Common mechanisms of PIKK regulation

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,304

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

Gottlieb, T. M., & Jackson, S. P. (1993) · Cell · doi:10.1016/0092-8674(93)90057-w · Cited by 1,233

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

Walker, J. R., Corpina, R. A., & Goldberg, J. D. (2001) · Nature · doi:10.1038/35088000 · Cited by 1,216

Targeting the ATM pathway in cancer: Opportunities, challenges and personalized therapeutic strategies

Lee, J. (2024) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2024.102808 · Cited by 50

The mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA

Choe, J., Ahn, S. H., & Kim, Y. K. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku610 · Cited by 43

Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2

Izumi, N., Yamashita, A., & Ohno, S. (2012) · Nucleus · doi:10.4161/nucl.18926 · Cited by 48

Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents

Min, J., Guo, K., Suryadevara, P. K., Zhu, F., Holbrook, G., Chen, Y., Féau, C., Young, B. M., Lemoff, A. S., Connelly, M., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01092 · Cited by 42

Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells

Faulhaber, E.-M., Jost, T., Symank, J., Scheper, J., Bürkel, F., Fietkau, R., Hecht, M., & Distel, L. V. (2021) · Genes · doi:10.3390/genes12060925 · Cited by 39

Molecular mechanisms involved in DNA repair in human cancers: An overview of PI3k/Akt signaling and PIKKs crosstalk

Alemi, F., Sadigh, A. R., Malakoti, F., Elhaei, Y., Ghaffari, S. H., Maleki, M., Asemi, Z., Yousefi, B., Targhazeh, N., & Majidinia, M. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30573 · Cited by 42

Disruption of Serine/Threonine Protein Phosphatase 5 (PP5:PPP5c) in Mice Reveals a Novel Role for PP5 in the Regulation of Ultraviolet Light-induced Phosphorylation of Serine/Threonine Protein Kinase Chk1 (CHEK1)

Amable, L., Grankvist, N., Largen, J. W., Ortsäter, H., Sjöholm, Å., & Honkanen, R. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.244053 · Cited by 41

DNA–dependent protein kinase in telomere maintenance and protection

Sui, J.-D., Zhang, S., & Chen, B. P. C. (2020) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-020-0199-0 · Cited by 39

Molecular targets that sensitize cancer to radiation killing: From the bench to the bedside

Sriramulu, S., Thoidingjam, S., Brown, S. L., Siddiqui, F., Movsas, B., & Nyati, S. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114126 · Cited by 39

Mechanism of auto-inhibition and activation of Mec1ATR checkpoint kinase

Tannous, E., Yates, L. A., Zhang, X., & Burgers, P. (2020) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-00522-0 · Cited by 35

TORC2 Is Required to Maintain Genome Stability during S Phase in Fission Yeast

Schonbrun, M., Kolesnikov, M., Kupiec, M., & Weisman, R. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.464974 · Cited by 36

Inhibition of Wee1 sensitizes AML cells to ATR inhibitor VE-822-induced DNA damage and apoptosis

Qi, W., Xu, X., Wang, M., Li, X., Wang, C., Sun, L., Zhao, D., & Sun, L. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.04.022 · Cited by 37

The distinctive cellular responses to DNA strand breaks caused by a DNA topoisomerase I poison in conjunction with DNA replication and RNA transcription

Sakasai, R., & Iwabuchi, K. (2015) · Genes & Genetic Systems · doi:10.1266/ggs.15-00023 · Cited by 34

The Connection Between Cell Fate and Telomere

Engin, A. B., & Engin, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-49844-3_3 · Cited by 39

Mec1ATR Autophosphorylation and Ddc2ATRIP Phosphorylation Regulates DNA Damage Checkpoint Signaling

Memişoğlu, G., Lanz, M. C., Eapen, V. V., Jordan, J. M., Lee, K., Smolka, M. B., & Haber, J. E. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.068 · Cited by 33

