Acute tryptophan depletion and sweet food consumption by overweight adults
Open accessAbstract
Serotonergic involvement has been implicated in preferential consumption of treat foods. We tested the effect of acute tryptophan depletion (ATD) on food consumption by overweight and lean adults with and without a history of recurrent major depressive disorder (MDD). ATD and taste-matched placebo challenges were administered double-blind in counter-balanced order. Participants were classified as lean (n=36) or overweight (n=19) on the basis of body mass index (BMI). Total calorie, carbohydrate, protein, and sweet food consumption were assessed via a test meal 8-h following ATD. Four food items of comparable palatability were offered as a part of the test: two sweet (one carbohydrate-rich, and one protein-rich) and two non-sweet (one carbohydrate-rich, and one protein-rich). As compared to the placebo challenge, ATD significantly increased sweet calorie intake among overweight participants and increased their propensity to consume sweet food first before any other type of food. Lean participants' sweet calorie intake and food preference were unaffected by ATD. Findings suggest serotonergic involvement in the sweet food consumption by overweight individuals.
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Lowering of CNS serotonin by acute tryptophan depletion resulted in increased sweet calorie intake and a heightened preference for sweet foods in overweight but not normal weight individuals.
“For example, a study of 55 women showed that lowering of CNS serotonin by acute tryptophan depletion resulted in increased sweet calorie intake and a heightened preference for sweet foods in overweight but not normal weight individuals 24.”
From History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity (2019) · cites this paper as [24]
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Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580 · see citing works
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346 · see citing works
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190 · see citing works
Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002.
Hedley, A. A., Ogden, C., Johnson, C. L., Carroll, M., Curtin, L. R., & Flegal, K. (2004) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.291.23.2847 · Cited by 4,670 · see citing works
Separate neural systems value immediate and delayed monetary rewards
McClure, S. M., Laibson, D. I., Loewenstein, G., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1100907 · Cited by 3,089 · see citing works
The psychology and neurobiology of addiction: an incentive–sensitization view
Robinson, T. E., & Berridge, K. C. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.19.x · Cited by 1,507 · see citing works
Time Discounting for Primary Rewards
McClure, S. M., Ericson, K. M., Laibson, D. I., Loewenstein, G., & Cohen, J. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4246-06.2007 · Cited by 971 · see citing works
Serotonin Function and the Mechanism of Antidepressant Action
Delgado, P. L. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810170011002 · Cited by 930 · see citing works
Randomized Trial of Lifestyle Modification and Pharmacotherapy for Obesity
Wadden, T. A., Berkowitz, R. I., Womble, L. G., Sarwer, D. B., Phelan, S., Cato, R. K., Hesson, L. A., Osei, S. Y., Kaplan, R., & Stunkard, A. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050156 · Cited by 794 · see citing works
Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops
Tanaka, S. C., Doya, K., Okada, G., Ueda, K., Okamoto, Y., & Yamawaki, S. (2004) · Nature Neuroscience · doi:10.1038/nn1279 · Cited by 779 · see citing works
Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission
Alex, K. D., & Pehek, E. A. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.08.004 · Cited by 658 · see citing works
Chronic stress and comfort foods: Self-medication and abdominal obesity
Dallman, M. F., Pecoraro, N. C., & la Fleur, S. E. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2004.11.004 · Cited by 656 · see citing works
Obesity: Responding to the global epidemic.
Wadden, T. A., Brownell, K. D., & Foster, G. D. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.70.3.510 · Cited by 594 · see citing works
Pecoraro, N., Reyes, F., Gomez, F., Bhargava, A., & Dallman, M. F. (2004) · Endocrinology · doi:10.1210/en.2004-0305 · Cited by 574 · see citing works
Hariri, A. R., Brown, S. M., Williamson, D. E., Flory, J. D., de Wit, H., & Manuck, S. B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3446-06.2006 · Cited by 557 · see citing works
Obesity: Responding to the global epidemic.
