Cortez, David

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 1,798

Chk1 is an essential kinase that is regulated by Atr and required for the G 2 /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 1,625

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 1,221

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 1,020

ATR and ATRIP: Partners in Checkpoint Signaling

Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 985

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Tibbetts, R. S., Cortez, D., Brumbaugh, K. M., Scully, R., Livingston, D., Elledge, S. J., & Abraham, R. T. (2000) · Genes & Development

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 512

ATR signalling: more than meeting at the fork

Nam, E. A., & Cortez, D. (2011) · Biochemical Journal

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 316

Direct DNA binding by Brca1

Paull, T. T., Cortez, D., Bowers, B., Elledge, S. J., & Gellert, M. (2001) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 282

Common mechanisms of PIKK regulation

Lovejoy, C. A., & Cortez, D. (2009) · DNA Repair

DNA Repair MechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 277

DNA Damage Response: Three Levels of DNA Repair Regulation

Sirbu, B. M., & Cortez, D. (2013) · Cold Spring Harbor Perspectives in Biology

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 272

Replication fork slowing and reversal upon DNA damage require PCNA polyubiquitination and ZRANB3 DNA translocase activity.

Vujanovic, M., Krietsch, J., Raso, M. C., Terraneo, N., Zellweger, R., Schmid, J. A., Taglialatela, A., Huang, J.-W., Holland, C. L., Zwicky, K., et al. (2017) · Molecular Cell

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 227

Preventing replication fork collapse to maintain genome integrity

Cortez, D. (2015) · DNA Repair

DNA Repair MechanismsBacterial Genetics and Biotechnology

Cited by 223

Dpb11 activates the Mec1-Ddc2 complex

Mordes, D. A., Nam, E. A., & Cortez, D. (2008) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsFungal and yeast genetics research

Cited by 121

A Synthetic Lethal Screen Identifies DNA Repair Pathways that Sensitize Cancer Cells to Combined ATR Inhibition and Cisplatin Treatments

Mohni, K. N., Thompson, P. S., Luzwick, J. W., Glick, G. G., Pendleton, C. S., Lehmann, B. D., Pietenpol, J. A., & Cortez, D. (2015) · PLOS ONE

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 108

HDAC3 is essential for DNA replication in hematopoietic progenitor cells

Summers, A. R., Fischer, M. A., Stengel, K. R., Zhao, Y., Kaiser, J. F., Wells, C. E., Hunt, A., Bhaskara, S., Luzwick, J. W., Sampathi, S., et al. (2013) · Journal of Clinical Investigation

Hematopoietic Stem Cell TransplantationHistone Deacetylase Inhibitors Research

Cited by 87

Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling: Figure 1.

Cortez, D. (2005) · Genes & Development

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 84

CRISPR-dependent Base Editing Screens Identify Separation of Function Mutants of RADX with Altered RAD51 Regulatory Activity

Adolph, M. B., Garje, A. S., Balakrishnan, S., Morati, F., Modesti, M., Chazin, W. J., & Cortez, D. (2023) · Journal of Molecular Biology

DNA Repair MechanismsCRISPR and Genetic Engineering

Cited by 4

CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity

Adolph, M. B., Garje, A. S., Balakrishnan, S., Morati, F., Modesti, M., Chazin, W. J., & Cortez, D. (2023) · Journal of Molecular Biology

DNA Repair MechanismsCRISPR and Genetic Engineering

Cited by 4