DNA repair mechanisms in dividing and non-dividing cells

The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092

Instability and decay of the primary structure of DNA

Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679

Genome maintenance mechanisms for preventing cancer

Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

Lieber, M. R. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.093131 · Cited by 2,882

DNA damage, aging, and Cancer

Hoeijmakers, J. H. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804615 · Cited by 2,239

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

Shibutani, S., Takeshita, M., & Grollman, A. P. (1991) · Nature · doi:10.1038/349431a0 · Cited by 2,224

Mechanism of Eukaryotic Homologous Recombination

Filippo, J. S., Sung, P., & Klein, H. L. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061306.125255 · Cited by 1,766

Double-Strand Break End Resection and Repair Pathway Choice

Symington, L. S., & Gautier, J. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132435 · Cited by 1,556

The multifaceted mismatch-repair system

Jiricny, J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1907 · Cited by 1,375

Human CtIP promotes DNA end resection

Sartori, A. A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J., & Jackson, S. P. (2007) · Nature · doi:10.1038/nature06337 · Cited by 1,362

Homologous recombination and non‐homologous end‐joining pathways of DNA double‐strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

Takata, M., Sasaki, M. S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi‐Iwai, Y., Shinohara, A., & Takeda, S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.18.5497 · Cited by 1,229

Xeroderma Pigmentosum

Kraemer, K. H. (1987) · Archives of Dermatology · doi:10.1001/archderm.123.2.241 · Cited by 1,216

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

Ma, Y., Pannicke, U., Schwarz, K., & Lieber, M. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00671-2 · Cited by 1,166

Single-strand break repair and genetic disease

Caldecott, K. W. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2380 · Cited by 1,097

Regulation of Homologous Recombination in Eukaryotes

Heyer, W.-D., Ehmsen, K. T., & Liu, J. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-051710-150955 · Cited by 1,066

MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings

McVey, M., & Lee, S. E. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.08.007 · Cited by 1,039

Free radical-induced damage to DNA: mechanisms and measurement

Dizdaroglu, M., Jaruga, P., Birincioglu, M., & Rodriguez, H. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00826-2 · Cited by 953

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

Loveless, A. H. (1969) · Nature · doi:10.1038/223206a0 · Cited by 945

Artemis, a Novel DNA Double-Strand Break Repair/V(D)J Recombination Protein, Is Mutated in Human Severe Combined Immune Deficiency

Moshous, D., Callebaut, I., de Chasseval, R., Corneo, B., Cavazzana, M., Deist, F. L., Tezcan, İ., Sanal, Ö., Bertrand, Y., Philippe, N., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00309-9 · Cited by 912

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

Maki, H., & Sekiguchi, M. (1992) · Nature · doi:10.1038/355273a0 · Cited by 901

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

Wang, M., Wu, W., Wu, W., Rosidi, B., Zhang, L., Wang, H., & Iliakis, G. E. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl840 · Cited by 892

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

Denchi, E. L., & de Lange, T. (2007) · Nature · doi:10.1038/nature06065 · Cited by 880

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

Roos, W. P., & Kaina, B. (2013) · Cancer Letters · doi:10.1016/j.canlet.2012.01.007 · Cited by 879

The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling

D'Amours, D., & Jackson, S. P. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm805 · Cited by 874

XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining

Ahnesorg, P., Smith, P., & Jackson, S. P. (2006) · Cell · doi:10.1016/j.cell.2005.12.031 · Cited by 794

DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination

Mol, C. D., Izumi, T., MITRA, S. P., & Tainer, J. A. (2000) · Nature · doi:10.1038/35000249 · Cited by 764

The Ubiquitin Ligase Activity in the DDB2 and CSA Complexes Is Differentially Regulated by the COP9 Signalosome in Response to DNA Damage

Groisman, R., Polanowska, J., Kuraoka, I., Sawada, J.-I., Saijo, M., Drapkin, R., Kisselev, A. F., Tanaka, K., & Nakatani, Y. (2003) · Cell · doi:10.1016/s0092-8674(03)00316-7 · Cited by 756

The MRE11 complex: starting from the ends

Stracker, T. H., & Petrini, J. H. J. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3047 · Cited by 734

ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes

Troelstra, C., van Gool, A., de Wit, J., Vermeulen, W., Bootsma, D., & Hoeijmakers, J. H. J. (1992) · Cell · doi:10.1016/0092-8674(92)90390-x · Cited by 729

Cernunnos, a Novel Nonhomologous End-Joining Factor, Is Mutated in Human Immunodeficiency with Microcephaly

Buck, D., Malivert, L., de Chasseval, R., Barraud, A., Fondanèche, M.-C., Sanal, O., Plebani, A., Stéphan, J.-L., Hufnagel, M., le Deist, F., et al. (2006) · Cell · doi:10.1016/j.cell.2005.12.030 · Cited by 722

Purified human BRCA2 stimulates RAD51-mediated recombination

Jensen, R. B., Carreira, A., & Kowalczykowski, S. C. (2010) · Nature · doi:10.1038/nature09399 · Cited by 715

Involvement of Poly(ADP-ribose) Polymerase-1 and XRCC1/DNA Ligase III in an Alternative Route for DNA Double-strand Breaks Rejoining

Audebert, M., Salles, B., & Calsou, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404524200 · Cited by 709

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

Gao, Y., Sun, Y., Frank, K. M., Dikkes, P., Fujiwara, Y., Seidl, K. J., Sekiguchi, J. M., Rathbun, G. A., Swat, W., Wang, J., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81714-6 · Cited by 688

