Regulation of hepatokine gene expression in response to fasting and feeding: Influence of PPAR-α and insulin-dependent signalling in hepatocytes
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Aim In hepatocytes, the peroxisome proliferator-activated receptor (PPAR)-α and insulin receptor (IR) are critical for transcriptional responses to fasting and feeding, respectively. The present report analyzes the effects of nutritional status (fasting vs feeding) on the expression of a large panel of hepatokines in hepatocyte-specific PPAR-α (Pparα hep-/-) and IR (IR hep-/-) null mice.Methods Pparα hep-/- and IR hep-/- mice, and their wild-type littermates, were subjected to fasting or feeding metabolic challenges, then analyzed for hepatokine gene expression. Experiments were conducted in mice of both genders.Results Our data confirmed that PPAR-α is essential for regulating fasting-induced Fgf21 and Angptl4 expression. In mice lacking PPAR-α, fasting led to increased Igfbp1 and Gdf15 gene expression. In the absence of hepatic IR, feeding induced overexpression of Igfbp1, follistatin (Fst) and adropin (Enho), and reduced activin E (Inhbe) expression. Gender had only a modest influence on hepatokine gene expression in the liver.Conclusion The present results highlight the potential roles of hepatokines as a class of hormones that substantially influence nutritional regulation in both female and male mice.
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Activin-E expression increases during fasting and is markedly suppressed by loss of the insulin receptor in the liver.
“Activin-E expression increases during fasting and is markedly suppressed by loss of the insulin receptor in the liver [10], suggesting dynamic regulation.”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [10]
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Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086 · see citing works
Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus
Kautzky-Willer, A., Harreiter, J., & Pacini, G. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1137 · Cited by 2,043 · see citing works
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., & Wahli, W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6223 · Cited by 1,649 · see citing works
Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504 · see citing works
Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495 · see citing works
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD
Montagner, A., Polizzi, A., Fouché, E., Ducheix, S., Lippi, Y., Lasserre, F., Barquissau, V., Régnier, M., Lukowicz, C., Benhamed, F., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310798 · Cited by 746 · see citing works
Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance
Meex, R. C. R., & Watt, M. J. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.56 · Cited by 631 · see citing works
Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding
Markan, K. R., Naber, M. C., Ameka, M. K., Anderegg, M. D., Mangelsdorf, D. J., Kliewer, S. A., Mohammadi, M., & Potthoff, M. J. (2014) · Diabetes · doi:10.2337/db14-0595 · Cited by 590 · see citing works
A liver-derived secretory protein, selenoprotein P, causes insulin resistance
Misu, H., Takamura, T., Takayama, H., Hayashi, H., Matsuzawa-Nagata, N., Kurita, S., Ishikura, K., Ando, H., Takeshita, Y., Ota, T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.015 · Cited by 583 · see citing works
Kersten, S., Mandard, S., Tan, N. S., Escher, P., METZGER, D., Chambon, P., Gonzalez, F. J., Desvergne, B., & Wahli, W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004029200 · Cited by 560 · see citing works
Guo, S., Rena, G., Cichy, S. B., He, X., Cohen, P., & Unterman, T. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17184 · Cited by 541 · see citing works
Kumar, K. G., Trevaskis, J. L., Lam, D. D., Sutton, G. M., Koza, R. A., Chouljenko, V. N., Kousoulas, K. G., Rogers, P. M., Kesterson, R. A., Thearle, M. S., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.011 · Cited by 511 · see citing works
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans
Patel, S., Alvarez-Guaita, A., Melvin, A., Rimmington, D., Dattilo, A., Miedzybrodzka, E. L., Cimino, I., Maurin, A.-C., Roberts, G. P., Meek, C. L., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.016 · Cited by 509 · cited 15× · see citing works
“Previous studies reported the fasting-mediated induction of Fgf21, Gdf15, and Igfbp1 expression in mice with defective fatty acid oxidation in hepatocytes resulting from carnitine palmitoyltransferase 2 (CPT2) deficiency [21].”
