Inositol for the prevention of gestational diabetes: a systematic review and meta-analysis of randomized controlled trials
Abstract
Purpose Inositol (ISL) embraces a family of simple carbohydrates with insulin-sensitizing properties, whose most common isoforms are Myo-inositol (MYO) and D-chiro inositol (DCI). The aim of the present study was to assess the efficacy and safety of ISL supplementation during pregnancy for the prevention of gestational diabetes (GDM).Methods We conducted a systematic literature search in electronic databases until October 2017. We included all randomized controlled trials (RCTs) comparing pregnant women with GDM who were randomized to either ISL (i.e., intervention group) or either placebo or no treatment (i.e., control group). The primary outcome was the preventive effect on GDM, defined as the rate of GDM in women without a prior diagnosis of GDM. Pooled results were expressed as odds ratio (OR) with a 95% confidence interval (95% CI).Results Five RCTs were included (including 965 participants). ISL supplementation was associated with lower rate of GDM (OR 0.49, 95% CI 0.24-1.03, p = 0.01) and lower preterm delivery rate (OR 0.35, 95% CI 0.17-0.74, p = 0.006). No adverse effects were reported. Adjusting for the type of intervention (MYO 2 g twice daily vs MYO 1100 mg plus DCI 27.6 mg daily), a significant effect was found only in patients receiving 2 g MYO twice daily.Conclusions ISLs administration during pregnancy appears to be safe and may represent a novel strategy for GDM prevention. In particular, the double administration of MYO 2 g per day may improve the glycemic homeostasis and may reduce GDM rate and preterm delivery rate.
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A systematic review and meta-analysis of five randomized controlled trials with 965 participants significantly supported therapy with myo-inositol alone or plus d-chiro-inositol in the prevention of gestational diabetes mellitus.
“Also, a very recent systematic review and meta-analysis [81] of five RCTs (965 participants) significantly supported the therapy with myo-inositol alone or plus d-chiro-inositol in the prevention of GDM.”
From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [81]
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- Authors
- Vitagliano, A., Saccone, G., Cosmi, E., Visentin, S., Dessole, F., Ambrosini, G., & Berghella, V.
- Affiliations
- University of Padua (IT)
- University of Naples Federico II (IT)
- University of Sassari (IT)
- Thomas Jefferson University (US)
- Corresponding author
- Vitagliano, Amerigo
- ORCID
- Venue
- Archives of Gynecology and Obstetrics
- Published
- 2018-12-18
- Volume
- 299
- Issue
- 1
- Pages
- 55-68
- ISSN
- 0003-9128 (ISSN-L)
- 0932-0067
- 1432-0711
- OpenAlex
- W2905576351
- Cited by
- 74
- References
- 41
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 6 · 2023: 13 · 2022: 11 · 2021: 13 · 2020: 15 · 2019: 6
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Gynecology and Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- inositol supplementation, gestational diabetes prevention, myo-inositol, D-chiro-inositol, pregnancy, preterm birth, insulin sensitivity, glycemic homeostasis, supplement dosage
- MeSH terms
- Adult, Blood Glucose, Female, Humans, Infant, Newborn, Inositol, Insulin, Pregnancy, Vitamin B Complex, Odds Ratio, Randomized Controlled Trials as Topic, Diabetes, Gestational, Premature Birth, Young Adult
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