Cited by 697DNA Repair MechanismsPARP inhibition in cancer therapyDNA and Nucleic Acid Chemistry

The DOI matches its Crossref record; 274 of the 280 references it cites were found in a registry or an index.

DNA repair mechanisms in dividing and non-dividing cells

Open access

Iyama, Teruaki, Wilson, David M.·2013·DNA Repair

DOI 10.1016/j.dnarep.2013.04.015PMC PMC3720834

Open this paper in CoChat — free account

Abstract

DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple forms, and if allowed to persist, can promote genome instability and directly lead to various human diseases, particularly cancer, neurological abnormalities, immunodeficiency and premature aging. To avoid such deleterious outcomes, cells have evolved an array of DNA repair pathways, which carry out what is typically a multiple-step process to resolve specific DNA lesions and maintain genome integrity. To fully appreciate the biological contributions of the different DNA repair systems, one must keep in mind the cellular context within which they operate. For example, the human body is composed of non-dividing and dividing cell types, including, in the brain, neurons and glial cells. We describe herein the molecular mechanisms of the different DNA repair pathways, and review their roles in non-dividing and dividing cells, with an eye toward how these pathways may regulate the development of neurological disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.dnarep.2013.04.015

Cites

274 of 274 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

2 retracted

Items 201–274 of 274

Importance of the cell cycle phase for the choice of the appropriate DSB repair pathway, for genome stability mintenance: the trans-S double-strand break repair model
Delacôte, F., & López, B. S. (2008) · Cell Cycle · doi:10.4161/cc.7.1.5149 · Cited by 100
The DNA polymerase is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells
Capp, J. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl380 · Cited by 99
Distinction of Hereditary Nonpolyposis Colorectal Cancer and Sporadic Microsatellite-Unstable Colorectal Cancer through Quantification of MLH1 Methylation by Real-time PCR
Bettstetter, M., Dechant, S., Ruemmele, P., Grabowski, M., Keller, G., Holinski‐Feder, E., Hartmann, A., Hofstaedter, F., & Dietmaier, W. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-3064 · Cited by 99
DNA repair in neural cells: basic science and clinical implications
Brooks, P. J. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00222-1 · Cited by 98
Role of Human DNA Glycosylase Nei-like 2 (NEIL2) and Single Strand Break Repair Protein Polynucleotide Kinase 3′-Phosphatase in Maintenance of Mitochondrial Genome
Mandal, S. M., Hegde, M. L., Chatterjee, A., Hegde, P. M., Szczęsny, B., Banerjee, D., Boldogh, I. R., Gao, R., Falkenberg, M., Gustafsson, C. M., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.272179 · Cited by 98
An Aromatic Sensor with Aversion to Damaged Strands Confers Versatility to DNA Repair
Maillard, O., Sólyom, S., & Naegeli, H. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050079 · Cited by 97
Strand- and site-specific DNA lesion demarcation by the xeroderma pigmentosum group D helicase
Mathieu, N., Kaczmarek, N., & Naegeli, H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004339107 · Cited by 97
Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH
Compe, E., Malerba, M., Soler, L., Marescaux, J., Borrelli, E., & Egly, J. (2007) · Nature Neuroscience · doi:10.1038/nn1990 · Cited by 95
DNA double-strand break signaling and human disorders
Bohgaki, T., Bohgaki, M., & Hakem, R. (2010) · Genome Integrity · doi:10.1186/2041-9414-1-15 · Cited by 95
Identification of C7orf11 (TTDN1) gene mutations and genetic heterogeneity in nonphotosensitive trichothiodystrophy
Nakabayashi, K., Amann, D., Ren, Y., Saarialho-Kere, U., Avidan, N., Gentles, S., MacDonald, J. R., Puffenberger, E. G., Christiano, A. M., Martinez-Mir, A., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/428141 · Cited by 90
The Involvement of DNA-Damage and -Repair Defects in Neurological Dysfunction
Kulkarni, A., & Wilson, D. M. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.009 · Cited by 89
Self-citation
The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.
Rai, R., Li, J.-M., Zheng, H., Lok, G. T.-M., Deng, Y., Huen, M. S.-Y., Chen, J., Jin, J., & Chang, S. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2172 · Cited by 88
Methylated DNA Causes a Physical Block to Replication Forks Independently of Damage Signalling, O6-Methylguanine or DNA Single-Strand Breaks and Results in DNA Damage
