Advanced molecular imaging for the characterisation of complex medicines
Abstract
A growing number and diversity of complex medicines is in development and reaching the market, with many of these medicines utilising innovative delivery technology to achieve appropriate biodistribution and exposure. Accurate assessment of biodistribution, cell penetration, internalised form, cargo release and efficacy are essential for the development of these medicines. Advanced imaging technologies, deploying different labelling techniques that allow the assessment of both carrier and cargo, are enabling in-depth analysis and providing a mechanistic understanding of each step in the drug delivery pathway. Translation across cell, tissue and whole-body settings using multiple imaging methods can provide decision-making information that is critical for clinical phase selection and for the development of complex medicines.
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Targeted radiopharmaceuticals hit the right spots and avoid causing trouble in other areas of the body.
“This collaboration between advanced labeling techniques and drug design means these medicines not only hit the right spots but also avoid causing trouble in other areas of our bodies [14].”
From Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation (2024) · cites this paper as [14]
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Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation
Dhoundiyal, S., Srivastava, S., Kumar, S., Singh, G., Ashique, S., Pal, R., Mishra, N., & Taghizadeh-Hesary, F. (2024) · European Journal of Medical Research · doi:10.1186/s40001-023-01627-0 · Cited by 144 · see citing works
“This collaboration between advanced labeling techniques and drug design means these medicines not only hit the right spots but also avoid causing trouble in other areas of our bodies [14].”
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Gai, Y., Li, Y., Wu, S., Xu, L., Lu, Y., Lan, X., Xiang, G., & Ma, X. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020401 · Cited by 6 · see citing works
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Radiopharmaceuticals: Status, Regulatory Landscape and Future Perspective
Maithania, H. V., John, R., Painoori, R., monpara, J., Swaminathan, S., & Kalhapure, R. S. (2026) · AAPS PharmSciTech · doi:10.1208/s12249-026-03346-1 · Cited by 4 · see citing works
- Authors
- Yilmaz, D., Sharp, P. S., Main, M. J., & Simpson, P. B.
- Affiliations
- Medicines Discovery Catapult (GB)
- Corresponding author
- Simpson, Peter B.
- ORCID
- Simpson, Peter B.
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 27
- Issue
- 6
- Pages
- 1716-1723
- ISSN
- 1359-6446 (ISSN-L)
- OpenAlex
- W4214884829
- Cited by
- 5
- References
- 66
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 1
- FWCI
- 0.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Drug Discovery Today (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- molecular imaging, drug delivery, tissue distribution, cell penetration, internalization, cargo release, drug carriers, drug development, translational imaging
- MeSH terms
- Pharmaceutical Preparations, Tissue Distribution, Molecular Imaging
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