Distribution of CB1 cannabinoid receptors and their relationship with mu-opioid receptors in the rat periaqueductal gray

Wilson-Poe, A.R.; Morgan, M.M.; Aicher, S.A.; Hegarty, D.M.

doi:10.1016/j.neuroscience.2012.03.038

Cited by 79Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsNeuropeptides and Animal Physiology

Distribution of CB1 cannabinoid receptors and their relationship with mu-opioid receptors in the rat periaqueductal gray

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Wilson-Poe, A.R., Morgan, M.M., Aicher, S.A., Hegarty, D.M.·2012·Neuroscience

DOI 10.1016/j.neuroscience.2012.03.038PMC PMC3367071

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Abstract

The periaqueductal gray (PAG) is part of a descending pain modulatory system that, when activated, produces widespread and profound antinociception. Microinjection of either opioids or cannabinoids into the PAG elicits antinociception. Moreover, microinjection of the cannabinoid 1 (CB1) receptor agonist HU-210 into the PAG enhances the antinociceptive effect of subsequent morphine injections, indicating a direct relationship between these two systems. The objective of this study was to characterize the distribution of CB1 receptors in the dorsolateral and ventrolateral PAG in relationship to mu-opioid peptide (MOP) receptors. Immunocytochemical analysis revealed extensive and diffuse CB1 receptor labeling in the PAG, 60% of which was found in somatodendritic profiles. CB1 and MOP receptor immunolabeling were co-localized in 32% of fluorescent Nissl-stained cells that were analyzed. Eight percent (8%) of PAG neurons that were MOP receptor-immunoreactive (-ir) received CB1 receptor-ir appositions. Ultrastructural analysis confirmed the presence of CB1 receptor-ir somata, dendrites and axon terminals in the PAG. These results indicate that behavioral interactions between cannabinoids and opioids may be the result of cellular adaptations within PAG neurons co-expressing CB1 and MOP receptors.

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Authors: Wilson-Poe, A. R., Morgan, M. M., Aicher, S. A., & Hegarty, D. M.
Affiliations: Washington State University Vancouver (US)
Oregon Health & Science University (US)
Corresponding author: Morgan, M.M.
Aicher, S.A.
Hegarty, D.M.
ORCID: Morgan, M.M.
Aicher, S.A.
Hegarty, D.M.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2012-06
Volume: 213
Pages: 191-200
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2012.03.038
PMC: PMC3367071
OpenAlex: W2085789686
Cited by: 79
References: 62
Citations by year: 2026: 3 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 8 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 2
FWCI: 4.70
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (DA-011322, R01DA011322, R03DA026591, DA026591)
National Institute of Neurological Disorders and Stroke (P30NS061800)
National Institute of Dental and Craniofacial Research (DE012640, R01DE012640)
National Center for Research Resources (S10RR016858, RR-016858)
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: CB1 receptor, mu-opioid receptor, periaqueductal gray, receptor colocalization, descending pain modulation, antinociception, morphine, HU-210, opioid-cannabinoid interaction, receptor ultrastructure
MeSH terms: Animals, Immunohistochemistry, Male, Neurons, Periaqueductal Gray, Rats, Sprague-Dawley, Receptors, Opioid, mu, Microscopy, Confocal, Receptor, Cannabinoid, CB1, Microscopy, Electron, Transmission, Rats

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Distribution of CB1 cannabinoid receptors and their relationship with mu-opioid receptors in the rat periaqueductal gray

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