Structural basis of allosteric regulation of Tel1/ATM kinase

Xin, J., Xu, Z., Wang, X., Tian, Y., Zhang, Z., & Cai, G. (2019) · Cell Research · doi:10.1038/s41422-019-0176-1 · Cited by 34

Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR

Baretić, D., de Oliveira, T. M., Nieß, M., Wan, P., Pollard, H., Johnson, C. M., Truman, C., McCall, E. J., Fisher, D. I., Williams, R., et al. (2019) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2019.06.003 · Cited by 33

Signaling pathways that control mRNA turnover

Thapar, R., & Denmon, A. P. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.03.026 · Cited by 32

ATM Modulates Nuclear Mechanics by Regulating Lamin A Levels

Shah, P., McGuigan, C. W., Cheng, S., Vanpouille‐Box, C., Demaria, S., Weiss, R. S., & Lammerding, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.875132 · Cited by 33

mEAK-7 Forms an Alternative mTOR Complex with DNA-PKcs in Human Cancer

Nguyen, J. T., Haidar, F., Fox, A. L., Ray, C., Mendonça, D. B. S., Kim, J. K., & Krebsbach, P. H. (2019) · iScience · doi:10.1016/j.isci.2019.06.029 · Cited by 30

Adeno-Associated Virus Type 2 Modulates the Host DNA Damage Response Induced by Herpes Simplex Virus 1 during Coinfection

Vogel, R., Seyffert, M., Strasser, R., de Oliveira, A. P., Dresch, C., Glauser, D. L., Jolinon, N., Salvetti, A., Weitzman, M. D., Ackermann, M., et al. (2011) · Journal of Virology · doi:10.1128/jvi.05694-11 · Cited by 31

Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens

Black, J. A., Crouch, K., Lemgruber, L., Lapsley, C. T., Dickens, N. J., Tosi, L. R. O., Mottram, J. C., & McCulloch, R. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.049 · Cited by 29

ATR signaling in mammalian meiosis: From upstream scaffolds to downstream signaling

Pereira, C., Smolka, M. B., Weiss, R. S., & Brieño‐Enríquez, M. A. (2020) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22401 · Cited by 26

Analysis of Individual Molecular Events of DNA Damage Response by Flow- and Image-Assisted Cytometry

Darżynkiewicz, Z., Traganos, F., Zhao, H. L., Halicka, H. D., Skommer, J., & Włodkowic, D. (2011) · Methods in cell biology · doi:10.1016/b978-0-12-385493-3.00006-1 · Cited by 27

The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair

Li, M., Lin, Y., Palchik, G. A., Matsunaga, S., Wang, D., & Chen, B. P. C. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.08.019 · Cited by 27

Environmental signaling through the mechanistic target of rapamycin complex 1

Workman, J. J., Chen, H., & Laribee, R. N. (2014) · Cell Cycle · doi:10.4161/cc.28112 · Cited by 27

PI3K inhibitors as novel cancer therapies: implications for cardiovascular medicine.

McLean, B. A., Zhabyeyev, P., Pituskin, E., Paterson, I., Haykowsky, M., & Oudit, G. Y. (2013) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2013.02.005 · Cited by 28

Versatility of the Mec1ATM/ATR signaling network in mediating resistance to replication, genotoxic, and proteotoxic stresses

Córcoles-Sáez, I., Dong, K., & Rita, S. (2019) · Current Genetics · doi:10.1007/s00294-018-0920-y · Cited by 25

Sin1-mediated mTOR signaling in cell growth, metabolism and immune response

Ruan, C., Ouyang, X., Liu, H., Li, S., Jin, J., Tang, W., Xia, Y., & Su, B. (2019) · National Science Review · doi:10.1093/nsr/nwz171 · Cited by 26

Activation of NF-κB by Human Papillomavirus 16 E1 Limits E1-Dependent Viral Replication through Degradation of E1

