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Cited by 24Celiac Disease Research and ManagementConnective tissue disorders researchGastrointestinal motility and disorders

Nationwide population-based cohort study of celiac disease and risk of Ehlers-Danlos syndrome and joint hypermobility syndrome

Laszkowska, Monika, Roy, Abhik, Lebwohl, Benjamin, Green, Peter H.R., Sundelin, Heléne E.K., Ludvigsson, Jonas F.·2016·Digestive and Liver Disease
DOI 10.1016/j.dld.2016.05.019
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Abstract

Background Patients with celiac disease (CD) often have articular complaints, and small prior studies suggest an association with Ehlers-Danlos syndrome (EDS)/joint hypermobility syndrome (JHS).Aims This study examines the risks of EDS/JHS in patients with CD.Methods This cohort study compared all individuals in Sweden diagnosed with CD based on small intestinal biopsy between 1969-2008 (n=28,631) to 139,832 matched reference individuals, and to a second reference group undergoing biopsy without having CD (n=16,104). Rates of EDS/JHS were determined based on diagnostic codes in the Swedish Patient Register. Hazard ratios (HRs) for EDS/JHS were estimated through Cox regression.Results There are 45 and 148 cases of EDS/JHS in patients with CD and reference individuals, respectively. This corresponds to a 49% increased risk of EDS/JHS in CD (95%CI=1.07-2.07). The HR for EDS was 2.43 (95%CI=1.20-4.91) and for JHS 1.34 (95%CI=0.93-1.95). Compared to reference individuals undergoing intestinal biopsy, CD was not a risk factor for EDS/JHS. A stronger association was seen in patients initially diagnosed with EDS/JHS and subsequently diagnosed with CD (odds ratio=2.29; 95%CI=1.21-4.34).Conclusions Individuals with CD have higher risk of EDS/JHS than the general population, which may be due to surveillance bias or factors intrinsic to celiac development.

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Crossref · 10.1016/j.dld.2016.05.019

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  • A large population-based Swedish registry identified a significant association of HSD/hEDS with histologically proven celiac disease (14 vs 9 per 100,000 person-years, hazard ratio 1.49, 95% CI 1.07-2.07, P = 0.018).

    “Subsequent interrogation of a large population‐based Swedish registry identified a significant association of HSD/hEDS with histologically proven celiac disease (14 vs 9 per 100 000 person‐years with a hazard ratio of 1.49, 95% CI, 1.07–2.07, P = 0.018). 33”

    From Hypermobile Ehlers–Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know (2022) · cites this paper as [33]

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Authors
Laszkowska, M., Roy, A., Lebwohl, B., Green, P. H. R., Sundelin, H. E. K., & Ludvigsson, J. F.
Affiliations
  • Columbia University Irving Medical Center (US)
  • Linköping University Hospital (SE)
  • University of Nottingham (GB)
Corresponding author
Ludvigsson, Jonas F.
ORCID
Venue
Digestive and Liver Disease
Publisher
Elsevier BV
Published
2016-09
Volume
48
Issue
9
Pages
1030-1034
ISSN
1590-8658 (ISSN-L)
DOI
10.1016/j.dld.2016.05.019
OpenAlex
W2409302289
Cited by
24
References
33
Citations by year
2026: 2 · 2025: 5 · 2024: 3 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 2
FWCI
2.91
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Digestive and Liver Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
celiac disease, Ehlers-Danlos syndrome, joint hypermobility syndrome, connective tissue diseases, comorbidities, risk factors, surveillance bias, intestinal biopsy
MeSH terms
Adolescent, Adult, Celiac Disease, Child, Child, Preschool, Ehlers-Danlos Syndrome, Female, Humans, Infant, Infant, Newborn, Intestine, Small, Joint Instability, Male, Middle Aged, Surveys and Questionnaires, Risk Factors, Sweden, Cohort Studies, Logistic Models, Proportional Hazards Models, Case-Control Studies, Young Adult

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