Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27489 · Cited by 3,374

A G Protein-coupled Receptor Responsive to Bile Acids

Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

Gao, Y., Dickerson, J. B., Guo, F., Zheng, J., & Zheng, Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307512101 · Cited by 1,091

Bile acids as regulatory molecules

Hylemon, P. B., Zhou, H., Pandak, W. M., Ren, S., Gil, G., & Dent, P. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r900007-jlr200 · Cited by 694

NADPH Oxidase Plays a Central Role in Blood-Brain Barrier Damage in Experimental Stroke

Kahles, T., Luedike, P., Endres, M., Galla, H., Steinmetz, H., Busse, R., Neumann‐Haefelin, T., & Brandes, R. P. (2007) · Stroke · doi:10.1161/strokeaha.107.489765 · Cited by 388

Targeting the protein kinase C family: are we there yet?

MacKay, H. J., & Twelves, C. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2168 · Cited by 377

Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules.

Alpini, G. D., Lenzi, R., Sárközi, L., & Tavoloni, N. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113355 · Cited by 333

Pathogenesis of cholestatic liver disease and therapeutic approaches

Hirschfield, G. M., Heathcote, E. J., & Gershwin, M. E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.09.004 · Cited by 287

Bile acid signalling and its role in anxiety disorders

Chen, S., Shao, Q., Chen, J., Lv, X., Ji, J., Liu, Y., & Song, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1268865 · Cited by 34

Intestinal Microbiota Remodeling Protects Mice from Western Diet-Induced Brain Inflammation and Cognitive Decline

Jena, P. K., Setayesh, T., Sheng, L., Lucente, J. D., Jin, L. W., & Wan, Y. Y. (2022) · Cells · doi:10.3390/cells11030504 · Cited by 26

Impact of nonalcoholic fatty liver disease-related metabolic state on depression

Ntona, S., Papaefthymiou, A., Kountouras, J., Gialamprinou, D., Kotronis, G., Boziki, M. K., Pοlyzos, S. A., Tzitiridou‐Chatzopoulou, M., Chatzopoulos, D., Thavayogarajah, T., et al. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105484 · Cited by 30

Liver Steatosis and Steatohepatitis Alter Bile Acid Receptors in Brain and Induce Neuroinflammation: A Contribution of Circulating Bile Acids and Blood-Brain Barrier

Fiaschini, N., Mancuso, M., Tanori, M., Colantoni, E., Vitali, R., Diretto, G., Lorenzo-Rebenaque, L., Stronati, L., & Negroni, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214254 · Cited by 31

Gut microbiota–astrocyte axis: new insights into age-related cognitive decline

Zhang, L., Wei, J., Liu, X., Li, D., Pang, X., Chen, F., Cao, H., & Lei, P. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01776 · Cited by 28

Early behavioral and metabolomic change after mild to moderate traumatic brain injury in the developing brain

Chitturi, J., Li, Y., Santhakumar, V., & Kannurpatti, S. S. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.08.003 · Cited by 27

Cerebral edema and liver disease: Classic perspectives and contemporary hypotheses on mechanism

Liotta, E. M., & Kimberly, W. T. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.134818 · Cited by 29

Direct and indirect effects of microbiota-derived metabolites on neuroinflammation in multiple sclerosis

Fettig, N. M., & Osborne, L. C. (2021) · Microbes and Infection · doi:10.1016/j.micinf.2021.104814 · Cited by 26

Resistant starch wheat increases PYY and decreases GIP but has no effect on self-reported perceptions of satiety

Hughes, R., Horn, W. F., Wen, A., RUST, B. M., Woodhouse, L. R., Newman, J. W. I., & Keim, N. L. (2021) · Appetite · doi:10.1016/j.appet.2021.105802 · Cited by 26

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Liang, J., Wang, Y., Liu, B., Dong, X., Cai, W., Zhang, N., & Zhang, H. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14704 · Cited by 27

Gut Dysbiosis and Blood-Brain Barrier Alteration in Hepatic Encephalopathy: From Gut to Brain

Shahbazi, A., Sepehrinezhad, A., Vahdani, E., Jamali, R., Ghasempour, M., Massoudian, S., Negah, S. S., & Larsen, F. S. (2023) · Biomedicines · doi:10.3390/biomedicines11051272 · Cited by 25

