DNA double-strand break repair: From mechanistic understanding to cancer treatment

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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Instability and decay of the primary structure of DNA

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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The double-strand-break repair model for recombination

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Alu repeats and human genomic diversity

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Brca1 Controls Homology-Directed DNA Repair

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Chromosomal stability and the DNA double-stranded break connection

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Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

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Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle

Rothkamm, K., Krüger, I., Thompson, L. H., & Lübrich, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5706-5715.2003 · Cited by 1,187

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

Ma, Y., Pannicke, U., Schwarz, K., & Lieber, M. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00671-2 · Cited by 1,166

Primary Immunodeficiency Diseases Associated with Neurologic Manifestations

Dehkordy, S. F., Aghamohammadi, A., Ochs, H. D., & Rezaei, N. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-011-9593-8 · Cited by 45

Residual γH2AX foci predict local tumour control after radiotherapy

Koch, U., Höhne, K., von Neubeck, C., Thames, H. D., Yaromina, A., Dahm‐Daphi, J., Baumann, M. A., & Krause, M. (2013) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2013.06.022 · Cited by 43

DNA damage accumulation, defective chromatin organization and deficient DNA repair capacity in patients with rheumatoid arthritis

Souliotis, V. L., Vlachogiannis, N. I., Pappa, M. B., Argyriou, A., & Sfikakis, P. P. (2019) · Clinical Immunology · doi:10.1016/j.clim.2019.03.009 · Cited by 42

Dual PI3K/mTOR Inhibitor NVP-BEZ235 Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Due to Suppressed Double-Strand Break (DSB) Repair by Non-Homologous End Joining

Schötz, U., Balzer, V., Brandt, F.-W., Ziemann, F., Subtil, F. S. B., Rieckmann, T., Köcher, S., Engenhart‐Cabillic, R., Dikomey, E., Wittig, A., et al. (2020) · Cancers · doi:10.3390/cancers12020467 · Cited by 41

Decreased expression of DNA repair genes (XRCC1, ERCC1, ERCC2, and ERCC4) in squamous intraepithelial lesion and invasive squamous cell carcinoma of the cervix

Bajpai, D., Banerjee, A., Pathak, S., Jain, S. K., & Singh, N. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1569-y · Cited by 43

MutS Homologues hMSH4 and hMSH5: Genetic Variations, Functions, and Implications in Human Diseases

Clark, N. C., Wu, X., & Her, C. (2013) · Current Genomics · doi:10.2174/1389202911314020002 · Cited by 38

γH2AX assay in ex vivo irradiated tumour specimens: A novel method to determine tumour radiation sensitivity in patient-derived material

Menegakis, A., von Neubeck, C., Yaromina, A., Thames, H. D., Hering, S., Hennenlotter, J., Scharpf, M. O., Noell, S., Krause, M., Zips, D., et al. (2015) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2015.03.026 · Cited by 42

Residual DNA double strand breaks in perfused but not in unperfused areas determine different radiosensitivity of tumours

Menegakis, A., Eicheler, W., Yaromina, A., Thames, H. D., Krause, M., & Baumann, M. A. (2011) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2011.07.001 · Cited by 41

PARP inhibitor olaparib enhances the efficacy of radiotherapy on XRCC2-deficient colorectal cancer cells

Qin, C., Ji, Z., Zhai, E., Xu, K., Zhang, Y., Li, Q., Jing, H., Wang, X., & Song, X. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04967-7 · Cited by 40

Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks

Hawtin, R. E., Stockett, D. E., Wong, O. K., Lundin, C., Helleday, T., & Fox, J. A. (2010) · Oncotarget · doi:10.18632/oncotarget.195 · Cited by 39

DNA repair of myeloma plasma cells correlates with clinical outcome: the effect of the nonhomologous end-joining inhibitor SCR7

Gkotzamanidou, M. A., Terpos, E., Bamia, C., Munshi, N. C., Dimopoulos, M. A., & Souliotis, V. L. (2016) · Blood · doi:10.1182/blood-2016-01-691618 · Cited by 39

AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway

Lou, J., Chen, H., Han, J., He, H., Huen, M. S. Y., Feng, X., Liu, T., & Huang, J. (2017) · Nature Communications · doi:10.1038/s41467-017-01151-w · Cited by 39

Role of Histone Methylation in Maintenance of Genome Integrity

Mushtaq, A., Mir, U. S., Hunt, C. R., Pandita, S., Tantray, W. W., Bhat, A., PANDITA, R. K., Altaf, M., & Pandita, T. K. (2021) · Genes · doi:10.3390/genes12071000 · Cited by 45

Human cell toxicogenomic analysis of bromoacetic acid: A regulated drinking water disinfection by‐product

Muellner, M. G., Attene‐Ramos, M. S., Hudson, M. E., Wagner, E. D., & Plewa, M. J. (2009) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20530 · Cited by 40

A Genomic Instability Score in Discriminating Nonequivalent Outcomes of BRCA1/2 Mutations and in Predicting Outcomes of Ovarian Cancer Treated with Platinum-Based Chemotherapy

Zhang, S., Yuan, Y., & Hao, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113169 · Cited by 39

Inhibition of DNA damage repair by artificial activation of PARP with siDNA

Croset, A., Cordelières, F. P., Berthault, N., Buhler, C., Sun, J., Quanz, M., & Dutreix, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt522 · Cited by 38

Increased DNA double-strand breaks and enhanced apoptosis in patients with lupus nephritis

Souliotis, V. L., & Sfikakis, P. P. (2014) · Lupus · doi:10.1177/0961203314565413 · Cited by 39

Mechanisms of Cell Killing Response from Low Linear Energy Transfer (LET) Radiation Originating from 177Lu Radioimmunotherapy Targeting Disseminated Intraperitoneal Tumor Xenografts

Yong, K. J., Milenic, D. E., Baidoo, K. E., & Brechbiel, M. W. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050736 · Cited by 38

The genetics of congenitally small brains

Duerinckx, S., & Abramowicz, M. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.09.015 · Cited by 38

The DNA damage repair protein Ku70 interacts with FOXO4 to coordinate a conserved cellular stress response

Brenkman, A. B., van den Broek, N. J. F., de Keizer, P. L. J., van Gent, D. C., & Burgering, B. M. T. (2010) · The FASEB Journal · doi:10.1096/fj.10-158717 · Cited by 41

Characterizing the DNA Damage Response by Cell Tracking Algorithms and Cell Features Classification Using High-Content Time-Lapse Analysis

Georgescu, W., Osseiran, A. I., Rojec, M., Liu, Y., Bombrun, M., Tang, J., & Costes, S. V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129438 · Cited by 36

Gimeracil sensitizes cells to radiation via inhibition of homologous recombination

Takagi, M., Sakata, K., Someya, M., Tauchi, H., Iijima, K., Matsumoto, Y., Torigoe, T., Takahashi, A., Hareyama, M., & Fukushima, M. (2010) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2010.05.020 · Cited by 37

Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2–ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells

Ko, J., Tsai, M., Weng, S., Kuo, Y., Chiu, Y., & Lin, Y. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.07.012 · Cited by 37

The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair

Liao, S., Tammaro, M., & Yan, H. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw274 · Cited by 36

Imatinib Radiosensitizes Bladder Cancer by Targeting Homologous Recombination

Qiao, B., Kerr, M., Grošelj, B., Teo, M. T. W., Knowles, M. A., Bristow, R. G., Phillips, R. M., & Kiltie, A. E. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-1170 · Cited by 37

Mechanism of cell killing after ionizing radiation by a dominant negative DNA polymerase beta

Neijenhuis, S., Verwijs-Janssen, M., Kasten-Pisula, U., Rumping, G., Borgmann, K., Dikomey, E., Begg, A. C., & Vens, C. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.11.008 · Cited by 37

High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation

Parplys, A. C., Seelbach, J. I., Becker, S., Behr, M., Wrona, A., Jend, C., Mansour, W. Y., Joosse, S. A., Stuerzbecher, H.-W., Pospiech, H., et al. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1055996 · Cited by 36

Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination

Sakata, K., Someya, M., Matsumoto, Y., Tauchi, H., Kai, M., Toyota, M., Takagi, M., Hareyama, M., & Fukushima, M. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.02004.x · Cited by 35