Nakahara, T., Tanaka, K., Ohno, S., Egawa, N., Yugawa, T., & Kiyono, T. (2015) · Journal of Virology · doi:10.1128/jvi.00389-15 · Cited by 25

Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair

Gavish-Izakson, M., Velpula, B. B., Elkon, R., Prados‐Carvajal, R., Barnabas, G. D., Ugalde, A. P., Agami, R., Geiger, T., Huertas, P., Ziv, Y., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1240 · Cited by 26

The circular RNA Ataxia Telangiectasia Mutated regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms

Fasolo, F., Winski, G., Li, Z. A., Wu, Z., Winter, H., Ritzer, J., Glukha, N., Roy, J., Hultgren, R., Pauli, J., et al. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.08.017 · Cited by 24

DNA‐PKcs and ATM modulate mitochondrial ADP‐ATP exchange as an oxidative stress checkpoint mechanism

Chen, W., Chiang, J., Shang, Z., Palchik, G. A., Newman, C., Zhang, Y., Davis, A. J., Lee, H., & Chen, B. P. C. (2023) · The EMBO Journal · doi:10.15252/embj.2022112094 · Cited by 22

Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy

McFaline‐Figueroa, J. L., Srivatsan, S. R., Hill, A. J., Gasperini, M. J., Jackson, D. L., Saunders, L. M., Domcke, S., Regalado, S. G., Lazarchuck, P., Alvarez, S., et al. (2024) · Cell Genomics · doi:10.1016/j.xgen.2023.100487 · Cited by 25

PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway

Lin, Y., Shih, H.-Y., Shang, Z., Kuo, C., Guo, J., Du, C., Lee, H., & Chen, B. P. C. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1298 · Cited by 23

In-Depth Quantitative Proteomic Analysis of Trophozoites and Pseudocysts of Trichomonas vaginalis

Dias-Lopes, G., Wiśniewski, J. R., Pinho, N., Vidal, V. E., Padrón, G., Britto, C., Cuervo, P., & de Jesus, J. B. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00343 · Cited by 24

The Cell Cycle

Yang, V. W. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00008-6 · Cited by 24

All Stressed Out Without ATM Kinase

Perry, J. J. P., & Tainer, J. A. (2011) · Science Signaling · doi:10.1126/scisignal.2001961 · Cited by 22

Genetic Evidence Links the ASTRA Protein Chaperone Component Tti2 to the SAGA Transcription Factor Tra1

Genereaux, J. L., Kvas, S., Dobransky, D., Karagiannis, J., Gloor, G. B., & Brandl, C. J. (2012) · Genetics · doi:10.1534/genetics.112.140459 · Cited by 22

Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response

Hoffman, K. S., Duennwald, M. L., Karagiannis, J., Genereaux, J. L., McCarton, A. S., & Brandl, C. J. (2016) · G3 Genes Genomes Genetics · doi:10.1534/g3.116.029520 · Cited by 22

TGF beta promotes repair of bulky DNA damage through increased ERCC1/XPF and ERCC1/XPA interaction

Zheng, H., Jarvis, I. W. H., Bottai, M., Dreij, K., & Stenius, U. (2018) · Carcinogenesis · doi:10.1093/carcin/bgy156 · Cited by 22

Phosphoproteomics of ATR signaling in mouse testes

Sims, J. R., Faça, V. M., Pereira, C., Ascenção, C., Comstock, W., Badar, J., Arroyo-Martinez, G. A., Freire, R., Cohen, P. E., Weiss, R. S., et al. (2021) · eLife · doi:10.7554/elife.68648 · Cited by 18

Genome instability: Linking ageing and brain degeneration

Barzilai, A., Schumacher, B., & Shiloh, Y. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.03.011 · Cited by 22

Impact of histone H4K16 acetylation on the meiotic recombination checkpoint in Saccharomyces cerevisiae

Cavero, S. C., Herruzo, E., Ontoso, D., & San-Segundo, P. A. (2016) · Microbial Cell · doi:10.15698/mic2016.12.548 · Cited by 20

Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan

Abusanad, A. M., Wang, Y., Hasheminasab, F., Panasci, J., Noë, A., Rosca, L., Davidson, D. L., Amrein, L., Sharif-Askari, B., Aloyz, R. S., et al. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00147 · Cited by 20

Transcriptomic analysis reveals differentially expressed genes and a unique apoptosis pathway in channel catfish ovary cells after infection with the channel catfish virus

Dawar, F. U., Hu, X., Zhao, L., Dong, X., Xiong, Y., Zhou, M., Liang, R., Babu, V. S., Li, J., Mei, J., et al. (2017) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2017.09.070 · Cited by 20

The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage Response

Imran, S. A. M., Yazid, M. D., Cui, W., & Lokanathan, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189900 · Cited by 19

ATM phosphorylates the FATC domain of DNA-PKcs at threonine 4102 to promote non-homologous end joining

Lu, H., Zhang, Q., Laverty, D. J., Puncheon, A. C., Augustine, M. M., Williams, G. J., Nagel, Z. D., Chen, B. P. C., & Davis, A. J. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad505 · Cited by 19

Discovery of a Meisoindigo-Derived PROTAC as the ATM Degrader: Revolutionizing Colorectal Cancer Therapy via Synthetic Lethality with ATR Inhibitors

Liu, T., Wang, Q., Zhou, Y., Ye, B., Liu, T., Yan, L., Fan, J., Xu, J., Zhou, Y., Xia, Z., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00454 · Cited by 21

NMR- and Circular Dichroism-monitored Lipid Binding Studies Suggest a General Role for the FATC Domain as Membrane Anchor of Phosphatidylinositol 3-Kinase-related Kinases (PIKK)

Sommer, L. A. M., Schaad, M., & Dames, S. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.467233 · Cited by 22

Lasiokaurin derivatives: synthesis, antimicrobial and antitumor biological evaluation, and apoptosis-inducing effects

Li, D., Hu, P., Xu, S., Fang, C.-Y., Tang, S., Wang, X., Sun, X., Li, H., Xu, Y., Gu, X., et al. (2017) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0867-9 · Cited by 19

The ATM protein: The importance of being active

Shiloh, Y., & Ziv, Y. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201207063 · Cited by 19

Phosphorylation Sites Identified in the NEIL1 DNA Glycosylase Are Potential Targets for the JNK1 Kinase

Prakash, A., Cao, V. B., & Doublié, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157860 · Cited by 18

Dysfunction of cerebellar microglia in Ataxia‐telangiectasia

Levi, H., Bar, E., Cohen‐Adiv, S., Sweitat, S., Kanner, S., Galron, R., Mitiagin, Y., & Barzilai, A. (2021) · Glia · doi:10.1002/glia.24122 · Cited by 19

High Dosage Lithium Treatment Induces DNA Damage and p57Kip2 Decrease

Stampone, E., Bencivenga, D., Barone, C., Aulitto, A., Verace, F., Ragione, F. D., & Borriello, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031169 · Cited by 18

Tel1 kinase butterfly symmetric dimer

Xin, J. (2019) · Worldwide Protein Data Bank · doi:10.2210/pdb6jxc/pdb · Cited by 19

Structure and function of the apical PIKKs in double-strand break repair

Xu, J., Bradley, N. P., & He, Y. (2023) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2023.102651 · Cited by 15

Effective Radiosensitization of HNSCC Cell Lines by DNA-PKcs Inhibitor AZD7648 and PARP Inhibitors Talazoparib and Niraparib

Mentzel, J., Hildebrand, L. S., Kuhlmann, L., Fietkau, R., & Distel, L. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115629 · Cited by 17

A new in vitro system for activating the cell cycle checkpoint

Wang, J., Engle, S. E., & Zhang, Y. (2011) · Cell Cycle · doi:10.4161/cc.10.3.14753 · Cited by 17

Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting

Cicco, M. D., Rahim, M. S. A., & Dames, S. A. (2015) · Membranes · doi:10.3390/membranes5040553 · Cited by 19

The canonical non-homologous end joining factor XLF promotes chromosomal deletion rearrangements in human cells

Bhargava, R., Lopezcolorado, F. W., Tsai, L. J., & Stark, J. M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010421 · Cited by 16

The Role for the DSB Response Pathway in Regulating Chromosome Translocations

Ghosh, R., Das, D., & Franco, S. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-0593-1_6 · Cited by 16

The Pseudokinase Domain of Saccharomyces cerevisiae Tra1 Is Required for Nuclear Localization and Incorporation into the SAGA and NuA4 Complexes

Berg, M. D., Genereaux, J. L., Karagiannis, J., & Brandl, C. J. (2018) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200288 · Cited by 16

Structure and Assembly of the PI3K-like Protein Kinases (PIKKs) Revealed by Electron Microscopy

Rivera-Calzada, Á., López‐Perrote, A., Melero, R., Boskovic, J., Muñoz-Hernández, H., Martino, F., & Llorca, Ó. (2015) · AIMS Biophysics · doi:10.3934/biophy.2015.2.36 · Cited by 17

FBXO31: A New Player in the Ever-Expanding DNA Damage Response Orchestra

Shiloh, Y. (2009) · Science Signaling · doi:10.1126/scisignal.296pe73 · Cited by 15

ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in Trypanosoma brucei

Marín, P. M., Obonaga, R., Pavani, R., da Silva, M. S., de Araujo, C. B., Lima, A. A., Avila, C. C., Cestari, I. D. S., Machado, C. R., & Elias, M. C. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.602956 · Cited by 15

c‑Abl‑mediated tyrosine phosphorylation of DNA damage response proteins and implications in important cellular functions (Review)

Bohio, A. A., Wang, R., Zeng, X., & Ba, X. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11156 · Cited by 15

Analysis of Mutations That Dissociate G2 and Essential S Phase Functions of Human Ataxia Telangiectasia-mutated and Rad3-related (ATR) Protein Kinase

Nam, E. A., Zhao, R., & Cortez, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.276113 · Cited by 13

The loss of the BH3-only Bcl-2 family member Bid delays T-cell leukemogenesis in Atm−/− mice

Biswas, S., Shi, Q., Wernick, A., Aiello, A., & Zinkel, S. S. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.16 · Cited by 14

DNA repair inhibitors to enhance radiotherapy: Progresses and limitations

Ferreira, S., & Dutreix, M. (2019) · Cancer/Radiothérapie · doi:10.1016/j.canrad.2019.08.008 · Cited by 14

Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas

Burrows, N., Williams, J., Telfer, B. A., Resch, J., Valentine, H. R., Fitzmaurice, R. J., Eustace, A., Irlam, J. J., Rowling, E. J., Hoang‐Vu, C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11056 · Cited by 13

Cell context-dependent involvement of ATR in early stages of retroviral replication

Yang, Y., Guen, V. J., Richard, J., Cohen, É. A., & Berthoux, L. (2009) · Virology · doi:10.1016/j.virol.2009.10.032 · Cited by 14

Caffeine stabilizes Cdc 25 independently of Rad 3 in S chizosaccharomyces pombe contributing to checkpoint override

Alao, J. P., Sjölander, J. J., Baar, J., Özbaki‐Yagan, N., Kakoschky, B., & Sunnerhagen, P. (2014) · Molecular Microbiology · doi:10.1111/mmi.12592 · Cited by 12

Studying the cerebellar DNA damage response in the tissue culture dish

Tzur-Gilat, A., Ziv, Y., Mittelman, L. A., Barzilai, A., & Shiloh, Y. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.04.001 · Cited by 12

Murine polyomavirus DNA transitions through spatially distinct nuclear replication subdomains during infection

