The DOI matches its Crossref record; 240 of the 240 references it cites were found in a registry or an index.
DNA replication as a target of the DNA damage checkpoint
Abstract
Faithful inheritance of the genome from mother to daughter cell requires that it is replicated accurately, in its entirety, exactly once. DNA replication not only has to have high fidelity, but also has to cope with exogenous and endogenous agents that damage DNA during the life cycle of a cell. The DNA damage checkpoint, which monitors and responds to defects in the genome, is critical for the completion of replication. The focus of this review is how DNA replication is regulated by the checkpoint response in the presence of DNA damage and fork stalling agents.
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“and to combined treatment with gemcitabine - a deoxycytidine analog that inhibits DNA synthesis and further depletes dNTP pools by targeting ribonucleotide reductase159- and CHK1 inhibitors, that abrogate the CHK1-mediated checkpoint response to replicative stress160, 161.”
From Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy (2019) · cites this paper as [161]
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The mechanism of checkpoint-dependent DNA replication fork stabilization in human cellsPreprint
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Function of the Rad53 Checkpoint Kinase Molecular Basis of the Essential S Phase
Pellicioli, A., Chabes, A., Tsai, M., Wang, S., Fazio, A., Hammet, A., Hoch, N. C., & Buckland, R. J. (2014)
The Bul2/Rsp5 ubiquitin ligase complex promotes cohesin-mediated fork re-start
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The inheritance of heterogeneity
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Environmental Toxicology: Carcinogenesis
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Computer simulations reveal mechanisms of spatio-temporal regulation of DNA replicationPreprint
Yousefi, R., & Rowicka, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.24.595841
Homiski, C., Dey-Rao, R., Shen, S., Qu, J., & Melendy, T. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae663
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Dynamique de la réplication du génome et réponses cellulaires au stress réplicatif
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Metadata
- Authors
- Zegerman, P., & Diffley, J. F. X.
- Affiliations
- Cancer Research UK (GB)
- Corresponding author
- Diffley, John F.X.
- Venue
- DNA Repair
- Publisher
- Elsevier BV
- Published
- 2009-09-02
- Volume
- 8
- Issue
- 9
- Pages
- 1077-1088
- ISSN
- 1568-7856 (ISSN-L)
- 1568-7864
- OpenAlex
- W2056492477
- Cited by
- 128
- References
- 240
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 11 · 2013: 18 · 2012: 17
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- DNA repair (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research UK
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- DNA replication, DNA damage checkpoint, replication fork stalling, replication fork restart, DNA damage response, replication regulation
- MeSH terms
- Replisomes, Animals, Cell Cycle, DNA Damage, DNA-Directed DNA Polymerase, DNA Replication, Eukaryotic Cells, Humans, Multienzyme Complexes, Replication Origin
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