Intratumoral Hypoxia as the Genesis of Genetic Instability and Clinical Prognosis in Prostate Cancer

Taiakina, D., Pra, A. D., & Bristow, R. G. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5915-6_9 · Cited by 34

The role of DNA ‐ PK in aging and energy metabolism

Chung, J. H. (2018) · FEBS Journal · doi:10.1111/febs.14410 · Cited by 34

C-Terminal Extensions of Ku70 and Ku80 Differentially Influence DNA End Binding Properties

Inagawa, T., Wennink, T., Lebbink, J. H. G., Keijzers, G., Florea, B. I., Verkaik, N. S., & van Gent, D. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186725 · Cited by 35

Biomarkers for DNA DSB inhibitors and radiotherapy clinical trials

Liu, S. K., Olive, P. L., & Bristow, R. G. (2008) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9137-8 · Cited by 35

Irradiated Esophageal Cells are Protected from Radiation-Induced Recombination by MnSOD Gene Therapy

Niu, Y., Wang, H., Wiktor‐Brown, D. M., Rugo, R. E., Shen, H., Huq, M. S., Engelward, B. P., Epperly, M. W., & Greenberger, J. S. (2010) · Radiation Research · doi:10.1667/rr1763.1 · Cited by 34

PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines

Camero, S., Ceccarelli, S., Felice, F. D., Marampon, F., Mannarino, O., Camicia, L., Vescarelli, E., Pontecorvi, P., Pizer, B. L., Shukla, R., et al. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2774-6 · Cited by 37

DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells

Jeyasekharan, A. D. D., Ayoub, N., Mahen, R., Ries, J., Esposito, A., Rajendra, E., Hattori, H., Kulkarni, R. P., & Venkitaraman, A. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009577107 · Cited by 33

Cdk-mediated phosphorylation of Chk1 is required for efficient activation and full checkpoint proficiency in response to DNA damage

Xu, N., Libertini, S., Black, E. J., Lao, Y., Hégarat, N., Walker, M., & Gillespie, D. A. (2011) · Oncogene · doi:10.1038/onc.2011.310 · Cited by 33

Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair

Lin, H., Ha, K., Lu, G., Fang, X., Cheng, R., Zuo, Q., & Zhang, P. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00233-15 · Cited by 33

Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus

Hollingworth, R., Horniblow, R. D., Forrest, C., Stewart, G. S., & Grand, R. J. A. (2017) · Journal of Virology · doi:10.1128/jvi.00930-17 · Cited by 34

Synthesis, spectroscopic investigation, and DFT study of N , N ′-disubstituted ferrocene-based thiourea complexes as potent anticancer agents

Asghar, F., Fatima, S., Rana, S., Badshah, A., Butler, I. S., & Tahir, M. N. (2017) · Dalton Transactions · doi:10.1039/c7dt04090c · Cited by 33

Heavy ions, radioprotectors and genomic instability: implications for human space exploration

Dziegielewski, J., Goetz, W., & Baulch, J. E. (2009) · Radiation and Environmental Biophysics · doi:10.1007/s00411-009-0261-9 · Cited by 32

Ligase IV Syndrome

Chistiakov, D. A. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6448-9_16 · Cited by 33

ATPase activity tightly regulates RecA nucleofilaments to promote homologous recombination

Zhao, B., Zhang, D., Li, C., Yuan, Z., Yu, F., Zhong, S., Jiang, G., Yang, Y., Le, X. C., Weinfeld, M., et al. (2017) · Cell Discovery · doi:10.1038/celldisc.2016.53 · Cited by 32

Identification of Pleiotropic Cancer Susceptibility Variants from Genome-Wide Association Studies Reveals Functional Characteristics

Wu, Y., Graff, R. E., Passarelli, M. N., Hoffman, J., Ziv, E., Hoffmann, T. J., & Witte, J. S. (2017) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-17-0516 · Cited by 31

Smooth Muscle Phenotype in Idiopathic Pulmonary Hypertension: Hyper-Proliferative but not Cancerous

