The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Implication of microRNAs in drug resistance for designing novel cancer therapy
Open accessAbstract
Recently, microRNAs (miRNAs) have received increasing attention in the field of cancer research. miRNAs play important roles in many normal biological processes; however, the aberrant miRNA expression and its correlation with the development and progression of cancers is an emerging field. Therefore, miRNAs could be used as biomarkers for diagnosis of cancer and prediction of prognosis. Importantly, some miRNAs could regulate the formation of cancer stem cells and the acquisition of epithelial-mesenchymal transition, which are critically associated with drug resistance. Moreover, some miRNAs could target genes related to drug-sensitivity, resulting in the altered sensitivity of cancer cells to anti-cancer drugs. Emerging evidences have also shown that knock-down or re-expression of specific miRNAs by synthetic antisense oligonucleotides or pre-miRNAs could induce drug sensitivity, leading to increased inhibition of cancer cell growth, invasion, and metastasis. More importantly, recent studies have shown that natural agents including isoflavone, 3,3′-diindolylmethane, and (−)-epigallocatechin-3-gallate altered miRNA expression profiles, leading to an increased sensitivity of cancer cells to conventional therapeutics. These emerging results suggest that specific targeting of miRNAs by different approaches could open new avenues for cancer treatment through overcoming drug resistance and thereby improve the outcome of cancer therapy.
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Cites
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Cited by
Structure and dynamics of molecular networks: A novel paradigm of drug discovery
Csermely, P., Korcsmáros, T., Kiss, H. J. M., London, G., & Nussinov, R. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.016 · Cited by 892
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Pancreatic cancer: understanding and overcoming chemoresistance
Wang, Z., Li, Y., Ahmad, A., Banerjee, S., Azmi, A. S., Kong, D., & Sarkar, F. H. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.188 · Cited by 364
Self-citationMicroRNA regulation of core apoptosis pathways in cancer
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miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2
Zhu, W., Zhu, D., Lu, S., Wang, T., Wang, J., Jiang, B., Shu, Y., & Liu, P. (2012) · Medical Oncology · doi:10.1007/s12032-010-9797-4 · Cited by 189
Metadata
- Authors
- Sarkar, F. H., Li, Y., Wang, Z., Kong, D., & Ali, S.
- Venue
- Drug Resistance Updates
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 13
- Issue
- 3
- Pages
- 57-66
- ISSN
- 1368-7646 (ISSN-L)
- OpenAlex
- W2000378868
- Cited by
- 215
- References
- 9
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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