DNA double-strand break repair: From mechanistic understanding to cancer treatment

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Items 301–400 of 644

1. ATM and DNA-PKcs make a complementary couple in DNA double strand break repair
   Marta Martı́n, Mariona Terradas, Laura Tusell, Anna Genescà · 2012 · Mutation Research/Reviews in Mutation Research
2. High expression of Rad51c predicts poor prognostic outcome and induces cell resistance to cisplatin and radiation in non-small cell lung cancer
   Xiuli Chen, Dong Qian, Jingjing Cheng, Yong Guan, Bin Zhang, Xiaofeng Ding, Jing Zeng, Xi Chen, Puchun Er, Furong Zhang et al. · 2016 · Tumor Biology
3. A functional ex vivo assay to detect PARP1‐EJ repair and radiosensitization by PARP‐inhibitor in prostate cancer
   Sabrina Köcher, Burkhard Beyer, Tobias Lange, Lena Nordquist, Jennifer Volquardsen, Susanne Burdak‐Rothkamm, Thorsten Schlomm, Cordula Petersen, Kai Rothkamm, Wael Yassin Mansour · 2018 · International Journal of Cancer
4. Targeting Homologous Recombination Repair in Cancer
   Henning Willers, Heike N. Pfäffle, Lee Zou · 2011 · Elsevier eBooks
5. Preliminary investigation of anticancer activity by determining the DNA binding and antioxidant potency of new ferrocene incorporated N,N′,N″-trisubstituted phenylguanidines
   Rukhsana Gul, Amin Badshah, Azim Khan, Asif Junaid, Muhammad Khawar Rauf · 2013 · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
6. Ferrocene-functionalized anilines as potent anticancer and antidiabetic agents: Synthesis, spectroscopic elucidation, and DFT calculations
   Faiza Asghar, Shamsa Munir, Saira Fatima, Babar Murtaza, Jahangeer Patujo, Amin Badshah, Ian Sydney Butler, Muhammad Babar Taj, Muhammad Nawaz Tahir · 2021 · Journal of Molecular Structure
7. DNA Repair Endonucleases: Physiological Roles and Potential as Drug Targets
   Rachel E. Doherty, Srinivasan Madhusudan · 2015 · SLAS DISCOVERY
8. ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and Repair
   Tilman Polonio-Vallon, Daniel Krüger, Thomas G. Hofmann · 2014 · Frontiers in Oncology
9. Genotoxicity of irinotecan and its modulation by vitamins A, C and E in human lymphocytes from healthy individuals and cancer patients
   Renata Kontek, Rafał Drozda, M. Śliwiński, Krzysztof Grzegorczyk · 2009 · Toxicology in Vitro
10. Sequence Conversion by Single Strand Oligonucleotide Donors via Non-homologous End Joining in Mammalian Cells
    Jia Liu, Alokes Majumdar, Jilan Liu, Lawrence H. Thompson, Michael M. Seidman · 2010 · Journal of Biological Chemistry
11. Internal priming: An opportunistic pathway for L1 and Alu retrotransposition in hominins
    Deepa Srikanta, Shurjo Kumar Sen, Erin M. Conlin, Mark A. Batzer · 2009 · Gene
12. Two hits in one: whole genome sequencing unveils LIG4 syndrome and urofacial syndrome in a case report of a child with complex phenotype
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13. Induction and repair rate of DNA damage: A unified model for describing effects of external and internal irradiation and contamination with heavy metals
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14. Principles and advances in ultrafast photoacoustics; applications to imaging cell mechanics and to probing cell nanostructure
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15. High risk of benzo[α]pyrene-induced lung cancer in E160D FEN1 mutant mice
    Zhenxing Wu, Yuanji Lin, Hong Xu, Huifang Dai, Mian Zhou, Sharlene Tsao, Li Zheng, Binghui Shen · 2011 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
16. Recombination hotspots: Models and tools for detection
    Prosenjit Paul, Debjyoti Nag, Supriyo Chakraborty · 2016 · DNA repair
17. Nm23-H1 is involved in the repair of ionizing radiation-induced DNA double-strand breaks in the A549 lung cancer cell line
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18. Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A
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19. Functional analyses of the C-terminal half of the Saccharomyces cerevisiae Rad52 protein
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20. Essential and distinct roles of the F-box and helicase domains of Fbh1 in DNA damage repair
    Chikako Sakaguchi, Takashi Morishita, Hideo Shinagawa, Takashi Hishida · 2008 · BMC Molecular Biology
