Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

Mechanisms of endocytosis

Doherty, G. J., & McMahon, H. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.081307.110540 · Cited by 3,075 · see citing works

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

Soutschek, J., Akinc, A., Bramlage, B., Charissé, K., Constien, R., Donoghue, M., Elbashir, S. M., Geick, A., Hadwiger, P., Harborth, J., et al. (2004) · Nature · doi:10.1038/nature03121 · Cited by 2,189 · see citing works

Dynasore, a Cell-Permeable Inhibitor of Dynamin

Macia, E., Ehrlich, M., Massol, R., Boucrot, E., Brunner, C., & Kirchhausen, T. L. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.002 · Cited by 2,038 · see citing works

Rational design of cationic lipids for siRNA delivery

Semple, S. C., Akinc, A., Chen, J., Sandhu, A. P., Mui, B. L., Cho, C. K., Sah, D. W. Y., Stebbing, D., Crosley, E. J., Yaworski, E., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1602 · Cited by 1,822 · see citing works

Rab Conversion as a Mechanism of Progression from Early to Late Endosomes

Rink, J. C., Ghigo, É., Kalaidzidis, Y. L., & Zerial, M. (2005) · Cell · doi:10.1016/j.cell.2005.06.043 · Cited by 1,680 · see citing works

Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo

Jayaraman, M., Ansell, S. M., Mui, B. L., Tam, Y. K., Chen, J., Du, X., Butler, D., Eltepu, L., Matsuda, S., Narayanannair, J. K., et al. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201203263 · Cited by 1,267 · see citing works

Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms

Akinc, A., Querbes, W., De, S., Qin, J., Frank-Kamenetsky, M., Jayaprakash, K. N., Jayaraman, M., Rajeev, K. G., Cantley, W. L., Dorkin, J. R., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.85 · Cited by 1,261 · see citing works

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

Akinc, A., Zumbuehl, A., Goldberg, M. S., Leshchiner, E. S., Busini, V., Hossain, N., Bacallado, S., Nguyen, D. N., Fuller, J. E., Alvarez, R., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1402 · Cited by 1,228 · see citing works

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

Wolfrum, C., Shi, S., Jayaprakash, K. N., Jayaraman, M., Wang, G., Pandey, R. K., Rajeev, K. G., Nakayama, T., Charrise, K., Ndungo, E. M., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1339 · Cited by 974 · see citing works

Lipid-like materials for low-dose, in vivo gene silencing

Love, K. T., Mahon, K. P., Levins, C. G., Whitehead, K. A., Querbes, W., Dorkin, J. R., Qin, J., Cantley, W., Qin, L. L., Racie, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910603106 · Cited by 969 · see citing works

Identification of the Switch in Early-to-Late Endosome Transition

Poteryaev, D., Datta, S., Ackema, K., Zerial, M., & Spang, A. (2010) · Cell · doi:10.1016/j.cell.2010.03.011 · Cited by 752 · see citing works

Small RNA sorting: matchmaking for Argonautes

Czech, B., & Hannon, G. J. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2916 · Cited by 692 · see citing works

Membrane transport in the endocytic pathway

Gruenberg, J. E., & Maxfield, F. R. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80013-1 · Cited by 645 · see citing works

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

Frank-Kamenetsky, M. D., Grefhorst, A., Anderson, N. N., Racie, T., Bramlage, B., Akinc, A., Butler, D., Charissé, K., Dorkin, J. R., Fan, Y., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805434105 · Cited by 635 · see citing works

Breaking down the barriers: siRNA delivery and endosome escape

Domińska, M., & Dykxhoorn, D. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.066399 · Cited by 632 · see citing works

On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids

Hafez, I., Maurer, N., & Cullis, P. R. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301506 · Cited by 601 · see citing works

Sheddable Coatings for Long-Circulating Nanoparticles

Romberg, B., Hennink, W. E., & Storm, G. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9348-7 · Cited by 554 · see citing works

Adenovirus triggers macropinocytosis and endosomal leakage together with its clathrin-mediated uptake

Meier, O. C., Boucke, K., Hammer, S. V., Keller, S., Stidwill, R. P., Hemmi, S., & Greber, U. F. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112067 · Cited by 470 · see citing works

