Common mechanisms of PIKK regulation

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,304

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

Gottlieb, T. M., & Jackson, S. P. (1993) · Cell · doi:10.1016/0092-8674(93)90057-w · Cited by 1,233

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

Walker, J. R., Corpina, R. A., & Goldberg, J. D. (2001) · Nature · doi:10.1038/35088000 · Cited by 1,216

Studies of ATM Kinase Activity Using Engineered ATM Sensitive to ATP Analogues (ATM-AS)

Enari, M., Matsushima‐Hibiya, Y., Miyazaki, M., & Otomo, R. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6955-5_11 · Cited by 6

Involvement of Atm and Trp53 in neural cell loss due to Terf2 inactivation during mouse brain development

Kim, J., Choi, I., & Lee, Y. (2017) · Histochemistry and Cell Biology · doi:10.1007/s00418-017-1591-3 · Cited by 6

The post translational modification of key regulators of ATR signaling in DNA replication

Chen, Y., & Yuan, J. (2021) · Genome Instability & Disease · doi:10.1007/s42764-021-00036-z · Cited by 6

NMR– and MD simulation–based structural characterization of the membrane-associating FATC domain of ataxia telangiectasia mutated

Rahim, M. S. A., Cherniavskyi, Y. K., Tieleman, D. P., & Dames, S. A. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.007653 · Cited by 6

Functional role of ATM in the cellular response to DNA damage

Liu, M., & Hu, W. (2010) · Frontiers of Chemical Science and Engineering · doi:10.1007/s11705-009-0268-4 · Cited by 6

Ataxia telangiectasia mutated (ATM) kinase as a predictive biomarker in clinical oncology: implications for a precision treatment approach

Pham, A. T., Yuan, F., Nagathihalli, N. S., & Dosch, A. R. (2026) · Neoplasia · doi:10.1016/j.neo.2026.101309 · Cited by 5

Leucine zipper and ICAT domain containing (LZIC) protein regulates cell cycle transitions in response to ionizing radiation

Skalka, G., Hall, H., Somers, J., Bushell, M., Willis, A. E., & Malewicz, M. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1601476 · Cited by 6

Structural insights into nonsense-mediated mRNA decay (NMD) by electron microscopy

Llorca, Ó. (2012) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2012.10.004 · Cited by 5

The activation mechanisms of master kinases in the DNA damage response

Xiao, J., Rao, Q., & Xu, Y. (2021) · Genome Instability & Disease · doi:10.1007/s42764-021-00045-y · Cited by 5

Involvement of a coumarin analog AD-013 in the DNA damage response pathways in MCF-7 cells

Długosz-Pokorska, A., Drogosz-Stachowicz, J., Deredas, D., Janecki, T., & Janecka, A. E. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4271-z · Cited by 4

The dichotomous effects of caffeine on homologous recombination in mammalian cells

Magwood, A. C., Mundia, M. M., Pladwig, S., Mosser, D. D., & Baker, M. D. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102805 · Cited by 4

Aging and Protein Kinases

Engin, A. B., & Engin, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-49844-3_2 · Cited by 4

The PCI domains are “winged” HEAT domains

Paul, E. E., & Marintchev, A. (2022) · PLOS ONE · doi:10.1371/journal.pone.0268664 · Cited by 4

NFBD1/MDC1: DNA damage response, cell cycle regulation and carcinogenesis

Ozaki, T., Bu, Y., & Nagase, H. (2015) · Cancer Research Frontiers · doi:10.17980/2015.49 · Cited by 5

The Myotubularin Related Proteins and the Untapped Interaction Potential of Their Disordered C‐Terminal Regions

Saar, D., Lennartsson, C., Weidner, P., Burgermeister, E., & Kragelund, B. B. (2024) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.26774 · Cited by 3

Everolimus in the Treatment of Neuroendocrine Tumors of the Respiratory and Gastroenteropancreatic Systems

