National des Arts et Métiers (FR)
- Corresponding author
- Lubin, V.
- ORCID
- Venue
- Diabetes & Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 42
- Issue
- 3
- Pages
- 192-195
- ISSN
- 1262-3636 (ISSN-L)
- OpenAlex
- W2338952488
- Cited by
- 21
- References
- 14
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 5 · 2018: 3 · 2016: 2
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- gestational diabetes mellitus, myo-inositol, insulin requirement, folic acid, labor induction, pregnancy outcomes
- MeSH terms
- Adult, Combined Modality Therapy, Diet, Female, Folic Acid, France, Humans, Inositol, Insulin, Pilot Projects, Pregnancy, Pregnancy Outcome, Blood Glucose Self-Monitoring, Diabetes, Gestational
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