BackgroundInfluentialUnraveling the Regulation of Hepatic Metabolism by Insulin
Titchenell, P. M., Lazar, M. A., & Birnbaum, M. J. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.03.003 · Cited by 434 · see citing works
FGF21 mediates endocrine control of simple sugar intake and sweet taste preference by the liver
von Holstein-Rathlou, S., BonDurant, L. D., Peltekian, L., Naber, M. C., Yin, T. C., Claflin, K. E., Urizar, A. I., Madsen, A. N., Ratner, C., Holst, B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.003 · Cited by 347 · see citing works
Zhang, R. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.07.038 · Cited by 345 · see citing works
Improved Insulin Sensitivity and Resistance to Weight Gain in Mice Null for the Ahsg Gene
Mathews, S. T., Singh, G. P., Ranalletta, M., Cintrón, V. J., Qiang, X., Goustin, A. S., Jen, K. C., Charron, M. J., Jahnen‐Dechent, W., & Grunberger, G. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2450 · Cited by 343 · see citing works
Yan, H., Yang, W., Zhou, F., Li, X., Pan, Q., Shen, Z., Han, G., Newell‐Fugate, A. E., Tian, Y., Majeti, R., et al. (2018) · Diabetes · doi:10.2337/db18-0638 · Cited by 340 · see citing works
Wheatcroft, S. B., & Kearney, M. T. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.01.002 · Cited by 278 · see citing works
Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism
Meex, R. C., Hoy, A. J., Morris, A., Brown, R. D., Lo, J. C. Y., Burke, M., Goode, R. J. A., Kingwell, B. A., Kraakman, M. J., Febbraio, M. A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.023 · Cited by 255 · see citing works
PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance
Guerre-Millo, M., Rouault, C., Poulain, P., André, J., Poitout, V., Peters, J. M., Gonzalez, F. J., Fruchart, J.-C., Reach, G., & Staels, B. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2809 · Cited by 241 · see citing works
Angiopoietin-related growth factor antagonizes obesity and insulin resistance
Oike, Y., Akao, M., Yasunaga, K., Yamauchi, T., Morisada, T., Ito, Y., Urano, T., Kimura, Y., Kubota, Y., Maekawa, H., et al. (2005) · Nature Medicine · doi:10.1038/nm1214 · Cited by 219 · see citing works
SerpinB1 Promotes Pancreatic β-Cell Proliferation
Ouaamari, A. E., Dirice, E., Gedeon, N., Hu, J., Zhou, J.-Y., Shirakawa, J., Hou, L., Goodman, J. L., Karampelias, C., Qiang, G., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.001 · Cited by 207 · see citing works
TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator
Tsai, V. W.-W., Macia, L., Johnen, H., Kuffner, T., Manadhar, R., Jørgensen, S. B., Lee-Ng, K. K. M., Zhang, H. P., Wu, L., Marquis, C. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055174 · Cited by 188 · see citing works
LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance
Lan, F., Misu, H., Chikamoto, K., Takayama, H., Kikuchi, A., Mohri, K., Takata, N., Hayashi, H., Matsuzawa-Nagata, N., Takeshita, Y., et al. (2014) · Diabetes · doi:10.2337/db13-0728 · Cited by 158 · see citing works
Misu, H., Takayama, H., Saito, Y., Mita, Y., Kikuchi, A., Ishii, K.-A., Chikamoto, K., Kanamori, T., Tajima, N., Lan, F., et al. (2017) · Nature Medicine · doi:10.1038/nm.4295 · Cited by 156 · see citing works
Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα
Lü, Y., Liu, X., Jiao, Y., Xiong, X., Wang, E., Wang, X., Zhang, Z., Zhang, H., Pan, L., Guan, Y., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74438 · Cited by 130 · see citing works
Hepatic Fatty Acid Oxidation Restrains Systemic Catabolism during Starvation
Lee, J., Choi, J., Scafidi, S., & Wolfgang, M. J. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.062 · Cited by 127 · see citing works
Inactivating hepatic follistatin alleviates hyperglycemia
Tao, R., Wang, C., Stöhr, O., Qiu, W., Hu, Y., Miao, J., Dong, X. C., Leng, S., Stefater, M., Stylopoulos, N., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0048-0 · Cited by 104 · see citing works
LEWITT, M. S., Hilding, A., Östenson, C., Efendić, S., Brismar, K., & Hall, K. E. (2008) · Diabetologia · doi:10.1007/s00125-008-1016-x · Cited by 98 · see citing works
Jousse, C., Bruhat, A., Ferrara, M., & Fafournoux, P. (1998) · Biochemical Journal · doi:10.1042/bj3340147 · Cited by 94 · see citing works
