Cited by 697DNA Repair MechanismsPARP inhibition in cancer therapyDNA and Nucleic Acid Chemistry

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DNA repair mechanisms in dividing and non-dividing cells

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Iyama, Teruaki, Wilson, David M.·2013·DNA Repair

DOI 10.1016/j.dnarep.2013.04.015PMC PMC3720834

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Abstract

DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple forms, and if allowed to persist, can promote genome instability and directly lead to various human diseases, particularly cancer, neurological abnormalities, immunodeficiency and premature aging. To avoid such deleterious outcomes, cells have evolved an array of DNA repair pathways, which carry out what is typically a multiple-step process to resolve specific DNA lesions and maintain genome integrity. To fully appreciate the biological contributions of the different DNA repair systems, one must keep in mind the cellular context within which they operate. For example, the human body is composed of non-dividing and dividing cell types, including, in the brain, neurons and glial cells. We describe herein the molecular mechanisms of the different DNA repair pathways, and review their roles in non-dividing and dividing cells, with an eye toward how these pathways may regulate the development of neurological disease.

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Authors: Iyama, T., & Wilson, D. M.
Affiliations: National Institutes of Health (US)
Corresponding author: Wilson, David M.
ORCID: Wilson, David M.
Venue: DNA Repair
Publisher: Elsevier BV
Published: 2013-08
Volume: 12
Issue: 8
Pages: 620-636
ISSN: 1568-7856 (ISSN-L)
1568-7864
DOI: 10.1016/j.dnarep.2013.04.015
PMC: PMC3720834
OpenAlex: W2004257622
Cited by: 697
References: 280
Citations by year: 2026: 20 · 2025: 37 · 2024: 49 · 2023: 56 · 2022: 43 · 2021: 69 · 2020: 58 · 2019: 59 · 2018: 65 · 2017: 57 · 2016: 72 · 2015: 62 · 2014: 47 · 2013: 2
FWCI: 27.17
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: DNA repair (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health
National Institute on Aging (ZIAAG000751)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: DNA repair pathways, genome stability, genetic damage, dividing cells, non-dividing cells, neurons, glial cells, neurological disorders, cancer, premature aging, immunodeficiency, DNA lesions
MeSH terms: Animals, Disease Models, Animal, DNA, DNA Damage, DNA Repair, Humans, Neurons, Pyrimidine Dimers, O(6)-Methylguanine-DNA Methyltransferase

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DNA repair mechanisms in dividing and non-dividing cells

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