Groth, P., Ausländer, S., Majumder, M. M., Schultz, N., Johansson, F., Petermann, E., & Helleday, T. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.07.010 · Cited by 86
Aprataxin localizes to mitochondria and preserves mitochondrial function
Sýkora, P., Croteau, D. L., Bohr, V. A., & Wilson, D. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100084108 · Cited by 86
Self-citation
Familial Mutations in PMS2 Can Cause Autosomal Dominant Hereditary Nonpolyposis Colorectal Cancer
Worthley, D. L., Walsh, M. D., Barker, M., Ruszkiewicz, A. R., Bennett, G., Phillips, K. D., & Suthers, G. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.04.008 · Cited by 83
Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin
El‐Khamisy, S. F., Katyal, S., Patel, P., Ju, L., McKinnon, P. J., & Caldecott, K. W. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.02.002 · Cited by 83
Age-Related Neuronal Degeneration: Complementary Roles of Nucleotide Excision Repair and Transcription-Coupled Repair in Preventing Neuropathology
Jaarsma, D., van der Pluijm, I., de Waard, M. C., Haasdijk, E. D., Brandt, R. M. C., Vermeij, M., Rijksen, Y., Maas, A., STEEG, H. V., Hoeijmakers, J. H. J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002405 · Cited by 80
Visualization of recombination intermediates produced by RAD52‐mediated single‐strand annealing
Dyck, E. V., Stasiak, A. Z., Stasiak, A., & West, S. C. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve201 · Cited by 78
Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity
Culmsee, C., Bondada, S., & Mattson, M. P. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00008-0 · Cited by 78
Transcription Domain-Associated Repair in Human Cells
Nouspikel, T., Hyka‐Nouspikel, N., & Hanawalt, P. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01263-06 · Cited by 76
Premature aging and cancer in nucleotide excision repair-disorders
Diderich, K. E. M., Alanazi, M. A., & Hoeijmakers, J. H. J. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.04.025 · Cited by 76
Transcriptional Mutagenesis Induced by 8-Oxoguanine in Mammalian Cells
Brégeon, D., Peignon, P.-A., & Sarasin, A. R. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000577 · Cited by 74
Differential correction of lagging-strand replication errors made by DNA polymerases α and δ
McElhinny, S. A. N., Kissling, G. E., & Kunkel, T. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013048107 · Cited by 74
Structure and expression of the excision repair geneERCC6, involved in the human disorder Cockayne's syndrome group B
Troelstra, C., Hesen, W., Bootsma, D., & Hoeijmakers, J. H. J. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.3.419 · Cited by 74
Nucleotide excision repair and neurological diseases
Nouspikel, T. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.015 · Cited by 73
Neurological manifestations in xeroderma pigmentosum
Mimaki, T., Itoh, N., Abe, J., Tagawa, T., Sato, K., Yabuuchi, H., & Takebe, H. (1986) · Annals of Neurology · doi:10.1002/ana.410200112 · Cited by 73
Terminally differentiated astrocytes lack DNA damage response signaling and are radioresistant but retain DNA repair proficiency
Schneider, L. X., Fumagalli, M., & di Fagagna, F. D. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.129 · Cited by 72
Requirement for DNA Ligase IV during Embryonic Neuronal Development
Gatz, S. A., Ju, L., Gruber, R., Hoffmann, E. R., Carr, A. M., Wang, Z.-Q., Liu, C., & Jeggo, P. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1324-11.2011 · Cited by 72
Long-term persistence of O6-methylguanine in rat brain DNA
Kleihues, P., & Bücheler, J. (1977) · Nature · doi:10.1038/269625a0 · Cited by 70
Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair
Reynolds, J. J., Walker, A. K., Gilmore, E. C., Walsh, C. A., & Caldecott, K. W. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks318 · Cited by 67
NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest
Iyama, T., Abolhassani, N., Tsuchimoto, D., Nonaka, M., & Nakabeppu, Y. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq249 · Cited by 67
Self-citation
Repair of persistent strand breaks in the mitochondrial genome
Sýkora, P., Wilson, D. M., & Bohr, V. A. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.11.003 · Cited by 67
Self-citation
Human Cockayne syndrome B protein reciprocally communicates with mitochondrial proteins and promotes transcriptional elongation
Berquist, B. R., Canugovi, C., Sýkora, P., Wilson, D. M., & Bohr, V. A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks565 · Cited by 67
Self-citation
Detecting UV‐lesions in the genome: The modular CRL4 ubiquitin ligase does it best!
