Cited by 80DNA Repair MechanismsGenomics and Chromatin DynamicsChromatin Remodeling and Cancer

Nucleotide excision repair in chromatin and the right of entry

Gong, Feng, Kwon, YoungHo, Smerdon, Michael J.·2005·DNA Repair

Abstract

DNA is packaged with histones and other accessory proteins into chromatin in eukaryotic cells. It is well established that the assembly of DNA into chromatin affects induction of DNA damage as well as repair of the damage. How the DNA repair machinery detects a lesion and 'fixes it' in chromatin has been an intriguing question since the dawn of understanding DNA packaging in chromatin. Direct recognition/binding by damaged DNA binding proteins is one obvious tactic to detect a lesion. Rearrangement of chromatin structure during DNA repair was reported more than two decades ago. This early observation suggests that unfolding of chromatin structure may be required to facilitate DNA repair after lesions are detected. Cells can also exploit DNA processing events to assist DNA repair. Transcription coupled repair (TCR) is such an example. During TCR, an RNA polymerase blocked by a lesion, may act as a signal to recruit DNA repair machinery. Possible roles of histone modification enzymes, ATP-dependent chromatin remodeling complexes and chromatin assembly factors in DNA repair are discussed.

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Crossref · 10.1016/j.dnarep.2005.04.007

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Authors
Gong, F., Kwon, Y., & Smerdon, M. J.
Affiliations
Washington State University (US)
Corresponding author
Smerdon, Michael J.
Venue
DNA Repair
Publisher
Elsevier BV
Published
2005-07
Volume
4
Issue
8
Pages
884-896
ISSN
  • 1568-7856 (ISSN-L)
  • 1568-7864
OpenAlex
W2082425829
Cited by
80
References
119
Citations by year
2025: 1 · 2023: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 7 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 5
FWCI
0.73
Type
journal article
Language
en
Open access
closed
Locations
  • DNA repair (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • National Institute of Environmental Health Sciences (R37ES002614, ES04106, R01ES002614, R01ES004106, ES02614)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
nucleotide excision repair, chromatin, DNA damage detection, transcription-coupled repair, histone modifications, chromatin remodeling complexes, chromatin assembly factor, DNA damage signaling
MeSH terms
Acetylation, Chromatin, DNA Repair, Histones, Poly Adenosine Diphosphate Ribose, Saccharomyces cerevisiae, Chromatin Assembly and Disassembly

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