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

Zeigerer, A., Gilleron, J., Bogorad, R. L., Marsico, G., Nonaka, H., Seifert, S., Epstein-Barash, H., Kuchimanchi, S., Peng, C. G., Ruda, V. M., et al. (2012) · Nature · doi:10.1038/nature11133 · Cited by 362 · see citing works

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

Bramsen, J. B., Laursen, M. B., Nielsen, A. F., Hansen, T. B., Bus, C., Langkjær, N., Babu, B. R., Højland, T., Abramov, M., Van Aerschot, A., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp106 · Cited by 332 · see citing works

Efficient and targeted delivery of siRNA in vivo

Shim, M. S., & Kwon, Y. J. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07904.x · Cited by 311 · see citing works

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

Andaloussi, S. E., Lehto, T., Mäger, I., Rosenthal-Aizman, K., Oprea, I. I., Simonson, O. E., Sork, H., Ezzat, K., Copolovici, D. M., Kurrikoff, K., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1299 · Cited by 302 · see citing works

Stabilized plasmid-lipid particles: construction and characterization

Wheeler, J. J., Palmer, L., Ossanlou, M., MacLachlan, I., Graham, R. W., Zhang, Y. P., Hope, M. J., Scherrer, P., & Cullis, P. R. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300821 · Cited by 300 · see citing works

A status report on RNAi therapeutics

Vaishnaw, A. K., Gollob, J., Gamba‐Vitalo, C., Hutabarat, R. M., Sah, D. W. Y., Meyers, R. E., de Fougerolles, T., & Maraganore, J. M. (2010) · Silence · doi:10.1186/1758-907x-1-14 · Cited by 297 · see citing works

Connexin‐specific cell‐to‐cell transfer of short interfering RNA by gap junctions

Valiūnas, V., Polosina, Y. Y., Miller, H., et al. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.090985 · Cited by 297 · see citing works

The Tetraspanin CD63/lamp3 Cycles between Endocytic and Secretory Compartments in Human Endothelial Cells

Kobayashi, T., Vischer, U. M., Rosnoblet, C., Lebrand, C., Lindsay, M. R., Parton, R. G., Kruithof, E. K. O., & Gruenberg, J. E. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.5.1829 · Cited by 283 · see citing works

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes

Ohya, T., Miączyńska, M., Coskun, Ü., Lommer, B. S., Runge, A., Drechsel, D. N., Kalaidzidis, Y. L., & Zerial, M. (2009) · Nature · doi:10.1038/nature08107 · Cited by 235 · see citing works

The Rab5 Effector Rabankyrin-5 Regulates and Coordinates Different Endocytic Mechanisms

Schnatwinkel, C., Christoforidis, S., Lindsay, M. R., Uttenweiler‐Joseph, S., Wilm, M. S., Parton, R. G., & Zerial, M. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020261 · Cited by 225 · see citing works

Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells

Basha, G., Novobrantseva, T. I., Rosin, N. L., Tam, Y. Y. C., Hafez, I. M., Wong, M., Sugo, T., Ruda, V. M., Qin, J., Klebanov, B., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.190 · Cited by 182 · see citing works

Thermally sensitive cationic polymer nanocapsules for specific cytosolic delivery and efficient gene silencing of siRNA: Swelling induced physical disruption of endosome by cold shock

Lee, S. H., Choi, S. H., Kim, S. H., et al. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.09.011 · Cited by 166 · see citing works

Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: Programmed endosomal escape and dissociation☆

Akita, H., Kogure, K., Moriguchi, R., Nakamura, Y., Higashi, T., Nakamura, T., Serada, S., Fujimoto, M., Naka, T., & Futaki, S. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.01.012 · Cited by 164 · see citing works

In vivo silencing of alpha-synuclein using naked siRNA

Lewis, J. M., Melrose, H. L., Bumcrot, D. A., et al. (2008) · Molecular Neurodegeneration · doi:10.1186/1750-1326-3-19 · Cited by 148 · see citing works

Construction and Characterization of a Lipotes vexillifer Genomic DNA BAC Library

Du, B. X., Zhang, X., Fang, S., & Wang, D. (2007) · ZOOLOGICAL SCIENCE · doi:10.2108/zsj.24.401 · Cited by 125 · see citing works

Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA

Sakurai, Y., Hatakeyama, H., Sato, Y., Akita, H., Takayama, K., Kobayashi, S., Futaki, S., & Harashima, H. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.047 · Cited by 114 · see citing works

Selective gene silencing by viral delivery of short hairpin RNA

Sliva, K., & Schnierle, B. S. (2010) · Virology Journal · doi:10.1186/1743-422x-7-248 · Cited by 107 · see citing works

Enhanced Cytoplasmic Delivery of siRNA Using a Stabilized Polyion Complex Based on PEGylated Nanogels with a Cross-Linked Polyamine Structure

Tamura, A., Oishi, M., & Nagasaki, Y. (2009) · Biomacromolecules · doi:10.1021/bm900252d · Cited by 101 · see citing works

Oligoribonucleotide Synthesis: The Silyl-Phosphoramidite Method

Damha, M. J., & Ogilvie, K. K. (2003) · Humana Press eBooks · doi:10.1385/0-89603-281-7:81 · Cited by 87 · see citing works

Quantitative evaluation of siRNA delivery in vivo

Pei, Y., Hancock, P. J., Zhang, H., Bartz, R., Cherrin, C., Innocent, N., Pomerantz, C. J., Seitzer, J. L., Koser, M. L., Abrams, M. T., et al. (2010) · RNA · doi:10.1261/rna.2255810 · Cited by 82 · see citing works

Excess vacuolar SNAREs drive lysis and Rab bypass fusion

Starai, V. J., Jun, Y., & Wickner, W. T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704741104 · Cited by 81 · see citing works

Antibody-Mediated Targeting of siRNA via the Human Insulin Receptor Using Avidin−Biotin Technology

Xia, C., Boado, R. J., & Pardridge, W. M. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800194y · Cited by 79 · see citing works

Modulation of thermal stability can enhance the potency of siRNA

Addepalli, H., Meena, M., Peng, C. G., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq568 · Cited by 74 · see citing works

Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape

Bartz, R., Fan, H., Zhang, J., Innocent, N., Cherrin, C., Beck, S. C., Pei, Y., Momose, A., Jadhav, V., Tellers, D. M., et al. (2011) · Biochemical Journal · doi:10.1042/bj20101021 · Cited by 63 · see citing works

In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR)

Landesman, Y., Svrzikapa, N., Cognetta, A. B., Zhang, X., Bettencourt, B. R., Kuchimanchi, S., Dufault, K., Shaikh, S., Gioia, M., Akinc, A., et al. (2010) · Silence · doi:10.1186/1758-907x-1-16 · Cited by 59 · see citing works

Novel siRNA Delivery System to Target Podocytes In Vivo

Hauser, P., Pippin, J. W., Kaiser, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009463 · Cited by 56 · see citing works

Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V

Schmees, C., Villaseñor, R., Zheng, W., Ma, H., Zerial, M., Heldin, C., & Hellberg, C. B. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-04-0317 · Cited by 49 · see citing works

RNA-Induced Silencing Complex-Bound Small Interfering RNA Is a Determinant of RNA Interference-Mediated Gene Silencing in Mice

Wei, J., Jones, J. J., Kang, J. X., et al. (2011) · Molecular Pharmacology · doi:10.1124/mol.110.070409 · Cited by 49 · see citing works

Non-viral vectors for the mediation of RNAi

Zhang, S., Zhao, Y., Zhi, D., & Zhang, S. (2011) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2011.07.005 · Cited by 40 · see citing works

Murine Cytomegalovirus Perturbs Endosomal Trafficking of Major Histocompatibility Complex Class I Molecules in the Early Phase of Infection

Tomaš, M. I., Kučić, N., Mahmutefendić, H., et al. (2010) · Journal of Virology · doi:10.1128/jvi.00988-10 · Cited by 30 · see citing works

Cancer nanomedicine: progress, challenges and opportunities

Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873 · see citing works

Lipid nanoparticles for mRNA delivery

Hou, X., Zaks, T., Langer, R., & Dong, Y. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00358-0 · Cited by 4,076 · see citing works