Perros, F., Sentenac, P., Boulate, D., Manaud, G., Kotsimbos, T. C., Lecerf, F., Lamrani, L., Fadel, É., Mercier, O. M., Londoño‐Vallejo, A., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143575 · Cited by 33

Regulation of DNA Damage Response and Homologous Recombination Repair by microRNA in Human Cells Exposed to Ionizing Radiation

Szatkowska, M., & Krupa, R. (2020) · Cancers · doi:10.3390/cancers12071838 · Cited by 33

Processing of nonconventional DNA strand break ends

Wilson, D. M. (2007) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20346 · Cited by 32

Essential Developmental, Genomic Stability, and Tumour Suppressor Functions of the Mouse Orthologue of hSSB1/NABP2

Shi, W., Bain, A. L., Schwer, B., Al‐Ejeh, F., Smith, C., Wong, L. H., Chai, H., Miranda, M. S., Ho, U. Y., Kawaguchi, M., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003298 · Cited by 31

BCL2-overexpressing prostate cancer cells rely on PARP1-dependent end-joining and are sensitive to combined PARP inhibitor and radiation therapy

Oing, C., Tennstedt, P., Simon, R., Volquardsen, J., Borgmann, K., Bokemeyer, C., Petersen, C., Dikomey, E., Rothkamm, K., & Mansour, W. Y. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.03.007 · Cited by 31

Analysis of illegitimate genomic integration mediated by zinc-finger nucleases: implications for specificity of targeted gene correction

Olsen, P. A., Gelazauskaite, M., Randøl, M., & Krauss, S. J. K. (2010) · BMC Molecular Biology · doi:10.1186/1471-2199-11-35 · Cited by 32

DNA ligase IV as a new molecular target for temozolomide

Kondo, N., Takahashi, A., Mori, E., Ohnishi, K., McKinnon, P. J., Sakaki, T., Nakase, H., & Ohnishi, T. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.045 · Cited by 30

Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1

Bakr, A., Köcher, S., Volquardsen, J., Petersen, C., Borgmann, K., Dikomey, E., Rothkamm, K., & Mansour, W. Y. (2016) · Oncotarget · doi:10.18632/oncotarget.11023 · Cited by 35

Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination

Nagasawa, H., Wilson, P. F., Chen, D. J., Thompson, L. H., Bedford, J. S., & Little, J. B. (2008) · DNA repair · doi:10.1016/j.dnarep.2007.11.014 · Cited by 30

Adeno-Associated Virus Type 2 Modulates the Host DNA Damage Response Induced by Herpes Simplex Virus 1 during Coinfection

Vogel, R., Seyffert, M., Strasser, R., de Oliveira, A. P., Dresch, C., Glauser, D. L., Jolinon, N., Salvetti, A., Weitzman, M. D., Ackermann, M., et al. (2011) · Journal of Virology · doi:10.1128/jvi.05694-11 · Cited by 31

Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice

Bakr, A., Köcher, S., Volquardsen, J., Reimer, R., Borgmann, K., Dikomey, E., Rothkamm, K., & Mansour, W. Y. (2015) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2015.11.001 · Cited by 29

The Rb binding domain of HPV31 E7 is required to maintain high levels of DNA repair factors in infected cells

Johnson, B. A., Aloor, H. L., & Moody, C. A. (2016) · Virology · doi:10.1016/j.virol.2016.09.029 · Cited by 32

Effect of Low Level Subchronic Microwave Radiation on Rat Brain.

Deshmukh, P. S., Megha, K., Nasare, N. V., Banerjee, B. D., Ahmed, R. S., Abegaonkar, M. P., Tripathi, A. K., & Mediratta, P. K. (2016) · PubMed · doi:10.3967/bes2016.115 · Cited by 29

Marker-free genome editing in Ustilago trichophora with the CRISPR-Cas9 technology

Huck, S., Bock, J., Girardello, J., Gauert, M., & Pul, Ü. (2018) · RNA Biology · doi:10.1080/15476286.2018.1493329 · Cited by 30

Radiation resistance of normal human astrocytes: the role of non-homologous end joining DNA repair activity

Bylicky, M. A., Mueller, G. P., & Day, R. M. (2018) · Journal of Radiation Research · doi:10.1093/jrr/rry084 · Cited by 30