Nucleotide excision repair and human syndromes

de Boer, J., & Hoeijmakers, J. H. J. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.453 · Cited by 674

Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair

Gillet, L. C. J., & Schärer, O. D. (2006) · Chemical Reviews · doi:10.1021/cr040483f · Cited by 642

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

Taccioli, G. E., Gottlieb, T. M., Blunt, T., Priestley, A., Demengeot, J., Mizuta, R., Lehmann, A. R., Alt, F. W., Jackson, S. P., & Jeggo, P. A. (1994) · Science · doi:10.1126/science.8073286 · Cited by 638

Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

Imai, K., Slupphaug, G., Lee, W., Revy, P., Nonoyama, S., Catalan, N., Yel, L., Forveille, M., Kavli, B., Krokan, H. E., et al. (2003) · Nature Immunology · doi:10.1038/ni974 · Cited by 633

DNA helicases Sgs1 and BLM promote DNA double-strand break resectionPreprint

Gravel, S., Chapman, J. R., Magill, C. P., & Jackson, S. P. (2008) · Genes & Development · doi:10.1101/gad.503108 · Cited by 595

Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A

New, J. H., Sugiyama, T., Zaitseva, E., & Kowalczykowski, S. C. (1998) · Nature · doi:10.1038/34950 · Cited by 589

DNA‐damage repair; the good, the bad, and the ugly

Hakem, R. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.15 · Cited by 577

DNA Ligase IV Mutations Identified in Patients Exhibiting Developmental Delay and Immunodeficiency

O’Driscoll, M., Cerosaletti, K. M., Girard, P.-M., Dai, Y., Stümm, M., Kysela, B. P., Hirsch, B. A., Gennery, A. R., Palmer, S. E., Seidel, J., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00408-7 · Cited by 565

Function of Yeast Rad52 Protein as a Mediator between Replication Protein A and the Rad51 Recombinase

Sung, P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.45.28194 · Cited by 563

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

Yun, M. H., & Hiom, K. (2009) · Nature · doi:10.1038/nature07955 · Cited by 556

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

Difilippantonio, M. J., Zhu, J., Chen, H. T., Meffre, E., Nussenzweig, M. C., Max, E. E., Ried, T., & Nussenzweig, A. (2000) · Nature · doi:10.1038/35006670 · Cited by 556

Shining a light on xeroderma pigmentosum

DiGiovanna, J. J., & Kraemer, K. H. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.426 · Cited by 547

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

Lee, J.-H., & Paull, T. T. (2007) · Oncogene · doi:10.1038/sj.onc.1210872 · Cited by 545

Mutation of TDP1, encoding a topoisomerase I–dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy

Takashima, H., Boerkoel, C. F., John, J., Saifi, G. M., Salih, M. A. M., Armstrong, D., Mao, Y., Quiocho, F. A., Roa, B. B., Nakagawa, M., et al. (2002) · Nature Genetics · doi:10.1038/ng987 · Cited by 522

DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy

Lehmann, A. (2003) · Biochimie · doi:10.1016/j.biochi.2003.09.010 · Cited by 518

Factors determining DNA double‐strand break repair pathway choice in G2 phase

Shibata, A., Conrad, S., Birraux, J., Geuting, V., Barton, O., Ismail, A., Kakarougkas, A., Meek, K., Taucher-Scholz, G., Löbrich, M., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.27 · Cited by 511

The Bloom's syndrome gene product promotes branch migration of Holliday junctions

Karow, J., Constantinou, A., Li, J., West, S. C., & Hickson, I. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100448097 · Cited by 502

Mechanism of open complex and dual incision formation by human nucleotide excision repair factors

Evans, E., Moggs, J. G., Hwang, J. R., Egly, J., & Wood, R. D. (1997) · The EMBO Journal · doi:10.1093/emboj/16.21.6559 · Cited by 500

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

Goth, R., & Rajewsky, M. F. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.3.639 · Cited by 490

Identification and Survival of Carriers of Mutations in DNA Mismatch-Repair Genes in Colon Cancer

Barnetson, R. A., Tenesa, A., Farrington, S. M., Nicholl, I. D., Cetnarskyj, R., Porteous, M. E., Campbell, H., & Dunlop, M. G. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa053493 · Cited by 481

Cancer and neurologic degeneration in xeroderma pigmentosum: long term follow-up characterises the role of DNA repair

Bradford, P. T., Goldstein, A. M., Tamura, D., Khan, S. G., Ueda, T., Boyle, J., Oh, K.-S., Imoto, K., Inui, H., Moriwaki, S.-I., et al. (2011) · Journal of Medical Genetics · doi:10.1136/jmg.2010.083022 · Cited by 480

AP Endonuclease-Independent DNA Base Excision Repair in Human Cells

Wiederhold, L. R., Leppard, J. B., Kedar, P. S., Karimi‐Busheri, F., Rasouli‐Nia, A., Weinfeld, M., Tomkinson, A. E., Izumi, T., Prasad, R., Wilson, S. H., et al. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.06.003 · Cited by 472

Stimulation by Rad52 of yeast Rad51- mediated recombination

Shinohara, A., & Ogawa, T. (1998) · Nature · doi:10.1038/34943 · Cited by 463

The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation

Fischer, E. S., Scrima, A., Böhm, K., Matsumoto, S., Lingaraju, G. M., Faty, M., Yasuda, T., Cavadini, S., Wakasugi, M., Hanaoka, F., et al. (2011) · Cell · doi:10.1016/j.cell.2011.10.035 · Cited by 460