Portosystemic shunt placement reveals blood signatures for the development of hepatic encephalopathy through mass spectrometry

Machado, A. C. D., Ramos, S. F., Gauglitz, J. M., Fassler, A.-M., Petras, D., Aksenov, A. A., Kim, U. B., Lazarowicz, M. P., Giustini, A. B., Aryafar, H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40741-9 · Cited by 23

Decoding the role of gut microbiota in Alzheimer’s pathogenesis and envisioning future therapeutic avenues

Liang, J., Liu, B., Dong, X., Wang, Y., Cai, W., Zhang, N., & Zhang, H. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1242254 · Cited by 26

The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer’s and Parkinson’s Diseases

Czarnik, W., Fularski, P., Gajewska, A., Jakubowska, P., Uszok, Z., Młynarska, E., Rysz, J., & Franczyk, B. (2024) · Nutrients · doi:10.3390/nu16020308 · Cited by 24

Research Progress on the Mechanism of Bile Acids and Their Receptors in Depression

Zhao, X., Zheng, I., Huang, W., Tang, D., Zhao, M., Hou, R., Huang, Y., Shi, Y., Zhu, W., & Wang, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094023 · Cited by 25

Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids

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Exploring the role of a novel postbiotic bile acid: Interplay with gut microbiota, modulation of the farnesoid X receptor, and prospects for clinical translation

Wang, B., Han, D. W., Hu, X., Chen, J., Liu, Y., & Wu, J. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127865 · Cited by 24

Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders

Darmanto, A. G., Yen, T., Jan, J., Linh, T. T. D., Taliyan, R., Yang, C. H., & Sheu, J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107564 · Cited by 23

Effects of Flavonoid-Rich Orange Juice Intervention on Major Depressive Disorder in Young Adults: A Randomized Controlled Trial

Choi, J., Kim, J., Park, M., & Lee, H. (2022) · Nutrients · doi:10.3390/nu15010145 · Cited by 21

Neurovascular crosstalk and cerebrovascular alterations: an underestimated therapeutic target in autism spectrum disorders

Wang, Y., Yu, S., & Li, M. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1226580 · Cited by 20

Bile salts: unlocking the potential as bio-surfactant for enhanced drug absorption

Chakravarthy, P. S. A., Popli, P., Challa, R. R., Vallamkonda, B., Singh, I., & Swami, R. (2024) · Journal of Nanoparticle Research · doi:10.1007/s11051-024-05985-6 · Cited by 21

Diabetic cognitive dysfunction is associated with increased bile acids in liver and activation of bile acid signaling in intestine

Wang, X., Wang, F., Zhang, Y., Xiong, H., Zhang, Y., Zhuang, P., & Zhang, Y. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.01.006 · Cited by 20

Blood-brain barrier dysfunction in hepatic encephalopathy: pathophysiology, diagnostic assessment and therapeutic perspectives

Guennec, L. L., Mouri, S., Thabut, D., & Weiss, N. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01645-3 · Cited by 19

Bileome: The bile acid metabolome of rat

Gaikwad, N. W. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.06.052 · Cited by 19

Gastrointestinal Changes and Alzheimer's Disease

Sohrabi, M., Sahu, B., Kaur, H., Hasler, W. A., Prakash, A. K., & Combs, C. K. (2022) · Current Alzheimer Research · doi:10.2174/1567205019666220617121255 · Cited by 18

Metabolomic analysis of the hippocampus in a rat model of chronic mild unpredictable stress-induced depression based on a pathway crosstalk and network module approach

Gao, Y., Mu, J., Xu, T., Linghu, T., Zhao, H., Tian, J., & Qin, X. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113755 · Cited by 21

Anti-Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct-Ligated Mice

Gee, L. M. V., Barron-Millar, B., Leslie, J., Richardson, C., Zaki, M. Y. W., Luli, S., Burgoyne, R. A., Cameron, R. I. T., Smith, G. R., Brain, J. G., et al. (2023) · The American Journal of Pathology · doi:10.1016/j.ajpath.2022.09.005 · Cited by 18

Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver Diseases

Lan, Z., Yan, M., Luo, Q., Qiu, W., Guo, Y., Guo, X. Q., Yu, H.-B., Huo, J.-R., Feng, Y., Wang, D., et al. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.101439 · Cited by 18

The Role of Gut Microbiota in Blood–Brain Barrier Disruption after Stroke

Zeng, M., Peng, M., Liang, J., & Sun, H. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03512-7 · Cited by 18

Dietary emulsifier polysorbate 80 exposure accelerates age-related cognitive decline

Zhang, L., Yin, Z., Liu, X., Jin, G., Wang, Y., He, L., Li, M., Pang, X., Yan, B., Jia, Z.-X., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.03.052 · Cited by 20

Metabolic Profiling of CSF from People Suffering from Sporadic and LRRK2 Parkinson’s Disease: A Pilot Study

Yılmaz, A., Ugur, Z., Ustun, I., Akyol, S., Bahado-Singh, R. O., Maddens, M. E., Aasly, J. O., & Graham, S. F. (2020) · Cells · doi:10.3390/cells9112394 · Cited by 18

Bile acids as novel enhancers of CNS targeting antitumor drugs: a comprehensive review

Gvoic, M., Vukmirović, S., Al‐Salami, H., Mooranian, A., Mikov, M., & Stankov, K. (2021) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2021.1916032 · Cited by 17

Formulations of deoxycholic for therapy: a patent review (2011 – 2014)

Hwang, S. R., Kim, I. J., & Park, J. W. (2015) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2016.1102888 · Cited by 17

The Gut-Brain Axis in Alzheimer’s Disease: Exploring Microbial Influences and Therapeutic Strategies

Mustafa, M. A., Vadia, N., Varma, P., Al‐Shaker, H., Mohanty, B., Dhyani, A., Kaur, I., Chauhan, A. S., & Garg, G. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05474-4 · Cited by 18

The Status of Bile Acids and Farnesoid X Receptor in Brain and Liver of Rats with Thioacetamide-Induced Acute Liver Failure

Czarnecka, A. M., Milewski, K., Albrecht, J., & Zielińska, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207750 · Cited by 16

Underneath the Gut–Brain Axis in IBD—Evidence of the Non-Obvious

Boldyreva, L. V., Evtushenko, A. A., Lvova, M. N., Morozova, K. N., & Владимировна, К. Е. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212125 · Cited by 16

Spinal cerebrotendinous xanthomatosis: A case report and literature review

Atallah, I., Millán, D. S., Wicki, B., Campos‐Xavier, B., Superti‐Furga, A., & Tran, C. (2021) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2021.100719 · Cited by 16

Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease: lessons from animal studies

Claeys, W., Geerts, A. M., Hoecke, L. V., Steenkiste, C. V., & Vandenbroucke, R. E. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00600 · Cited by 17

Postbiotics and the gut–brain axis: A mechanistic review on modulating neuroinflammation and cognitive aging

Lahariya, R., Anand, G., Kumari, B., & Priyadarshi, K. (2026) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2026.578870 · Cited by 20

Determining the emotional regulation function of Bifidobacterium breve : the role of gut metabolite regulation over colonization capability

Qian, X., Tian, P., Guo, M., Yang, H., Zhang, H., Wang, G., & Chen, W. (2024) · Food & Function · doi:10.1039/d3fo02739b · Cited by 18

Neuroprotection vs. Neurotoxicity: The Dual Impact of Brain Lipids in Depression

Yan, Y., Zhang, Y., Liu, M., Li, L., & Zheng, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062722 · Cited by 17

Shexiang Baoxin Pill, a Formulated Chinese Herbal Mixture, Induces Neuronal Differentiation of PC12 Cells: A Signaling Triggered by Activation of Protein Kinase A

Xu, M. L., Zheng, Z.-Y., Xia, Y., Liu, E. Y. L., Chan, S. K.-H., Hu, W., Duan, R., Dong, T. T.-X., Zhan, C., Shang, X.-H., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01130 · Cited by 14

Grape Polyphenols May Prevent High-Fat Diet–Induced Dampening of the Hypothalamic–Pituitary–Adrenal Axis in Male Mice

