Cited by 400Adipokines, Inflammation, and Metabolic DiseasesVitamin D Research StudiesImmune cells in cancer

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Monocytes from type 2 diabetic patients have a pro-inflammatory profile

Giulietti, Annapaula, van Etten, Evelyne, Overbergh, Lut, Stoffels, Katinka, Bouillon, Roger, Mathieu, Chantal·2007·Diabetes Research and Clinical Practice

DOI 10.1016/j.diabres.2006.10.007

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Abstract

The exact factors contributing to the pathogenesis of type 2 diabetes remain elusive. Lately, it was suggested that inflammation and activation of the innate immune system could be linked to type 2 diabetes pathogenesis and also to the development of common diabetic complications, mainly atherosclerosis. The aim of this study was to investigate the role of monocytes in this sub-clinical inflammatory state and test 1,25-dihydroxyvitamin D(3), the active form of Vitamin D, as an anti-inflammatory agent. For this purpose, monocytes from type 2 diabetic patients were compared to monocytes from healthy controls and type 1 diabetic patients. The expression profile of inflammatory markers in freshly isolated and immune-stimulated monocytes was measured by quantitative real-time RT-PCR. Type 2 diabetic patients showed significantly higher expression levels of TNF-alpha, IL-6, IL-1, IL-8, COX-2, ICAM-1 and B7-1 compared to controls and type 1 diabetic patients. 1,25-Dihydroxyvitamin D(3) was able to down-regulate the expression of TNF-alpha, IL-6, IL-1, and IL-8, confirming its immunomodulatory properties. From these data we concluded that monocytes from type 2 diabetic patients have a pro-inflammatory profile. In addition, 1,25-dihydroxyvitamin D(3) was able to modulate inflammation in these monocytes.

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Authors: Giulietti, A., van Etten, E., Overbergh, L., Stoffels, K., Bouillon, R., & Mathieu, C.
Affiliations: KU Leuven (BE)
Corresponding author: Mathieu, Chantal
ORCID: Bouillon, Roger
Mathieu, Chantal
Venue: Diabetes Research and Clinical Practice
Publisher: Elsevier BV
Published: 2007-07
Volume: 77
Issue: 1
Pages: 47-57
ISSN: 0168-8227 (ISSN-L)
DOI: 10.1016/j.diabres.2006.10.007
OpenAlex: W198103589
Cited by: 400
References: 60
Citations by year: 2026: 5 · 2025: 15 · 2024: 21 · 2023: 29 · 2022: 28 · 2021: 19 · 2020: 30 · 2019: 22 · 2018: 27 · 2017: 18 · 2016: 15 · 2015: 21 · 2014: 22 · 2013: 17 · 2012: 22
FWCI: 7.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Diabetes Research and Clinical Practice (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: type 2 diabetes, monocytes, inflammation, 1,25-dihydroxyvitamin D3, vitamin D, TNF-α, interleukin-6, interleukin-1, interleukin-8, cyclooxygenase-2, ICAM-1, CD80, type 1 diabetes, innate immunity, atherosclerosis, immunomodulation
MeSH terms: Adolescent, Adult, Aged, 80 and over, Anti-Inflammatory Agents, Calcitriol, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Interferon-gamma, Interleukins, Male, Middle Aged, Monocytes, Tumor Necrosis Factor-alpha, Down-Regulation, B7-1 Antigen, Intercellular Adhesion Molecule-1, Cyclooxygenase 2

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Monocytes from type 2 diabetic patients have a pro-inflammatory profile

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