Effect of dietary myo-inositol supplementation in pregnancy on the incidence of maternal gestational diabetes mellitus and fetal outcomes: a randomized controlled trial
Abstract
OBJECTIVE: To test the hypothesis that dietary myo-inositol may improve insulin resistance and the development of gestational diabetes mellitus (GDM) in women at high risk of this disorder. DESIGN: A prospective, randomized, double-blind, placebo controlled clinical trial, pilot study. PARTICIPANTS: Non-obese singleton pregnant women with an elevated fasting glucose in the first or early second trimester were studied throughout pregnancy. INTERVENTION: Supplementation with myo-inositol or placebo during pregnancy. MAIN OUTCOME MEASURE: Development of GDM on a 75 g oral glucose tolerance test at 24-28 weeks' gestation. Secondary outcome measures were increased in BMI, need for maternal insulin therapy, macrosomia, polyhydramnios, neonatal birthweight and hypoglycemia. RESULTS: Thirty-six women were allocated to receive myo-inositol and 39 placebo. The incidence of GDM in mid-pregnancy was significantly reduced (p = 0.001) in women randomized to receive myo-inositol compared to placebo (relative risk 0.127). Women randomized to receive myo-inositol also required less insulin therapy, delivered at a later gestational age, had significantly smaller babies with fewer episodes of neonatal hypoglycemia. CONCLUSIONS: Myo-inositol supplementation in pregnancy reduced the incidence of GDM in women at high risk of this disorder. The reduction in incidence of GDM in the treatment arm was accompanied by improved outcomes.
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Several clinical studies demonstrated significant efficacy of inositols, mainly myo-inositol, in gestational diabetes mellitus prevention.
“In the last years, several clinical studies demonstrated the significant efficacy of inositols (mainly myo-inositol) in GDM prevention [76–80].”
From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [77]
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- Authors
- Matarrelli, B., Vitacolonna, E., D’angelo, M., Pavone, G., Mattei, P. A., Liberati, M., & Celentano, C.
- Affiliations
- University of Chieti-Pescara (IT)
- Corresponding author
- Celentano, Claudio
- ORCID
- Venue
- The Journal of Maternal-Fetal & Neonatal Medicine
- Publisher
- Informa UK Limited
- Published
- 2013-03
- Volume
- 26
- Issue
- 10
- Pages
- 967-972
- ISSN
- 1476-4954 (ISSN-L)
- 1476-7058
- OpenAlex
- W2103767048
- Cited by
- 114
- References
- 19
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 9 · 2023: 9 · 2022: 11 · 2021: 8 · 2020: 12 · 2019: 10 · 2018: 8 · 2017: 12 · 2016: 7 · 2015: 8 · 2014: 4 · 2013: 4
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Italfarmaco
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- myo-inositol, dietary supplementation, gestational diabetes mellitus, insulin resistance, pregnancy, neonatal hypoglycemia, macrosomia, polyhydramnios, birth weight, high-risk pregnancy
- MeSH terms
- Adult, Double-Blind Method, Female, Fetus, Glucose Tolerance Test, Humans, Inositol, Insulin Resistance, Middle Aged, Pilot Projects, Placebos, Pregnancy, Incidence, Case-Control Studies, Diabetes, Gestational, Dietary Supplements, Young Adult
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