Cited by 400Adipokines, Inflammation, and Metabolic DiseasesVitamin D Research StudiesImmune cells in cancer

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Monocytes from type 2 diabetic patients have a pro-inflammatory profile

Giulietti, Annapaula, van Etten, Evelyne, Overbergh, Lut, Stoffels, Katinka, Bouillon, Roger, Mathieu, Chantal·2007·Diabetes Research and Clinical Practice

DOI 10.1016/j.diabres.2006.10.007

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Abstract

The exact factors contributing to the pathogenesis of type 2 diabetes remain elusive. Lately, it was suggested that inflammation and activation of the innate immune system could be linked to type 2 diabetes pathogenesis and also to the development of common diabetic complications, mainly atherosclerosis. The aim of this study was to investigate the role of monocytes in this sub-clinical inflammatory state and test 1,25-dihydroxyvitamin D(3), the active form of Vitamin D, as an anti-inflammatory agent. For this purpose, monocytes from type 2 diabetic patients were compared to monocytes from healthy controls and type 1 diabetic patients. The expression profile of inflammatory markers in freshly isolated and immune-stimulated monocytes was measured by quantitative real-time RT-PCR. Type 2 diabetic patients showed significantly higher expression levels of TNF-alpha, IL-6, IL-1, IL-8, COX-2, ICAM-1 and B7-1 compared to controls and type 1 diabetic patients. 1,25-Dihydroxyvitamin D(3) was able to down-regulate the expression of TNF-alpha, IL-6, IL-1, and IL-8, confirming its immunomodulatory properties. From these data we concluded that monocytes from type 2 diabetic patients have a pro-inflammatory profile. In addition, 1,25-dihydroxyvitamin D(3) was able to modulate inflammation in these monocytes.