Flaum, N., Valle, J. W., Mansoor, W., & McNamara, M. G. (2016) · Future Oncology · doi:10.2217/fon.16.23 · Cited by 3

Role of Quercetin in DNA Repair and Dysregulated Metabolism. Possible Target to Combat Drug Resistance in Cancer

Alam, W., Ali, A., Khan, F., Martins, A. M. C., Hussain, Y., & Khan, H. Z. (2022) · Phytonutrients · doi:10.62368/pn.v1i01.11 · Cited by 3

Phenotypic Analysis of ATM Protein Kinase in DNA Double-Strand Break Formation and Repair

Mian, E., & Wiesmüller, L. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6955-5_23 · Cited by 3

AGC Kinases in mTOR Signaling

Jacinto, E. (2010) · The Enzymes · doi:10.1016/s1874-6047(10)27007-5 · Cited by 3

Ataxia-Telangiectasia and Nijmegen Breakage Syndrome

Kobayashi, J. (2018) · Springer eBooks · doi:10.1007/978-981-10-6722-8_13 · Cited by 3

Editorial: Meiosis: From Molecular Basis to Medicine

Li, W., Zhang, L., Shinohara, A., & Keeney, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.812292 · Cited by 3

Inhibition of ATR Reverses a Mitochondrial Respiratory Insufficiency

Borror, M. B., Girotti, M., Kar, A., Cain, M. K., Gao, X., MacKay, V. L., Herron, B., Bhaskaran, S., Becerra, S. C., Novy, N., et al. (2022) · Cells · doi:10.3390/cells11111731 · Cited by 2

Control of embryo size by inositol phosphate signaling revealed by big embryo mutants of maize

Suzuki, M., Wu, S., Sato, Y., Jones, N. T., & McCarty, D. R. (2026) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiag005 · Cited by 2

Cellular profiling identifies an early profibrotic alveolar type 2 cell signature in lung fibrosis

Naikawadi, R. P., Bazarov, A. V., Wax, M., Boostanpour, K., Kukreja, J., Traglia, M., Agrawal, A., Thomas, R., Bhattacharya, M., & Wolters, P. J. (2026) · American Journal of Respiratory and Critical Care Medicine · doi:10.1093/ajrccm/aamag044 · Cited by 3

Antagonistic pleiotropy governing reproductive aging: evolutionary regulation of endometrial receptivity

Kobayashi, H., Nishio, M., Umetani, M., Shigetomi, H., Imanaka, S., & Hashimoto, H. (2026) · Reproduction · doi:10.1093/reprod/xaag044 · Cited by 2

Loss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1

Kvas, S., Gloor, G. B., & Brandl, C. J. (2012) · BMC Genetics · doi:10.1186/1471-2156-13-19 · Cited by 3

TORC2 is required for the accumulation of γH2A in response to DNA damage

Cohen, A., Lubenski, L., Mouzon, A., Kupiec, M., & Weisman, R. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107531 · Cited by 1

REV7 associates with ATRIP and inhibits ATR kinase activity

Biller, M., Kabir, S., Nipper, S., Allen, S., Kayali, Y., Kuncik, S., Sasanuma, H., Zhou, P., Vaziri, C., & Tomida, J. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkaf1527 · Cited by 1

Targeting ATR in Cancer therapy: A drug discovery perspective

Lai, Y., Zhao, W., Wang, Y., & Zhang, L. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109707 · Cited by 1

Tilting the balance of life and death: navigating DNA replication stress in cancer therapy

Lo, N., & Kim, H. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01745-9 · Cited by 2

1H, 15N, and 13C chemical shift assignments of the micelle immersed FAT C-terminal (FATC) domains of the human protein kinases ataxia-telangiectasia mutated (ATM) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) fused to the B1 domain of streptococcal protein G (GB1)

Rahim, M. S. A., Sommer, L. A. M., Wacker, A. S., Schaad, M., & Dames, S. A. (2018) · Biomolecular NMR Assignments · doi:10.1007/s12104-018-9798-3 · Cited by 1