Mechanisms in Eukaryotic Mismatch Repair

Modrich, P. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600022200 · Cited by 459

Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair

Svendsen, J. M., Smogorzewska, A., Sowa, M. E., O’Connell, B. C., Gygi, S. P., Elledge, S. J., & Harper, J. W. (2009) · Cell · doi:10.1016/j.cell.2009.06.030 · Cited by 450

Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study

Gedik, C. M., & Collins, A. R. (2004) · The FASEB Journal · doi:10.1096/fj.04-1767fje · Cited by 449

Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: A complex genotype–phenotype relationship

Kraemer, K. H., Patronas, N. J., Schiffmann, R., Brooks, B. P., Tamura, D., & DiGiovanna, J. J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.020 · Cited by 443

Mutations Associated with HNPCC Predisposition — Update of ICG‐HNPCC/INSiGHT Mutation Database

Peltomäki, P., & Vasen, H. F. A. (2004) · Disease Markers · doi:10.1155/2004/305058 · Cited by 442

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

Barnes, D. E., Stamp, G., Rosewell, I. R., Denzel, A., & Lindahl, T. L. (1998) · Current Biology · doi:10.1016/s0960-9822(98)00021-9 · Cited by 438

The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin

Moreira, M.-C., Barbot, C., Tachi, N., Kozuka, N., Uchida, E., Gibson, T. J., Mendonça, P., Costa, M. M. R., Barros, J., Yanagisawa, T., et al. (2001) · Nature Genetics · doi:10.1038/ng1001-189 · Cited by 434

Recognition of DNA damage by the Rad4 nucleotide excision repair protein

Min, J., & Pavletich, N. P. (2007) · Nature · doi:10.1038/nature06155 · Cited by 431

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

El‐Khamisy, S. F., Saifi, G. M., Weinfeld, M., Johansson, F., Helleday, T., Lupski, J. R., & Caldecott, K. W. (2005) · Nature · doi:10.1038/nature03314 · Cited by 428

Cancer in xeroderma pigmentosum and related disorders of DNA repair

Cleaver, J. E. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1652 · Cited by 427

Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases

Fekairi, S., Scaglione, S., Chahwan, C., Taylor, E. R., Tissier, A., Coulon, S., Dong, M., Ruse, C. I., Yates, J. R., Russell, P. R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.06.029 · Cited by 418

Identification of Holliday junction resolvases from humans and yeast

Ip, S. C. Y., Rass, U., Blanco, M. G., Flynn, H. R., Skehel, M. J., & West, S. C. (2008) · Nature · doi:10.1038/nature07470 · Cited by 416

The major human abasic endonuclease: formation, consequences and repair of abasic lesions in DNA

Wilson, D. M., & Barsky, D. (2001) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(01)00063-5 · Cited by 415

Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient

Riballo, E., Critchlow, S. E., Teo, S., Doherty, A. J., Priestley, A., Broughton, B. C., Kysela, B. P., Beamish, H., Plowman, N. P., Arlett, C. F., et al. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80311-x · Cited by 400

Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells

Ogi, T., Limsirichaikul, S., Overmeer, R. M., Volker, M., Takenaka, K., Cloney, R., Nakazawa, Y., Niimi, A., Miki, Y., Jaspers, N. G., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.02.009 · Cited by 392

Werner's syndrome protein (WRN) migrates Holliday junctions and co‐localizes with RPA upon replication arrest

Constantinou, A., Tarsounas, M., Karow, J., Brosh, R. M., Bohr, V. A., Hickson, I. D., & West, S. C. (2000) · EMBO Reports · doi:10.1093/embo-reports/kvd004 · Cited by 387

Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene

Date, H., Onodera, O., Tanaka, H., Iwabuchi, K., Uekawa, K., Igarashi, S., Koike, R., Hiroi, T., Yuasa, T., Awaya, Y., et al. (2001) · Nature Genetics · doi:10.1038/ng1001-184 · Cited by 386

ATM Activation and DNA Damage Response

Lavin, M. F., & Kozlov, S. (2007) · Cell Cycle · doi:10.4161/cc.6.8.4180 · Cited by 386

Yeast Gene for a Tyr-DNA Phosphodiesterase that Repairs Topoisomerase I Complexes

Pouliot, J. J., Yao, K. C., Robertson, C. A., & Nash, H. A. (1999) · Science · doi:10.1126/science.286.5439.552 · Cited by 382

Synergistic actions of Rad51 and Rad52 in recombination and DNA repair

Benson, F. E., Baumann, P., & West, S. C. (1998) · Nature · doi:10.1038/34937 · Cited by 379

ATP-Dependent Chromatin Remodeling by the Cockayne Syndrome B DNA Repair-Transcription-Coupling Factor

Citterio, E., van den Boom, V., Schnitzler, G. R., Kanaar, R., Bonte, E. J., Kingston, R. E., Hoeijmakers, J. H. J., & Vermeulen, W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.20.7643-7653.2000 · Cited by 376

DNA repair deficiency in neurodegeneration

Jeppesen, D. K., Bohr, V. A., & Stevnsner, T. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.04.013 · Cited by 374

The mechanics of base excision repair, and its relationship to aging and disease

WILSONIII, D., & Bohr, V. A. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.10.017 · Cited by 364

Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DMA mismatch repair

Prolla, T. A., Baker, S. M., Harris, A. C., Tsao, J., Yao, X., Bronner, C. E., Zheng, B., Gordon, M. D., Reneker, J., Arnheim, N., et al. (1998) · Nature Genetics · doi:10.1038/ng0398-276 · Cited by 363

