The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Modafinil for the treatment of cocaine dependence
Open accessAbstract
Aim Modafinil was tested for efficacy in facilitating abstinence in cocaine-dependent patients, compared to placebo.Methods This was a double-blind placebo-controlled study, with 12 weeks of treatment and a 4-week follow-up. Six outpatient substance abuse treatment clinics participated in the study. There were 210 treatment-seekers randomized, having a diagnosis of cocaine dependence; 72 participants were randomized to placebo, 69 to modafinil 200mg, and 69 to modafinil 400mg, taken once daily on awakening. Participants came to the clinic three times per week for assessments and urine drug screens, and had one hour of individual psychotherapy weekly. The primary outcome measure was the weekly percentage of cocaine non-use days.Results The GEE regression analysis showed that for the total sample, there was no significant difference between either modafinil group and placebo in the change in average weekly percent of cocaine non-use days over the 12-week treatment period (p>0.79). However, two secondary outcomes showed significant effects by modafinil 200mg: the maximum number of consecutive non-use days for cocaine (p=0.02), and a reduction in craving (p=0.04). Also, a post hoc analysis showed a significant effect of modafinil that increased the weekly percentage of non-use days in the subgroup of those cocaine patients who did not have a history of alcohol dependence (p<0.02).Conclusions These data suggest that modafinil, in combination with individual behavioral therapy, was effective for increasing cocaine non-use days in participants without co-morbid alcohol dependence, and in reducing cocaine craving.
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In the citing paper
“In addition, StUD is associated with moderate cognitive deficits.224”
From The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder (2024) · cites this paper as [224]
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“Modafinil is a non-amphetamine stimulant with DA and glutamatergic effects, and with moderate effectiveness for the treatment of cocaine dependence [178] and possibly methamphetamine dependence [179].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [178]
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Cites
Results from the 2003 National Survey on Drug Use and Health: National Findings
(2004) · PsycEXTRA Dataset · doi:10.1037/e400442005-001 · Cited by 1,245
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
Boutrel, B., Kenny, P. J., Specio, S. E., Martin-Fardon, R., Markou, A., Koob, G. F., & de Lecea, L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507480102 · Cited by 520 · cited 1×
“N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript administration in rats (Boutrel et al., 2005).”
Hypothalamic Arousal Regions Are Activated during Modafinil-Induced Wakefulness
Scammell, T. E., Estabrooke, I. V., McCarthy, M. T., Chemelli, R. M., Yanagisawa, M., Miller, M. S., & Saper, C. B. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08620.2000 · Cited by 484 · cited 1×
“Via its actions on the hypocretin/orexin system (Scammell et al., 2000) and the glutamate/GABA (gammaAminobutyric Acid) systems (Ferraro et al., 1997) modafinil could help restore the homeostasis disturbed by chronic cocaine use.”
BackgroundA Double-Blind, Placebo-Controlled Trial of Modafinil for Cocaine Dependence
Dackis, C. A., Kampman, K. M., Lynch, K. G., Pettinati, H. M., & O'Brien, C. P. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300600 · Cited by 391 · cited 3×
“Finally, modafinil was safe and well tolerated in Phase I interaction studies with cocaine (Donovan et al., 2005; Dackis et al., 2003), and in a pilot study on cocaine dependence treatment (n = 62) it was superior to placebo at promoting cocaine abstinence (Dackis et al., 2005).”
BackgroundMethodResultSelf-citationA pilot trial of topiramate for the treatment of cocaine dependence
Kampman, K. M., Pettinati, H. M., Lynch, K. G., Dackis, C. A., Sparkman, T., Weigley, C., & O’Brien, C. P. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.03.008 · Cited by 313 · cited 1×
“Our results are in line with those from other recent clinical trials for treatment of stimulant dependence (Kampman et al., 2004; Elkashef et al., 2008), where no single medication has been shown to help most patients, but rather, some subgroups seem to respond to a specific medication.”
ResultSelf-citationProperties of the urn randomization in clinical trials
Wei, L. J., & Lachin, J. M. (1988) · Controlled Clinical Trials · doi:10.1016/0197-2456(88)90048-7 · Cited by 308
Turner, D. C., Clark, L., Dowson, J., Robbins, T. W., & Sahakian, B. J. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.008 · Cited by 301 · cited 1×
“Modafinil improves cognition and mood (Turner et al., 2004; Taneja et al., 2007), and has shown efficacy in the treatment of child and adult attention deficit hyperactivity disorder (Lindsay et al., 2006).”