Evolution of techniques and tools for replication fork proteome and protein interaction studies

Jurkovic, C.-M., & Boisvert, F. (2023) · Biochemistry and Cell Biology · doi:10.1139/bcb-2023-0215 · Cited by 1

ATM: Its Recruitment, Activation, Signalling and Contribution to Tumour Suppression

Shibata, A., & Jeggo, P. A. (2018) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-75836-7_6 · Cited by 1

Computational Analysis of Apicomplexan Kinomes

Talevich, E., Kannan, N., & Miranda‐Saavedra, D. (2013) · Wiley eBooks · doi:10.1002/9783527675401.ch01 · Cited by 2

Functional Analysis of the Pseudoprotease iRhom2 and Nonsense-mediated mRNA Decay Factor Smg1 using Gene Deficient Mice

McIlwain, D. R. (2012) · TSpace (University of Toronto) · Cited by 1

The Mediator Kinase Module regulates cell cycle re-entry and transcriptional responses following DNA damagePreprint

Memişoğlu, G., Bohn, S., Krogan, N. J., Haber, J. E., & Ruthenburg, A. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.26.530133 · Cited by 1

PRECLINICAL STUDIES ON ATM KINASE INHIBITORS AS ANTI-CANCER AGENTS

Choi, S. (2011) · D-Scholarship@Pitt (University of Pittsburgh)

The Role of the ATR-CHEK1 Pathway in Therapeutic Resistance Resulting from Distal 11q Loss in Carcinoma Cells

Sankunny, M. (2013) · D-Scholarship@Pitt (University of Pittsburgh)

Alterações na Cinética de Reparo do DNA e nos Perfis de Expressão de Genes de Resposta ao Estresse em Linfócitos de Portadores da Doença de Alzheimer.

Leandro, G. D. S. (2011) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2011.tde-26092011-113731

Serine/Threonine Protein Phosphatase 5 - a Double-edged Sword - in the Progression towards Diabetes

Grankvist, N. (2012) · Figshare

Caracterización molecular y celular de una cohorte de pacientes con ataxiatelangiectasia

Vega, A. K. (2014) · Institutional Repository of the University of Granada (University of Granada)

Effects of space-relevant radiation on pre-osteoblasts

Hu, Y. (2014) · elib (German Aerospace Center)

“A DNA Damage Response (DDR) –independent Role for the Ataxia-Telangiectasia Mutated (ATM) Gene Product"

Palazzo, L. (2010) · Università degli Studi di Napoli Federico II · doi:10.6092/unina/fedoa/8313

Analysis of the epigenetics of meiotic silencing and its role in germ cell loss

Cloutier, J. M. (2016) · UCL Discovery (University College London)

Role of VHL in DNA double-strand break repair and genomic instability in renal cell carcinoma

Metcalf, J. L. (2013) · TSpace (University of Toronto)

Control of DNA Replication by ATR

Lecona, E., & Fernández-Capetillo, Ó. (2018) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-75836-7_3

A deficiência das proteínas de checkpoint HUS1 e RAD9 promove a variação do número de cópias no genoma de Leishmania major

Gomez, R. O. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2018.tde-25042018-163036

The ATR kinase of Trypanosoma brucei links DNA damage signalling and monoallelic control of surface antigen gene expression during antigenic variationPreprint

Black, J. A., Crouch, K., Lemgruber, L., Lapsley, C. T., Dickens, N. J., Mottram, J. C., & McCulloch, R. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/435198

Understanding the biological functions of POPX2 phosphatase through its interactome

Kim, P. (2019) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/136952

Phospho-regulation of the DNA Damage Response Kinase ATR

Nam, E. A. (2011)

Regulation of the ATR Pathway in the Replication Stress Response

Luzwick, J. W. (2016)

Analyzing genome integrity during DNA replication using iPOND (isolation of Proteins On Nascent DNA)

