Open PHACTS: semantic interoperability for drug discovery
Open accessAbstract
Open PHACTS is a public-private partnership between academia, publishers, small and medium sized enterprises and pharmaceutical companies. The goal of the project is to deliver and sustain an 'open pharmacological space' using and enhancing state-of-the-art semantic web standards and technologies. It is focused on practical and robust applications to solve specific questions in drug discovery research. OPS is intended to facilitate improvements in drug discovery in academia and industry and to support open innovation and in-house non-public drug discovery research. This paper lays out the challenges and how the Open PHACTS project is hoping to address these challenges technically and socially.
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The growth of the CC resource is restricted by the number and quality of publicly accessible data sets.
“The growth of the CC resource is restricted by the number and quality of publicly accessible data sets, a limitation that is likely to be ameliorated with the implementation of private-public partnerships and the general awareness that, in the markedly gene-centric omics era, the depth of small-molecule annotation lags behind genomes and proteomes39,40.”
From Bioactivity descriptors for uncharacterized chemical compounds (2021) · cites this paper as [39]
The depth of small-molecule annotation lags behind genomes and proteomes.
“the depth of small-molecule annotation lags behind genomes and proteomes39,40.”
From Bioactivity descriptors for uncharacterized chemical compounds (2021) · cites this paper as [39]
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“These challenges have directly influenced some of the approaches associated with the Open PHACTS semantic web project [48] where a “ chemical lenses ” approach has been utilised to focus the user in on various forms of the chemical [49].”
BackgroundSelf-citation
- Authors
- Williams, A. J., Harland, L., Groth, P., Pettifer, S., Chichester, C., Willighagen, E. L., Evelo, C. T., Blomberg, N., Ecker, G., Goble, C., & Mons, B.
- Affiliations
- Royal Society of Chemistry (GB)
- Vrije Universiteit Amsterdam (NL)
- SIB Swiss Institute of Bioinformatics (CH)
- Maastricht University (NL)
- Leiden University Medical Center (NL)
- AstraZeneca (Sweden) (SE)
- University of Vienna (AT)
- University of Manchester (GB)
- Corresponding author
- Williams, Antony J.
- ORCID
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 17
- Issue
- 21-22
- Pages
- 1188-1198
- ISSN
- 1359-6446 (ISSN-L)
- OpenAlex
- W2116238734
- Cited by
- 321
- References
- 51
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 8 · 2023: 11 · 2022: 10 · 2021: 15 · 2020: 13 · 2019: 25 · 2018: 22 · 2017: 30 · 2016: 45 · 2015: 48 · 2014: 48 · 2013: 24 · 2012: 12
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Drug Discovery Today (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, cc-by-nc-nd)
- Research Explorer (The University of Manchester) (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › Semantic Web and Ontologies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biomedical Text Mining and Ontologies
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
- Keywords
- Open PHACTS, semantic interoperability, semantic web, drug discovery, public-private partnerships, open innovation
- MeSH terms
- Drug Industry, Humans, Organizational Innovation, Research, Semantics, Drug Design, Information Storage and Retrieval, Internet, Drug Discovery, Public-Private Sector Partnerships
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