Mezhibovsky, E., Tveter, K. M., Villa-Rodríguez, J. A., Bacalia, K. M. A., Kshatriya, D., Desai, N., Cabales, A., Wu, Y., Sui, K., Duran, R. M., et al. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad095 · Cited by 12

IUPHAR review: From gut to brain: The role of gut dysbiosis, bacterial amyloids, and metabolic disease in Alzheimer’s disease

Inan, S., Wilson, R. P., & Tükel, Ç. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107693 · Cited by 15

Metabolomic response to collegiate football participation: Pre- and Post-season analysis

Vike, N. L., Bari, S., Stetsiv, K., Talavage, T. M., Nauman, E. A., Papa, L., Slobounov, S., Breiter, H. C., & Cornelis, M. C. (2022) · Scientific Reports · doi:10.1038/s41598-022-07079-6 · Cited by 13

tDCS Regulates ASBT-3-OxoLCA-PLOD2-PTEN Signaling Pathway to Confer Neuroprotection Following Rat Cerebral Ischemia-Reperfusion Injury

Kong, X., Yao, X., Ren, J., Gao, J., Cui, Y., Sun, J., Xu, X., Hu, W., Wang, H., Li, H., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03504-7 · Cited by 13

Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Cholesterol Metabolism in Alzheimer’s DiseasePreprint

Baloni, P., Funk, C. C., Yan, J., Yurkovich, J. T., Kueider‐Paisley, A., Nho, K. T., Heinken, A., Jia, W. P., MahmoudianDehkordi, S., Louie, G., et al. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3596216 · Cited by 13

Mitochondrial Changes in Rat Brain Endothelial Cells Associated with Hepatic Encephalopathy: Relation to the Blood–Brain Barrier Dysfunction

Milewski, K., Orzeł-Gajowik, K., & Zielińska, M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03698-7 · Cited by 12

Exploring the management and treatment of IBD from the perspective of psychological comorbidities

Feng, L., Cai, X., Zou, Q., Peng, Y., Xu, L., Wang, L., Liu, Q., & Lou, T. (2024) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848241290685 · Cited by 14

Testicular immunohistochemical and Ultrastructural changes associated with chronic cholestasis in rats: Effect of ursodeoxycholic acid

Mahmoud, Y. I. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.05.027 · Cited by 12

Coordinated Targeting of Galanin Receptors on Cholangiocytes and Hepatic Stellate Cells Ameliorates Liver Fibrosis in Multidrug Resistance Protein 2 Knockout Mice

Petrescu, A. D., Grant, S. M., Williams, E., Frampton, G. A., Parks, N., Blaney, H. L., Davies, M., John, R., Reinhart, E. H., McMillin, M., et al. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.10.023 · Cited by 12

Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorderPreprint

Leclercq, S., Ahmed, H., Amadieu, C., Petit, G., Koistinen, V., Leyrolle, Q., Poncin, M., Stärkel, P., Kok, E., Karhunen, P. J., et al. (2024) · eLife · doi:10.7554/elife.96937 · Cited by 12

The link between gut microbiota and multiple sclerosis from the perspective of barrier function

Ren, J., Niu, Z., Wang, J., Guo, J., Hao, H.-J., Gao, F., Liu, R., & Wang, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1652796 · Cited by 13

The contributions of bacteria metabolites to the development of hepatic encephalopathy

Gilbert, M. C., Setayesh, T., & Wan, Y. Y. (2022) · Liver Research · doi:10.1016/j.livres.2022.11.005 · Cited by 10

Further evidence for blood-to-brain influx of unconjugated bile acids by passive diffusion: Determination of their brain-to-serum concentration ratios in rats by LC/MS/MS

Shibuya, T., Sato, A., Nishimoto‐Kusunose, S., Yoshizawa, K., & Higashi, T. (2024) · Steroids · doi:10.1016/j.steroids.2024.109397 · Cited by 14

The bile acid chenodeoxycholic acid associates with reduced stroke in humans and mice

