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Cited by 67Prenatal Substance Exposure EffectsMaternal Mental Health During Pregnancy and PostpartumSubstance Abuse Treatment and Outcomes

Binge alcohol exposure once a week in early pregnancy predicts temperament and sleeping problems in the infant

Alvik, Astrid, Torgersen, Anne Mari, Aalen, Odd O., Lindemann, Rolf·2011·Early Human Development
DOI 10.1016/j.earlhumdev.2011.06.009
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Abstract

Background Prenatal alcohol exposure can cause several cognitive and behavioral difficulties. Few studies have investigated the associations with infant temperament or sleeping patterns. Our aim was to study potential associations between early prenatal binge exposure and infant temperament and sleeping pattern.Methods In a population based longitudinal study, representative of pregnant women in Oslo, questionnaires were answered at 17 and 30weeks of pregnancy and 6months after term. Two factors, difficult temperament and sleeping problems, were identified using Principal Component Analysis and dichotomized at the least optimal 14-15%. Logistic regression analyses identified predictive factors.Results Maternal binge drinking (≥5 drinks per occasion) once a week during pregnancy week 0-6 significantly predicted both difficult temperament (Odds Ratio OR 3.3**; 95% Confidence interval CI 1.4-7.9) and sleeping problems (OR 5.3**; 95% CI 2.1-13.7) in the infant, after adjusting for other confounding factors. Including binge drinking more often than once a week, further increased the OR of sleeping problems (6.0***; 2.7-13.7). Prenatal maternal depressive symptoms also predicted both outcomes. Reduced birth weight predicted difficult temperament. Maternal satisfaction with life reduced the probability of sleeping problems. Maternal smoking, and work stress, during pregnancy had no predictive power. The results were not explained by binge drinking later during pregnancy or higher consumption per occasion.Conclusions Binge drinking once a week during pregnancy week 0-6 had stronger predictive power of difficult temperament and sleeping problems during infancy, than other covariates. The findings support advising women to avoid binge drinking when planning pregnancy.

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Authors
Alvik, A., Torgersen, A. M., Aalen, O. O., & Lindemann, R.
Affiliations
  • University of Oslo (NO)
  • Oslo University Hospital (NO)
Corresponding author
Alvik, Astrid
ORCID
Aalen, Odd O.
Venue
Early Human Development
Publisher
Elsevier BV
Published
2011-12
Volume
87
Issue
12
Pages
827-833
ISSN
0378-3782 (ISSN-L)
DOI
10.1016/j.earlhumdev.2011.06.009
OpenAlex
W2025014175
Cited by
67
References
47
Citations by year
2026: 3 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 5
FWCI
3.55
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Early Human Development (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Sogn Centre for Child and Adolescent Psychiatry, University of Oslo
  • Centre for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo
  • The Norwegian ExtraFoundation for Health and Rehabilitation
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
prenatal alcohol exposure, binge drinking, early pregnancy, infant temperament, difficult temperament, infant sleep problems, maternal depressive symptoms, birth weight, maternal smoking, occupational stress, pregnancy advice
MeSH terms
Adult, Alcohol Drinking, Female, Humans, Infant, Longitudinal Studies, Norway, Pregnancy, Prenatal Exposure Delayed Effects, Sleep Wake Disorders, Temperament, Logistic Models, Principal Component Analysis

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