Examining the psychological mechanisms of psilocybin-assisted smoking cessation treatment: a pilot study
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Acute disruption of the default-mode network and mystical-type experiences have been strongly correlated with observed benefits of psychedelics, but the remaining proposed mechanisms still require conclusive testing.
“Of these proposed mechanisms, the acute disruption of the DMN, as well as mystical-type experiences, have been strongly correlated with observed benefits, but the remainder still require conclusively testing (49, 50).”
From Examining the Potential Synergistic Effects Between Mindfulness Training and Psychedelic-Assisted Therapy (2021) · cites this paper as [49]
The anti-depressive and anxiolytic effects of psychedelic-assisted therapy are thought to be mediated by mystical experiences and disrupted cortical connectivity.
“These anti-depressive and anxiolytic effects are thought to in turn be mediated by enhancements in decentring and cognitive flexibility, in the case of mindfulness intervention (16, 19), vs. mystical experiences and disrupted cortical connectivity in the case of psychedelic-assisted therapy (49, 50).”
From Examining the Potential Synergistic Effects Between Mindfulness Training and Psychedelic-Assisted Therapy (2021) · cites this paper as [49]
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Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study
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Roseman, L., Nutt, D. J., & Carhart-Harris, R. L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00974 · Cited by 808 · see citing works
Psychedelics, meditation, and self-consciousness
Millière, R., Carhart-Harris, R. L., Roseman, L., Trautwein, F.-M., & Berkovich-Ohana, A. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.01475 · Cited by 390 · see citing works
Emotional breakthrough and psychedelics: Validation of the Emotional Breakthrough Inventory
Roseman, L., Haijen, E., Idialu-Ikato, K., Kaelen, M., Watts, R., & Carhart-Harris, R. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119855974 · Cited by 413 · see citing works
A systematic study of microdosing psychedelics
Polito, V., & Stevenson, R. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211023 · Cited by 235 · see citing works
Hartogsohn, I. (2020) · The MIT Press eBooks · doi:10.7551/mitpress/11888.001.0001 · Cited by 158 · see citing works
Van Court, R. C., Wiseman, M. S., Meyer, K. W., Ballhorn, D. J., Amses, K. R., Slot, J. C., Dentinger, B. T. M., Garibay-Orijel, R., & Uehling, J. K. (2022) · Fungal Biology · doi:10.1016/j.funbio.2022.01.003 · Cited by 94 · see citing works
Eleftheriou, M. E., & Thomas, E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.707057 · Cited by 39 · see citing works
“The intensity of mystical experiences has been strongly linked with the magnitude of psychedelic-interventions’ therapeutic effect in numerous studies, where it was shown to be predictive of positive outcomes for depression, addiction and well-being (28, 36, 49, 50, 74, 83, 84), and has been proposed as the treatmentm…”
BackgroundInfluentialPredictors and potentiators of psychedelic-occasioned mystical experiences
Gandy, S. (2022) · Journal of Psychedelic Studies · doi:10.1556/2054.2022.00198 · Cited by 26 · see citing works
Dressler, H. M., Bright, S. J., & Polito, V. (2021) · Journal of Psychedelic Studies · doi:10.1556/2054.2021.00157 · Cited by 14 · see citing works
A Systematic Study of Microdosing PsychedelicsPreprint
Polito, V., & Stevenson, R. J. (2018) · doi:10.31234/osf.io/cw9qs · Cited by 13 · see citing works
Klučková, T., Nikolič, M., Tylš, F., Viktorin, V., Vejmola, Č., Viktorinová, M., Bravermanová, A., Androvičová, R., Andrashko, V., Korčák, J., et al. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00742-5 · Cited by 8 · see citing works
Shaw, L. (2018) · UVic’s Research and Learning Repository (University of Victoria)
- Authors
- Garcia-Romeu, A. P., Johnson, M. W., & Griffiths, R. R.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 140
- Pages
- e66
- ISSN
- 0376-8716 (ISSN-L)
- OpenAlex
- W2111139037
- Cited by
- 13
- References
- 1
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 4 · 2015: 1
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- smoking cessation, psychological mechanisms, modafinil, methamphetamine dependence, motivational interviewing, dose selection
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