21. Transcription-associated recombination is independent of XRCC2 and mechanistically separate from homology-directed DNA double-strand break repair
    L. Savolainen, Thomas Helleday · 2008 · Nucleic Acids Research
22. A Role for the Malignant Brain Tumour (MBT) Domain Protein LIN-61 in DNA Double-Strand Break Repair by Homologous Recombination
    Nicholas M. Johnson, Bennie B. L. G. Lemmens, Marcel Tijsterman · 2013 · PLoS Genetics
23. Nanoscale battery cathode materials induce DNA damage in bacteria
    Tian Autumn Qiu, Valeria Guidolin, Khoi Nguyen L. Hoang, Thomas Pho, Andrea Carrà, Peter W. Villalta, Jiayi He, Xiaoxiao Yao, Robert J. Hamers, Silvia Balbo et al. · 2020 · Chemical Science
24. Possible mechanisms and simulation modeling of FLASH radiotherapy
    Yuta Shiraishi, Yusuke Matsuya, Hisanori Fukunaga · 2024 · Radiological Physics and Technology
25. Somatic Mutations and Genome Stability Maintenance in Clonal Coral Colonies
    López, Elora H, Palumbi, Stephen R · 2020 · Molecular Biology and Evolution
26. Abnormalities of DNA repair mechanisms in common hematological malignancies
    Panagiota Economopoulou, Vasiliki Pappa, Sotirios G. Papageorgiou, John Dervenoulas, Theofanis Economopoulos · 2011 · Leukemia & lymphoma/Leukemia and lymphoma
27. MutS homologue hMSH4: interaction with eIF3f and a role in NHEJ-mediated DSB repair
    Yen-Lin Chu, Xiling Wu, Yang Xu, Chengtao Her · 2013 · Molecular Cancer
28. Chk2 Phosphorylation of Survivin-ΔEx3 Contributes to a DNA Damage–Sensing Checkpoint in Cancer
    Alessia Lopergolo, Michele Tavecchio, Sofia Lisanti, Jagadish C. Ghosh, Takehiko Dohi, Alice Faversani, Valentina Vaira, Silvano Bòsari, Nobuhiko Tanigawa, Domenico Delia et al. · 2012 · Cancer Research
29. DNA Repair
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30. ATR Suppresses Endogenous DNA Damage and Allows Completion of Homologous Recombination Repair
    Adam Brown, Brian W. Sager, Aparna Gorthi, Sonal S. Tonapi, Eric J. Brown, Alexander J.R. Bishop · 2014 · PLoS ONE
31. Induction of DNA Double-Strand Breaks in the H4IIE Cell Line Exposed to Environmentally Relevant Concentrations of Copper, Cadmium, and Zinc, Singly and in Combinations
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32. Overview of DNA repair pathways, current targets, and clinical trials bench to clinic
    Mark R. Kelley, Melissa L. Fishel · 2016 · Elsevier eBooks
33. Real-World Delivery of Rucaparib to Patients with Ovarian Cancer: Recommendations Based on an Integrated Safety Analysis of ARIEL2 and Study 10
    Yvette Drew, Rebecca Sophie Kristeleit, Ana Oaknin, Isabelle Laure Ray-Coquard, Noor Md Haris, Elizabeth M. Swisher · 2019 · The Oncologist
34. “Designer babies?!” A CRISPR ‐based learning module for undergraduates built around the CCR5 gene
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35. Lysophosphatidic acid increases in vitro maturation efficiency via uPA-uPAR signaling pathway in cumulus cells
    Seon‐Ung Hwang, Kyu-Jun Kim, Eunhye Kim, Junchul David Yoon, Kyu Mi Park, Minghui Jin, Yongquan Han, Mirae Kim, Gabsang Lee, Sang‐Hwan Hyun · 2018 · Theriogenology
36. Changes in intra-nuclear mechanics in response to DNA damaging agents revealed by time-domain Brillouin micro-spectroscopy
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37. Role of the functional variant (−652T>G) in the XRCC4 promoter in prostate cancer
    Ning Shao, Jiuming Li, Bin Xu, Yang Wang, Xiaojie Lu, Ninghan Feng · 2014 · Molecular Biology Reports
38. Characteristics of replication-independent endogenous double-strand breaks in Saccharomyces cerevisiae
    Monnat Pongpanich, Maturada Patchsung, Jirapan Thongsroy, Apiwat Mutirangura · 2014 · BMC Genomics
39. DNA repair as treatment target
    Thomas Helleday · 2011 · European Journal of Cancer
40. Modeling the biological response of normal human cells, including repair processes, to fractionated carbon beam irradiation
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41. Effects of Micrornas and Long Non-Coding RNAs on Chemotherapy Response in Glioma
    Sara Ahmadpour, Tarannomsadat Taghavi, Amirhossein Sheida, Seyed Saeed Tamehri Zadeh, Michael Richard Hamblin, Hamed Mirzaei · 2022 · Epigenomics
