Cited by 280DNA Repair MechanismsPI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

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Common mechanisms of PIKK regulation

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Lovejoy, Courtney A., Cortez, David·2009·DNA Repair

DOI 10.1016/j.dnarep.2009.04.006PMC PMC2725225

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Abstract

Kinases in the phosphoinositide three-kinase-related kinase (PIKK) family include ATM (ataxia-telangiectasia mutated), ATR (ATM- and Rad3-related), DNA-PKcs (DNA-dependent protein kinase catalytic subunit), mTOR (mammalian target of rapamycin), and SMG1 (suppressor with morphological effect on genitalia family member). These atypical protein kinases regulate DNA damage responses, nutrient-dependent signaling, and nonsense-mediated mRNA decay. This review focuses on the mechanisms regulating the PIKK family with a strong emphasis on the DNA damage regulated kinases. We outline common regulatory themes and suggest how discoveries about the regulation of one PIKK can be informative for the other family members.

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Authors: Lovejoy, C. A., & Cortez, D.
Affiliations: Vanderbilt University (US)
Corresponding author: Cortez, David
ORCID: Lovejoy, Courtney A.
Cortez, David
Venue: DNA Repair
Publisher: Elsevier BV
Published: 2009-09-02
Volume: 8
Issue: 9
Pages: 1004-1008
ISSN: 1568-7856 (ISSN-L)
1568-7864
DOI: 10.1016/j.dnarep.2009.04.006
PMC: PMC2725225
OpenAlex: W2023620387
Cited by: 277
References: 64
Citations by year: 2026: 11 · 2025: 3 · 2024: 14 · 2023: 12 · 2022: 9 · 2021: 23 · 2020: 15 · 2019: 22 · 2018: 16 · 2017: 16 · 2016: 19 · 2015: 15 · 2014: 16 · 2013: 22 · 2012: 17
FWCI: 8.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: DNA repair (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA102729)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: ATM, ATR, DNA-PKcs, mTOR, SMG1, kinase regulation, DNA damage response, nutrient signaling, nonsense-mediated mRNA decay, protein kinase signaling
MeSH terms: Animals, Humans, Protein Kinases, Protein Processing, Post-Translational, Enzyme Activators, Protein Transport

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