Cellular uptake of nanoparticles: Journey inside the cell

Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859 · see citing works

Progress and challenges towards targeted delivery of cancer therapeutics

Rosenblum, D., Joshi, N., Tao, W., Karp, J. M., & Peer, D. (2018) · Nature Communications · doi:10.1038/s41467-018-03705-y · Cited by 2,220 · see citing works

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

Zuris, J. A., Thompson, D. B., Shu, Y., Guilinger, J. P., Bessen, J. L., Hu, J. H., Maeder, M. L., Joung, J. K., Chen, Z.-Y., & Liu, D. R. (2015) · Nature Biotechnology · doi:10.1038/nbt.3081 · Cited by 1,460 · see citing works

Lipid Nanoparticle Systems for Enabling Gene Therapies

Cullis, P. R., & Hope, M. J. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.013 · Cited by 1,208 · see citing works

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

Kowalski, P. S., Rudra, A., Miao, L., & Anderson, D. G. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.02.012 · Cited by 1,127 · see citing works

In vitro and ex vivo strategies for intracellular delivery

Stewart, M. P., Sharei, A., Ding, X., Sahay, G., Langer, R., & Jensen, K. F. (2016) · Nature · doi:10.1038/nature19764 · Cited by 885 · see citing works

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

Finn, J. D., Smith, A. R., Patel, M. C., Shaw, L., Youniss, M. R., van Heteren, J., Dirstine, T., Ciullo, C., Lescarbeau, R., Seitzer, J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.014 · Cited by 878 · see citing works

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

Sabnis, S., Kumarasinghe, E. S., Salerno, T., Mihai, C., Ketova, T., Senn, J. J., Lynn, A., Bulychev, A., McFadyen, I., Chan, J., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.03.010 · Cited by 820 · see citing works

Tools for translation: non-viral materials for therapeutic mRNA delivery

Hajj, K. A., & Whitehead, K. A. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.56 · Cited by 799 · see citing works

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

Miao, L., Li, L., Huang, Y., Delcassian, D., Chahal, J., Han, J., Shi, Y., Sadtler, K., Gao, W., Lin, J., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0247-3 · Cited by 723 · see citing works

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

Wittrup, A., Ai, A., Liu, X., Hamar, P., Trifonova, R., Charisse, K., Manoharan, M., Kirchhausen, T., & Lieberman, J. (2015) · Nature Biotechnology · doi:10.1038/nbt.3298 · Cited by 693 · see citing works

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing

Liu, S., Cheng, Q., Wei, T., Yu, X., Johnson, L. T., Farbiak, L., & Siegwart, D. J. (2021) · Nature Materials · doi:10.1038/s41563-020-00886-0 · Cited by 653 · see citing works

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

Billingsley, M. M., Singh, N., Ravikumar, P., Zhang, R., June, C. H., & Mitchell, M. J. (2020) · Nano Letters · doi:10.1021/acs.nanolett.9b04246 · Cited by 636 · see citing works

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

Maier, M. A., Jayaraman, M., Matsuda, S., Liu, J., Barros, S., Querbes, W., Tam, Y. K., Ansell, S. M., Kumar, V., Qin, J., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.124 · Cited by 625 · see citing works

DNA nanotechnology from the test tube to the cell

Chen, Y.-J., Groves, B., Muscat, R. A., & Seelig, G. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.195 · Cited by 594 · see citing works

Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

Patel, S., Ashwanikumar, N., Robinson, E., Xia, Y., Mihai, C., Griffith, J. P., Hou, S., Esposito, A. A., Ketova, T., Welsher, K., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14527-2 · Cited by 601 · see citing works

Nanomaterial Delivery Systems for mRNA Vaccines

Buschmann, M. D., Carrasco, M. J., Alishetty, S., Paige, M., Alameh, M. G., & Weissman, D. (2021) · Vaccines · doi:10.3390/vaccines9010065 · Cited by 582 · see citing works

Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA

Miller, J. B., Zhang, S., Kos, P., Xiong, H., Zhou, K., Perelman, S. S., Zhu, H., & Siegwart, D. J. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201610209 · Cited by 540 · see citing works