Defective DNA Repair and Neurodegenerative Disease

Rass, U., Ahel, I., & West, S. C. (2007) · Cell · doi:10.1016/j.cell.2007.08.043 · Cited by 358

Interaction of human apurinic endonuclease and DNA polymerase β in the base excision repair pathway

Bennett, R. A. O., Wilson, D. M., Wong, D., & Demple, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7166 · Cited by 348

Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAKPreprint

Araújo, S. J., Tirode, F., Coin, F., Pospiech, H., Syväoja, J. E., Stucki, M., Hübscher, U., Egly, J., & Wood, R. D. (2000) · Genes & Development · doi:10.1101/gad.14.3.349 · Cited by 344

Defective Transcription-Coupled Repair in Cockayne Syndrome B Mice Is Associated with Skin Cancer Predisposition

van der Horst, G. T. J., STEEG, H. V., Berg, R. J. W., van Gool, A. J., de Wit, J., Weeda, G., Morreau, H., Beems, R. B., van Kreijl, C. F., de Gruijl, F. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80223-8 · Cited by 339

DNA Ligase III as a Candidate Component of Backup Pathways of Nonhomologous End Joining

Wang, H., Rosidi, B., Perrault, A. R., Wang, M., Zhang, L., Windhofer, F., & Iliakis, G. E. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3055 · Cited by 334

A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A

Giglia‐Mari, G., Coin, F., Ranish, J. A., Hoogstraten, D., Theil, A. F., Wijgers, N., Jaspers, N. G. J., Raams, A., Argentini, M., van der Spek, P. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1387 · Cited by 334

Collaboration and competition between DNA double‐strand break repair pathways

Kass, E. M., & Jasin, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.07.057 · Cited by 326

DNA repair deficiency and neurological disease

McKinnon, P. J. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2559 · Cited by 323

Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

Nimonkar, A. V., Özsoy, A. Z., Genschel, J., Modrich, P. L., & Kowalczykowski, S. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809380105 · Cited by 322

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents

Hickman, M. J., & Samson, L. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10764 · Cited by 313

ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks

Lavin, M. F. (2007) · Oncogene · doi:10.1038/sj.onc.1210880 · Cited by 311

Cockayne syndrome group B protein enhances elongation by RNA polymerase II

Selby, C. P., & Sancar, A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11205 · Cited by 309

Human DNA Polymerase η Promotes DNA Synthesis from Strand Invasion Intermediates of Homologous Recombination

McIlwraith, M. J., Vaisman, A., Liu, Y., Fanning, E., Woodgate, R., & West, S. C. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.001 · Cited by 304

Repair tracts in mismatched DNA heteroduplexes.

Wagner, R. E., & Meselson, M. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.4135 · Cited by 303

Distinct Roles for the XPB/p52 and XPD/p44 Subcomplexes of TFIIH in Damaged DNA Opening during Nucleotide Excision Repair

Coin, F., Oksenych, V., & Egly, J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.009 · Cited by 294

Mutations in PNKP cause microcephaly, seizures and defects in DNA repair

Shen, J., Gilmore, E. C., Marshall-Walker, C. A., Haddadin, M. H., Reynolds, J. J., Eyaid, W., Bodell, A., Barry, B. J., Gleason, D., Allen, K., et al. (2010) · Nature Genetics · doi:10.1038/ng.526 · Cited by 294

Role of hMLH1 promoter hypermethylation in drug resistance to 5‐fluorouracil in colorectal cancer cell lines

Arnold, C. N., Goel, A., & Boland, C. R. (2003) · International Journal of Cancer · doi:10.1002/ijc.11176 · Cited by 280

Mammalian base excision repair and DNA polymerase beta

Wilson, S. H. (1998) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(98)00002-0 · Cited by 277

Involvement of human polynucleotide kinase in double‐strand break repair by non‐homologous end joining

Chappell, C., Hanakahi, L. A., Karimi‐Busheri, F., Weinfeld, M., & West, S. C. (2002) · The EMBO Journal · doi:10.1093/emboj/21.11.2827 · Cited by 275

CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome.

Groisman, R., Kuraoka, I., Chevallier, O., Gaye, N., Magnaldo, T., Tanaka, K., Kisselev, A. F., Harel-Bellan, A., & Nakatani, Y. (2006) · Genes & Development · doi:10.1101/gad.378206 · Cited by 268

Trichothiodystrophy: a systematic review of 112 published cases characterises a wide spectrum of clinical manifestations

Faghri, S., Tamura, D., Kraemer, K. H., & DiGiovanna, J. J. (2008) · Journal of Medical Genetics · doi:10.1136/jmg.2008.058743 · Cited by 264

The Cockayne syndrome B protein, involved in transcription‐coupled DNA repair, resides in an RNA polymerase II‐containing complex

van Gool, A. J., Citterio, E., Rademakers, S., Os, R. I. V. R.-V., Vermeulen, W., Constantinou, A., Egly, J., Bootsma, D., & Hoeijmakers, J. H. J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.19.5955 · Cited by 261

PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair

Pluciennik, A., Dzantiev, L., Iyer, R. R., Constantin, N., Kadyrov, F. A., & Modrich, P. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010662107 · Cited by 259

Dysfunctional telomeres activate an ATM‐ATR‐dependent DNA damage response to suppress tumorigenesis

Guo, X., Deng, Y., Lin, Y., Cosme‐Blanco, W., Chan, S., He, H., Yuan, G., Brown, E. J., & Chang, S. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601893 · Cited by 258

O6-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: Enzyme activity, promoter methylation and immunohistochemistry

Christmann, M., Verbeek, B., Roos, W. P., & Kaina, B. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.06.002 · Cited by 242

Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant.