Scrima, A., Fischer, E. S., Lingaraju, G. M., Böhm, K., Cavadini, S., & Thomä, N. H. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.04.064 · Cited by 66
XPG: Its Products and Biological Roles
Schärer, O. D. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09599-8_9 · Cited by 65
Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3′-phosphate and 3′-phosphoglycolate ends
Takahashi, T., Tada, M., Igarashi, S., Koyama, A., Date, H., Yokoseki, A., Shiga, A., Yoshida, Y., Tsuji, S., Nishizawa, M., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm158 · Cited by 65
Rapid repair of O6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas.
Liu, L., Allay, E. R., Dumenco, L. L., & Gerson, S. L. (1994) · PubMed · Cited by 65
NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals
Abolhassani, N., Iyama, T., Tsuchimoto, D., Sakumi, K., Ohno, M., Behmanesh, M., & Nakabeppu, Y. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp1250 · Cited by 64
Self-citation
Limited terminal transferase in human DNA polymerase μ defines the required balance between accuracy and efficiency in NHEJ
Andrade, P. B., Martín, M. J., Juárez, R., de Saro, F. J. L., & Blanco, L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908492106 · Cited by 63
Involvement of mammalian MLH1 in the apoptotic response to peroxide-induced oxidative stress.
Hardman, R. A., Afshari, C. A., & Barrett, J. C. (2001) · PubMed · Cited by 62
Relatively Small Increases in the Steady-State Levels of Nucleobase Deamination Products in DNA from Human TK6 Cells Exposed to Toxic Levels of Nitric Oxide
Dong, M., & Dedon, P. C. (2005) · Chemical Research in Toxicology · doi:10.1021/tx050252j · Cited by 60
XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes
Saribasak, H., Maul, R. W., Cao, Z., McClure, R. L., Yang, W. W., McNeill, D. R., Wilson, D. M., & Gearhart, P. J. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20111135 · Cited by 59
Self-citation
Hit proteins, mitochondria and cancer
Martin, J., St–Pierre, M. V., & Dufour, J. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.02.001 · Cited by 58
Expression of the endogenous O6-methylguanine-DNA-methyltransferase protects Chinese hamster ovary cells from spontaneous G:C to A:T transitions.
Aquilina, G., Biondo, R., Eugenia Dogliotti, Y., Meuth, M., & Bignami, M. (1992) · PubMed · Cited by 55
Mutation of a BRCT domain selectively disrupts DNA single-strand break repair in noncycling Chinese hamster ovary cells
Moore, D. J., Taylor, R., Clements, P. M., & Caldecott, K. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250477597 · Cited by 55
Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates.
Yanamadala, S., & Ljungman, M. E. (2003) · PubMed · Cited by 55
DNA repair modulates the vulnerability of the developing brain to alkylating agents
Kisby, G. E., Olivas, A., Park, T., Churchwell, M. I., Doerge, D. R., Samson, L. D., Gerson, S. L., & Turker, M. S. (2009) · DNA repair · doi:10.1016/j.dnarep.2008.12.002 · Cited by 54
Detection of O6-methylguanine, O4-methylthymine and O4-ethylthymine in human liver and peripheral blood leukocyte DNA
Kang, H., Konishi, C., Kuroki, T., & Huh, N. (1995) · Carcinogenesis · doi:10.1093/carcin/16.6.1277 · Cited by 53
Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity
Akbari, M., Peña-Dı́az, J., Andersen, S. B., Liabakk, N., Otterlei, M., & Krokan, H. E. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.002 · Cited by 53
Positive Regulation of DNA Double Strand Break Repair Activity during Differentiation of Long Life Span Cells: The Example of Adipogenesis
Meulle, A., Salles, B., Daviaud, D., Valet, P., & Muller, C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003345 · Cited by 52
A Conserved Interaction between the Replicative Clamp Loader and DNA Ligase in Eukaryotes
Levin, D. S., Vijayakumar, S., Liu, X., Bermudez, V. P., Hurwitz, J., & Tomkinson, A. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409250200 · Cited by 50
Promoter structure and cell cycle dependent expression of the human methylpurine-DNA glycosylase gene
Bouziane, M., Miao, F., Bates, S., Somsouk, L., Sang, B., Denissenko, M. F., & O'Connor, T. R. (2000) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(00)00036-7 · Cited by 46
Ionizing radiation-induced apoptosis via separate Pms2- and p53-dependent pathways.
Zeng, M., Narayanan, L., Xu, X., Prolla, T. A., Liskay, R. M., & Glazer, P. M. (2000) · PubMed · Cited by 45
Cockayne syndrome group B protein has novel strand annealing and exchange activities
Müftüoğlu, M. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj410 · Cited by 44
Protein kinase Cγ, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin
