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Cited by 106Antifungal resistance and susceptibilityBacterial Identification and Susceptibility TestingYeasts and Rust Fungi Studies

Time to positive culture and identification for Candida blood stream infections

Fernandez, Julianna, Erstad, Brian L., Petty, Wanda, Nix, David E.·2009·Diagnostic Microbiology and Infectious Disease
DOI 10.1016/j.diagmicrobio.2009.04.002
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Abstract

Candidemia and delay to appropriate therapy contribute to increased morbidity and mortality. Current literature addresses the delay between blood culture collection and final identification; however, it fails to delineate differences among species. The purpose of this study was to quantify the time to yeast detection and identification relative to blood culture collection and determine whether differences exist among species. In this retrospective study, all cases of Candida isolation for 2 years were reviewed. The time delays between blood culture and detection of Candida growth were quantified as well as the additional time required for final species identification. Initiation of antifungal therapy was assessed in relation to culture collection, detection of yeast, and final identification. The appropriateness of therapy at each time point was also analyzed. Most Candida infections were caused by either Candida albicans (n = 43) or Candida glabrata (n = 27). Mean time to positive yeast detection for C. albicans was 35.3 +/- 18.1 h, whereas that of C. glabrata was 80.0 +/- 22.4 h (P < 0.0001). Mean time to final identification for C. albicans was 85.8 +/- 30.9, whereas that of C. glabrata was 154 +/- 43.8 h (P < 0.0001). Mean time to appropriate therapy for C. albicans isolates was 43.3 +/- 27.6 h compared with 98.1 +/- 38.3 h (P < 0.0001) for C. glabrata isolates. The time delay between blood culture collection and yeast detection as well as final identification was significantly longer for C. glabrata isolates when compared with C. albicans. As a result, mean time to appropriate antifungal therapy was significantly longer in patients with C. glabrata isolates.

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Crossref · 10.1016/j.diagmicrobio.2009.04.002

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  • In the same study, time to appropriate therapy was 43.3 ± 27.6 hours for Candida albicans isolates compared with 98.1 ± 38.3 hours for Candida glabrata isolates.

    “In this study, the time to appropriate therapy for C albicans isolates was 43.3 Æ 27.6 hours compared with 98.1 Æ 38.3 hours for C glabrata isolates.”

    From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [56]

  • Detection of candidemia by blood culture often takes more than 24 hours, and for species such as Candida glabrata the time to positive culture can be even longer.

    “Furthermore, detection of candidemia by blood culture often takes more than 24 hours.For certain species, such as C glabrata, the time to positive culture can be even longer.[56][57][58][59][60]”

    From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [56]

  • Mean time to final identification to species level was 85.8 ± 30.9 hours for Candida albicans compared with 154 ± 43.8 hours for Candida glabrata.

    “Mean time to final identification to species level for C albicans was 85.8 Æ 30.9 hours compared with 154 Æ 43.8 hours for C glabrata.”

    From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [56]

  • In a study by Fernandez and colleagues, mean time to yeast detection in blood cultures was 35.3 ± 18.1 hours for Candida albicans and 80.0 ± 22.4 hours for Candida glabrata.

    “In a study by Fernandez and colleagues, 56 the mean time to yeast detection in blood cultures for C albicans was 35.3 Æ 18.1 hours, whereas that of C glabrata was 80.0 Æ 22.4 hours.”

    From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [56]

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Authors
Fernandez, J., Erstad, B. L., Petty, W., & Nix, D. E.
Affiliations
University of Arizona (US)
Corresponding author
Nix, David E.
ORCID
Venue
Diagnostic Microbiology and Infectious Disease
Publisher
Elsevier BV
Published
2009-08
Volume
64
Issue
4
Pages
402-407
ISSN
0732-8893 (ISSN-L)
DOI
10.1016/j.diagmicrobio.2009.04.002
OpenAlex
W2033083353
Cited by
106
References
16
Citations by year
2026: 5 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 6 · 2018: 1 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 7
FWCI
6.19
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Diagnostic Microbiology and Infectious Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Keywords
candidemia, Candida albicans, Candida glabrata, yeast identification, treatment delay, fungemia
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Antifungal Agents, Blood, Candida albicans, Candidiasis, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Time Factors, Fungemia, Candida glabrata, Young Adult

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