Getts, R. C., & Stamato, T. D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33960-1 · Cited by 237

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

Koch, C. A., Agyei, R., Galicia, S., Metalnikov, P. S., O’Donnell, E., Starostine, A., Weinfeld, M., & Durocher, D. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600375 · Cited by 237

The Prevention of Thymic Lymphomas in Transgenic Mice by Human O 6 -Alkylguanine-DNA Alkyltransferase

Dumenco, L. L., Allay, E. R., Norton, K., & Gerson, S. L. (1993) · Science · doi:10.1126/science.8421782 · Cited by 236

Structure of hsDDB1-drDDB2 bound to a 13 bp CPD-duplex (purine at D-1 position) at 3.0 A resolution (CPD 1)

Scrima, A., Fischer, E. S., Iwai, S., Gut, H., & Thomä, N. H. (2011) · Worldwide Protein Data Bank · doi:10.2210/pdb4a08/pdb · Cited by 233

Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene Amplification

Difilippantonio, M. J., Petersen, S., Chen, H. T., Johnson, R., Jasin, M., Kanaar, R., Ried, T., & Nussenzweig, A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020851 · Cited by 231

Molecular and biological roles of Ape1 protein in mammalian base excision repair

Demple, B., & Sung, J. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.09.004 · Cited by 218

Ubiquitination-Dependent Proteolysis of O6-Methylguanine-DNA Methyltransferase in Human and Murine Tumor Cells following Inactivation with O6-Benzylguanine or 1,3-Bis(2-chloroethyl)-1-nitrosourea

Srivenugopal, K. S., Yuan, X., Friedman, H. S., & Ali‐Osman, F. (1996) · Biochemistry · doi:10.1021/bi9518205 · Cited by 218

Interaction between PCNA and DNA ligase I is critical for joining of Okazaki fragments and long-patch base-excision repair

Levin, D. S., McKenna, A. E., Motycka, T. A., Matsumoto, Y., & Tomkinson, A. E. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00619-9 · Cited by 216

DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factories

Montecucco, A., Rossi, R., Levin, D. S., Gary, R., Park, M. S., Motycka, T. A., Ciarrocchi, G., Villa, A., Biamonti, G., & Tomkinson, A. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.13.3786 · Cited by 211

DNA Damage: Repair

Heenan, E. J., & Sancar, A. (2008) · Wiley Encyclopedia of Chemical Biology · doi:10.1002/9780470048672.wecb131 · Cited by 209

TDP1 facilitates chromosomal single‐strand break repair in neurons and is neuroprotective in vivo

Katyal, S., El‐Khamisy, S. F., Russell, H. R., Li, Y., Ju, L., Caldecott, K. W., & McKinnon, P. J. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601869 · Cited by 209

Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy

Scheibye‐Knudsen, M., Ramamoorthy, M., Sýkora, P., Maynard, S., Lin, P., Minor, R. K., Wilson, D. M., Cooper, M. P., Spencer, R. G. S., de Cabo, R., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111721 · Cited by 209

An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome

O’Driscoll, M., Gennery, A. R., Seidel, J., CONCANNON, P. J., & Jeggo, P. A. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.025 · Cited by 208

Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning

Sugasawa, K., Akagi, J.-I., Nishi, R., Iwai, S., & Hanaoka, F. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.035 · Cited by 205

Multiple roles for MRE11 at uncapped telomeres

Deng, Y., Guo, X., Ferguson, D. O., & Chang, S. S. (2009) · Nature · doi:10.1038/nature08196 · Cited by 204

The ataxia–oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

Clements, P. M., Breslin, C., Deeks, E. D., Byrd, P. J., Ju, L., Bieganowski, P., Brenner, C., Moreira, M.-C., Taylor, A. M. R., & Caldecott, K. W. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.06.017 · Cited by 203

Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

Gu, Y., Sekiguchi, J., Gao, Y., Dikkes, P., Frank, K. M., Ferguson, D. O., Hasty, P., Chun, J. J. M., & Alt, F. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.6.2668 · Cited by 198

Double‐check probing of DNA bending and unwinding by XPA–RPA: an architectural function in DNA repair

Missura, M., Buterin, T., Hindges, R., Hübscher, U., Kašpárková, J., Brabec, V., & Naegeli, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.13.3554 · Cited by 195

Terminally Differentiated Human Neurons Repair Transcribed Genes but Display Attenuated Global DNA Repair and Modulation of Repair Gene Expression

Nouspikel, T., & Hanawalt, P. C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1562-1570.2000 · Cited by 194

Identification of hMutLβ, a Heterodimer of hMLH1 and hPMS1

Räschle, M., Marra, G., Nyström, M., Schär, P., & Jiricny, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32368 · Cited by 192

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

Orii, K. E., Lee, Y., Kondo, N., & McKinnon, P. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602436103 · Cited by 192

Lymphocyte-Specific Compensation for XLF/Cernunnos End-Joining Functions in V(D)J Recombination

Li, G., Alt, F. W., Cheng, H.-L., Brush, J. W., Goff, P. H., Murphy, M., Franco, S., Zhang, Y., & Zha, S. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.07.017 · Cited by 191

Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation

DeWeese, T. L., Shipman, J. M., Larrier, N., Buckley, N. M., Kidd, L. R., Groopman, J. D., Cutler, R. G., Riele, H. T., & Nelson, W. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11915 · Cited by 190

Nucleotide Excision Repair Driven by the Dissociation of CAK from TFIIH

Coin, F., Oksenych, V., Mocquet, V., Groh, S., Blattner, C., & Egly, J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.024 · Cited by 188

Regulation of endonuclease activity in human nucleotide excision repair

Fagbemi, A. F., Orelli, B., & Schärer, O. D. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.04.022 · Cited by 183

Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging

Kamenisch, Y., Fousteri, M. I., Knoch, J., von Thaler, A., Fehrenbacher, B., Kato, H., Becker, T., Dollé, M. E. T., Kuiper, R., Majora, M., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091834 · Cited by 182

In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.

