Nanoparticle delivery in vivo: A fresh look from intravital imaging
Open accessAbstract
Nanomedicine has proven promising in preclinical studies. However, only few formulations have been successfully translated to clinical use. A thorough understanding of how nanoparticles interact with cells in vivo is essential to accelerate the clinical translation of nanomedicine. Intravital imaging is a crucial tool to reveal the mechanisms of nanoparticle transport in vivo, allowing for the development of new strategies for nanomaterial design. Here, we first review the most recent progress in using intravital imaging to answer fundamental questions about nanoparticle delivery in vivo. We then elaborate on how nanoparticles interact with different cell types and how such interactions determine the fate of nanoparticles in vivo. Lastly, we discuss ways in which the use of intravital imaging can be expanded in the future to facilitate the clinical translation of nanomedicine.
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Liver-targeted delivery strategies have shown efficacy for other ion channel modulators and could be adapted to Piezo1-targeted therapies.
“Liver-targeted delivery strategies—for instance, nanoparticle-based systems or ligand-directed conjugates—have shown efficacy for other ion channel modulators and could be adapted to Piezo1-targeted therapies.145”
From Mechanosensitive calcium ion channels Piezo1: A therapeutic target in liver disease (2025) · cites this paper as [145]
The section on nanoparticle–endothelial cell interactions (page unavailable) reports that melittin nanoparticles rapidly targeted liver sinusoidal endothelial cells and altered the hepatic immune environment. It does not report efficacy for ion-channel modulators or propose adapting liver-targeted delivery to Piezo1 therapies. Piezo1 appears in the supplied References passage, not as a delivery application. (LLM, conf=0.85)
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- Authors
- Lin, Q., Fathi, P., & Chen, X.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Chen, Xiaoyuan
- Venue
- eBioMedicine
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 59
- Pages
- 102958
- ISSN
- 2352-3964 (ISSN-L)
- PMC
- PMC7452383
- OpenAlex
- W3080342211
- Cited by
- 48
- References
- 69
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 9 · 2023: 10 · 2022: 7 · 2021: 4 · 2020: 2
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- EBioMedicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- nanoparticle delivery, intravital imaging, nanomedicine, nanoparticle-cell interactions, nanoparticle transport, clinical translation of nanomedicine, nanomaterial design
- MeSH terms
- Theranostic Nanomedicine, Intravital Microscopy, Animals, Humans, Macrophages, Monocytes, Neutrophils, Permeability, Endothelial Cells, Nanoparticles, Molecular Imaging
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