Sirbu, B. M. (2013)

A role for the p38 MAPK in animal cell size regulation

Leung, C. Y. B. (2018) · TSpace (University of Toronto)

The Human Single-Stranded DNA Binding Protein 2 (HSSB2) and Its Novel Role in the Base Excision Repair Pathway

Jaffary, S. A. N. R. (2018) · Queensland University of Technology · doi:10.5204/thesis.eprints.119175

Cell Cycle Control by Ataxia Telangiectasia Mutated Protein Through Regulating Retinoblastoma Protein Phosphorylation

Pizarro, J. G., Camins, A., Junyent, F., Verdaguer, E., Auladell, C., Beas‐Zárate, C., Pallàs, M., & Folch, J. (2012) · Springer eBooks · doi:10.1007/978-94-007-4213-0_11

Cell Cycle | Cell Cycle: DNA Damage Checkpoints

Weitzman, M. D., Wang, J. Y. J., & Verma, V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819460-7.00178-x

Der Rolle der DNA-Schadensantwort bei granulomatösen Erkrankungen

Fabry, L. A. R., & Triantafyllopoulou, A. (2022) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-022-01260-y

Data from Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations

Cheruiyot, A., Li, S., Srivatsan, S. N., Ahmed, T., Chen, Y., Lemacon, D. S., Li, Y., Yang, Z., Wadugu, B. A., Warner, W. A., et al. (2023) · doi:10.1158/0008-5472.c.6513051.v1

Data from Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations

Cheruiyot, A., Li, S., Srivatsan, S. N., Ahmed, T., Chen, Y., Lemacon, D. S., Li, Y., Yang, Z., Wadugu, B. A., Warner, W. A., et al. (2023) · doi:10.1158/0008-5472.c.6513051

Exploring the Mechanisms of Telomerase Regulation in Saccharomyces cerevisiae

Fekete-Szücs, E. (2023) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.777966042

The structure-function paradigm reshaped by intrinsically disordered regions

Gui, T. (2023) · Utrecht University Repository (Utrecht University) · doi:10.33540/1971

Insights into Nitrogen-Associated Protein 50 (NAP50) as a Tyrosyl–DNA Phosphodiesterase in Dinoflagellates

Tang, L., Tam, N. F. Y., Lam, W., Lee, T. C., Xu, S. J., & Lee, F. W. F. (2024) · Microorganisms · doi:10.3390/microorganisms12112286

Hypoxia-Induced DNA Damage Response and Genomic Instability Dictate Cancer Treatment Response

Ahuja, S., Gupta, P., Ajay, G., & Ghorai, A. (2025) · Springer eBooks · doi:10.1007/978-981-96-1016-7_4 · Cited by 1

ATR inhibitors: from targeting the DNA damage response to exploiting synthetic lethality—A paradigm shift in Cancer therapy

Zhou, X. H., Qin, Q., Yao, H., Fu, Y., Wang, L., Zhu, W., & Lv, Q. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109538 · Cited by 2

Contrôles épigénétiques du cycle cellulaire : fonctions et régulation de la lysine méthyltransférase PR-Set7

Tardat, M. (2010) · theses.fr (ABES) · doi:10.70675/70c17820z15a7z4e16za35azefe1230b5350

Etude des nouvelles fonctions de l’insulin degrading enzyme par l’analyse de son homologue chez schizosaccharomyces pombe

Beuzelin, C. (2011) · theses.fr (ABES) · doi:10.70675/fe422cfazf532z49e5z9e05z6a74f014f272

A nonsense mutation in the DNA repair factor Hebo causes mild bone marrow failure and microcephaly

Zhang, S. (2016) · theses.fr (ABES) · doi:10.70675/378524f1ze627z4e3dzbcf5z15f09d7cce33

Rôle des facteurs d'assemblage et du système HSP90/R2TP dans la biogenèse des particules C/D snoRNP et U4 snRNP