Peters, D. K., & Garcea, R. L. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008403 · Cited by 11

Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM)

Tannous, E., & Burgers, P. (2021) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2021.1925218 · Cited by 11

The SAGA and NuA4 component Tra1 regulates Candida albicans drug resistance and pathogenesis

Razzaq, I., Berg, M. D., Jiang, Y., Genereaux, J. L., Uthayakumar, D., Kim, G. H., Agyare-Tabbi, M. R., Halder, V., Brandl, C. J., Lajoie, P., et al. (2021) · Genetics · doi:10.1093/genetics/iyab131 · Cited by 9

CC-115, a Dual Mammalian Target of Rapamycin/DNA-Dependent Protein Kinase Inhibitor in Clinical Trial, Is a Substrate of ATP-Binding Cassette G2, a Risk Factor for CC-115 Resistance

Beebe, J., & Zhang, J. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.258392 · Cited by 11

Energy-Sensing Pathways in Ischemia: The Counterbalance Between AMPK and mTORC

Céspedes-Rubio, Á. E., Villa, M., Benito‐Cuesta, I., Pérez-Álvarez, M. J., Ordóñez‐Gutiérrez, L., & Wandosell, F. G. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191210152156 · Cited by 11

The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect

Hewitt, S. L., Wong, J. B., Lee, J., Nishana, M., Chen, H., Coussens, M., Arnal, S. M., Blumenberg, L. M., Roth, D. B., Paull, T. T., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.084 · Cited by 11

ATM and ATR checkpoint kinase pathways: A concise review

Chauhan, N., Wagh, V., Joshi, P., & Jariyal, H. (2020) · Advances in Human Biology · doi:10.4103/aihb.aihb_78_19 · Cited by 9

Methyleugenol and selected oxidative metabolites affect DNA-Damage signalling pathways and induce apoptosis in human colon tumour HT29 cells

Groh, I. A. M., & Esselen, M. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.08.014 · Cited by 10

Different Impacts of DNA-PK and mTOR Kinase Inhibitors in Combination with Ionizing Radiation on HNSCC and Normal Tissue Cells

Klieber, N., Hildebrand, L. S., Faulhaber, E.-M., Symank, J., Häck, N., Härtl, A., Fietkau, R., & Distel, L. V. (2024) · Cells · doi:10.3390/cells13040304 · Cited by 9

Current state of mTOR targeting in human breast cancer.

Wazir, U., Wazir, A., Khanzada, Z. S., Jiang, W. G., Sharma, A. K., & Mokbel, K. (2014) · PubMed · Cited by 9

The C-terminal Residues ofSaccharomyces cerevisiaeMec1 Are Required for Its Localization, Stability, and Function

DaSilva, L. F., Pillon, S. A., Genereaux, J. L., Davey, M. J., Gloor, G. B., Karagiannis, J., & Brandl, C. J. (2013) · G3 Genes Genomes Genetics · doi:10.1534/g3.113.006841 · Cited by 9

TTT and PIKK Complex Genes Reverted to Single Copy Following Polyploidization and Retain Function Despite Massive Retrotransposition in Maize

Garcia, N., & Messing, J. W. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01723 · Cited by 8

A quantitative description of the peptide sharing between poliovirus and Homo sapiens

Novello, G., Capone, G., Fasano, C., Bavaro, S. L., Polito, A. N., & Kanduc, D. (2011) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2011.608360 · Cited by 8

The molecular crosstalk between innate immunity and DNA damage repair/response: Interactions and effects in cancers

Omidvar, S., Vahedian, V., Sourani, Z., Yari, D., Asadi, M., Jafari, N., Khodavirdilou, L., Bagherieh, M., Shirzad, M., & Hosseini, V. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155405 · Cited by 9

Recent Advances in ATM Inhibitors As Potential Therapeutic Agents

Dong, C., Wang, Y., Tu, Z., Yan, J., Jiang, Y., Lu, T., Chen, Y., & Liu, H. (2022) · Future Medicinal Chemistry · doi:10.4155/fmc-2022-0252 · Cited by 8