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

Yanez Arteta, M., Kjellman, T., Bartesaghi, S., Wallin, S., Wu, X., Kvist, A. J., Dabkowska, A., Székely, N., Radulescu, A., Bergenholtz, J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720542115 · Cited by 534 · see citing works

mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases

Maruggi, G., Zhang, C., Li, J., Ulmer, J. B., & Yu, D. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.01.020 · Cited by 507 · see citing works

Gold Nanoparticles for Nucleic Acid Delivery

Ding, Y., Jiang, Z., Saha, K., Kim, C. S., Kim, S. T., Landis, R. F., & Rotello, V. M. (2014) · Molecular Therapy · doi:10.1038/mt.2014.30 · Cited by 521 · see citing works

Self-assembled mRNA vaccines

Kim, J., Eygeris, Y., Gupta, M., & Sahay, G. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.014 · Cited by 514 · see citing works

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

Maugeri, M., Nawaz, M., Papadimitriou, A., Angerfors, A., Camponeschi, A., Na, M., Hölttä, M., Skantze, P., Johansson, S., Sundqvist, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12275-6 · Cited by 428 · see citing works

Apolipoprotein E binding drives structural and compositional rearrangement of mRNA-containing lipid nanoparticles

Sebastiani, F., Yanez Arteta, M., Lerche, M., Porcar, L., Lang, C., Bragg, R. A., Elmore, C. S., Krishnamurthy, V. R., Russell, R. A., Darwish, T., et al. (2021) · ACS Nano · doi:10.1021/acsnano.0c10064 · Cited by 409 · see citing works

Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles

Schlich, M., Palomba, R., Costabile, G., Mizrahy, S., Pannuzzo, M., Peer, D., & Decuzzi, P. (2021) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10213 · Cited by 387 · see citing works

Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems

Guan, S., & Rosenecker, J. (2017) · Gene Therapy · doi:10.1038/gt.2017.5 · Cited by 389 · see citing works

Self-assembly of extracellular vesicle-like metal–organic framework nanoparticles for protection and intracellular delivery of biofunctional proteins

Cheng, G., Li, W., Ha, L., Han, X., Hao, S., Wan, Y., Wang, Z., Dong, F., Zou, X., Mao, Y., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b03584 · Cited by 371 · see citing works

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

Chen, S., Tam, Y. Y. C., Lin, P. J. C., Sung, M. M. H., Tam, Y. K., & Cullis, P. R. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.059 · Cited by 366 · see citing works

Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems

Leung, A. K. K., Tam, Y. Y. C., Chen, S., Hafez, I. M., & Cullis, P. R. (2015) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.5b02891 · Cited by 359 · see citing works

Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver

Miao, L., Lin, J., Huang, Y., Li, L., Delcassian, D., Ge, Y., Shi, Y., & Anderson, D. G. (2020) · Nature Communications · doi:10.1038/s41467-020-16248-y · Cited by 343 · see citing works

State-of-the-art design and rapid-mixing production techniques of lipid nanoparticles for nucleic acid delivery

Evers, M. J. W., Kulkarni, J. A., van der Meel, R., Cullis, P. R., Vader, P., & Schiffelers, R. M. (2018) · Small Methods · doi:10.1002/smtd.201700375 · Cited by 332 · see citing works

High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing

Sago, C. D., Lokugamage, M. P., Paunovska, K., Vanover, D. A., Monaco, C. M., Shah, N. N., Gamboa Castro, M., Anderson, S. E., Rudoltz, T. G., Lando, G. N., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811276115 · Cited by 313 · see citing works

Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of <i>in vivo</i> imaging

Jung, H. N., Lee, S.-Y., Lee, S., Youn, H., & Im, H.-J. (2022) · Theranostics · doi:10.7150/thno.77259 · Cited by 282 · see citing works

A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation

Paunovska, K., Sago, C. D., Monaco, C. M., Hudson, W. H., Castro, M. G., Rudoltz, T. G., Kalathoor, S., Vanover, D. A., Santangelo, P. J., Ahmed, R., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b00432 · Cited by 277 · see citing works

Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis

Robinson, E., MacDonald, K. D., Slaughter, K., McKinney, M., Patel, S., Sun, C., & Sahay, G. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.05.014 · Cited by 272 · see citing works