Asai, H., Hirano, M., Shimada, K., Kiriyama, T., Furiya, Y., Ikeda, M., Iwamoto, T., Mori, T., Nishinaka, K., Konishi, N., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp298 · Cited by 44
O 6-Methylguanine induces altered proteins at the level of transcription in human cells
Burns, J. A., Dreij, K., Cartularo, L., & Scicchitano, D. A. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq706 · Cited by 44
Roles of transcription and repair in alkylation mutagenesis
Ito, T., Nakamura, T., Maki, H., & Sekiguchi, M. (1994) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(94)90071-x · Cited by 43
Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription
Bécherel, O. J., Gueven, N., Birrell, G. W., Schreiber, V., Suraweera, A., Jakob, B., Taucher-Scholz, G., & Lavin, M. F. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl149 · Cited by 42
Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging
Kamenisch, Y., Fousteri, M. I., Knoch, J., von Thaler, A., Fehrenbacher, B., Kato, H., Becker, T., Dollé, M. E. T., Kuiper, R., Majora, M., et al. (2010) · F1000Research · doi:10.7490/f1000research.515.1 · Cited by 42
O6-Methylguanine-induced replication blocks
Voigt, J. M., & Topal, M. D. (1995) · Carcinogenesis · doi:10.1093/carcin/16.8.1775 · Cited by 41
Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease
Gredilla, R., Weissman, L., Yang, J., Bohr, V. A., & Stevnsner, T. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.06.019 · Cited by 40
Implication of Localization of Human DNA Repair Enzyme O6-Methylguanine-DNA Methyltransferase at Active Transcription Sites in Transcription-Repair Coupling of the Mutagenic O6-Methylguanine Lesion
Ali, R. B., Teo, A. K.-C., Oh, H.-K., Chuang, L. S.-H., Ayi, T.-C., & Li, B. F. L. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1660 · Cited by 36
Achieving Broad Substrate Specificity in Damage Recognition by Binding Accessible Nondamaged DNA
Schärer, O. D. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.10.006 · Cited by 35
DNA damage and nonhomologous end joining in excitotoxicity: Neuroprotective role of DNA-PKcs in kainic acid-induced seizures
Neema, M., Navarro-Quiroga, I., Chechlacz, M., Gilliams-Francis, K. L., Liu, J., LaMonica, K., Lin, S. L., & Naegele, J. R. (2005) · Hippocampus · doi:10.1002/hipo.20123 · Cited by 35
Transcription elongation past O6-methylguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase
Dimitri, A., Burns, J. A., Broyde, S. B., & Scicchitano, D. A. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn657 · Cited by 33
XRCC1 haploinsufficiency in mice has little effect on aging, but adversely modifies exposure-dependent susceptibility
McNeill, D. R., Lin, P., Miller, M. G., Pistell, P. J., de Souza-Pinto, N. C., Fishbein, K. W., Spencer, R. G. S., Liu, Y., Pettan-Brewer, C., Ladiges, W., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr280 · Cited by 29
Self-citation
Distribution and kainate-mediated induction of the DNA mismatch repair protein MSH2 in rat brain
Belloni, M., Uberti, D. L., Rizzini, C., Ferrari‐Toninelli, G., Rizzonelli, P., Jiricny, J., Spano, P., & Memo, M. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00380-2 · Cited by 26
O6-Methylguanine in DNA inhibits replication in vitro by human cell extracts
Ceccotti, S., Eugenia Dogliotti, Y., Gannon, J., Karran, P., & Bignami, M. (1993) · Biochemistry · doi:10.1021/bi00212a035 · Cited by 24
DNA-PK promotes the survival of young neurons in the embryonic mouse retina
Baleriola, J., Suárez, T., & de la Rosa, E. J. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.46 · Cited by 21
Cell cycle-dependent modulation of O6-methylguanine-DNA methyltransferse in C3H/10T1/2 cells
Dunn, W. C., Foote, R. S., Hand, R. E., & MITRA, S. P. (1986) · Carcinogenesis · doi:10.1093/carcin/7.5.807 · Cited by 17
Xeroderma Pigmentosum and Medulloblastoma: Chromosomal Damage to Lymphocytes during Radiotherapy
Giannelli, F., Avery, J., Polani, P. E., Terrell, C., & Giammusso, V. (1981) · Radiation Research · doi:10.2307/3575764 · Cited by 16
Mechanism of perinatal tumor induction by neuro-oncogenic alkylnitrosoureas and dialkylaryltriazenes.
Kleihues, P., Cooper, H. K., Buecheler, J., Kolar, G. F., & Diessner, H. (1979) · PubMed · Cited by 12
A Highly Sensitive and Specific Method for Quantitation of O-Alkylated DNA Adducts and Its Application to the Analysis of Human Tissue DNA
Kang, H., Konishi, C., Kuroki, T., & Huh, N. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.9399269 · Cited by 10
O 6-Alkylguanine-DNA alkyltransferase content in synchronised human cancer cells
Coccia, P., Sen, S., Erba, E., Pagani, P., Marinello, C., & D’Incalci, M. (1992) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00686490 · Cited by 5

