Cited by 654DNA Repair MechanismsGenetics, Aging, and Longevity in Model OrganismsAlzheimer's disease research and treatments

DNA damage and its links to neurodegeneration

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Madabhushi, Ram, Pan, Ling, Tsai, Li-Huei·2014·Neuron

Abstract

The integrity of our genetic material is under constant attack from numerous endogenous and exogenous agents. The consequences of a defective DNA damage response are well studied in proliferating cells, especially with regards to the development of cancer, yet its precise roles in the nervous system are relatively poorly understood. Here we attempt to provide a comprehensive overview of the consequences of genomic instability in the nervous system. We highlight the neuropathology of congenital syndromes that result from mutations in DNA repair factors and underscore the importance of the DNA damage response in neural development. In addition, we describe the findings of recent studies, which reveal that a robust DNA damage response is also intimately connected to aging and the manifestation of age-related neurodegenerative disorders such as Alzheimer's disease and amyotrophic lateral sclerosis.

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Crossref · 10.1016/j.neuron.2014.06.034

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Authors
Madabhushi, R., Pan, L., & Tsai, L.-H.
Affiliations
Massachusetts Institute of Technology (US)
Corresponding author
Tsai, Li-Huei
Venue
Neuron
Publisher
Elsevier BV
Published
2014-07
Volume
83
Issue
2
Pages
266-282
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2080053685
Cited by
654
References
151
Citations by year
2026: 55 · 2025: 53 · 2024: 65 · 2023: 55 · 2022: 66 · 2021: 70 · 2020: 78 · 2019: 69 · 2018: 46 · 2017: 28 · 2016: 35 · 2015: 28 · 2014: 6
FWCI
3.05
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
Funders
  • Glenn Foundation for Medical Research
  • National Institute on Aging (R01AG046174)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
DNA damage response, neurodegeneration, genomic instability, DNA repair, congenital syndromes, neural development, aging, Alzheimer's disease, amyotrophic lateral sclerosis, nervous system
MeSH terms
Aging, DNA Damage, DNA Repair, Humans, Nerve Degeneration, Neurons, Neurodegenerative Diseases

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