Lipid nanoparticles for delivery of messenger RNA to the back of the eye

Patel, S., Ryals, R. C., Weller, K. K., Pennesi, M. E., & Sahay, G. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.04.015 · Cited by 260 · see citing works

Boosting intracellular delivery of lipid nanoparticle-encapsulated mRNA

Patel, S., Ashwanikumar, N., Robinson, E., DuRoss, A., Sun, C., Murphy-Benenato, K. E., Mihai, C., Almarsson, Ö., & Sahay, G. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b02664 · Cited by 251 · see citing works

Dendrimer‐Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I

Cheng, Q., Wei, T., Jia, Y., Farbiak, L., Zhou, K., Zhang, S., Wei, Y., Zhu, H., & Siegwart, D. J. (2018) · Advanced Materials · doi:10.1002/adma.201805308 · Cited by 221 · see citing works

Optimization of a degradable polymer–lipid nanoparticle for potent systemic delivery of mRNA to the lung endothelium and immune cells

Kaczmarek, J. C., Kauffman, K. J., Fenton, O. S., Sadtler, K., Patel, A. K., Heartlein, M. W., DeRosa, F., & Anderson, D. G. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b02917 · Cited by 218 · see citing works

Lipid nanoparticle-mediated efficient delivery of CRISPR/Cas9 for tumor therapy

Zhang, L., Wang, P., Feng, Q., Wang, N., Chen, Z., Huang, Y., Zheng, W., & Jiang, X. (2017) · NPG Asia Materials · doi:10.1038/am.2017.185 · Cited by 218 · see citing works

Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses

Paunovska, K., Da Silva Sanchez, A. J., Sago, C. D., Gan, Z., Lokugamage, M. P., Islam, F. Z., Kalathoor, S., Krupczak, B. R., & Dahlman, J. E. (2019) · Advanced Materials · doi:10.1002/adma.201807748 · Cited by 205 · see citing works

Safety Evaluation of Lipid Nanoparticle–Formulated Modified mRNA in the Sprague-Dawley Rat and Cynomolgus Monkey

Sedic, M., Senn, J. J., Lynn, A., Laska, M., Smith, M., Platz, S. J., Bolen, J., Hoge, S., Bulychev, A., Jacquinet, E., et al. (2018) · Veterinary Pathology · doi:10.1177/0300985817738095 · Cited by 195 · see citing works

Uses and abuses of macropinocytosis

Bloomfield, G., & Kay, R. R. (2016) · Journal of Cell Science · doi:10.1242/jcs.176149 · Cited by 193 · see citing works

Lipid-based nanoparticle formulations for small molecules and RNA drugs

Ickenstein, L. M., & Garidel, P. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1669558 · Cited by 193 · see citing works

Lipid nanoparticles for targeted siRNA delivery - going from bench to bedside

Zatsepin (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s106625 · Cited by 162 · see citing works

Lipid nanoparticles for short interfering RNA delivery

Leung, A. K. K., Tam, Y. Y. C., & Cullis, P. R. (2014) · Advances in genetics · doi:10.1016/b978-0-12-800148-6.00004-3 · Cited by 158 · see citing works

Visualization of self-delivering hydrophobically modified siRNA cellular internalization

Ly, S., Navaroli, D. M., Didiot, M.-C., Cardia, J., Pandarinathan, L., Alterman, J. F., Fogarty, K., Standley, C., Lifshitz, L. M., Bellve, K. D., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1005 · Cited by 132 · see citing works

Nanoplatforms for mRNA Therapeutics

Meng, C., Chen, Z., Li, G., Welte, T., & Shen, H. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202000099 · Cited by 130 · see citing works

Self-degradable lipid-like materials based on “hydrolysis accelerated by the intra-particle enrichment of reactant (HyPER)” for messenger RNA delivery

Tanaka, H., Takahashi, T., Konishi, M., Takata, N., Gomi, M., Shirane, D., Miyama, R., Hagiwara, S., Yamasaki, Y., Sakurai, Y., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910575 · Cited by 126 · see citing works

Mild Innate Immune Activation Overrides Efficient Nanoparticle‐Mediated RNA Delivery

Lokugamage, M. P., Gan, Z., Zurla, C., Levin, J., Islam, F. Z., Kalathoor, S., Sato, M., Sago, C. D., Santangelo, P. J., & Dahlman, J. E. (2020) · Advanced Materials · doi:10.1002/adma.201904905 · Cited by 126 · see citing works