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Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
Kern, P. A., Ranganathan, S., Li, C., Wood, L., & Ranganathan, G. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e745 · Cited by 1,883
Innate Immunity
Medzhitov, R. M., & Janeway, C. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008033430506 · Cited by 1,827
Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid
Fried, S. K., Bunkin, D. A., & Greenberg, A. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4660 · Cited by 1,756
Hypovitaminosis D is associated with insulin resistance and β cell dysfunction
Chiu, K. C., Chu, A. Y., Go, V. L. W., & Saad, M. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.820 · Cited by 1,648
Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes
Spranger, J., Kroke, A., Möhlig, M., Hoffmann, K., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · Diabetes · doi:10.2337/diabetes.52.3.812 · Cited by 1,493
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Pickup, J. C. (2004) · Diabetes Care · doi:10.2337/diacare.27.3.813 · Cited by 1,414
An Overview of Real-Time Quantitative PCR: Applications to Quantify Cytokine Gene Expression
Giulietti, A., Overbergh, L., Valckx, D., Decallonne, B., Bouillon, R., & Mathieu, C. (2001) · Methods · doi:10.1006/meth.2001.1261 · Cited by 1,403
Self-citation
NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X
Pickup, J. C., Mattock, M. B., Chusney, G. D., & Burt, D. J. (1997) · Diabetologia · doi:10.1007/s001250050822 · Cited by 1,246
Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study
Schmidt, M. I., Duncan, B. B., Sharrett, A. R., Lindberg, G., Savage, P. J., Offenbacher, S., Azambuja, M. I. R., Tracy, R. P., & HEISS, G. M. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01046-6 · Cited by 1,080
Low-Grade Systemic Inflammation and the Development of Type 2 Diabetes
Duncan, B. B., Schmidt, M. I., Pankow, J. S., Ballantyne, C. M., Couper, D., Vigo, A., Hoogeveen, R., Folsom, A. R., & Heiss, G. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1799 · Cited by 1,036
Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis
Hansson, G. K., Libby, P., Schönbeck, U., & Yan, Z.-Q. (2002) · Circulation Research · doi:10.1161/01.res.0000029784.15893.10 · Cited by 1,019
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Frostegård, J., Ulfgren, A., Nyberg, P., Hedin, U., Swedenborg, J., Andersson, U., & Hansson, G. K. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00011-8 · Cited by 1,002
Interleukin-6 induces cellular insulin resistance in hepatocytes.
Senn, J. J., Klover, P. J., Nowak, I. A., & Mooney, R. A. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3391 · Cited by 883
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Mallat, Z., Besnard, S., Duriez, M., Deleuze, V., Emmanuel, F., Bureau, M. F., Soubrier, F., Esposito, B., Duez, H., Fiévet, C., et al. (1999) · Circulation Research · doi:10.1161/01.res.85.8.e17 · Cited by 846
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Pittas, A. G., Dawson‐Hughes, B., Li, T., van Dam, R. M., Willett, W. C., Manson, J. E., & Hu, F. B. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-1961 · Cited by 837
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Hu, F. B., Meigs, J. B., Li, T. Y., Rifai, N., & Manson, J. E. (2004) · Diabetes · doi:10.2337/diabetes.53.3.693 · Cited by 788
Expression of 1,25-Dihydroxyvitamin D3 Receptor in the Immune System
Veldman, C. M., Cantorna, M. T., & DeLuca, H. F. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1605 · Cited by 712
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Mathieu, C., Gysemans, C. A., Giulietti, A., & Bouillon, R. (2005) · Diabetologia · doi:10.1007/s00125-005-1802-7 · Cited by 612
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Cosentino, F., Eto, M., Paolis, P. D., van der Loo, B., Bachschmid, M. M., Ullrich, V., Kouroedov, A., Gatti, C., Joch, H., Volpe, M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000051367.92927.07 · Cited by 419
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Østerud, B., & Bjørklid, E. (2003) · Physiological Reviews · doi:10.1152/physrev.00005.2003 · Cited by 417
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Overbergh, L., Decallonne, B., Valckx, D., Verstuyf, A., Depovere, J., Laureys, J., Rutgeerts, O., Saint-Arnaud, R., Bouillon, R., & Mathieu, C. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01204.x · Cited by 274
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Wang, N., Tabas, I. A., WINCHESTER, R. J., Stefano Ravalli, A., Rabbani, L. E., & Tall, A. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.8837 · Cited by 252
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Geerlings, S. E., Brouwer, E. C., van Kessel, K. P. M., Gaastra, W., Stolk, R. P., & Hoepelman, A. I. M. (2000) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2000.00745.x · Cited by 150
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Tashiro, K., Koyanagi, I., Saitoh, A., Shimizu, A., Shike, T., Ishiguro, C., Koizumi, M., Funabïki, K., Horikoshi, S., Shirato, I., et al. (2002) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.2057 · Cited by 141
Cyclooxygenase-2 and inflammation in atherosclerosis
Linton, M. F. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.12.003 · Cited by 133
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Available, N. A. N. (1999) · Diabetologia · doi:10.1007/s001250051124 · Cited by 127
Normalization of Plasma Lipid Peroxides, Monocyte Adhesion, and Tumor Necrosis Factor-α Production in NIDDM Patients After Gliclazide Treatment
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Vitamin D and 1,25-dihydroxyvitamin D3 as modulators in the immune system
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Pop‐Busui, R., Marinescu, V., Huysen, C. V., Li, F. Y., Sullivan, K., Greene, D. A., Larkin, D. D., & Stevens, M. J. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2619 · Cited by 108
Interleukin-10 serum levels and systemic endothelial vasoreactivity in patients with coronary artery disease
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Effect of High Glucose Concentrations on Expression of ELAM 1, VCAM-1 and ICAM-1 in HUVEC with and without Cytokine Activation.
Altannavch, T., Roubalová, K., Kučera, P., & Anděl, M. (2004) · Physiological Research · doi:10.33549/physiolres.930343 · Cited by 99
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Jude, E. B., Douglas, J. T., Anderson, S. G., Young, M. J., & Boulton, A. J. M. (2002) · European Journal of Internal Medicine · doi:10.1016/s0953-6205(02)00014-6 · Cited by 94
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Ceriello, A., Falleti, E., Bortolotti, N., Motz, E., Cavarape, A., Russo, A., Gonano, F., & Bartoli, E. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90226-7 · Cited by 87
In vitro production of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in insulin-dependent diabetes mellitus.
Ohno, Y., Aoki, N., & Nishimura, A. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.4.8408455 · Cited by 85
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Conti, G., Scarpini, E., Baron, P., Livraghi, S., Tiriticco, M., Bianchi, R., Vedeler, C., & Scarlato, G. (2002) · Journal of Neurological Sciences · doi:10.1016/s0022-510x(01)00684-0 · Cited by 73
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Elner, S. G. (1998) · Archives of Ophthalmology · doi:10.1001/archopht.116.12.1597 · Cited by 70
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Authors: Giulietti, A., van Etten, E., Overbergh, L., Stoffels, K., Bouillon, R., & Mathieu, C.
Affiliations: KU Leuven (BE)
Corresponding author: Mathieu, Chantal
ORCID: Bouillon, Roger
Mathieu, Chantal
Venue: Diabetes Research and Clinical Practice
Publisher: Elsevier BV
Published: 2007-07
Volume: 77
Issue: 1
Pages: 47-57
ISSN: 0168-8227 (ISSN-L)
DOI: 10.1016/j.diabres.2006.10.007
OpenAlex: W198103589
Cited by: 400
References: 60
Citations by year: 2026: 5 · 2025: 15 · 2024: 21 · 2023: 29 · 2022: 28 · 2021: 19 · 2020: 30 · 2019: 22 · 2018: 27 · 2017: 18 · 2016: 15 · 2015: 21 · 2014: 22 · 2013: 17 · 2012: 22
FWCI: 7.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Diabetes Research and Clinical Practice (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: type 2 diabetes, monocytes, inflammation, 1,25-dihydroxyvitamin D3, vitamin D, TNF-α, interleukin-6, interleukin-1, interleukin-8, cyclooxygenase-2, ICAM-1, CD80, type 1 diabetes, innate immunity, atherosclerosis, immunomodulation
MeSH terms: Adolescent, Adult, Aged, 80 and over, Anti-Inflammatory Agents, Calcitriol, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Interferon-gamma, Interleukins, Male, Middle Aged, Monocytes, Tumor Necrosis Factor-alpha, Down-Regulation, B7-1 Antigen, Intercellular Adhesion Molecule-1, Cyclooxygenase 2

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Monocytes from type 2 diabetic patients have a pro-inflammatory profile

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