42. DNA Damage Protection and Induction of Repair by Dietary Phytochemicals and Cancer Prevention: What Do We Know?
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43. DNA glycosylase activity and cell proliferation are key factors in modulating homologous recombination in vivo
    O. Kiraly, Guanyu Gong, Megan Roytman, Y. Yamada, Leona D. Samson, Bevin P. Engelward · 2014 · Carcinogenesis
44. PCNA-Ub polyubiquitination inhibits cell proliferation and induces cell-cycle checkpoints
    Zhoushuai Qin, Zhiqiang Bai, Ying Jie Sun, Xiaohong Niu, Wei Xiao · 2016 · Cell Cycle
45. A universal fluorescence-based toolkit for real-time quantification of DNA and RNA nuclease activity
    Emily C. Sheppard, Sally L. Rogers, Nicholas J. Harmer, Richard Chahwan · 2019 · Scientific Reports
46. DNA-Dependent Protein Kinase Mediates YB-1 (Y-Box Binding Protein)-Induced Double Strand Break Repair
    Till Nöthen, Mohsen Abdi Sarabi, Sönke Weinert, Werner Zuschratter, Ronnie Morgenroth, Peter Rene Mertens, Ruediger Christian Braun-Dullaeus, Senad Medunjanin · 2022 · Arteriosclerosis Thrombosis and Vascular Biology
47. p53 null Fluorescent Yellow Direct Repeat (FYDR) mice have normal levels of homologous recombination
    Dominika M. Wiktor‐Brown, Michelle R. Sukup-Jackson, Saja A. Fakhraldeen, Carrie A. Hendricks, Bevin P. Engelward · 2011 · DNA repair
48. Downregulation of Rad51 participates in OTA-induced DNA double-strand breaks in GES-1 cells in vitro
    Hongguang Lian, Jinfeng Cui, Yuan Wang, Jing Liu, Juan Wang, Haitao Shen, Lingxiao Xing, Junling Wang, Yan Xia, Xianghong Zhang · 2014 · Toxicology Letters
49. Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer
    Christine Kuhmann, Carmen Li, Matthias Kloor, Mariam Haffa, Christoph Weigel, Christopher R. Schmidt, Linda W.C. Ng, Wendy W.Y. Tsui, Suet Y. Leung, Siu Tsan Yuen et al. · 2013 · Human Molecular Genetics
50. Exposure to 50 Hz magnetic field at 100 µT exert no DNA damage in cardiomyocytes
    Yong Wang, Xingfa Liu, Yemao Zhang, Baoquan Wan, Jiangong Zhang, Wei He, Dong Hu, Yang Yong, Jinsheng Lai, Mengying He et al. · 2019 · Biology Open
51. The forkhead box M1 (FOXM1) expression and antitumor effect of FOXM1 inhibition in malignant rhabdoid tumor
    Yuichi Shibui, Kenichi Kohashi, Akihiko Tamaki, Izumi Kinoshita, Yuichi Yamada, Hidetaka Yamamoto, Tomoaki Taguchi, Yoshinao Oda · 2020 · Journal of Cancer Research and Clinical Oncology
52. Integrated one- and two-photon imaging platform reveals clonal expansion as a major driver of mutation load
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53. Protective effect of chitosan oligosaccharide lactate against DNA double-strand breaks induced by a model methacrylate dental adhesive
    Joanna Szczepańska, Elżbieta Pawłowska, Ewelina Synowiec, Piotr Lech Czarny, Marek Rękas, Janusz Błasiak, Jacek Paweł Szaflik · 2011 · Medical Science Monitor
54. Oxaliplatin Regulates DNA Repair Responding to Ionizing Radiation and Enhances Radiosensitivity of Human Cervical Cancer Cells
    Yuh‐Cheng Yang, K. S. Clifford Chao, Chin‐Ping Lin, Yu-Yawn Chen, Kung-Liahng Wang, Yu-Jen Chen · 2009 · International Journal of Gynecological Cancer