Flagged first, then by citations

6 of the 280 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Clements, 2004, The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4, DNA Repair (Amst), 3, 1493, 10.1016/j.dnarep.2004.06.017 · DOI

Sorted by citations

DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy
Huang, R., & Zhou, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00648-7 · Cited by 1,015
Oxidative stress and male infertility
Bisht, S., Faiq, M. A., Tolahunase, M., & Dada, R. (2017) · Nature Reviews Urology · doi:10.1038/nrurol.2017.69 · Cited by 918
MutationalPatterns: comprehensive genome-wide analysis of mutational processes
Blokzijl, F., Janssen, R., van Boxtel, R., & Cuppen, E. (2018) · Genome Medicine · doi:10.1186/s13073-018-0539-0 · Cited by 660
DNA damage and its links to neurodegeneration
Madabhushi, R., Pan, L., & Tsai, L.-H. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.034 · Cited by 654
NAD(+) in aging: molecular mechanisms and translational implications
Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P., & Bohr, V. A. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.08.001 · Cited by 501

See all 697

Authors: Iyama, T., & Wilson, D. M.
Affiliations: National Institutes of Health (US)
Corresponding author: Wilson, David M.
ORCID: Wilson, David M.
Venue: DNA Repair
Publisher: Elsevier BV
Published: 2013-08
Volume: 12
Issue: 8
Pages: 620-636
ISSN: 1568-7856 (ISSN-L)
1568-7864
DOI: 10.1016/j.dnarep.2013.04.015
PMC: PMC3720834
OpenAlex: W2004257622
Cited by: 697
References: 280
Citations by year: 2026: 20 · 2025: 37 · 2024: 49 · 2023: 56 · 2022: 43 · 2021: 69 · 2020: 58 · 2019: 59 · 2018: 65 · 2017: 57 · 2016: 72 · 2015: 62 · 2014: 47 · 2013: 2
FWCI: 27.17
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: DNA repair (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health
National Institute on Aging (ZIAAG000751)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: DNA repair pathways, genome stability, genetic damage, dividing cells, non-dividing cells, neurons, glial cells, neurological disorders, cancer, premature aging, immunodeficiency, DNA lesions
MeSH terms: Animals, Disease Models, Animal, DNA, DNA Damage, DNA Repair, Humans, Neurons, Pyrimidine Dimers, O(6)-Methylguanine-DNA Methyltransferase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

DNA repair mechanisms in dividing and non-dividing cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks