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Abuse liability assessment of the JUUL system in four flavors relative to combustible cigarette, nicotine gum and a comparator electronic nicotine delivery system among adult smokers

Goldenson, Nicholas I., Buchhalter, August R., Augustson, Erik M., Rubinstein, Mark L., Henningfield, Jack E.·2020·Drug and Alcohol Dependence
DOI 10.1016/j.drugalcdep.2020.108395
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Abstract

Background The abuse liability of the JUUL System (JS) in four flavors were evaluated compared to combustible cigarettes, nicotine gum, and a comparator electronic nicotine delivery system (ENDS) with pharmacokinetics (PK) and subjective effects. Methods Adult smokers (N = 66; 50.0 % female; mean age = 41.1; 63.6 % white) completed a 7-arm within-subjects cross-over product-use study while confined to a clinical laboratory. Participants used JS in four flavors (Virginia Tobacco, Mango, Mint, Creme, [5.0 % nicotine; 59 mg/mL]), their usual brand (UB) cigarette, a comparator ENDS (VUSE Solo; 4.8 % nicotine, tobacco-flavor), and mint nicotine gum (4 mg) under controlled use conditions. After each product use, nicotine PK and subjective effects were assessed. Results Maximum plasma nicotine levels (C max-BL ), rate of plasma nicotine rise, overall nicotine exposure (AUC 0-60-BL ), and subjective liking and satisfaction of JS were significantly lower than UB cigarettes. These parameters were generally greater for JS than nicotine gum; the comparator ENDS was somewhat lower but within the range of JS. Nicotine PK did not differ among the Mint, Mango, and Virginia Tobacco JS flavors. Mint and Mango were rated as more satisfying than Virginia Tobacco and Creme. Conclusions Controlled use of JS among adult smokers resulted in nicotine delivery, product liking, and satisfaction that were less than that of combustible cigarettes but generally greater than nicotine gum. These results sup…

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Metadata

Authors
Goldenson, N. I., Buchhalter, A. R., Augustson, E. M., Rubinstein, M. L., & Henningfield, J. E.
Venue
Drug and Alcohol Dependence
Publisher
Elsevier BV
Published
2020-12
Volume
217
Pages
108395
ISSN
0376-8716
DOI
10.1016/j.drugalcdep.2020.108395
Cited by
30
References
2
Language
en
Licence
Funders
Juul Labs, Inc.

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CoChat. (2026). Citation check: Abuse liability assessment of the JUUL system in four flavors relative to combustible cigarette, nicotine gum and a comparator electronic nicotine delivery system among adult smokers. https://app.cochat.ai/papers/10.1016/j.drugalcdep.2020.108395
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Goldenson, N. I., Buchhalter, A. R., Augustson, E. M., Rubinstein, M. L., & Henningfield, J. E. (2020). Abuse liability assessment of the JUUL system in four flavors relative to combustible cigarette, nicotine gum and a comparator electronic nicotine delivery system among adult smokers. Drug and Alcohol Dependence. https://doi.org/10.1016/j.drugalcdep.2020.108395