Tsai, V. W.-W., Macia, L., Feinle‐Bisset, C., Manandhar, R., Astrup, A. V., Raben, A., Lorenzen, J. K., Schmidt, P. T., Wiklund, F. E., Pedersen, N. L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133362 · Cited by 94 · see citing works
The role of hepassocin in the development of non-alcoholic fatty liver disease
Wu, H.-T., Lu, F.-H., Ou, H.-Y., Su, Y.-C., Hung, H.-C., Wu, J.-S., Yang, Y.-C., Wu, C.-L., & Chang, C.-J. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.06.004 · Cited by 92 · see citing works
Activin E controls energy homeostasis in both Brown and white adipose tissues as a hepatokine
Hashimoto, O., Funaba, M., Sekiyama, K., Doi, S., Shindo, D., Satoh, R., Itoi, H., Oiwa, H., Morita, M., Suzuki, C., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.008 · Cited by 77 · see citing works
The hepatokine Tsukushi gates energy expenditure via brown fat sympathetic innervation
Wang, Q., Sharma, V. P., Shen, H., Xiao, Y., Zhu, Q., Xiong, X., Guo, L., Jiang, L., Ohta, K., Li, S., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0020-9 · Cited by 71 · see citing works
Cathepsin D regulates lipid metabolism in murine steatohepatitis
Houben, T., Oligschlaeger, Y., Hendrikx, T., Bitorina, A. V., Walenbergh, S. M. A., van Gorp, P. J., Gijbels, M. J., Friedrichs, S., Plat, J., Schaap, F. G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03796-5 · Cited by 66 · see citing works
Nemazanyy, I., Montagnac, G., Russell, R. C., Morzyglod, L., Burnol, A., Guan, K., Pende, M., & Panasyuk, G. (2015) · Nature Communications · doi:10.1038/ncomms9283 · Cited by 61 · see citing works
Avérous, J., Maurin, A., Bruhat, A., Jousse, C., Arliguie, C., & Fafournoux, P. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.03.077 · Cited by 33 · see citing works
Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Markan KR, Naber MC, Ameka MK, Anderegg MD, Mangelsdorf DJ, Kliewer SA, et al. Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding. Diabetes 2014;63:4057-63. doi:10.2337/db14-0595. · DOI · Paper page
- Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005;436:356-62. doi:10.1038/nature03711. · DOI · Paper page
Cited by
Sorted by citations
PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice
Wang, Y., Nakajima, T., Gonzalez, F. J., & Tanaka, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062061 · Cited by 545 · see citing works
Hepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works
The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?
Breit, S. N., Brown, D. A., & Tsai, V. W.-W. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022020-045449 · Cited by 228 · see citing works
Biological Functions of RBP4 and Its Relevance for Human Diseases
Steinhoff, J. S., Lass, A., & Schupp, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.659977 · Cited by 182 · see citing works
Fougerat, A., Montagner, A., Loiseau, N., Guillou, H., & Wahli, W. (2020) · Cells · doi:10.3390/cells9071638 · Cited by 143 · see citing works
ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity
Fougerat, A., Schoiswohl, G., Polizzi, A., Régnier, M., Wagner, C., Smati, S., Fougeray, T., Lippi, Y., Lasserre, F., Raho, I., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110910 · Cited by 106 · see citing works
Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges
Martínez‐Garza, Ú., Torres‐Oteros, D., Yarritu, A., Marrero, P. F., Haro, D., & Relat, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194692 · Cited by 87 · see citing works
Duszka, K., Gregor, A., Guillou, H., König, J. S., & Wahli, W. (2020) · Cells · doi:10.3390/cells9071708 · Cited by 82 · see citing works
Retinoid Homeostasis and Beyond: How Retinol Binding Protein 4 Contributes to Health and Disease
Steinhoff, J. S., Lass, A., & Schupp, M. (2022) · Nutrients · doi:10.3390/nu14061236 · Cited by 73 · see citing works
Fougerat, A., Bruse, J., Polizzi, A., Montagner, A., Guillou, H., & Wahli, W. (2024) · Progress in Lipid Research · doi:10.1016/j.plipres.2024.101303 · Cited by 54 · see citing works
Mitochondrial Lipid Homeostasis at the Crossroads of Liver and Heart Diseases
Dabravolski, S. A., Bezsonov, E. E., Baig, M. S., Попкова, Т. В., & Orekhov, A. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136949 · Cited by 41 · see citing works