55. Human DNA Helicase B Functions in Cellular Homologous Recombination and Stimulates Rad51-Mediated 5′-3′ Heteroduplex Extension In Vitro
    Hanjian Liu, Peijun Yan, Ellen Fanning · 2015 · PLoS ONE
56. Plastid Genome Stability and Repair
    Éric Zampini, Sébastien Truche, Étienne Lepage, Samuel Tremblay‐Belzile, Normand Brisson · 2017 · Wiley eBooks
57. Sequence features of HLA-DRB1 locus define putative basis for gene conversion and point mutations
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58. Essential Roles for Polymerase Theta-Mediated End Joining in Repair of Chromosome Breaks
    David W. Wyatt · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
59. Computational approaches to studying methylated H4K20 recognition by DNA repair factor 53BP1
    Zhendong Li, Jingxiao Bao, Yifei Qi, John Z. H. Zhang · 2020 · Physical Chemistry Chemical Physics
60. XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase
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61. Evaluation of phototoxicity induced by the anticancer drug rucaparib
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62. Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic Enhancement of Cisplatin and Radiation in Both HPV-Negative and -Positive HNSCC Cell Lines
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63. Role and regulation of human XRCC4‐like factor/cernunnos
    Kirsten Dahm · 2008 · Journal of Cellular Biochemistry
64. A Conditional Mouse Model for Measuring the Frequency of Homologous Recombination Events In Vivo in the Absence of Essential Genes
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65. New bioactive ferrocene-substituted heteroleptic copper(I) complex: Synthesis, structural elucidation, DNA interaction, and DFT study
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66. Molecular Carcinogenesis
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67. A caveat in mouse genetic engineering: ectopic gene targeting in ES cells by bidirectional extension of the homology arms of a gene replacement vector carrying human PARP-1
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68. BRCA2 Function and the Central Nervous System
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69. Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta
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70. Catalytically Active Ti‐Based Nanomaterials for Hydroxyl Radical Mediated Clinical X‐Ray Enhancement
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71. DNA binding proteins: outline of functional classification
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72. Synthesis, structural characterization, in vitro bioactivities, interaction with SS-DNA and DFT study of 4-chloro-3-ferrocenylaniline
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73. Exogenous nitric oxide potentiate DNA damage and alter DNA repair in cells exposed to ionising radiation.
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74. Quercetin 3-O rutinoside prevents gastrointestinal injury through regulation of apoptosis in 7.5 Gy total body irradiated mice
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75. Enhanced neutrophil and eosinophil adhesion in patients with primary Sjögren's syndrome.
