The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Monocytes from type 2 diabetic patients have a pro-inflammatory profile
Abstract
The exact factors contributing to the pathogenesis of type 2 diabetes remain elusive. Lately, it was suggested that inflammation and activation of the innate immune system could be linked to type 2 diabetes pathogenesis and also to the development of common diabetic complications, mainly atherosclerosis. The aim of this study was to investigate the role of monocytes in this sub-clinical inflammatory state and test 1,25-dihydroxyvitamin D(3), the active form of Vitamin D, as an anti-inflammatory agent. For this purpose, monocytes from type 2 diabetic patients were compared to monocytes from healthy controls and type 1 diabetic patients. The expression profile of inflammatory markers in freshly isolated and immune-stimulated monocytes was measured by quantitative real-time RT-PCR. Type 2 diabetic patients showed significantly higher expression levels of TNF-alpha, IL-6, IL-1, IL-8, COX-2, ICAM-1 and B7-1 compared to controls and type 1 diabetic patients. 1,25-Dihydroxyvitamin D(3) was able to down-regulate the expression of TNF-alpha, IL-6, IL-1, and IL-8, confirming its immunomodulatory properties. From these data we concluded that monocytes from type 2 diabetic patients have a pro-inflammatory profile. In addition, 1,25-dihydroxyvitamin D(3) was able to modulate inflammation in these monocytes.
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“The most efficient triggers of the postprandial inflammatory response appear to be TAG, SFA, oxysterols and glucose (158 -161) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [160]
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Cites
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Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3041 · Cited by 2,470
Vitamin D: modulator of the immune system
Baeke, F., Takiishi, T., Korf, H., Gysemans, C. A., & Mathieu, C. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.04.001 · Cited by 1,333
Self-citationDietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
The Role of Inflammation in Diabetic Retinopathy
Forrester, J. V., Kuffová, L., & Delibegović, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.583687 · Cited by 462
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Metadata
- Authors
- Giulietti, A., van Etten, E., Overbergh, L., Stoffels, K., Bouillon, R., & Mathieu, C.
- Affiliations
- KU Leuven (BE)
- Corresponding author
- Mathieu, Chantal
- Venue
- Diabetes Research and Clinical Practice
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 77
- Issue
- 1
- Pages
- 47-57
- ISSN
- 0168-8227 (ISSN-L)
- OpenAlex
- W198103589
- Cited by
- 400
- References
- 60
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 21 · 2023: 29 · 2022: 28 · 2021: 19 · 2020: 30 · 2019: 22 · 2018: 27 · 2017: 18 · 2016: 15 · 2015: 21 · 2014: 22 · 2013: 17 · 2012: 22
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Research and Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- type 2 diabetes, monocytes, inflammation, 1,25-dihydroxyvitamin D3, vitamin D, TNF-α, interleukin-6, interleukin-1, interleukin-8, cyclooxygenase-2, ICAM-1, CD80, type 1 diabetes, innate immunity, atherosclerosis, immunomodulation
- MeSH terms
- Adolescent, Adult, Aged, 80 and over, Anti-Inflammatory Agents, Calcitriol, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Interferon-gamma, Interleukins, Male, Middle Aged, Monocytes, Tumor Necrosis Factor-alpha, Down-Regulation, B7-1 Antigen, Intercellular Adhesion Molecule-1, Cyclooxygenase 2
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