Monteiro-Cardoso, V. F., Yeo, X. Y., Bae, H., Mayan, D. C., Wehbe, M., Lee, S., Krishna-K, K., Baek, S. H., Palomera, L. F., Wu, L. H., et al. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100712 · Cited by 11

Regulation of Physiological Barrier Function by the Commensal Microbiota

McArthur, S. (2023) · Life · doi:10.3390/life13020396 · Cited by 12

Quantification of Bile Acids in Cerebrospinal Fluid: Results of an Observational Trial

Harnisch, L.-O., Neugebauer, S., Mihaylov, D., Eidizadeh, A., Zechmeister, B., Maier, I., & Moerer, O. (2023) · Biomedicines · doi:10.3390/biomedicines11112947 · Cited by 10

Effects of Pringle maneuver and partial hepatectomy on the pharmacokinetics and blood–brain barrier permeability of sodium fluorescein in rats

Miah, M. K., Shaik, I. H., Bickel, U., & Mehvar, R. (2015) · Brain Research · doi:10.1016/j.brainres.2015.05.038 · Cited by 10

Cross-sectional and longitudinal associations of circulating bile acids and dementia: a systematic review

Zhang, Y., Li, J., Li, J., Wang, Y., Cui, M., Li, W., Chen, X., & Jiang, Y. (2025) · GeroScience · doi:10.1007/s11357-025-01790-8 · Cited by 10

Osteopontin-Rac1 on Blood-Brain Barrier Stability Following Rodent Neonatal Hypoxia-Ischemia

Dixon, B. J., Malaguit, J., Casel, D., Doycheva, D. M., Tang, J., Zhang, J. H., & Lekic, T. (2016) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-319-18497-5_46 · Cited by 9

Olive- and Coconut-Oil-Enriched Diets Decreased Secondary Bile Acids and Regulated Metabolic and Transcriptomic Markers of Brain Injury in the Frontal Cortexes of NAFLD Pigs

Maj, M. A., Gehani, T. R., Immoos, C. E., Medrano, M. S., Fanter, R. K., Strand, C. R., Glanz, H., Piccolo, B. D., Abo-Ismail, M. K., Frano, M. R. L., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12091193 · Cited by 9

The role of the microbiota-gut-brain axis in schizophrenia: an immunological perspective

Su, B.-W., Li, Y., Yang, L.-Y., Yang, H., Wang, W., Ren, H., Bao, Y.-N., Lao, J.-Y., & Luan, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1711756 · Cited by 11

Interactions of bile acids and gut microbiota modulate neurological health: a comprehensive review on mechanisms and therapeutic potential of dietary phytochemicals

Wang, J., Zhang, Y., Wu, Q., Zhong, Y., Xu, Z., & Yang, J. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1757551 · Cited by 10

Microbiota and Alzheimer’s disease: mechanistic insights from a multi-organ perspective

Liao, J., Mou, H., Luo, S., Shen, L., & Jiao, B. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00541-9 · Cited by 11

Plasma metabonomic study on the effect of Para‑hydroxybenzaldehyde intervention in a rat model of transient focal cerebral ischemia

Yu, X., Luo, Y., Yang, L., & Duan, X. (2023) · Molecular Medicine Reports · doi:10.3892/mmr.2023.13111 · Cited by 8

Diagnostic Potential of Alternations of Bile Acid Profiles in the Plasma of Patients with Huntington’s Disease

Chiang, P.-I., Chang, K., Tang, H.-Y., Wu, Y., Cheng, M., & Chen, C. (2024) · Metabolites · doi:10.3390/metabo14070394 · Cited by 8

Chronic Morphine Treatment and Antiretroviral Therapy Exacerbate HIV-Distal Sensory Peripheral Neuropathy and Induce Distinct Microbial Alterations in the HIV Tg26 Mouse Model

Chupikova, I., Antoine, D., Jalodia, R., Singh, P. K., & Roy, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031569 · Cited by 9

Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats

Hambuchen, M. D., Berquist, M. D., Simecka, C. M., McGill, M. R., Gunnell, M. G., Hendrickson, H. P., & Owens, S. M. (2019) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/jpps30471 · Cited by 8

The Role of Hypothalamic Neuropeptides in Regulation of Liver Functions in Health and Disease

