Drug-related stimuli impair inhibitory control in cocaine abusers
Open accessAbstract
Background Cocaine users show impaired inhibitory control on cued go/no-go tasks and attention bias to drug-related stimuli in the emotional Stroop task. The results of a previous study suggested that there is a relationship between inhibitory control and attention bias in alcohol drinkers such that the presentation of alcohol-related images as a go cue in a cued go/no-go task significantly impaired inhibitory control compared to neutral images as a go cue. The present study determined the generality of these previous findings by assessing inhibitory control in cocaine users utilizing a modified cued go/no-go task with cocaine or neutral images as the cues.Methods Non-treatment seeking cocaine users (N=30) completed the modified task after completing detailed measures of demographics and drug use. Participants were matched on basic demographic factors and were assigned to groups in which they saw either a cocaine or neutral image as the go cue.Results Participants assigned to the cocaine image go cue condition had a significantly higher proportion of inhibitory failures to the no-go target than their counterparts assigned to the neutral cue condition, but there were no group differences on reaction time (i.e., accuracy was not traded for speed).Conclusions Cocaine users were less able to inhibit pre-potent responses when a cocaine-related image served as the go cue than when a neutral image served as the go cue, consistent with previous research in alcohol users. The outcomes suggest that cocaine-related cues produce disinhibition, perhaps contributing to the high incidence of relapse or continued cocaine use.
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Subjects with specific Internet-use disorders may have difficulties in inhibiting responses to stimuli, which represent their first-choice-use.
“We hypothesize that subjects with specific Internet-use disorders may have difficulties in inhibiting responses to stimuli, which represent their first-choice-use, as has been shown in binge drinkers (Czapla et al., 2015) and substancedependent individuals (e.g., Pike et al., 2013).”
From Integrating psychological and neurobiological considerations regarding the development and maintenance of specific Internet-use disorders: An Interaction of Person-Affect-Cognition-Execution (I-PACE) model (2016) · cites this paper as Pike et al., 2013
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- Authors
- Pike, E., Stoops, W. W., Fillmore, M. T., & Rush, C. R.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Rush, Craig R.
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 133
- Issue
- 2
- Pages
- 768-771
- ISSN
- 0376-8716 (ISSN-L)
- PMC
- PMC3818419
- OpenAlex
- W2014370373
- Cited by
- 46
- References
- 10
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 12 · 2016: 3 · 2015: 7 · 2014: 6
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01DA025591, R21DA035481, R21DA034095, R01DA025032, R01DA032254, R01 DA025031)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- cocaine use, inhibitory control, drug-related cues, attentional bias, emotional Stroop task, disinhibition, relapse, substance use disorders
- MeSH terms
- Adult, Attention, Cues, Female, Humans, Inhibition, Psychological, Male, Middle Aged, Psychomotor Performance, Socioeconomic Factors, Cocaine-Related Disorders
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