Signalling DNA Damage

Joaquin, A., & Fernández-Capetillo, Ó. (2012) · InTech eBooks · doi:10.5772/50863 · Cited by 14

R2TP/PAQosome as a promising chemotherapeutic target in cancer

Kakihara, Y., Kiguchi, T., Ohazama, A., & Saeki, M. (2019) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2019.08.001 · Cited by 9

A TRilogy of ATR’s Non-Canonical Roles Throughout the Cell Cycle and Its Relation to Cancer

Joo, Y. K., Ramírez, C. D., & Kabeche, L. (2024) · Cancers · doi:10.3390/cancers16203536 · Cited by 8

ATM in immunobiology: From lymphocyte development to cancer immunotherapy

Lee, J. (2025) · Translational Oncology · doi:10.1016/j.tranon.2024.102268 · Cited by 8

Caffeine Stabilises Fission Yeast Wee1 in a Rad24-Dependent Manner but Attenuates Its Expression in Response to DNA Damage

Alao, J. P., Johansson-Sjölander, J., Rallis, C., & Sunnerhagen, P. (2020) · Microorganisms · doi:10.3390/microorganisms8101512 · Cited by 7

AZD1390, an Ataxia telangiectasia mutated inhibitor, enhances cisplatin mediated apoptosis in breast cancer cells

ÖZDEMİR, D., & Ağca, C. A. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114382 · Cited by 7

Class I PI3-kinase or Akt inhibition do not impair axonal polarization, but slow down axonal elongation

Díez, H., Benitez, M. J., Fernández, S., Torres‐Alemán, I., Garrido, J. J., & Wandosell, F. G. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.07.002 · Cited by 9

Characterization of SMG7 14-3-3-like domain reveals phosphoserine binding-independent regulation of p53 and UPF1

Cowen, L. E., Luo, H., & Tang, Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-49229-3 · Cited by 8

Caffeine as a tool for investigating the integration of Cdc25 phosphorylation, activity and ubiquitin-dependent degradation in Schizosaccharomyces pombe

Alao, J. P., & Sunnerhagen, P. (2020) · Cell Division · doi:10.1186/s13008-020-00066-1 · Cited by 7

ATM-Dependent Phosphorylation of Hepatitis B Core Protein in Response to Genotoxic Stress

Lubyová, B., Tikalová, E., Krulova, K., Hodek, J., Zábranský, A., Hirsch, I., & Weber, J. (2021) · Viruses · doi:10.3390/v13122438 · Cited by 7

A multi‐organ analysis of the role of mTOR in fetal alcohol spectrum disorders

Carabulea, A. L., Janeski, J. D., Naik, V. D., Chen, K., Mor, G., & Ramadoss, J. (2023) · The FASEB Journal · doi:10.1096/fj.202201865r · Cited by 7

PI 3-kinase related kinases: ?big? players in stress-induced signaling pathways

Abraham, R. T. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.04.002 · Cited by 461

The PIKK Family of Protein Kinases

Smith, G. C. M., & Jackson, S. P. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00077-2 · Cited by 7

It takes three to the DNA damage response tango

Schlam‐Babayov, S., Ziv, Y., & Shiloh, Y. (2021) · Molecular & Cellular Oncology · doi:10.1080/23723556.2021.1881395 · Cited by 7

DNA Damage Checkpoint Response

(2008) · Springer eBooks · doi:10.1007/978-1-4020-6754-9_4633

Phosphoproteomics reveals novel modes of function and inter‐relationships among PIKKs in response to genotoxic stress

Schlam‐Babayov, S., Bensimon, A., Harel, M., Geiger, T., Aebersold, R. H., Ziv, Y., & Shiloh, Y. (2020) · The EMBO Journal · doi:10.15252/embj.2020104400 · Cited by 48