Impact of filmarray meningitis encephalitis panel on HSV testing and empiric acyclovir use in children beyond the neonatal period
Open accessAbstract
Following implementation of the FilmArray meningitis and encephalitis panel, which enables rapid syndromic cerebrospinal fluid testing, HSV testing doubled in children >60 days with suspected central nervous system infection at Children's Hospital Colorado. Acyclovir initiation was unchanged, but duration decreased. Diagnostic and antimicrobial stewardship is needed for MEP optimization.
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Implementation of the ME Panel has been shown to reduce acyclovir days of therapy in several clinical pre-post analyses.
“Implementation of the ME Panel has also been shown to reduce acyclovir days of therapy in several clinical pre-post analyses [12,13,14,15].”
The reduction in acyclovir days of therapy mirrors findings from other studies.
“This mirrors findings from other studies, as previously discussed [12,13,14,15].”
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Cites
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Self-citationImpact of a Rapid Herpes Simplex Virus PCR Assay on Duration of Acyclovir Therapy
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Markovich, K., Wingler, M. J. B., Stover, K. R., Barber, K. E., Wagner, J. L., & Cretella, D. A. (2022) · Diseases · doi:10.3390/diseases10040110 · Cited by 22 · see citing works
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- Authors
- Messacar, K., Gaensbauer, J. T., Birkholz, M., Palmer, C., Todd, J. K., Tyler, K. L., & Dominguez, S. R.
- Affiliations
- Children's Hospital Colorado (US)
- University of Colorado Anschutz (US)
- Corresponding author
- Messacar, Kevin
- ORCID
- Venue
- Diagnostic Microbiology and Infectious Disease
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 97
- Issue
- 4
- Pages
- 115085
- ISSN
- 0732-8893 (ISSN-L)
- PMC
- PMC7384938
- OpenAlex
- W3024334675
- Cited by
- 20
- References
- 11
- Citations by year
- 2025: 5 · 2024: 1 · 2023: 1 · 2022: 7 · 2021: 5 · 2020: 1
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Diagnostic Microbiology and Infectious Disease (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Keywords
- herpes simplex virus, acyclovir, empiric antiviral therapy, central nervous system infection, cerebrospinal fluid analysis, antimicrobial stewardship, children, molecular diagnosis
- MeSH terms
- Antimicrobial Stewardship, Acyclovir, Adolescent, Antiviral Agents, Central Nervous System Infections, Child, Child, Preschool, Female, Hospitals, Pediatric, Humans, Infant, Male, Meningitis, Viral, Retrospective Studies, Simplexvirus, Encephalitis, Herpes Simplex, Molecular Diagnostic Techniques, Multiplex Polymerase Chain Reaction
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