Activated or Impaired: An Overview of DNA Repair in Neurodegenerative Diseases

Qin, N., Geng, A., & Xue, R. (2022) · Aging and Disease · doi:10.14336/ad.2021.1212 · Cited by 31

Modification of radiation‐induced DNA double strand break repair pathways by chemicals extracted from Podophyllum hexandrum: An in vitro study in human blood leukocytes

Srivastava, N. N., Shukla, S. K., Yashavarddhan, M. H., Devi, M., Tripathi, R. P., & Gupta, M. L. (2014) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21853 · Cited by 29

Combining Bevacizumab with Radiation or Chemoradiation for Solid Tumors: A Review of the Scientific Rationale, and Clinical Trials

Schmidt, B. H., Lee, H., Ryeom, S. W., & Yoon, S. S. (2012) · Current Angiogenesis · doi:10.2174/2211552811201030169 · Cited by 29

The Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax Controls Forkhead Box O4 Activity through Degradation by the Proteasome

Oteiza, A., & Mechti, N. (2011) · Journal of Virology · doi:10.1128/jvi.00036-11 · Cited by 30

Elevated MRE11 expression associated with progression and poor outcome in prostate cancer

Wang, J., Xu, W., Yu, W., Zhu, Y., Qin, X.-J., Zhang, H., & Ye, D. (2019) · Journal of Cancer · doi:10.7150/jca.31454 · Cited by 29

HSP90 inhibition induces cytotoxicity via down-regulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells

Ko, J., Chen, H.-J., Huang, Y., Tseng, S.-C., Weng, S., Wo, T., Huang, Y., Chiu, H., Tsai, M., Chiou, R. Y. ‐., et al. (2012) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2012.10.003 · Cited by 29

Functions of ADP-ribose transferases in the maintenance of telomere integrity

Muoio, D., Laspata, N., & Fouquerel, E. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04235-z · Cited by 34

The DNA repair function ofCUX1contributes to radioresistance

Ramdzan, Z. M., Ginjala, V., Pinder, J. B., Chung, D., Donovan, C. M., Kaur, S. J., Leduy, L., Dellaire, G., Ganesan, S., & Nepveu, A. (2017) · Oncotarget · doi:10.18632/oncotarget.14875 · Cited by 30

Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC

Liu, X., Wang, Y., Benaissa, S., Matsuda, A., Kantarjian, H. M., Estrov, Z. E., & Plunkett, W. K. (2010) · Blood · doi:10.1182/blood-2009-05-220376 · Cited by 28

To Nick or Not to Nick: Comparison of I-SceI Single- and Double-Strand Break-Induced Recombination in Yeast and Human Cells

Katz, S. S., Gimble, F. S., & Storici, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088840 · Cited by 27

The role of RecQ helicases in non-homologous end-joining

Keijzers, G., Maynard, S., Shamanna, R. A., Rasmussen, L. J., Croteau, D. L., & Bohr, V. A. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2014.942450 · Cited by 26

An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs

Yu, H., Zhao, H., Wang, L., Han, Y., Chen, W. V., Amos, C. I., Rafnar, Þ., Sulem, P., Stefánsson, K., Landi, M. T., et al. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.01.005 · Cited by 28

WRN protects against topo I but not topo II inhibitors by preventing DNA break formation

Christmann, M., Tomicic, M. T., Gestrich, C., Roos, W. P., Bohr, V. A., & Kaina, B. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.08.008 · Cited by 27

Parp Inhibitors and Radiotherapy: A New Combination for Prostate Cancer (Systematic Review)

BELENCHON, I. R., Ruiz, C. B. C., Sáez, C., Osmán-García, I., & López, R. A. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612978 · Cited by 30

MutS homologue hMSH5: role in cisplatin-induced DNA damage response

Tompkins, J. D., Wu, X., & Her, C. (2012) · Molecular Cancer · doi:10.1186/1476-4598-11-10 · Cited by 27

Association of single nucleotide polymorphisms of nucleotide excision repair genes with laryngeal cancer risk and interaction with cigarette smoking and alcohol drinking