Petrescu, A. D., An, S. Y., Venter, J., McMillin, M., & DeMorrow, S. (2023) · Endocrines · doi:10.3390/endocrines4020034 · Cited by 6

White matter hyperintensity severity modifies gut metabolite association with cognitive outcomes

Kijpaisalratana, N., Phuah, C., Ament, Z., Bhave, V. M., Guarniz, A. G., Duskin, J. A., Couch, C. A., Irvin, M. R., & Kimberly, W. T. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100086 · Cited by 7

Targeting the Gut Microbiota: Mechanistic Investigation of Polyphenol Modulation of the Gut–Brain Axis in Alzheimer’s Disease

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Exercise training ameliorates carbon tetrachloride-induced liver fibrosis and anxiety-like behaviors

Tomiga, Y., Tanaka, K., Kusuyama, J., Takano, A., Higaki, Y., Anzai, K., & Takahashi, K. (2024) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00161.2024 · Cited by 8

The current pediatric perspective on type B and C hepatic encephalopathy

McLin, V. A., & D’Antiga, L. (2022) · Analytical Biochemistry · doi:10.1016/j.ab.2022.114576 · Cited by 7

Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets

Henriksen, N. L., Hansen, S. H., Lycas, M. D., Pan, X., Eriksen, T., Johansen, L. S., Sprenger, R. R., Ejsing, C. S., Burrin, D. G., Skovgaard, K., et al. (2022) · Physiological Reports · doi:10.14814/phy2.15368 · Cited by 7

Plasma unconjugated bile acids as novel biomarker for schizophrenia

Koike, S., Miyaji, Y., Suzuki, K., Miyashita, M., Itokawa, M., Arai, M., & Ogasawara, Y. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.09.110 · Cited by 7

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Katsigianni, S., & Koutsouraki, E. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05914-9 · Cited by 7

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Mamedova, E., Árting, L. B., & Rekling, J. C. (2022) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2022.101288 · Cited by 6

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Orzeł-Gajowik, K., Milewski, K., & Zielińska, M. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00484-7 · Cited by 6

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Wang, M., Ma, Y., Zeng, B., Yang, W., Huang, C., & Tang, B.-Q. (2024) · Current Clinical Pharmacology · doi:10.2174/0127724328335219241202142003 · Cited by 7

Dysregulation of bile acid signal transduction causes neurological dysfunction in cirrhosis rats

Ren, C., Cha, L., Huang, S.-Y., Bai, G.-H., Li, J., Xiong, X., Feng, Y., Feng, D.-P., Gao, L., & Li, J. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i3.101340 · Cited by 6

Identifying differences in bile acid pathways for cholesterol clearance in Alzheimer’s disease using metabolic networks of human brain regionsPreprint

Baloni, P., Funk, C. C., Yan, J.-W., Yurkovich, J., Kueider-Paisley, A., Nho, K., Heinken, A., Jia, W., Mahmoudiandehkordi, S., Louie, G., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/782987 · Cited by 5

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Huarcaya, L. R. D. (2025) · Acta Neurologica Taiwanica · doi:10.4103/ant.ant_113_0046 · Cited by 5

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Giangiulio, O., & Maccarone, R. (2025) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.70703 · Cited by 6

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Yen, N. T. H., Tien, N. T. N., Anh, N. T. V., Le, Q., Eunsu, C., Kim, H.-S., Moon, K., Nguyen, H. T., Kim, D. H., & Long, N. P. (2024) · Toxicology Letters · doi:10.1016/j.toxlet.2024.03.009 · Cited by 5

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Foster, T., Lim, P., Jones, M., Wagle, S. R., Kovačević, B., Ionescu, C. M., Wong, E. Y. M., Mooranian, A., & Al‐Salami, H. (2024) · ChemMedChem · doi:10.1002/cmdc.202400038 · Cited by 6

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Zhang, Y., Chen, X., Mo, X., Xiao, R., Cheng, Q., Wang, H., Liu, L., & Xie, P. (2023) · Expert Review of Proteomics · doi:10.1080/14789450.2023.2279984 · Cited by 5