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76. Core and Linker Histone Modifications Involved in the DNA Damage Response
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77. G2-Phase Chromosomal Radiosensitivity of Primary Fibroblasts from Hereditary Retinoblastoma Family Members and Some Apparently Normal Controls
    Paul F. Wilson, Hatsumi Nagasawa, Markus M. Fitzek, John B. Little, Joel S. Bedford · 2009 · Radiation Research
78. Tissue-specific differences in the accumulation of sequence rearrangements with age
    Dominika M. Wiktor‐Brown, Werner Olipitz, Carrie A. Hendricks, Rebecca E. Rugo, Bevin P. Engelward · 2008 · DNA repair
79. Homologous recombination repair capacity in peripheral blood lymphocytes and breast cancer risk
    Jie Shen, Renduo Song, Wong‐Ho Chow, Hua Zhao · 2020 · Carcinogenesis
80. Fully automated counting of DNA damage foci in tumor cell culture: A matter of cell separation
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81. Effect of X-ray exposure on the pharmaceutical quality of drug tablets using X-ray inspection equipment
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82. Quantitative Proteomics Analysis Reveals Nuclear Perturbation in Human Glioma U87 Cells treated with Temozolomide
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83. Impact of Chromatin Dynamics and DNA Repair on Genomic Stability and Treatment Resistance in Pediatric High-Grade Gliomas
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84. Genetic variation in radiation and platinum pathways predicts severe acute radiation toxicity in patients with esophageal adenocarcinoma treated with cisplatin-based preoperative radiochemotherapy: results from the Eastern Cooperative Oncology Group
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85. MutS Homologue hMSH5: Recombinational DSB Repair and Non-Synonymous Polymorphic Variants
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86. DNA Damage Response/Repair in Cancer Stem Cells — Potential vs. Controversies
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87. Developing a clinically relevant radiosensitizer for temozolomide-resistant gliomas
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88. BRCC36 prevents vascular calcification in chronic kidney disease through the β-catenin signalling pathway
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89. Assessment of Anti-recombination and Double-strand Break-induced Gene Conversion in Human Cells by a Chromosomal Reporter
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90. Double-Strand Breaks from a Radical Commonly Produced by DNA-Damaging Agents
    Marisa L. Taverna Porro, Marc M. Greenberg · 2015 · Chemical Research in Toxicology
91. Clinical importance of DNA repair inhibitors in cancer therapy
    Noriko Hosoya, Kiyoshi Miyagawa · 2009 · memo - Magazine of European Medical Oncology
92. Critical Interaction Domains between Bloom Syndrome Protein and RAD51
    Krystal L. Bergeron, Eileen L. Murphy, Lily W. Brown, Karen H. Almeida · 2010 · The Protein Journal
93. High expression of MRE11 correlates with poor prognosis in gastric carcinoma
    Junqing Li, Taiqiang Su, Liang Yang, Changhua Zhang, Yulong He · 2019 · Diagnostic Pathology
94. eIF3a Regulation of NHEJ Repair Protein Synthesis and Cellular Response to Ionizing Radiation
    Rima Tumia, Chao J. Wang, Tianhan Dong, Shijie Ma, Jenny Beebe, Juan Chen, Zizheng Dong, Jingyuan Liu, Jian‐Ting Zhang · 2020 · Frontiers in Cell and Developmental Biology
95. Essential Role for an Isoform of Escherichia coli Translation Initiation Factor IF2 in Repair of Two-Ended DNA Double-Strand Breaks
    Jillella Mallikarjun, Jayaraman Gowrishankar · 2022 · Journal of Bacteriology
96. The combination of hyperthermia or chemotherapy with gimeracil for effective radiosensitization
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97. Radiation induction of delayed recombination in Schizosaccharomyces pombe
    Jun Takeda, Norio Uematsu, Satomi Shiraishi, Megumi Toyoshima, Tomohiro Matsumoto, Ohtsura Niwa · 2008 · DNA repair
98. Induction of Rad51 protein levels by p38 MAPK decreases cytotoxicity and mutagenicity in benzo[a]pyrene-exposed human lung cancer cells
    Show‐Mei Chuang, Lyu-Han Wang, Jhao-Hao Hong, Yun‐Wei Lin · 2008 · Toxicology and Applied Pharmacology
99. Fidelity of end joining in mammalian episomes and the impact of Metnase on joint processing
    Abhijit Rath, Robert Hromas, Arrigo De Benedetti · 2014 · BMC Molecular Biology
100. Optimizing Protonation States for Selective Double-Strand DNA Photocleavage in Hypoxic Tumors: pH-Gated Transitions of Lysine Dipeptides
     Kemal Kaya, Saumya Roy, Juan Carlos Nogues, Juan Camilo Rojas Echeverri, Zlatko Sokolikj, Diego A. R. Zorio, Igor V. Alabugin · 2016 · Journal of Medicinal Chemistry