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Cited by 165Psychedelics and Drug StudiesAlkaloids: synthesis and pharmacologyForensic Toxicology and Drug Analysis

The DOI matches its Crossref record; 26 of the 29 references it cites were found in a registry or an index.

Pattern of use and subjective effects of Salvia divinorum among recreational users

González, Débora, Riba, Jordi, Bouso, José Carlos, Gómez-Jarabo, Gregorio, Barbanoj, Manel J.·2006·Drug and Alcohol Dependence
DOI 10.1016/j.drugalcdep.2006.04.001
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Abstract

Background Salvia divinorum is a member of the Lamiaceae family and contains the psychotropic diterpene and kappa-opioid receptor agonist salvinorin-A. Originally a shamanic inebriant used by the Mexican Mazatec Indians, the plant and its preparations are becoming increasingly popular among non-traditional users.Methods Demographic data and information on pattern of use and subjective effects were obtained by means of self-report questionnaires from a sample of 32 recreational users of salvia and other psychedelics.Results Involvement with salvia appeared to be a recent phenomenon. Smoking the extract was the preferred form of administration. Subjective effects were described as intense but short-lived, appearing in less than 1 min and lasting 15 min or less. They included psychedelic-like changes in visual perception, mood and somatic sensations, and importantly, a highly modified perception of external reality and the self, leading to a decreased ability to interact with oneself or with one's surroundings.Conclusions Although some aspects of the subjective effects reported were similar to high doses of classical psychedelics with serotonin-2A receptor agonist activity, the intense derealization and impairment reported appear to be a characteristic of salvia. The observed simultaneous high scores on the LSD and PCAG subscales of the Addiction Research Center Inventory (ARCI) have been previously reported for other kappa-opioid agonists, and support kappa receptor activation as the probable pharmacologic mechanism underlying the modified state of awareness induced by salvia.

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Research works printed but not linked: 2

  1. Ott, 1995, Ethnopharmacognosy and human pharmacology of Salvia divinorum and salvinorin A, Curare, 18, 103
  2. Wasson, 1962, vol. 20

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Metadata

Authors
González, D., Riba, J., Bouso, J. C., Gómez-Jarabo, G., & Barbanoj, M. J.
Affiliations
  • Universidad Autónoma de Madrid (ES)
  • Universitat Autònoma de Barcelona (ES)
Corresponding author
Barbanoj, Manel J.
ORCID
Venue
Drug and Alcohol Dependence
Publisher
Elsevier BV
Published
2006-11
Volume
85
Issue
2
Pages
157-162
ISSN
0376-8716 (ISSN-L)
DOI
10.1016/j.drugalcdep.2006.04.001
OpenAlex
W2168830964
Cited by
163
References
29
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 12 · 2015: 7 · 2014: 6 · 2013: 9 · 2012: 19
FWCI
12.16
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Drug and Alcohol Dependence (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
Keywords
Salvia divinorum, salvinorin A, kappa opioid receptor agonists, recreational drug use, subjective effects, derealization, psychedelic effects, Addiction Research Center Inventory
MeSH terms
Adult, Affect, Cross-Sectional Studies, Diterpenes, Euphoria, Female, Humans, Male, Perception, Plant Extracts, Reality Testing, Retrospective Studies, Sensation, Spain, Illicit Drugs, Receptors, Opioid, kappa, Substance-Related Disorders, Salvia, Diterpenes, Clerodane

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