Xiao, W., & Samson, L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2117 · Cited by 181

V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining

Soulas-Sprauel, P., Rivera-Muñoz, P., Malivert, L., Guyader, G. L., Abramowski, V., Revy, P., & de Villartay, J. (2007) · Oncogene · doi:10.1038/sj.onc.1210875 · Cited by 180

3'-Phosphodiesterase activity of human apurinic/apyrimidinic endonuclease at DNA double-strand break ends

Suh, D., Wilson, D. M., & Povirk, L. F. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.12.2495 · Cited by 178

Effect of meiotic recombination on the production of aneuploid gametes in humans

Lamb, N. E., Sherman, S. L., & Hassold, T. J. (2005) · Cytogenetic and Genome Research · doi:10.1159/000086896 · Cited by 178

Aprataxin, a novel protein that protects against genotoxic stress

Gueven, N. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh122 · Cited by 177

Impaired Nonhomologous End-Joining Provokes Soft Tissue Sarcomas Harboring Chromosomal Translocations, Amplifications, and Deletions

Sharpless, N. E., Ferguson, D. O., O’Hagan, R. C., Castrillón, D. H., Lee, C., Farazi, P. A., Alson, S., Fleming, J., Morton, C. C., Frank, K. M., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00425-7 · Cited by 173

Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step

Mocquet, V., Lainé, J., Riedl, T., Yajin, Z., Lee, M. Y., & Egly, J. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601948 · Cited by 172

Proliferating Cell Nuclear Antigen Facilitates Excision in Long-patch Base Excision Repair

Gary, R., Kim, K., Cornelius, H. L., Park, M. S., & Matsumoto, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.7.4354 · Cited by 170

Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

Toft, N. J., Winton, D. J., Kelly, J., Howard, L., Dekker, M., Riele, H. T., Arends, M. J., Wyllie, A. H., Margison, G. P., & Clarke, A. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3911 · Cited by 168

Degradation of the alkylated form of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase

Xu‐Welliver, M. (2002) · Carcinogenesis · doi:10.1093/carcin/23.5.823 · Cited by 168

A DNA End-Binding Factor Involved in Double-Strand Break Repair and V(D)J Recombination

Rathmell, W. K., & Chu, G. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4741 · Cited by 166

Structural basis for the recruitment of ERCC1‐XPF to nucleotide excision repair complexes by XPA

Tsodikov, O. V., Ivanov, D., Orelli, B., Staresincic, L., Shoshani, I., Oberman, R., Schärer, O. D., Wagner, G., & Ellenberger, T. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601894 · Cited by 166

DNA damage stabilizes interaction of CSB with the transcription elongation machinery

van den Boom, V., Citterio, E., Hoogstraten, D., Zotter, A., Egly, J., van Cappellen, W. A., Hoeijmakers, J. H. J., Houtsmuller, A. B., & Vermeulen, W. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200401056 · Cited by 166

DNA repair in mammalian mitochondria: Much more than we thought?

Liu, P., & Demple, B. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20576 · Cited by 164

Cockayne syndrome B protein regulates the transcriptional program after UV irradiation

Proietti‐De‐Santis, L., Drané, P., & Egly, J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601071 · Cited by 163

Erratum: DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination

Mol, C. D., Izumi, T., MITRA, S. P., & Tainer, J. A. (2000) · Nature · doi:10.1038/35006693 · Cited by 162

Human Mre11/Human Rad50/Nbs1 and DNA Ligase IIIα/XRCC1 Protein Complexes Act Together in an Alternative Nonhomologous End Joining Pathway

Della-Maria, J., Zhou, Y., Tsai, M.-S., Kuhnlein, J., Carney, J. P., Paull, T. T., & Tomkinson, A. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.274159 · Cited by 161

MUTYH-associated polyposis—From defect in base excision repair to clinical genetic testing

Cheadle, J. P., & Sampson, J. R. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.11.001 · Cited by 157

Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

Zhou, T. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki170 · Cited by 153

Up-regulation of WRN and DNA ligase IIIα in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks

Sallmyr, A., Tomkinson, A. E., & Rassool, F. V. (2008) · Blood · doi:10.1182/blood-2007-07-104257 · Cited by 152

Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents

Rasouli‐Nia, A., Karimi‐Busheri, F., & Weinfeld, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400099101 · Cited by 151

Protein–protein interactions and posttranslational modifications in mammalian base excision repair

Fan, J., & WILSONIII, D. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.01.012 · Cited by 148

Mitochondrial DNA repair and association with aging – An update

Gredilla, R., Bohr, V. A., & Stevnsner, T. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.017 · Cited by 147

DNA mismatch repair defects: role in colorectal carcinogenesis

Jacob, S., & Praz, F. (2002) · Biochimie · doi:10.1016/s0300-9084(01)01362-1 · Cited by 147