Delivery of mRNA Therapeutics for the Treatment of Hepatic Diseases

Trepotec, Z., Lichtenegger, E., Plank, C., Aneja, M. K., & Rudolph, C. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2018.12.012 · Cited by 115 · see citing works

A single methylene group in oligoalkylamine‐based cationic polymers and lipids promotes enhanced mRNA delivery

Jarzębińska, A., Pasewald, T., Lambrecht, J., Mykhaylyk, O., Kümmerling, L., Beck, P., Hasenpusch, G., Rudolph, C., Plank, C., & Dohmen, C. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201603648 · Cited by 101 · see citing works

Exosome-based small RNA delivery: Progress and prospects

Lu, M., Xing, H., Xun, Z., Yang, T., Ding, P., Cai, C., Wang, D., & Zhao, X. (2018) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2017.07.008 · Cited by 97 · see citing works

Protamine-Based Strategies for RNA Transfection

Jarzebska, N. T., Mellett, M., Frei, J., Kündig, T. M., & Pascolo, S. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13060877 · Cited by 95 · see citing works

Naturally Derived Membrane Lipids Impact Nanoparticle-Based Messenger RNA Delivery

Kim, J., Jozic, A., & Sahay, G. (2020) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-020-00619-y · Cited by 61 · see citing works

Negative Surface Shielded Polymeric Micelles with Colloidal Stability for Intracellular Endosomal/Lysosomal Escape

Zhu, Y., Meng, T., Tan, Y., Yang, X., Liu, Y., Liu, X., Yu, F., Wen, L., Dai, S., Yuan, H., et al. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00842 · Cited by 42 · see citing works

pH-Responsive polymer boosts cytosolic siRNA release for retinal neovascularization therapy

Guo, S., Li, C., Wang, C., Cao, X., Liu, X., Liang, X.-J., Huang, Y., & Weng, Y. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.09.001 · Cited by 36 · see citing works

Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation

Boto, C., Quartin, E., Cai, Y., Martín-Lorenzo, A., Cenador, M. B. G., Pinto, S., Gupta, R., Enver, T., Sánchez-García, I., Hong, D., et al. (2017) · Nature Communications · doi:10.1038/ncomms15204 · Cited by 28 · see citing works

Advancing mRNA technologies for therapies and vaccines: An African context

Kairuz, D., Samudh, N., Ely, A., Arbuthnot, P., & Bloom, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1018961 · Cited by 25 · see citing works

Enhancing siRNA delivery by employing lipid nanoparticles

Hope, M. J. (2014) · Therapeutic Delivery · doi:10.4155/tde.14.37 · Cited by 22 · see citing works

APOE polymorphism in ATTR amyloidosis patients treated with lipid nanoparticle siRNA

Niemietz, C., Nadzemova, O., Zibert, A., & Schmidt, H. H.-J. (2020) · Amyloid · doi:10.1080/13506129.2019.1681392 · Cited by 22 · see citing works

Advanced molecular imaging for the characterisation of complex medicines

Yilmaz, D., Sharp, P. S., Main, M. J., & Simpson, P. B. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.03.001 · Cited by 5 · see citing works

Fluid phase endocytosis and galactosyl receptor-mediated endocytosis employ different early endosomes

Synnes, M., Prydz, K., Løvdal, T., et al. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00134-0 · Cited by 31 · see citing works

The emergence of clathrin-independent pinocytic pathways

Lamaze, C., & Schmid, S. L. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80015-8 · Cited by 283 · see citing works

Study progress of cell endocytosis

Li, Chen, Hui, et al. (2009) · Acta Scientiarum Naturalium Universitatis Sunyatseni

Revealing macropinocytosis using nanoparticles

Means, N., Elechalawar, C. K., Chen, W. R., Bhattacharya, R., & Mukherjee, P. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100993 · Cited by 109 · see citing works

Endocytosis of Peptide Hormones and Other Ligands

Posner, B. I., Khan, M. N., & Bergeron, J. J. M. (1982) · Endocrine Reviews · doi:10.1210/edrv-3-3-280 · Cited by 92 · see citing works