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Sun, R., Chen, C., Fu, Z., He, L., Fan, H., Xu, L., Ma, C., You, R., Li, Z., & Chai, Z. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120787 · Cited by 4

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Vu, B., Kawamoto, R., Villalba‐Davila, P., Dong, X., & Karnsakul, W. W. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1732854 · Cited by 5

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Zhai, J., Li, Y., Liu, J., & Dai, C. (2026) · Clinical and Translational Discovery · doi:10.1002/ctd2.70117 · Cited by 4

In vitro models of microbiota-gut-brain axis communication at the blood-brain-barrier interface

Davies, M. R., Cross, C., Aburto, M. R., Cryan, J. F., & Wardill, H. R. (2026) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x261419964 · Cited by 4

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Liu, Z., Chai, Z., Wu, F., Zhang, L., Wang, X., Xu, Z., Weng, Y., Gong, J., Shen, J. F., Zhan, R., et al. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01363-2 · Cited by 5

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Zielińska, M., Popek, M. P., & Albrecht, J. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19102-2.00011-9 · Cited by 4

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Biswal, B., Satapathy, B. S., Maharana, L., & Pattnaik, S. (2025) · Journal of Dispersion Science and Technology · doi:10.1080/01932691.2025.2488455 · Cited by 4

Bile Acid Profile Differs Between Brain Regions in Rodents and Is Disrupted in a Rodent Model of Alzheimer's Disease

Reuter, M. A., Moreno, R., Tucker, M., Shishani, R., Bustamante, J. M., Marfori, Z., Richieri, T., Valenzuela, A. E., Taha, A. Y., Lein, P. J., et al. (2025) · Comprehensive physiology · doi:10.1002/cph4.70034 · Cited by 4

Using metabolomics to investigate the relationship between the metabolomic profile of the intestinal microbiota derivatives and mental disorders in inflammatory bowel diseases: a narrative review

Zarei, P., Adibi, P., Vaez, A., & Keshteli, A. H. (2025) · Research in Pharmaceutical Sciences · doi:10.4103/rps.rps_273_23 · Cited by 4

Pathologic and therapeutic insights into cholestatic liver disease-associated depressive disorder

Li, X., Wang, H., Li, Y., Huang, M., Li, X., Yu, Z., Li, P., & Liu, R. (2025) · Acta Materia Medica · doi:10.15212/amm-2024-0082 · Cited by 6

Neurodevelopment and the gut microbiome

Oliphant, K., & Lu, J. N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820602-7.00006-4 · Cited by 6

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Li, Z., Liu, X., Liu, Y., Xue, Y., Liu, J., Teng, H. W., Xi, Z., & Yao, Y. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0649-8 · Cited by 4

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Yang, X. J., Louwies, T., Mars, R. A. T., & Kashyap, P. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230013 · Cited by 14

Increased serum bile acids after extrahepatic biliary obstruction causes leakiness to the blood brain barrier via the disruption of tight junctions

DeMorrow, S., Frampton, G. A., Galindo, C., Pae, H. Y., & Quinn, M. A. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.1110.7 · Cited by 3

Blood-brain barrier permeability is markedly decreased in cholestasis in the rat

Wahler, J. B., Swain, M. G., Carson, R. E., Bergasa, N. V., & Jones, E. A. (1993) · Hepatology · doi:10.1002/hep.1840170625 · Cited by 18

Increased Serum Bile Acids After Extraheptic Biliary Obstruction Causes Leakiness to the Blood Brain Barrier via the Disruption of Tight Junctions

Quinn, M. A., Frampton, G. A., Pae, H. Y., Horvat, D., Huang, L., & DeMorrow, S. (2011) · Gastroenterology · doi:10.1016/s0016-5085(11)63890-0 · Cited by 1

The Effect of Bile Salts on the Permeability and Ultrastructure of the Perfused, Energy-Depleted, Rat Blood-Brain Barrier

Greenwood, J., Adu, J., DAVEY, A. J., Abbott, N. J., & Bradbury, M. W. B. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.116 · Cited by 71

Bile duct ligation-induced cirrhosis does not alter the blood-brain barrier permeability to sucrose in rats

Miah, M. K., Bickel, U., & Mehvar, R. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01486-6 · Cited by 3