DNA mismatch repair and DNA methylation in adult brain neurons

Brooks, P. J., Marietta, C. A., & Goldman, D. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-03-00939.1996 · Cited by 145

Defective neurogenesis resulting from DNA ligase IV deficiency requires AtmPreprint

Lee, Y., Barnes, D. E., Lindahl, T. L., & McKinnon, P. J. (2000) · Genes & Development · doi:10.1101/gad.837100 · Cited by 144

A New XRCC1-Containing Complex and Its Role in Cellular Survival of Methyl Methanesulfonate Treatment

Luo, H., Chan, D. W., Yang, T., Rodriguez, M. A., Chen, B. P.-C., Leng, M., Mu, J., Chen, D. J., Songyang, Z., Wáng, Y., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8356-8365.2004 · Cited by 144

Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane

Aamann, M. D., Sorensen, M. M., Hvitby, C., Berquist, B. R., Müftüoğlu, M., Tian, J., de Souza-Pinto, N. C., Scheibye‐Knudsen, M., Wilson, D. M., Stevnsner, T., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-147991 · Cited by 142

Evidence for Involvement of HMGB1 Protein in Human DNA Mismatch Repair

Yuan, F., Gu, L., Guo, S., Wang, C., & Li, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401931200 · Cited by 140

Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria

Das, B. B., Dexheimer, T. S., Maddali, K., & Pommier, Y. G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009814107 · Cited by 139

Quantification of DNA damage products resulting from deamination, oxidation and reaction with products of lipid peroxidation by liquid chromatography isotope dilution tandem mass spectrometry

Taghizadeh, K., McFaline‐Figueroa, J. L., Pang, B., Sullivan, M. R., Dong, M., Plummer, E. F., & Dedon, P. C. (2008) · Nature Protocols · doi:10.1038/nprot.2008.119 · Cited by 138

O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis.

Nakatsuru, Y., Matsukuma, S., Nemoto, N., Sugano, H., Sekiguchi, M., & Ishikawa, T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6468 · Cited by 138

Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1

Wu, J., Zhang, X., Zhang, L., Wu, C., Rezaeian, A. H., Chan, C., Li, J.-M., Wang, J., Gao, Y., Han, F., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.02.018 · Cited by 135

Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52–ssDNA complexes

Grimme, J. M., Honda, M., Wright, R., Okuno, Y., Rothenberg, E., Mazin, A. V., Ha, T., & Spies, M. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp1249 · Cited by 135

Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain

Iida, T., Furuta, A., Nishioka, K., Nakabeppu, Y., & Iwaki, T. (2001) · Acta Neuropathologica · doi:10.1007/s004010100418 · Cited by 135

Translocation of Cockayne syndrome group A protein to the nuclear matrix: Possible relevance to transcription-coupled DNA repair

Kamiuchi, S., Saijo, M., Citterio, E., de Jager, M., Hoeijmakers, J. H. J., & Tanaka, K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012473199 · Cited by 133

Neurological symptoms and natural course of xeroderma pigmentosum

Anttinen, A., Koulu, L., Nikoskelainen, E., Portin, R., Kurki, T., Erkinjuntti, M., Jaspers, N. G. J., Raams, A., Green, M. H. L., Lehmann, A. R., et al. (2008) · Brain · doi:10.1093/brain/awn126 · Cited by 132

Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice.

Sakumi, K., Shiraishi, A., Shimizu, S., Tsuzuki, T., Ishikawa, T., & Sekiguchi, M. (1997) · PubMed · Cited by 131

Mismatch Repair Processing of Carcinogen-DNA Adducts Triggers Apoptosis

Wu, J., Gu, L., Wang, H., Geacintov, N. E., & Li, G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8292 · Cited by 130

Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase

Endres, M., Biniszkiewicz, D., Sobol, R. W., Harms, C., Ahmadi, M., Lipski, A., Katchanov, J., Mergenthaler, P., Dirnagl, U., Wilson, S. H., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420926 · Cited by 128

A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genomePreprint

Ohno, M., Miura, T., Furuichi, M., Tominaga, Y., Tsuchimoto, D., Sakumi, K., & Nakabeppu, Y. (2006) · Genome Research · doi:10.1101/gr.4769606 · Cited by 126

Variation in base excision repair capacity

Wilson, D. M., Kim, D., Berquist, B. R., & Sigurdson, A. J. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.12.004 · Cited by 126

Expression of the MutL Homologue hMLH3 in Human Cells and its Role in DNA Mismatch Repair

Cannavò, E., Marra, G., Sabates–Bellver, J., Menigatti, M., Lipkin, S. M., Fischer, F., Ćejka, P., & Jiricny, J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2528 · Cited by 125

A comprehensive description of the severity groups in Cockayne syndrome

Natale, V. (2011) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33933 · Cited by 125

Identification and characterization of OGG1 mutations in patients with Alzheimer's disease

Mao, G., Pan, X., Zhu, B., Zhang, Y., Yuan, F., Huang, J. V., Lovell, M. A., Lee, M. P., Markesbery, W. R., Li, G., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm189 · Cited by 124

DNA Repair Synthesis Facilitates RAD52-Mediated Second-End Capture during DSB Repair

McIlwraith, M. J., & West, S. C. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.11.037 · Cited by 123

Evidence that OGG1 Glycosylase Protects Neurons against Oxidative DNA Damage and Cell Death under Ischemic Conditions

Liu, D., Croteau, D. L., de Souza-Pinto, N. C., PITTA, M. G. R., Tian, J., Wu, C. W., Jiang, H., Mustafa, K., Keijzers, G., Bohr, V. A., et al. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.147 · Cited by 123