BackgroundBupropion for the treatment of methamphetamine dependence
Elkashef, A. M., Rawson, R. A., Anderson, A. L., Li, S.-H., Holmes, T., Smith, E. V., Chiang, N., Kahn, R., Vocci, F., Ling, W., et al. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301481 · Cited by 234 · cited 1×
“Our results are in line with those from other recent clinical trials for treatment of stimulant dependence (Kampman et al., 2004; Elkashef et al., 2008), where no single medication has been shown to help most patients, but rather, some subgroups seem to respond to a specific medication.”
ResultSelf-citationAn evaluation of the abuse potential of modafinil using methylphenidate as a reference
Jasinski, D. R. (2000) · Journal of Psychopharmacology · doi:10.1177/026988110001400107 · Cited by 234 · cited 1×
“Briefly, modafinil has stimulant properties, which could be therapeutic for alleviating some stimulant withdrawal symptoms (Malcolm et al., 2002; Jasinski, 2000), and in human laboratory test paradigms it has been found to attenuate subjective responses to cocaine (Dackis et al., 2003) and the…”
BackgroundA double-blind, placebo-controlled trial of modafinil for cocaine dependence
Dackis, C. A., Kampman, K. M., Lynch, K. G., Plebani, J. G., Pettinati, H. M., Sparkman, T., & O'Brien, C. P. (2012) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2011.12.014 · Cited by 187
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Research works printed but not linked: 1
- United Nations Office on Drugs and Crime, 2007. World Drug Report 2007. United Nations: New York, NY, pp. 82f.
Cited by
Sorted by citations
Scofield, M. D., Heinsbroek, J. A., Gipson, C. D., Kupchik, Y. M., Spencer, S., Smith, A. C. W., Roberts-Wolfe, D., & Kalivas, P. W. (2016) · Pharmacological Reviews · doi:10.1124/pr.116.012484 · Cited by 598
“A third trial (Anderson et al., 2009) demonstrated no overall efficacy in the primary outcome measure (total percentage of nonuse days) but post hoc analyses revealed an increased number of consecutive nonuse days, reduced craving, and an increased percentage of nonuse days among patients without a history of alcohol…”
BackgroundAngarita, G. A., Emadi, N., Hodges, S. E., & MORGAN, P. T. (2016) · Addiction Science & Clinical Practice · doi:10.1186/s13722-016-0056-7 · Cited by 376
“, [12, 63, 64, 176]), its effects on sleep and its pro-cognitive effects position it as the best candidate at present for a viable pharmacotherapy for cocaine use disorders.”
BackgroundDichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299
“for the treatment of cocaine dependence [178] and possibly methamphetamine dependence [179].”
BackgroundFeil, J., Sheppard, D., Fitzgerald, P. B., Yücel, M., Lubman, D. I., & Bradshaw, J. L. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.03.001 · Cited by 342
“For example, Modafinil, a catecholaminergic agonist, increases extracellular dopamine in the prefrontal cortex, and has been investigated for its applicability in treating cocaine dependence (Anderson et al., 2009; Dackis et al., 2004).”
BackgroundThe treatment of cocaine use disorder
Kampman, K. M. (2019) · Science Advances · doi:10.1126/sciadv.aax1532 · Cited by 250
Metadata
- Authors
- Anderson, A. L., Reid, M. S., Li, S.-H., Holmes, T., Shemanski, L., Slee, A., Smith, E. V., Kahn, R., Chiang, N., Vocci, F., Ciraulo, D., Dackis, C., Roache, J. D., Salloum, I. M., Somoza, E., Urschel, H. C., & Elkashef, A. M.
- Affiliations
- National Institutes of Health (US)
- New York University (US)
- Stanford Medicine (US)
- Boston University (US)
- University of Pennsylvania (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Miami (US)
- Corresponding author
- Anderson, Ann L.
- ORCID
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 104
- Issue
- 1-2
- Pages
- 133-139
- ISSN
- 0376-8716 (ISSN-L)
- PMC
- PMC2818032
- OpenAlex
- W2140991283
- Cited by
- 235
- References
- 27
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 15 · 2023: 10 · 2022: 10 · 2021: 15 · 2020: 8 · 2019: 9 · 2018: 7 · 2017: 4 · 2016: 20 · 2015: 15 · 2014: 20 · 2013: 15 · 2012: 28
- FWCI
- 15.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 DA999999)
- National Institute on Drug Abuse (N01DA-3-8838)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- modafinil, cocaine dependence, cocaine abstinence, cocaine craving, stimulant use disorder, individual psychotherapy
- MeSH terms
- Modafinil, Adult, Alcoholism, Central Nervous System Stimulants, Benzhydryl Compounds, Combined Modality Therapy, Double-Blind Method, Ethnicity, Female, Humans, Male, Patient Compliance, Psychiatric Status Rating Scales, Psychotherapy, Risk Factors, Socioeconomic Factors, Urinalysis, Treatment Outcome, Cocaine-Related Disorders
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