Bizarro, J. (2013) · theses.fr (ABES) · doi:10.70675/7ea370b3z86e5z4d67zb563z470e005ed8ec

Drugging non-canonical kinases in cancer therapeutics: Molecular targets, underlying mechanisms and small-molecule inhibitors

Ma, X., Wen, Z., Wang, Z., Peng, Z., Wu, D., Wang, J., & Liu, B. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.03.047

Comprendre et perturber le choix de la voie de réparation des cassures double brin de l'ADN pour augmenter l'efficacité et la sélectivité des agents anticancéreux génotoxiques

Chanut, P. (2017) · theses.fr (ABES) · doi:10.70675/8712c9e0za693z4ff3zac1cz5973c1d276f9

DNA double-strand break formation and signalling in response to transcription-blocking topoisomerase I complexes

Cristini, A. (2015) · theses.fr (ABES) · doi:10.70675/89719cadza51cz4509zbd9fz3da99c280491

Etude des défauts héréditaires atypiques de la réparation de l'ADN

Fiévet, A. (2019) · theses.fr (ABES) · doi:10.70675/d981a983z0d97z44f5z8430z501446e5ce4d

Development and Mechanism of Action of the DNA Repair Inhibitor AsiDNA in the Treatment of Medulloblastoma with Radiotherapy

Ferreira, S. (2019) · theses.fr (ABES) · doi:10.70675/31c9df92z532dz4630zab37z3dc9c58d0320

A novel H2A.Z deposition pathway involving the Ku70/Ku80 heterodimer

Iftikhar, A. (2019) · theses.fr (ABES) · doi:10.70675/ed42220dz616ez42e5z9603zef71b1522b94

The multifaceted role of ATM protein in neural stem/progenitor cell biology and neurogenesis: beyond DNA damage response

Boni, G., & Grilli, M. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1751635

The Nature of Brain Degenerative Diseases as Reflected by the Genome Instability Disease Ataxia-Telangiectasia

Mitiagin, Y., Trop-Steinberg, S., Zemach, N., Ronen, S. A., & Barzilai, A. (2026) · Springer eBooks · doi:10.1007/978-3-032-21135-4_26

BindingDB Entry 50040433: Identification of pyrimidine derivatives as hSMG-1 inhibitors.

BindingDB (2013) · UC San Diego · doi:10.7270/q2tb181n

BindingDB Entry 50047031: Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents.

BindingDB (2017) · UC San Diego · doi:10.7270/q2tm7d0w

BindingDB Entry 50021047: Discovery of a Meisoindigo-Derived PROTAC as the ATM Degrader: Revolutionizing Colorectal Cancer Therapy via Synthetic Lethality with ATR Inhibitors.

BindingDB (2025) · UC San Diego · doi:10.7270/q24j0kr8

The interaction of CtIP with DNA damage response proteins

Abramowiçz, I. (2010) · University of Birmingham Institutional Research Archive (University of Birmingham)

PI 3-kinase related kinases: ?big? players in stress-induced signaling pathways

Abraham, R. T. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.04.002 · Cited by 461

The PIKK Family of Protein Kinases

Smith, G. C. M., & Jackson, S. P. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00077-2 · Cited by 7

It takes three to the DNA damage response tango

Schlam‐Babayov, S., Ziv, Y., & Shiloh, Y. (2021) · Molecular & Cellular Oncology · doi:10.1080/23723556.2021.1881395 · Cited by 7

DNA Damage Checkpoint Response

(2008) · Springer eBooks · doi:10.1007/978-1-4020-6754-9_4633

Phosphoproteomics reveals novel modes of function and inter‐relationships among PIKKs in response to genotoxic stress

Schlam‐Babayov, S., Bensimon, A., Harel, M., Geiger, T., Aebersold, R. H., Ziv, Y., & Shiloh, Y. (2020) · The EMBO Journal · doi:10.15252/embj.2020104400 · Cited by 48