Reconstitution of the strand invasion step of double-strand break repair using human Rad51 Rad52 and RPA proteins

McIlwraith, M. J., Dyck, E. V., Masson, J., Stasiak, A. Z., Stasiak, A., & West, S. C. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4180 · Cited by 121

Transcriptional mutagenesis: causes and involvement in tumour development

Brégeon, D., & Doetsch, P. W. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3006 · Cited by 120

Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)

Boboilă, C., Oksenych, V., Gostissa, M., Wang, J. H., Zha, S., Zhang, Y., Chai, H., Lee, C., Janković, M., Albertorio-Sáez, L. M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121470109 · Cited by 120

Cooperation of the Cockayne Syndrome Group B Protein and Poly(ADP-Ribose) Polymerase 1 in the Response to Oxidative Stress

Thorslund, T., von Kobbe, C., Harrigan, J. A., Indig, F. E., Christiansen, M., Stevnsner, T., & Bohr, V. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7625-7636.2005 · Cited by 118

Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates

Wong, H., Müftüoğlu, M., Beck, G., Imam, S. Z., Bohr, V. A., & Wilson, D. M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm404 · Cited by 117

ACCELERATED PAPER: Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent

Tsuzuki, T., Sakumi, K., Shiraishi, A., Kawate, H., Igarashi, H., Iwakuma, T., Tominaga, Y., Zhang, S., Shimizu, S., Ishikawa, T., et al. (1996) · Carcinogenesis · doi:10.1093/carcin/17.6.1215 · Cited by 116

The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways

Orelli, B., McClendon, T. B., Tsodikov, O. V., Ellenberger, T., Niedernhofer, L. J., & Schärer, O. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.067538 · Cited by 116

The Heterochromatic Barrier to DNA Double Strand Break Repair: How to Get the Entry Visa

Goodarzi, A. A., & Jeggo, P. A. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms130911844 · Cited by 113

Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair

Tahbaz, N., Subedi, S., & Weinfeld, M. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1245 · Cited by 113

Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase

Endres, M., Biniszkiewicz, D., Sobol, R. W., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20926 · Cited by 111

UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice

van der Horst, G. T. J., Meira, L. B., Gorgels, T. G. M. F., de Wit, J., Velasco-Miguel, S., Richardson, J. A., Kamp, Y., Vreeswijk, M. P. G., Smit, B., Bootsma, D., et al. (2002) · DNA repair · doi:10.1016/s1568-7864(01)00010-6 · Cited by 110

p8/TTD-A as a Repair-Specific TFIIH Subunit

Coin, F., Proietti‐De‐Santis, L., Nardò, T., Zlobinskaya, O., Stefanini, M., & Egly, J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.10.024 · Cited by 109

Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repair

Camenisch, U., Dip, R., Schumacher, S. B., Schuler, B., & Naegeli, H. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1061 · Cited by 109

Cockayne Syndrome Group B Protein Stimulates Repair of Formamidopyrimidines by NEIL1 DNA Glycosylase

Müftüoğlu, M., de Souza-Pinto, N. C., Doğan, A., Aamann, M. D., Stevnsner, T., Rybanská, I., Kırkalı, G., Dizdaroğlu, M., & Bohr, V. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807006200 · Cited by 106

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Larrea, A. A., Lujan, S. A., & Kunkel, T. A. (2010) · Cell · doi:10.1016/j.cell.2010.05.002 · Cited by 106

Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBSPreprint

Shull, E. R. P., Lee, Y., Nakane, H., Stracker, T. H., Zhao, J., Russell, H. R., Petrini, J. H. J., & McKinnon, P. J. (2009) · Genes & Development · doi:10.1101/gad.1746609 · Cited by 106

Responding to DNA double strand breaks in the nervous system

Lee, Y., & McKinnon, P. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.026 · Cited by 105

Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes

Miao, Z., Agama, K., Sordet, O., Povirk, L. F., Kohn, K. W., & Pommier, Y. G. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.07.004 · Cited by 102

Human Rad52-mediated homology search and annealing occurs by continuous interactions between overlapping nucleoprotein complexes

Rothenberg, E., Grimme, J. M., Spies, M., & Ha, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810317106 · Cited by 100

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Huang, R., & Zhou, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00648-7 · Cited by 1,015

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Bisht, S., Faiq, M. A., Tolahunase, M., & Dada, R. (2017) · Nature Reviews Urology · doi:10.1038/nrurol.2017.69 · Cited by 918

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Blokzijl, F., Janssen, R., van Boxtel, R., & Cuppen, E. (2018) · Genome Medicine · doi:10.1186/s13073-018-0539-0 · Cited by 660

DNA damage and its links to neurodegeneration

Madabhushi, R., Pan, L., & Tsai, L.-H. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.034 · Cited by 654

NAD(+) in aging: molecular mechanisms and translational implications

Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P., & Bohr, V. A. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.08.001 · Cited by 501

Genome integrity and disease prevention in the nervous systemPreprint

McKinnon, P. J. (2017) · Genes & Development · doi:10.1101/gad.301325.117 · Cited by 161

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Overview of DNA Repair Pathways

Croteau, D. L., & Bohr, V. A. (2013) · CRC Press eBooks · doi:10.1201/b14587-5 · Cited by 2

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Abugable, A. A., Morris, J. L. M., Palminha, N. M., Zaksauskaite, R., Ray, S., & El‐Khamisy, S. F. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.102669 · Cited by 53

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