Wadden, T. A., Brownell, K. D., & Foster, G. D. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.70.3.510 · Cited by 433 · see citing works
Relapse of depression after rapid depletion of tryptophan
Smith, K., Fairburn, C. G., & Cowen, P. J. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07044-4 · Cited by 428 · see citing works
Minireview: Glucocorticoids—Food Intake, Abdominal Obesity, and Wealthy Nations in 2004
Dallman, M. F., la Fleur, S. E., Pecoraro, N. C., Gómez-Oliver, F., Houshyar, H., & Akana, S. F. (2004) · Endocrinology · doi:10.1210/en.2004-0037 · Cited by 413 · see citing works
Food preferences in human obesity: Carbohydrates versus fats
Drewnowski, A., Kurth, C., Holden‐Wiltse, J., & Saari, J. (1992) · Appetite · doi:10.1016/0195-6663(92)90198-f · Cited by 292 · see citing works
Delgado, P. L. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950110025005 · Cited by 289 · see citing works
Neumeister, A., Nugent, A. C., Waldeck, T., Geraci, M., Schwarz, M., Bonne, O., Bain, E. E., Luckenbaugh, D. A., Herscovitch, P., Charney, D. S., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.765 · Cited by 273 · see citing works
Serotonin and tolerance to delay of reward in rats
Bizot, J., Bihan, C. L., Puech, A. J., Hamon, M., & Thiébot, M.-H. (1999) · Psychopharmacology · doi:10.1007/pl00005485 · Cited by 252 · see citing works
Jimerson, D. C. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820020052007 · Cited by 219 · see citing works
Salamone, J. D., Cousins, M. S., McCullough, L. D., Carriero, D. L., & Berkowitz, R. J. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90452-9 · Cited by 196 · see citing works
Kelley, A. E., Schiltz, C. A., & Landry, C. F. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.06.018 · Cited by 193 · see citing works
Hypothalamic serotonin in the control of meal patterns and macronutrient selection
Shor‐Posner, G., Grinker, J. A., Marinescu, C., Brown, O., & LEIBOWITZ, S. F. (1986) · Brain Research Bulletin · doi:10.1016/0361-9230(86)90198-x · Cited by 193 · see citing works
Separate systems for serotonin and leptin in appetite control
Halford, J. C. G., & Blundell, J. E. (2000) · Annals of Medicine · doi:10.3109/07853890008998829 · Cited by 182 · see citing works
Avena, N. M., & Hoebel, B. G. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)01050-x · Cited by 170 · see citing works
Wurtman, J. J., Wurtman, R. J., Growdon, J. H., Henry, P., Lipscomb, A., & Zeisel, S. H. (1981) · International Journal of Eating Disorders · doi:10.1002/1098-108x(198123)1:1 · Cited by 165 · see citing works
Crean, J. P., Richards, J. B., & de Wit, H. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00132-8 · Cited by 155 · see citing works
LeMarquand, D. G., Benkelfat, C., Pihl, R. O., Palmour, R. M., & Young, S. N. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.11.1771 · Cited by 150 · see citing works
Acute Tryptophan Depletion. Part I: Rationale and Methodology
Hood, S. D., Bell, C. J., & Nutt, D. J. (2005) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2005.01627.x · Cited by 135 · see citing works
Rothman, R. B., & Baumann, M. H. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1369.064 · Cited by 123 · see citing works
Carbohydrates, tryptophan, and behavior: A methodological review.
Spring, B. J., Chiodo, J., & Bowen, D. J. (1987) · Psychological Bulletin · doi:10.1037/0033-2909.102.2.234 · Cited by 113 · see citing works
Self-citationMcTavish, D., & Heel, R. C. (1992) · Drugs · doi:10.2165/00003495-199243050-00007 · Cited by 109 · see citing works
Yokogoshi, H., & Wurtman, R. J. (1986) · Metabolism · doi:10.1016/0026-0495(86)90225-8 · Cited by 102 · see citing works
Levitan, R., Masellis, M., Lam, R. W., Muglia, P., Basile, V., Jain, U., Kaplan, A. S., Tharmalingam, S., Kennedy, S. H., & Kennedy, J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300314 · Cited by 100 · see citing works
Roiser, J. P., Blackwell, A. D., Cools, R., Clark, L., Rubinsztein, D. C., Robbins, T. W., & Sahakian, B. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301055 · Cited by 98 · see citing works
Symptomatic Relapse in Bulimia Nervosa Following Acute Tryptophan Depletion
Smith, K., Fairburn, C. G., & Cowen, P. J. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.2.171 · Cited by 88 · see citing works
Acute tryptophan depletion and increased food intake and irritability in bulimia nervosa
Weltzin, T. E., Fernstrom, M. H., Fernstrom, J. D., Neuberger, S. K., & Kaye, W. H. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.11.1668 · Cited by 76 · see citing works
Ruetsch, O., Viala, A., Bardou, H., Martin, P., & Vacheron, M. N. (2005) · L Encéphale · doi:10.1016/s0013-7006(05)82412-1 · Cited by 76 · see citing works
Miller, H., Delgado, P. L., Salomon, R. M., Licinio, J., Barr, L. C., & Charney, D. S. (1992) · The Journal of Clinical Psychiatry · Cited by 70 · see citing works
Olausson, P., Engel, J. A., & Söderpalm, B. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00673-6 · Cited by 69 · see citing works
Wogar, M. A., Bradshaw, C. M., & Szabadi, E. (1991) · Psychopharmacology · doi:10.1007/bf02316873 · Cited by 68 · see citing works
Effects of acute tryptophan depletion on mood in bulimia nervosa
Kaye, W. H., Gendall, K. A., Fernstrom, M. H., Fernstrom, J. D., McConaha, C. W., & Weltzin, T. E. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00108-0 · Cited by 61 · see citing works
Leyton, M. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00262-x · Cited by 60 · see citing works
Nosology of atypical depression
Paykel, E. S., Parker, R. R., Rowan, P., Rao, B., & Taylor, C. N. (1983) · Psychological Medicine · doi:10.1017/s0033291700050133 · Cited by 57 · see citing works
Altered reward value of carbohydrate snacks for female smokers withdrawn from nicotine
Spring, B. J. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.08.008 · Cited by 56 · see citing works
Self-citationPijl, H., Koppeschaar, H. P. F., Willekens, F. L. A., de Kamp, I. O., Veldhuis, H. D., & Meinders, A. E. (1991) · PubMed · Cited by 54 · see citing works
Roiser, J. P., Blackwell, A. D., Cools, R., Clark, L., Rubinsztein, D. C., Robbins, T. W., & Sahakian, B. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301084 · Cited by 47 · see citing works
Dexfenfluramine, Fluoxetine, and Weight Loss Among Female Carbohydrate Cravers
Wurtman, J. J., Wurtman, R. J., Berry, E., Gleason, R. E., Goldberg, H., Mcdermott, J., Kahne, M. J., & Tsay, R. H. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.56 · Cited by 44 · see citing works
Differential effects of serotonergic and catecholaminergic drugs on ingestive behavior
Asin, K. E., Davis, J. D., & Bednarz, L. (1992) · Psychopharmacology · doi:10.1007/bf02247717 · Cited by 41 · see citing works
A Comparison of Sibutramine and Dexfenfluramine in the Treatment of Obesity
Hanotin, C., Thomas, F., Jones, S. P., Leutenegger, É., & Drouin, P. (1998) · Obesity Research · doi:10.1002/j.1550-8528.1998.tb00351.x · Cited by 33 · see citing works
The interaction of diet and stress in rats: High-energy food and sucrose treatment.
Dess, N. K., Choe, S., & Minor, T. R. (1998) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037//0097-7403.24.1.60 · Cited by 32 · see citing works
Oldman, A., Walsh, A. E. L., Salkovskis, P. M., Fairburn, C. G., & Cowen, P. J. (1995) · Psychological Medicine · doi:10.1017/s003329170003748x · Cited by 32 · see citing works
Medial hypothalamic serotonin in the control of eating behavior.
LEIBOWITZ, S. F., Weiss, G. F., & Shor‐Posner, G. (1987) · PubMed · Cited by 24 · see citing works
The interaction of diet and stress in rats: High-energy food and sucrose treatment.
Dess, N. K., Choe, S., & Minor, T. R. (1998) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.24.1.60 · Cited by 24 · see citing works
Spring, B. J., Hitsman, B. L., Pingitore, R., McChargue, D. E., Gunnarsdóttir, E. D., Corsica, J. A., Pergadia, M. L., Doran, N., Crayton, J. W., Baruah, S., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.050 · Cited by 14 · see citing works
Self-citationL-tryptophan does not increase weight loss in carbohydrate-craving obese subjects.