Li, X., Xu, J., Yang, X., Wu, Y., Cheng, B., Chen, D., & Bai, B. (2014) · Tumor Biology · doi:10.1007/s13277-014-1610-0 · Cited by 26

Differential Requirement for SUB1 in Chromosomal and Plasmid Double-Strand DNA Break Repair

Yu, L., & Volkert, M. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058015 · Cited by 26

Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair

Kelm, J. M., Samarbakhsh, A., Pillai, A., VanderVere-Carozza, P. S., Aruri, H., Pandey, D. S., Pawelczak, K. S., Turchi, J. J., & Gavande, N. S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.850883 · Cited by 27

Molecular basis for DNA strand displacement by NHEJ repair polymerases

Bartlett, E. J., Brissett, N. C., Płociński, P., Carlberg, T., & Doherty, A. J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv965 · Cited by 26

Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: a retrospective cohort study of the Eastern Cooperative Oncology Group

Yoon, H. H., Catalano, P. J., Murphy, K. M., Skaar, T. C., Philips, S., Powell, M. E., Montgomery, E. A., Hafez, M. J., Offer, S. M., Liu, G., et al. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-176 · Cited by 26

Genomic Instability in Chronic Myeloid Leukemia: Targets for Therapy?

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Influence of homologous recombinational repair on cell survival and chromosomal aberration induction during the cell cycle in γ-irradiated CHO cells

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DNA Damage-Response Pathway Heterogeneity of Human Lung Cancer A549 and H1299 Cells Determines Sensitivity to 8-Chloro-Adenosine

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LIG4 syndrome: clinical and molecular characterization in a Chinese cohort

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ATR-p53 Restricts Homologous Recombination in Response to Replicative Stress but Does Not Limit DNA Interstrand Crosslink Repair in Lung Cancer Cells

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NRAGE is involved in homologous recombination repair to resist the DNA-damaging chemotherapy and composes a ternary complex with RNF8–BARD1 to promote cell survival in squamous esophageal tumorigenesis

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MYB regulates the DNA damage response and components of the homology-directed repair pathway in human estrogen receptor-positive breast cancer cells

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Correlation between gene expression and mutator phenotype predicts homologous recombination deficiency and outcome in ovarian cancer

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DNA Repair: Exploiting the Fanconi Anemia Pathway As a Potential Therapeutic Target

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Ionizing radiation and genetic risks. XVII. Formation mechanisms underlying naturally occurring DNA deletions in the human genome and their potential relevance for bridging the gap between induced DNA double-strand breaks and deletions in irradiated germ cells

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EAF2 regulates DNA repair through Ku70/Ku80 in the prostate

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Advances in Delivery Vectors for Gene Therapy in Liver Cancer

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XRCC4 controls nuclear import and distribution of Ligase IV and exchanges faster at damaged DNA in complex with Ligase IV

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Effect of ganglioside GT1b on the in vitro maturation of porcine oocytes and embryonic development

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BLM and RAD51 Genes Polymorphism and Susceptibility to Breast Cancer

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CREB-Binding Protein Regulates Ku70 Acetylation in Response to Ionization Radiation in Neuroblastoma

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Polymorphisms of DNA repair genes are related to the pathogenesis of myelodysplastic syndrome

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XRCC 3 is a promising target to improve the radiotherapy effect of esophageal squamous cell carcinoma

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Research progress in the radioprotective effect of superoxide dismutase

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Rotavirus activates a noncanonical ATM‐Chk2 branch of DNA damage response during infection to positively regulate viroplasm dynamics

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Second-Generation Antiandrogen Therapy Radiosensitizes Prostate Cancer Regardless of Castration State through Inhibition of DNA Double Strand Break Repair

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Characterization of the Holliday Junction Resolving Enzyme Encoded by the Bacillus subtilis Bacteriophage SPP1

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Sensing and repairing DNA double-strand breaks

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Wenn Stränge reißen – Wege der DNA-Doppelstrangbruch-Reparatur

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DNA Double Strand Break Repair: Mechanisms and Therapeutic Potential

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Chemotherapeutic Compounds Targeting the DNA Double-Strand Break Repair Pathways: The Good, the Bad, and the Promising

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