The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression
Fougeray, T., Polizzi, A., Régnier, M., Fougerat, A., Ellero‐Simatos, S., Lippi, Y., Smati, S., Lasserre, F., Tramunt, B., Huillet, M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110674 · Cited by 40 · see citing works
Bini, S., D'Erasmo, L., Costanzo, A. D., Minicocci, I., Pecce, V., & Arca, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020742 · Cited by 36 · see citing works
Griffin, J. D., Buxton, J. M., Culver, J. A., Barnes, R., Jordan, E. A., White, A. R., Flaherty, S. E., Bernardo, B. L., Ross, T. T., Bence, K. K., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101830 · Cited by 38 · see citing works
Miao, X., Alidadipour, A., Saed, V., Sayyadi, F., Jadidi, Y., Davoudi, M., Amraee, F., Jadidi, N., & Afrisham, R. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02335-9 · Cited by 34 · see citing works
Circulating Follistatin and Activin A and Their Regulation by Insulin in Obesity and Type 2 Diabetes
Sylow, L., Vind, B. F., Kruse, R., Møller, P. M., Wojtaszewski, J. F. P., Richter, E. A., & Højlund, K. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa090 · Cited by 34 · see citing works
Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective
Zhang, Y., Wang, Y., & Liu, J. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2021.12.011 · Cited by 24 · see citing works
Review article: vascular effects of PPARs in the context of NASH
Guixé‐Muntet, S., Biquard, L., Szabó, G., Dufour, J., Tacke, F., Francque, S., Rautou, P., & Gracia‐Sancho, J. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.17046 · Cited by 22 · see citing works
The endocrine role of hepatokines: implications for human health and disease
Iglesias, P. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1663353 · Cited by 22 · see citing works
Unveiling the multifaceted role of adropin in various diseases (Review)
Chen, L., Lu, J., Hu, J., & Gong, X. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5414 · Cited by 17 · see citing works
Xia, H., Dufour, C. R., Medkour, Y., Scholtes, C., Chen, Y., Guluzian, C., B'Chir, W., & Giguère, V. (2023) · Nature Communications · doi:10.1038/s41467-023-42785-3 · Cited by 16 · see citing works
Hepatic interoception in health and disease
Berthoud, H., Münzberg, H., Morrison, C. D., & Neuhuber, W. (2024) · Autonomic Neuroscience · doi:10.1016/j.autneu.2024.103174 · Cited by 17 · see citing works
Sex differences feed into nuclear receptor signaling along the digestive tract
Dean, A. E., Reichardt, F., & Anakk, S. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166211 · Cited by 14 · see citing works
Zhao, B.-C., Tang, Y.-X., Qiu, B.-H., Xu, H.-L., Wang, T., Elsherbeni, A. I. A., Gharib, H. B., & Li, J. (2022) · Journal of Animal Science · doi:10.1093/jas/skac244 · Cited by 15 · see citing works
Liu, T., Xing, Y., Fan, X., Chen, Z., Zhao, C., Liu, L., Zhao, M., Hu, X., Dong, B., Wang, J., et al. (2020) · Poultry Science · doi:10.1016/j.psj.2020.11.057 · Cited by 14 · see citing works
Follistatin and follistatin-like 3 in metabolic disorders
Bielka, W., Przezak, A., & Pawlik, A. (2023) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2023.106785 · Cited by 15 · see citing works
Adipocyte HSL is required for maintaining circulating vitamin A and RBP4 levels during fasting
Steinhoff, J. S., Wagner, C., Dähnhardt, H. E., Košić, K., Meng, Y., Taschler, U., Pajed, L., Yang, N. Y., Wulff, S., Kiefer, M. F., et al. (2024) · EMBO Reports · doi:10.1038/s44319-024-00158-x · Cited by 13 · see citing works
Jiang, H., Zhou, Y., Zhou, P., Zhang, T., Hu, J., & Bai, X. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.662666 · Cited by 12 · see citing works
Diago, C. A. A., Martín-Audera, P., Calvo, J. A., Lavín, B. A., Guerra-Ruiz, A. R., Muñoz, P., Berja, A., Casanova, C., & García‐Unzueta, M. T. (2022) · Scientific Reports · doi:10.1038/s41598-022-21757-5 · Cited by 11 · see citing works
Li, G., Zhang, H., & Ryan, A. S. (2020) · Metabolites · doi:10.3390/metabo10090354 · Cited by 9 · see citing works
Alsaleem, M. A., Al-Kuraishy, H. M., Al-Gareeb, A. I., Abdel‐Fattah, M. M., Alrouji, M., Al‐Harchan, N. A., Alruwaili, M., Papadakis, M., Alexiou, A. T., & Batiha, G. E. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70378 · Cited by 9 · see citing works