Strain, G. W., Strain, J. J., & Zumoff, B. (1985) · PubMed · Cited by 10 · see citing works
Predictors of weight loss during treatment with d‐fenfluramine
Toornvliet, A. C., Pijl, H., Hopman, E. G. D., Westendorp, R. G. J., & Meinders, A. E. (1997) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1997.131151000.x · Cited by 6 · see citing works
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Gupta, A., Osadchiy, V., & Mayer, E. A. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0341-5 · Cited by 268 · see citing works
Tryptophan metabolism in animals important roles in nutrition and health
Yin, Y. (2010) · Frontiers in Bioscience-Scholar · doi:10.2741/s152 · Cited by 141 · see citing works
The Obesity Epidemic and Food Addiction: Clinical Similarities to Drug Dependence
Fortuna, J. L. (2012) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2012.662092 · Cited by 110 · see citing works
Acute tryptophan depletion in humans: a review of theoretical, practical and ethical aspects
Young, S. N. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120209 · Cited by 110 · see citing works
Occupational burnout, eating behavior, and weight among working women
Nevanperä, N., Hopsu, L., Kuosma, E., Ukkola, O. H., Uitti, J., & Laitinen, J. H. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.014191 · Cited by 107 · see citing works
Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism
Hu, S., Luo, L., Bian, X., Liu, R. H., Zhao, S., Chen, Y., Sun, K., Jiang, J., Liu, Z., & Zeng, L. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c01883 · Cited by 56 · see citing works
Osadchiy, V., Mayer, E. A., Bhatt, R., Labus, J. S., Gao, L., Kilpatrick, L. A., Liu, C., Tillisch, K., Naliboff, B., Chang, L., et al. (2019) · Obesity Science & Practice · doi:10.1002/osp4.362 · Cited by 44 · see citing works
Role of herbal medicine and gut microbiota in the prevention and treatment of obesity
Zhang, Q., Bai, Y., Wang, W., Li, J., Zhang, L., Tang, Y., & Yue, S. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.116127 · Cited by 33 · see citing works
Rebelos, E., Iozzo, P., Guzzardi, M. A., Brunetto, M. R., & Bonino, F. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i30.4999 · Cited by 29 · see citing works
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Plaßmann, H., Schelski, D. S., Simon, M., & Koban, L. (2021) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1562 · Cited by 26 · see citing works
Nutritional Controls of Food Reward
Fernandes, M. F., Sharma, S., Hryhorczuk, C., Auguste, S., & Fulton, S. E. (2013) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2013.04.004 · Cited by 27 · see citing works
Hildebrandt, C. S., Helmbold, K., Linden, M., Langen, K., Filss, C. P., Runions, K., Stewart, R. M., Rao, P., Moore, J. K., Mahfouda, S., et al. (2018) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2018.1428357 · Cited by 26 · see citing works
Brownley, K. A., Boettiger, C. A., Young, L., & Cefalu, W. T. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.03.020 · Cited by 25 · see citing works
Hu, S., Luo, L., & Zeng, L. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2040945 · Cited by 21 · see citing works
Yoo, E.-S., Li, L., Jia, L., Lord, C. C., Lee, C. E., Birnbaum, S. G., Vianna, C. R., Berglund, E. D., Cunningham, K. A., Xu, Y., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109997 · Cited by 15 · see citing works
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Rintamäki, R. M., & Partonen, T. (2011) · Springer eBooks · doi:10.1007/978-0-387-92271-3_37 · Cited by 2 · see citing works
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- Authors
- Pagoto, S. L., Spring, B., McChargue, D., Hitsman, B., Smith, M., Appelhans, B., & Hedeker, D.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Northwestern University (US)
- University of Nebraska–Lincoln (US)
- Brown University (US)
- University of Illinois Chicago (US)
- Corresponding author
- Pagoto, Sherry L.
- ORCID
- Venue
- Eating Behaviors
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 10
- Issue
- 1
- Pages
- 36-41
- ISSN
- 1471-0153 (ISSN-L)
- PMC
- PMC2663793
- OpenAlex
- W1987224160
- Cited by
- 22
- References
- 59
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 1 · 2015: 1 · 2013: 2 · 2012: 2
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Eating Behaviors (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Lincoln (University of Nebraska) (submittedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Institutes of Health (5r01hl059348-04)
- National Heart, Lung, and Blood Institute (K23HL073381, R01 HL59348)
- National Institute on Drug Abuse (K08DA00467, K08DA017145, K08DA000467)
- National Center for Research Resources (UL1RR025741)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- acute tryptophan depletion, serotonergic system, sweets consumption, overweight, food preferences, major depressive disorder, dietary intake, body mass index, carbohydric foods, protein-rich foods
- MeSH terms
- Adult, Dietary Carbohydrates, Dietary Proteins, Double-Blind Method, Female, Food, Food Preferences, Humans, Male, Sweetening Agents, Tryptophan, Body Mass Index, Overweight
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