Pathogenesis of cholestatic liver disease and therapeutic approaches

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Primary biliary cirrhosis # †

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Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

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Primary Biliary Cirrhosis Associated with <i>HLA, IL12A,</i> and <i>IL12RB2</i> Variants

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Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis

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ARE STEROID INHALERS SAFER THAN TABLETS?

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SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS

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Ursodiol for the Long-Term Treatment of Primary Biliary Cirrhosis

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Primary biliary cirrhosis in monozygotic and dizygotic twins: Genetics, epigenetics, and environment

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The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

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Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

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Improved Prognosis of Patients With Primary Biliary Cirrhosis That Have a Biochemical Response to Ursodeoxycholic Acid

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Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: A tight junction disease

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Drug Insight: mechanisms and sites of action of ursodeoxycholic acid in cholestasis

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High lifetime risk of cancer in primary sclerosing cholangitis

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Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

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The apical conjugate efflux pump ABCC2 (MRP2)

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Baseline Ductopenia and Treatment Response Predict Long-Term Histological Progression in Primary Biliary Cirrhosis

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Genome-Wide Association Analysis in Primary Sclerosing Cholangitis

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Hepatic Endothelial CCL25 Mediates the Recruitment of CCR9+ Gut-homing Lymphocytes to the Liver in Primary Sclerosing Cholangitis

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Pharmacogenomics of human OATP transporters

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Identification of a Novel Antibody Associated with Autoimmune Pancreatitis

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The Biliary HCO3 − Umbrella: A Unifying Hypothesis on Pathogenetic and Therapeutic Aspects of Fibrosing Cholangiopathies

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Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans

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Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome

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Patients With Primary Biliary Cirrhosis React Against A Ubiquitous Xenobiotic–Metabolizing Bacterium

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Epithelial‐to‐mesenchymal transitions in the liver†

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Liver‐targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis†

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HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases.

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24-norUrsodeoxycholic Acid Is Superior to Ursodeoxycholic Acid in the Treatment of Sclerosing Cholangitis in Mdr2 (Abcb4) Knockout Mice

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Cholangiocyte Cilia Detect Changes in Luminal Fluid Flow and Transmit Them Into Intracellular Ca2+ and cAMP Signaling

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PRIMARY BILIARY CIRRHOSIS: IDENTIFICATION OF TWO MAJOR M2 MITOCHONDRIAL AUTOANTIGENS

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Identification of HLA-A2–restricted CD8+ Cytotoxic T Cell Responses in Primary Biliary Cirrhosis

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The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders #

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Primary biliary cirrhosis: an orchestrated immune response against epithelial cells

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Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis.

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Frequency of monosomy X in women with primary biliary cirrhosis

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The Pathophysiology of Biliary Epithelia

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Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease

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Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase.

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Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis.

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Anti-Mitochondrial Antibodies and Primary Biliary Cirrhosis in TGF-β Receptor II Dominant-Negative Mice

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The Spectrum of Liver Diseases Related toABCB4Gene Mutations: Pathophysiology and Clinical Aspects

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The role of notch signaling in the development of intrahepatic bile ducts

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Liver and kidney disease in ciliopathies

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Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver

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Demographic, lifestyle, medical and familial factors associated with primary biliary cirrhosis

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Genome-wide association meta-analysis for total serum bilirubin levels

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IL-2 receptor α−/− mice and the development of primary biliary cirrhosis

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Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver

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Multiple TLRs Are Expressed in Human Cholangiocytes and Mediate Host Epithelial Defense Responses to Cryptosporidium parvum via Activation of NF-κB

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Sclerosing cholangitis: a focus on secondary causes

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Effects of ursodeoxycholic acid on survival in patients with primary biliary cirrhosis

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Genetic Labeling Does Not Detect Epithelial-to-Mesenchymal Transition of Cholangiocytes in Liver Fibrosis in Mice

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Liver Autoimmunity Triggered by Microbial Activation of Natural Killer T Cells

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Apotopes and the biliary specificity of primary biliary cirrhosis†

Lleo, A., Selmi, C., Invernizzi, P., Podda, M., Coppel, R. L., Mackay, I. R., Gores, G. J., Ansari, A. A., Van de Water, J., & Gershwin, M. E. (2009) · Hepatology · doi:10.1002/hep.22736 · Cited by 222 · see citing works

Increased prevalence of primary biliary cirrhosis near Superfund toxic waste sites

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Quantitative and functional analysis of PDC-E2–specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis

Kita, H., Matsumura, S., He, X.-S., Ansari, A. A., Lian, Z., de Water, J. V., Coppel, R. L., Kaplan, M. M., & Gershwin, M. E. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14698 · Cited by 222 · see citing works

Quantitative and functional analysis of PDC‐E2‐specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis

Kita, H., Matsumura, S., He, X.-S., Ansari, A. A., Lian, Z.-X., Van de Water, J., Coppel, R. L., Kaplan, M. M., & Gershwin, M. E. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214698 · Cited by 222 · see citing works

Bcl-2–dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis

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Mechanisms of Cholestasis

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Combined analysis of the effect of treatment with ursodeoxycholic acid on histologic progression in primary biliary cirrhosis

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Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis

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Biliary Apotopes and Anti-Mitochondrial Antibodies Activate Innate Immune Responses in Primary Biliary Cirrhosis†

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It's all about bile†

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B-Cell Depletion With Rituximab in Patients With Primary Biliary Cirrhosis Refractory to Ursodeoxycholic Acid

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Ileal Bile Acid Transporter Inhibition for the Treatment of Chronic Constipation, Cholestatic Pruritus, and NASH

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The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway

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Cholestasis-associated reproductive toxicity in male and female rats: The fundamental role of mitochondrial impairment and oxidative stress

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C/EBP homologous protein–induced loss of intestinal epithelial stemness contributes to bile duct ligation–induced cholestatic liver injury in mice

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The Role and Study of Mitochondrial Impairment and Oxidative Stress in Cholestasis

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The Epidermal Growth Factor Receptor Ligand Amphiregulin Protects From Cholestatic Liver Injury and Regulates Bile Acids Synthesis

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Geniposide attenuates ANIT-induced cholestasis through regulation of transporters and enzymes involved in bile acids homeostasis in rats

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Obeticholic acid for the treatment of primary biliary cirrhosis

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Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation

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Sorting through the extensive and confusing roles of sortilin in metabolic disease

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The Spectrum of Sclerosing Cholangitis and the Relevance of IgG4 Elevations in Routine Practice

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Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice

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Targeting the FGF19–FGFR4 pathway for cholestatic, metabolic, and cancerous diseases

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Circulating FGF19 closely correlates with bile acid synthesis and cholestasis in patients with primary biliary cirrhosis

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Sweroside ameliorates α-naphthylisothiocyanate-induced cholestatic liver injury in mice by regulating bile acids and suppressing pro-inflammatory responses

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Animal Models in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis

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The Pathophysiology of Cholestasis and Its Relevance to Clinical Practice

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Inhibition of JNK signalling mediates PPARα‐dependent protection against intrahepatic cholestasis by fenofibrate

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N-acetyl cysteine treatment mitigates biomarkers of oxidative stress in different tissues of bile duct ligated rats

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In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach

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Primary biliary cholangitis as a roadmap for the development of novel treatments for cholestatic liver diseases†

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