Shi, Y., Li, W., Yu, X., Zhao, Y., Zhu, D., Song, Y., Zhao, Z., Gu, Y., Wei, B. K., Li, L., et al. (2025) · Advanced Science · doi:10.1002/advs.202415956 · Cited by 8 · see citing works
PPARα regulates ER–lipid droplet protein Calsyntenin-3β to promote ketogenesis in hepatocytes
Uchiyama, L. F., Nguyen, A. T., Qian, K., Cui, L., Pham, K. T., Xu, X., Gao, Y., Shimanaka, Y., Tol, M. J. P. M., Vergnes, L., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2426338122 · Cited by 8 · see citing works
Li, P., Zeng, B., Cao, X., Liu, B., Liu, L., Chai, Y., & Li, Z. (2025) · Aquaculture · doi:10.1016/j.aquaculture.2025.742889 · Cited by 6 · see citing works
Yang, B., Yang, X., Tan, X., Lu, L., Fan, W., Barbier‐Torres, L., Steggerda, J. A., Liu, T., & Yang, H. (2022) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2022/6799414 · Cited by 7 · see citing works
Chen, R., Wang, Q., Wang, Y. Y., Wang, Y., Liu, J., Liao, Z., & Xiao, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1094458 · Cited by 5 · see citing works
Chiglitazar ameliorates dehydroepiandrosterone-induced polycystic ovary syndrome in rats
Zhao, F., Cui, W., Fang, C., Luo, Y., & Zhang, C. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-024-01554-6 · Cited by 4 · see citing works
Jamshed, L., Jamshed, S., Frank, R. A., Hewitt, L. M., Thomas, P. J., & Holloway, A. C. (2024) · Toxics · doi:10.3390/toxics12090631 · Cited by 3 · see citing works
Muroya, S., Ojima, K., Shimamoto, S., Sugasawa, T., & Gotoh, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157540 · Cited by 3 · see citing works
Yu, X., Zhang, Y., Wu, B., Zhao, B., & Wang, C. (2025) · Drug metabolism reviews (Softcover ed.) · doi:10.1080/03602532.2025.2558654 · Cited by 3 · see citing works
Follistatin levels and endocrine disorders: A two-sample Mendelian randomization study
Zhang, W. D., Wu, T., Zhao, X., Ma, Y., & Han, X. (2025) · Medicine · doi:10.1097/md.0000000000045566 · Cited by 2 · see citing works
Choline attenuates NEFA-induced hepatic steatosis via GNMT regulation in hepatocytes
Du, X., Wang, L., Dai, Y., Lu, J., Li, H., Wang, D., Zhang, J., Cai, C., Liu, S., Yao, J., et al. (2025) · Stress Biology · doi:10.1007/s44154-025-00264-3 · Cited by 1 · see citing works
Колоскова, Е. М., & Г.Г., Ч. (2025) · Problemy biologii produktivnyh životnyh · doi:10.25687/1996-6733.prodanimbiol.2025.2.5-40
周轶琳, Gan, X., Cheng, J., Ren, K., Guo, Y., Zhang, A., Jin, Y., Ge, Z., Wang, J., Ju, Z., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117662
- Authors
- Smati, S., Régnier, M., Fougeray, T., Polizzi, A., Fougerat, A., Lasserre, F., Lukowicz, C., Tramunt, B., Guillaume, M., Burnol, A.-F., Postic, C., Wahli, W., Montagner, A., Gourdy, P., & Guillou, H.
- Affiliations
- Inserm (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Centre National de la Recherche Scientifique (FR)
- Nanyang Technological University (SG)
- Corresponding author
- Guillou, H.
- ORCID
- Venue
- Diabetes & Metabolism
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 46
- Issue
- 2
- Pages
- 129-136
- ISSN
- 1262-3636 (ISSN-L)
- OpenAlex
- W2946964144
- Cited by
- 47
- References
- 39
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 9 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 9 · 2019: 1
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Diabetes & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- Nanyang Technological University
- Agence Nationale de la Recherche (ANR-15-CE14-0026)
- Institut National de la Santé et de la Recherche Médicale
- École Polytechnique Fédérale de Lausanne
- Société Française de Nutrition
- Société Francophone du Diabète
- Région Occitanie Pyrénées-Méditerranée
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- hepatokines, PPARα, insulin receptor, fasting, feeding, hepatocyte-specific knockout mice, FGF21, ANGPTL4, IGFBP-1, GDF15, follistatin, adropin, nutritional regulation, sex differences, hepatic gene expression
- MeSH terms
- Angiopoietin-Like Protein 4, Animals, Eating, Fasting, Fibroblast Growth Factors, Insulin, Receptor, Insulin, Signal Transduction, Gene Expression, Mice, Knockout, Hepatocytes, PPAR alpha, Mice
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